基本信息
![](/self/img/8116e0aa-cdf5-49db-be95-639bfb945696.jpg)
张华威 男 硕导 中国科学院深圳先进技术研究院
电子邮件: hw.zhang@siat.ac.cn
通信地址: 广东省南山区学苑大道1068号
邮政编码: 518055
电子邮件: hw.zhang@siat.ac.cn
通信地址: 广东省南山区学苑大道1068号
邮政编码: 518055
招生信息
招生专业
086000-生物与医药
071010-生物化学与分子生物学
071010-生物化学与分子生物学
招生方向
蛋白质结构和功能
新药研发
新药研发
教育背景
2013-08--2017-07 香港中文大学 博士
2009-09--2012-06 复旦大学 硕士
2005-09--2009-06 贵州大学 学士
2009-09--2012-06 复旦大学 硕士
2005-09--2009-06 贵州大学 学士
工作经历
工作简历
2023-05~现在, 中国科学院深圳先进技术研究院, 副研究员
2020-01~2023-04,南方科技大学, 副研究员
2018-05~2018-07,斯坦福大学, 访问学者
2012-07~2013-07,中国科学院上海应用物理研究所, 研究助理
2020-01~2023-04,南方科技大学, 副研究员
2018-05~2018-07,斯坦福大学, 访问学者
2012-07~2013-07,中国科学院上海应用物理研究所, 研究助理
专利与奖励
专利成果
[1] 霍斯特·梵格, 饶智丽, 王学颖, 张小康, 袁曙光, 张华威. 使用冷冻电子显微镜解析蛋白质结构的方法. CN: CN116626305A, 2023-08-22.
出版信息
发表论文
[1] J Am Chem Soc. 2024, 第 3 作者
[2] Proc Natl Acad Sci U S A. 2024, 第 3 作者
[3] J Biomol Struct Dyn. 2023, 通讯作者
[4] Hang Zhang, Shiyu Wang, Zhenzhen Zhang, Mengzhuo Hou, Chunyu Du, Zhenye Zhao, Horst Vogel, Zhifang Li, Kaige Yan, Xiaokang Zhang, Jianping Lu, Yujie Liang, Shuguang Yuan, Daping Wang, Huawei Zhang. Cryo-EM structure of human heptameric pannexin 2 channel. NATURE COMMUNICATIONS[J]. 2023, 第 15 作者 通讯作者 14(1): 1-12, http://dx.doi.org/10.1038/s41467-023-36861-x.
[5] Tao Ma, Lei Wang, Anping Chai, Chao Liu, Wenqiang Cui, Shuguang Yuan, Shannon Wing Ngor Au, Liang Sun, Xiaokang Zhang, Zhenzhen Zhang, Jianping Lu, Yuanzhu Gao, Peiyi Wang, Zhifang Li, Yujie Liang, Horst Vogel, Yu Tian Wang, Daping Wang, Kaige Yan, Huawei Zhang. Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. NATURE COMMUNICATIONS[J]. 2023, 第 20 作者 通讯作者 14(3424): 1-13, https://www.nature.com/articles/s41467-023-39218-6.
[6] Kong-Fu Zhu, Chuang Yuan, Yong-Ming Du, Kai-Lei Sun, Xiao-Kang Zhang, Horst Vogel, Xu-Dong Jia, Yuan-Zhu Gao, Qin-Fen Zhang, Da-Ping Wang, Hua-Wei Zhang. Applications and prospects of cryo-EM in drug discovery. MILITARY MEDICAL RESEARCH[J]. 2023, 第 11 作者 通讯作者 10(1): 1-14, http://dx.doi.org/10.1186/s40779-023-00446-y.
[7] Guo, Hanhan, Huang, Jianghong, Liang, Yujie, Wang, Daping, Zhang, Huawei. Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis. EUROPEAN JOURNAL OF MEDICAL RESEARCH. 2022, 第 5 作者 通讯作者 27(1): http://dx.doi.org/10.1186/s40001-022-00926-2.
