071011-生物物理学
071010-生物化学与分子生物学
0710J3-生物信息学

结构生物学
分子设计育种
生物工程

1998-09--2002-07   清华大学   博士
1994-09--1998-07   北京医科大学   学士

   

2012-11~现在, 中国科学院遗传与发育生物学研究所, 研究员
2006-04~2012-10,哥伦比亚大学生物化学与分子生物物理系, 博士后，助理研究员
2002-09~2006-03,美国哥伦比亚大学生物系, 博士后

2019-10-01-2023-10-31,中国生物物理学会《膜生物学分会》, 理事

蛋白质组学
结构生物学前沿研讨课
信号转导
医学蛋白质组学

   

（1） 信号转导课程教学过程的探索和改革, 二等奖, 院级, 2020
（2） 研究生优秀课程, 研究所（学校）, 2019
（3） 研究生优秀课程, 院级, 2019

[1] 高彩霞, 陈宇航, 冉毅东, 张瑞, 李超, 陈沙, 张康, 徐虎. 除草剂抗性植物. CN: CN114901674A, 2022-08-12.

   

[1] Zhang, xiangyun, Tang, Linghui, Nie, Jiawei, Chen,Yuhang. Structure and activation mechanism of the rice Salt Overly Sensitive 1(SOS1) Na+/H+ antiporter. Nature Plants[J]. 2023, [2] Yusen Zhou, Tian Zhang, Xiaocui Wang, Wenqiang Wu, Jingjing Xing, Zuliang Li, Xin Qiao, Chunrui Zhang, Xiaohang Wang, Guangshun Wang, Wenhui Li, Shenglong Bai, Zhi Li, Yuanzhen Suo, Jiajia Wang, Yanli Niu, Junli Zhang, Chen Lan, Zhubing Hu, Baozhu Li, Xuebin Zhang, Wei Wang, David W. Galbraith, Yuhang Chen, Siyi Guo, Chun-Peng Song. A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-13, http://dx.doi.org/10.1038/s41467-023-40013-6.
[3] Wang, Wei, Qin, Li, Zhang, Wenjing, Tang, Linghui, Zhang, Chao, Dong, Xiaojing, Miao, Pei, Shen, Meng, Du, Huilong, Cheng, Hangyuan, Wang, Ke, Zhang, Xiangyun, Su, Min, Lu, Hongwei, Li, Chang, Gao, Qiang, Zhang, Xiaojuan, Huang, Yun, Liang, Chengzhi, Zhou, JianMin, Chen, Yuhang. WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance. CELL[J]. 2023, 186(12): 2656-+, http://dx.doi.org/10.1016/j.cell.2023.05.023.
[4] Foerderer, Alexander, Li, Ertong, Lawson, Aaron W, Deng, Yanan, Sun, Yue, Logemann, Elke, Zhang, Xiaoxiao, Wen, Jie, Han, Zhifu, Chang, Junbiao, Chen, Yuhang, SchulzeLefert, Paul, Chai, Jijie. A wheat resistosome defines common principles of immune receptor channels. NATURE[J]. 2022, 610(7932): 532-+, http://dx.doi.org/10.1038/s41586-022-05231-w.
[5] Qin, Li, Tang, Linghui, Xu, Jiashu, Zhang, Xianhui, Zhu, Yun, Zhang, Chunrui, Wang, Meihua, Liu, Xuelei, Li, Fei, Sun, Fei, Su, Min, Zhai, Yujia, Chen, Yuhang. Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels. SCIENCE ADVANCES[J]. 2022, 8(9): http://dx.doi.org/10.1126/sciadv.abm3238.
[6] Pei, Yuanrong, Deng, Yanan, Zhang, Huairen, Zhang, Zhaogui, Liu, Jie, Chen, Zhibin, Cai, Darun, Li, Kai, Du, Yimo, Zang, Jie, Xin, Peiyong, Chu, Jinfang, Chen, Yuhang, Zhao, Li, Liu, Juan, Chen, Huabang. EAR APICAL DEGENERATION1 regulates maize ear development by maintaining malate supply for apical inflorescence. PLANT CELL[J]. 2022, 34(6): 2222-2241, http://dx.doi.org/10.1093/plcell/koac093.
[7] Bi, Guozhi, Su, Min, Li, Nan, Liang, Yu, Dang, Song, Xu, Jiachao, Hu, Meijuan, Wang, Jizong, Zou, Minxia, Deng, Yanan, Li, Qiyu, Huang, Shijia, Li, Jiejie, Chai, Jijie, He, Kangmin, Chen, Yuhang, Zhou, JianMin. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. CELL[J]. 2021, 184(13): 3528-+, http://dx.doi.org/10.1016/j.cell.2021.05.003.
