RNA生物学技术研发及调控机制和功能解析

   

071010-生物化学与分子生物学
0710J3-生物信息学

RNA表观转录组学

2009-09--2014-07   中国科学院北京基因组研究所（国家生物信息中心）   理学博士
2005-09--2009-07   山东大学   理学学士

研究生

博士

2023-03~现在, 中国科学院北京基因组研究所（国家生物信息中心）, 卓越青年研究员
2018-05~现在, 中国科学院北京基因组研究所（国家生物信息中心）, 副研究员
2014-07~2018-05,中国科学院北京基因组研究所（国家生物信息中心）, 助理研究员

2023-05-01-今,Genomics, Proteomics & Bioinformatics期刊, 青年编委
2022-11-30-今,The Innovation期刊, 青年编委
2018-05-01-今,中国生物化学与分子生物学会核糖核酸协会, 青年工作委员会委员

分子遗传学和表观遗传学
基因组学概述
生物化学与分子生物学实验

   

（1） 2023年度科睿唯安“全球高被引科学家“, 其他, 2023
（2） 2022年度科睿唯安“全球高被引科学家”, , 其他, 2022
（3） 中国科学院大学2020年校级研究生优秀课程, 部委级, 2020
（4） 中国科学院大学2019年学院级研究生优秀课程, , 部委级, 2019
（5） 第三届中国科协优秀科技论文, 国家级, 2018
（6） 2017年中国生命科学研究领域十大进展, , 国家级, 2017
（7） 2017年Sanofi-Cell Research杰出研究文章奖, 其他, 2017

（ 1 ） 链置换引物和细胞转录组文库构建方法, 发明专利, 2021, 第 7 作者, 专利号: CN111549025B

（ 2 ） RNA 5mC重亚硫酸盐测序的文库构建方法及其应用, 2018, 第 2 作者, 专利号: CN105132409B

   

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[53] Ying Yang, YiChang Zhang, YunGui Yang, Lifan Xu, Lilin Ye, Wenhui Guo, Jingjing Liu, Zhen Sun, Tianyan Zhao, Guotao Yu, Juanjuan Liu, Xiao Cui, Zhihong Qi, Fang Wang, Menghao You, Yingpeng Yao, Shuyang Yu. METTL3-dependent m6A modification programs T follicular helper cell differentiation. SPRINGER. 第 1 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202106293328549ZK.

（1） 《精准医学基础系列》（第11章. RNA修饰与疾病的精准医疗）, 上海交通大学出版社有限公司, 2018-03, 第 其他 作者
（2） RNA甲基化表观转录组学, 浙江大学出版社, 2021-02, 第 其他 作者
（3） 表观遗传学, 科学出版社, 2022-11, 第 其他 作者

   

（ 1 ） RNA甲基化修饰调控血液血管发育机制研究, 参与, 国家任务, 2019-09--2024-08
（ 2 ） 中国科学院青年创新促进会优秀会员, 负责人, 中国科学院计划, 2023-01--2025-12
（ 3 ） 基因组修饰多维组学分析技术与标准化研究, 参与, 中国科学院计划, 2020-01--2024-12
（ 4 ） 单细胞RNA甲基化测序技术开发与应用, 负责人, 地方任务, 2020-09--2023-08
（ 5 ） 单细胞RNA m5C测序技术研发, 负责人, 国家任务, 2021-01--2023-12
（ 6 ） 新型核酸修饰的检测鉴定、功能调控与化学干预, 参与, 国家任务, 2022-01--2024-12
（ 7 ） 日本三角涡虫再生RNA表观遗传学研究, 负责人, 国家任务, 2018-01--2021-12
（ 8 ） RNA新型修饰调控多能性干细胞初始态和始发态转变机制研究, 参与, 国家任务, 2018-07--2022-12

（1）scm6A-seq reveals single-cell landscape of the dynamic m6A during oocyte maturation and early embryonic development   第四届全国核糖核酸（RNA）青年学术会议   2023-04-20
（2）RNA甲基化修饰调控发育和疾病机制   万方医学助力颠覆性前沿技术应用发展系列论坛   2023-03-07
（3）RNA甲基化修饰调控再生和T细胞免疫   中国抗癌协会肿瘤病理专业委员会肿瘤分子病理协作组第四届年会   2022-09-18
（4）WTAP-mediated cell-cell communication controls planarian regeneration   中国生物化学与分子生物学会2021年全国学术大会   2021-11-24
（5）m6A-mediated cell-cell communication controls planarian regeneration   第十一届全国核糖核酸（RNA）会议   2021-07-04
（6）RNA methylation regulates regeneration of the planarian Schmidtea mediterranea   中科院青促会第三届青年生命科学论坛   2021-06-06
（7）Mettl3-mediated N6-methylcytosine regulates RNA abundance of SARS-CoV-2   2020-12-19
（8）RNA 5-methylcytosine facilitates maternal-to-zygotic transition through preventing maternal RNA decay   第一届全国核糖核酸（RNA）青年学术会议   2019-05-11
（9）RNA m5C修饰影响斑马鱼胚胎发育的分子机制   首届群英汇智青年学者论坛   2019-05-10
（10）RNA m5C修饰的分布及功能研究   中国细胞生物学学会2018年全国学术大会   2018-04-10

已指导学生

郭静云  硕士研究生  085238-生物工程  

梁承志  硕士研究生  071010-生物化学与分子生物学  

陈静  硕士研究生  085238-生物工程  

普俊铭  硕士研究生  071007-遗传学  

现指导学生

夏双燕  硕士研究生  0710J3-生物信息学  

古烨  硕士研究生  071010-生物化学与分子生物学  

钟帅  硕士研究生  0710Z1-基因组学