[8] Lu, Ping, Zhang, Huawei, Gao, Yuanzhu, Jia, Xudong, Liu, Zhe, Wang, Daping, Au, Shannon Wing Ngor, Zhang, Qinfen. Cryo-electron Tomography Reveals the Roles of FliY in Helicobacter pylori Flagellar Motor Assembly. MSPHERE[J]. 2022, 第 2 作者7(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000762192400013.
[9] Zhang, Zhenzhen, Hou, Mengzhuo, Ou, Huaxing, Wang, Daping, Li, Zhifang, Zhang, Huawei, Lu, Jianping. Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders. FRONTIERS IN ENDOCRINOLOGY[J]. 2022, 第 6 作者 通讯作者 13: http://dx.doi.org/10.3389/fendo.2022.1067529.
[10] Zhu, Kongfu, Liu, Chao, Gao, Yuanzhu, Lu, Jianping, Wang, Daping, Zhang, Huawei. Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. FRONTIERS IN PHARMACOLOGY[J]. 2022, 第 6 作者 通讯作者 13: http://dx.doi.org/10.3389/fphar.2022.907437.
[11] Zhang, Kaiming, Zhang, Huawei, Li, Shanshan, Pintilie, Grigore D, Mou, TungChung, Gao, Yuanzhu, Zhang, Qinfen, van den Bedeme, Henry, Schmid, Michael F, Au, Shannon Wing Ngor, Chiu, Wah. Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 2 作者116(14): 6800-6805,
[12] Zhang, Huawei, Lam, Kwok Ho, Lam, Wendy Wai Ling, Wong, Sandra Yuen Yuen, Chan, Vera Sau Fong, Au, Shannon Wing Ngor. A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. MOLECULAR MICROBIOLOGY[J]. 2017, 第 1 作者106(5): 690-703,
[13] Zhang, Huawei, Au, Shannon Wing Ngor. Helicobacter pylori does not use spermidine synthase to produce spermidine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 1 作者490(3): 861-867, http://dx.doi.org/10.1016/j.bbrc.2017.06.132.
[14] Zhang, HuaWei, Zeng, Ximin, Qi, Qi, Sun, KaiLei, Ma, ChongJun, Hu, XiaoJian, Lin, Jun. The in vitro interaction of CmeA with CmeC. CHINESE SCIENCE BULLETIN[J]. 2014, 第 1 作者59(25): 3114-3119, https://www.webofscience.com/wos/woscc/full-record/WOS:000339400500005.
[2] Proc Natl Acad Sci U S A. 2024, 第 3 作者
[3] J Biomol Struct Dyn. 2023, 通讯作者
[4] Hang Zhang, Shiyu Wang, Zhenzhen Zhang, Mengzhuo Hou, Chunyu Du, Zhenye Zhao, Horst Vogel, Zhifang Li, Kaige Yan, Xiaokang Zhang, Jianping Lu, Yujie Liang, Shuguang Yuan, Daping Wang, Huawei Zhang. Cryo-EM structure of human heptameric pannexin 2 channel. NATURE COMMUNICATIONS[J]. 2023, 第 15 作者 通讯作者 14(1): 1-12, http://dx.doi.org/10.1038/s41467-023-36861-x.
[5] Tao Ma, Lei Wang, Anping Chai, Chao Liu, Wenqiang Cui, Shuguang Yuan, Shannon Wing Ngor Au, Liang Sun, Xiaokang Zhang, Zhenzhen Zhang, Jianping Lu, Yuanzhu Gao, Peiyi Wang, Zhifang Li, Yujie Liang, Horst Vogel, Yu Tian Wang, Daping Wang, Kaige Yan, Huawei Zhang. Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. NATURE COMMUNICATIONS[J]. 2023, 第 20 作者 通讯作者 14(3424): 1-13, https://www.nature.com/articles/s41467-023-39218-6.
