基本信息
焦保卫  男  博导  中国科学院昆明动物研究所
电子邮件: jiaobaowei@mail.kiz.ac.cn
通信地址: 云南省昆明市教场东路32号
邮政编码: 650201

研究领域

乳腺干细胞;乳腺癌;表观遗传


招生信息

   
招生专业
071009-细胞生物学
071007-遗传学
招生方向
乳腺发育,表观遗传
进化发育

教育背景

2003-09--2007-03 香港中文大学 博士
1996-09--2003-06 西南大学 硕士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2008-10--2013-04 美国马萨诸塞大学医学院 博士后
社会兼职
2013-11--今 云南省细胞学会,秘书长

教授课程

中国科学院大学**论坛

出版信息

   
发表论文
[1] NATURE COMMUNICATIONS. 2024,   通讯作者  
[2] NATURE COMMUNICATIONS. 2024,   通讯作者  
[3] Haili Shao, Jipeng Huang, Hui Wang, Guolei Wang, Xu Yang, Mei Cheng, Changjie Sun, Li Zou, Qin Yang, Dandan Zhang, Zhen Liu, Xuelong Jiang, Lei Shi, Peng Shi, Baowei Han, Baowei Jiao. Fused in sarcoma (FUS) inhibits milk production efficiency in mammals. NATURE COMMUNICATIONS[J]. 2024, 第 16 作者15(1): 1-17, http://dx.doi.org/10.1038/s41467-024-48428-5.
[4] Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. NATURE COMMUNICATIONS[J]. 2024, 第 14 作者15(1): 1-15, https://doaj.org/article/ff1e55a2af4c44968ffc3ccf963bd45c.
[5] Guo, Lu, Ke, Hao, Zhang, Honglei, Zou, Li, Yang, Qin, Lu, Xuemei, Zhao, Limin, Jiao, Baowei. TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms. CELL DEATH & DISEASE[J]. 2022, 第 8 作者  通讯作者  13(5): http://dx.doi.org/10.1038/s41419-022-04867-w.
[6] Li, Xiyin, Wang, Hairui, Yang, Xing, Wang, Xiaoqi, Zhao, Lina, Zou, Li, Yang, Qin, Hou, Zongliu, Tan, Jing, Zhang, Honglei, Nie, Jianyun, Jiao, Baowei. GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling. CANCER LETTERS[J]. 2021, 第 12 作者  通讯作者  514: 90-102, http://dx.doi.org/10.1016/j.canlet.2021.04.028.
[7] Zhao, Lina, Qiu, Ting, Jiang, Dewei, Xu, Haibo, Zou, Li, Yang, Qin, Chen, Ceshi, Jiao, Baowei. SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR. ADVANCED SCIENCE[J]. 2020, 第 8 作者  通讯作者  7(14): https://doaj.org/article/212269c52e6444efb47c9c20c8dcffd1.
[8] Wang, Yue, Zhang, Honglei, Jiao, Baowei, Nie, Jianyun, Li, Xiyin, Wang, Wenhuan, Wang, Hairui. The Roles of Alternative Splicing in Tumor-immune Cell Interactions. CURRENT CANCER DRUG TARGETS. 2020, 第 3 作者  通讯作者  20(10): 729-740, http://dx.doi.org/10.2174/1568009620666200619123725.
[9] Xu, Haibo, Zhao, Lina, Feng, Xu, Ma, Yujie, Chen, Wei, Zou, Li, Yang, Qin, Sun, Jihong, Yu, Hong, Jiao, Baowei. Landscape of genomic imprinting and its functions in the mouse mammary gland. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2020, 第 10 作者  通讯作者  12(11): 857-869, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883822/.
[10] Xu, Haibo, Yang, Xing, Huang, Weiren, Ma, Yujie, Ke, Hao, Zou, Li, Yang, Qin, Jiao, Baowei. Single-cell profiling of long noncodingRNAsand their cell lineage commitment roles viaRNA-DNA-DNAtriplex formation in mammary epithelium. STEM CELLS[J]. 2020, 第 8 作者  通讯作者  38(12): 1594-1611, http://dx.doi.org/10.1002/stem.3274.
[11] Limin Zhao, Hao Ke, Haibo Xu, GuoDong Wang, Honglei Zhang, Li Zou, Shu Xiang, Mengyuan Li, Li Peng, Mingfang Zhou, Lingling Li, Lei Ao, Qin Yang, CheKun James Shen, Ping Yi, Lu Wang, Baowei Jiao. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. NATURE COMMUNICATIONS[J]. 2020, 第 17 作者  通讯作者  11(1): http://dx.doi.org/10.1038/s41467-019-14183-1.
[12] Zhang, Jin, Wei, Feiyu, Ding, Liqun, Wang, Lilin, Zhang, Xi, Yu, Lin, Liu, Rui, Kuang, Xiaohui, Jiao, Baowei, Yang, Bin, Fan, Jie. MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Ca(v)1.2 and Ca(v)1.3 ion channels. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY[J]. 2019, 第 9 作者134: 74-85, http://dx.doi.org/10.1016/j.yjmcc.2019.06.018.
[13] Zhao, Limin, Li, Lingling, Xu, Haibo, Ke, Hao, Zou, Li, Yang, Qin, Shen, CheKun James, Nie, Jianyun, Jiao, Baowei. TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. STEM CELLS AND DEVELOPMENT[J]. 2019, 第 9 作者  通讯作者  28(14): 944-953, 
[14] Zhang, Honglei, Yang, Xing, Feng, Xu, Xu, Haibo, Yang, Qin, Zou, Li, Yan, Mei, Liu, Dequan, Su, Xiaosan, Jiao, Baowei. Chromosome-wide gene dosage rebalance may benefit tumor progression. MOLECULAR GENETICS AND GENOMICS[J]. 2018, 第 10 作者  通讯作者  293(4): 895-906, http://159.226.149.26:8080/handle/152453/12389.
[15] Chen, Wei, Wang, Hui, Cheng, Mei, Ni, Ling, Zou, Li, Yang, Qin, Cai, Xianghai, Jiao, Baowei. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2018, 第 8 作者  通讯作者  103: 435-442, http://dx.doi.org/10.1016/j.biopha.2018.04.076.
[16] Shaowei Wang, Hao Ke, Honglei Zhang, Yujie Ma, Lei Ao, Li Zou, Qin Yang, Hao Zhu, Jianyun Nie, Chunlian Wu, Baowei Jiao. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. CELL DEATH AND DISEASE[J]. 2018, 第 11 作者9(8): 1-11, https://doaj.org/article/77a02454c9aa4ef0866aef0fb382211e.
[17] Yang, Liu, Wang, Jun, Fan, Yaodong, Yu, Kun, Jiao, Baowei, Su, Xiaosan. Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245. RESPIRATORY RESEARCH[J]. 2018, 第 5 作者19(1): http://159.226.149.26:8080/handle/152453/12372.
[18] Haibo Xu, Xu Feng, Hao Ke, Limin Zhao, Honglei Zhang, Baowei Jiao, Jianyun Nie, Yang Wang, Chunlian Wu, Liqiong Wang, Xiaosan Su, Li Zou, Qin Yang, Shaowei Wang, Junjun Hao. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. PNAS[J]. 2018, 第 6 作者115(15): 3426–3435, http://159.226.149.26:8080/handle/152453/12266.
[19] Wang, Shaowei, Ke, Hao, Zhang, Honglei, Ma, Yujie, Ao, Lei, Zou, Li, Yang, Qin, Zhu, Hao, Nie, Jianyun, Wu, Chunlian, Jiao, Baowei. LncRNA MIR100HG promotes cell proliferation in triple- negative breast cancer through triplex formation with p27 loci. CELL DEATH & DISEASE[J]. 2018, 第 11 作者  通讯作者  9: http://159.226.149.26:8080/handle/152453/12349.