[6] Kong-Fu Zhu, Chuang Yuan, Yong-Ming Du, Kai-Lei Sun, Xiao-Kang Zhang, Horst Vogel, Xu-Dong Jia, Yuan-Zhu Gao, Qin-Fen Zhang, Da-Ping Wang, Hua-Wei Zhang. Applications and prospects of cryo-EM in drug discovery. MILITARY MEDICAL RESEARCH[J]. 2023, 第 11 作者 通讯作者 10(1): 1-14, http://dx.doi.org/10.1186/s40779-023-00446-y.
[7] Guo, Hanhan, Huang, Jianghong, Liang, Yujie, Wang, Daping, Zhang, Huawei. Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis. EUROPEAN JOURNAL OF MEDICAL RESEARCH. 2022, 第 5 作者 通讯作者 27(1): http://dx.doi.org/10.1186/s40001-022-00926-2.
[8] Lu, Ping, Zhang, Huawei, Gao, Yuanzhu, Jia, Xudong, Liu, Zhe, Wang, Daping, Au, Shannon Wing Ngor, Zhang, Qinfen. Cryo-electron Tomography Reveals the Roles of FliY in Helicobacter pylori Flagellar Motor Assembly. MSPHERE[J]. 2022, 第 2 作者7(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000762192400013.
[9] Zhang, Zhenzhen, Hou, Mengzhuo, Ou, Huaxing, Wang, Daping, Li, Zhifang, Zhang, Huawei, Lu, Jianping. Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders. FRONTIERS IN ENDOCRINOLOGY[J]. 2022, 第 6 作者 通讯作者 13: http://dx.doi.org/10.3389/fendo.2022.1067529.
[10] Zhu, Kongfu, Liu, Chao, Gao, Yuanzhu, Lu, Jianping, Wang, Daping, Zhang, Huawei. Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. FRONTIERS IN PHARMACOLOGY[J]. 2022, 第 6 作者 通讯作者 13: http://dx.doi.org/10.3389/fphar.2022.907437.
[11] Zhang, Kaiming, Zhang, Huawei, Li, Shanshan, Pintilie, Grigore D, Mou, TungChung, Gao, Yuanzhu, Zhang, Qinfen, van den Bedeme, Henry, Schmid, Michael F, Au, Shannon Wing Ngor, Chiu, Wah. Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 2 作者116(14): 6800-6805,
[12] Zhang, Huawei, Lam, Kwok Ho, Lam, Wendy Wai Ling, Wong, Sandra Yuen Yuen, Chan, Vera Sau Fong, Au, Shannon Wing Ngor. A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. MOLECULAR MICROBIOLOGY[J]. 2017, 第 1 作者106(5): 690-703,
[13] Zhang, Huawei, Au, Shannon Wing Ngor. Helicobacter pylori does not use spermidine synthase to produce spermidine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 1 作者490(3): 861-867, http://dx.doi.org/10.1016/j.bbrc.2017.06.132.
[14] Zhang, HuaWei, Zeng, Ximin, Qi, Qi, Sun, KaiLei, Ma, ChongJun, Hu, XiaoJian, Lin, Jun. The in vitro interaction of CmeA with CmeC. CHINESE SCIENCE BULLETIN[J]. 2014, 第 1 作者59(25): 3114-3119, https://www.webofscience.com/wos/woscc/full-record/WOS:000339400500005.
科研活动
科研项目
( 1 ) 幽门螺旋杆菌亚精胺合成的替代路 径研究, 负责人, 国家任务, 2020-01--2022-12
( 2 ) SPIN90在幽门螺杆菌空泡毒素VacA致病中的作用及机制研究, 负责人, 国家任务, 2024-01--2027-12
( 2 ) SPIN90在幽门螺杆菌空泡毒素VacA致病中的作用及机制研究, 负责人, 国家任务, 2024-01--2027-12