[20] Ke, Hao, Zhao, Limin, Zhang, Honglei, Feng, Xu, Xu, Haibo, Hao, Junjun, Wang, Shaowei, Yang, Qin, Zou, Li, Su, Xiaosan, Wang, Liqiong, Wu, Chunlian, Wang, Yang, Nie, Jianyun, Jiao, Baowei. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 第 15 作者  通讯作者  115(15): E3426-E3435, http://dx.doi.org/10.1073/pnas.1714573115.
[21] Wang H, Jiao B, Yang Q, Ni L, Zou L, Cheng M, Chen W, Cai X. Isoharringtonine inhibits breast cancer stem-like properties and stat3 signaling.. BIOMED PHARMACOTHER[J]. 2018, Vol.103: 435-442, http://www.corc.org.cn/handle/1471x/2155499.
[22] Yang, Xing, Wang, Hui, Jiao, Baowei. Mammary gland stem cells and their application in breast cancer. ONCOTARGET. 2017, 第 3 作者  通讯作者  8(6): 10675-10691, http://dx.doi.org/10.18632/oncotarget.12893.
[23] 吴瑜, 冯旭, 高岚, 焦保卫. 印记基因:发育中的重要调节因子. 遗传[J]. 2016, 第 4 作者38(6): 508-522, http://www.chinagene.cn/CN/10.16288/j.yczz.15-512.
[24] Li, Minghui, Wu, Fengrui, Gu, Yuan, Wang, Tingru, Wang, Hai, Yang, Shijie, Sun, Yunlv, Zhou, Linyan, Huang, Xigui, Jiao, Baowei, Cheng, Christopher H K, Wang, Deshou. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION[J]. 2012, 第 10 作者86(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000306547700030.
[25] Jiao Baowei. Paternal RLIM/Rnf12 is a survial factor for Milk-Producing alveolar cells. Cell. 2012, 第 1 作者
[26] Shin, JongDae, Bossenz, Michael, Chung, Young, Ma, Hong, Byron, Meg, TaniguchiIshigaki, Naoko, Zhu, Xiaochun, Jiao, Baowei, Hall, Lisa L, Green, Michael R, Jones, Stephen N, HermansBorgmeyer, Irm, Lawrence, Jeanne B, Bach, Ingolf. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. NATURE[J]. 2010, 第 8 作者467(7318): 977-U157, https://www.webofscience.com/wos/woscc/full-record/WOS:000283254700041.
[27] Wang, DeShou, Jiao, Baowei, Hu, Chongjiang, Huang, Xigui, Liu, Zhihao, Cheng, Christopher H K. Discovery of a gonad-specific IGF subtype in teleost. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2008, 第 2 作者367(2): 336-341, https://www.webofscience.com/wos/woscc/full-record/WOS:000252834700016.
[28] 章力, 黄希贵, 焦保卫, 吴风瑞, 王德寿. 南方鲇两种生长激素受体的结构分析及其组织分布和激素调节. 动物学报[J]. 2006, 第 3 作者52(6): 1096-1106, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=2633249&detailType=1.
[29] 

科研活动

   
科研项目
(1) 中科院B类先导专项课题,主持,部委级,2014-07--2019-06
(2) 自然科学基金面上项目,主持,国家级,2014-01--2017-12
(3) 青年****,主持,部委级,2013-06--2016-04
(4) 启动项目,主持,研究所(学校)级,2013-04--2016-04
参与会议
(1) Sex-specific epigenetic regulation of mammary gland by the RLIM/Rnf12 in mice,遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛,2014-04,焦保卫
(2) Function of RLIM/Rnf12 in mammary gland development ,第二届中国乳腺癌干细胞高峰论坛,2013-10,焦保卫

指导学生

现指导学生

赵丽敏  硕士研究生  071009-细胞生物学  

柯浩  博士研究生  071009-细胞生物学  

杨星  硕士研究生  071009-细胞生物学  

赵丽娜  博士研究生  071009-细胞生物学  

马玉洁  硕士研究生  071009-细胞生物学