[8] Deng, Yanan, Kashtoh, Hamdy, Wang, Quan, Zhen, Guangxiao, Li, Qiyu, Tang, Linghui, Gao, Hailong, Zhang, Chunrui, Qin, Li, Su, Min, Li, Fei, Huang, Xiahe, Wang, Yingchun, Xie, Qi, Clarke, Oliver B, Hendrickson, Wayne A, Chen, Yuhang. Structure and activity of SLAC1 channels for stomatal signaling in leaves. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(18): http://dx.doi.org/10.1073/pnas.2015151118.
[9] Jin, Shuai, Fei, Hongyuan, Zhu, Zixu, Luo, Yingfeng, Liu, Jinxing, Gao, Shenghan, Zhang, Feng, Chen, YuHang, Wang, Yanpeng, Gao, Caixia. Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity. MOLECULAR CELL[J]. 2020, 79(5): 728-+, http://dx.doi.org/10.1016/j.molcel.2020.07.005.
[10] Li, Chao, Zhang, Rui, Meng, Xiangbing, Chen, Sha, Zong, Yuan, Lu, Chunju, Qiu, JinLong, Chen, YuHang, Li, Jiayang, Gao, Caixia. Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors. NATURE BIOTECHNOLOGY[J]. 2020, 38(7): 875-U66, http://dx.doi.org/10.1038/s41587-019-0393-7.
[11] Wang, Xiaohui, Su, Min, Gao, Feng, Xie, Wenjun, Zeng, Yang, Li, Delin, Liu, Xuelei, Zhao, Hong, Qin, Li, Li, Fei, Liu, Qun, Clarke, Oliver B, Lam, Sin Man, Shui, GuangHou, Hendrickson, Wayne A, Chen, Yuhang. Structural basis for activity of TRIC counter-ion channels in calcium release. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(10): 4238-4243, https://www.webofscience.com/wos/woscc/full-record/WOS:000460242100051.
[12] Yang, Jinpu, Sun, Siyu, Zhang, Shu, Gonzalez, Marlyn, Dong, Qianhua, Chi, Zhongxuan, Chen, Yuhang, Li, Fei. Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. PLOS GENETICS[J]. 2018, 14(8): https://doaj.org/article/5377bea61f57428499953b7942d3924a.
[13] Min Su, Feng Gao, Qi Yuan, Yang Mao, Delin Li, Youzhong Guo, Cheng Yang, Xiaohui Wang, Renato Bruni, Brian Kloss, Hong Zhao, Yang Zeng, Faben Zhang, Andrew R Marks, Wayne A Hendrickson, Yuhang Chen. Structural basis for conductance through TRIC cation channels. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/2a4a9abd619e4a199b9d5f94dba0f20f.
[14] He, Haijin, Li, Yang, Dong, Qianhua, Chang, AnYun, Gao, Feng, Chi, Zhongxuan, Su, Min, Zhang, Faben, Ban, Hyoju, Martienssen, Rob, Chen, Yuhang, Li, Fei. Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(47): 12524-12529, https://www.webofscience.com/wos/woscc/full-record/WOS:000416503700063.
[15] Wu, Yan, Gao, Feng, Qi, Jianxun, Bi, Yuhai, Fu, Lifeng, Mohan, Sankar, Chen, Yuhang, Li, Xuebing, Pinto, B Mario, Vavricka, Christopher J, Tien, Po, Gao, George F. Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor. JOURNAL OF VIROLOGY[J]. 2016, 90(23): 10693-10700, https://www.webofscience.com/wos/woscc/full-record/WOS:000389904500021.
[16] Dong, Qianhua, Yin, FengXiang, Gao, Feng, Shen, Yuan, Zhang, Faben, Li, Yang, He, Haijin, Gonzalez, Marlyn, Yang, Jinpu, Zhang, Shu, Su, Min, Chen, YuHang, Li, Fei. Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading. MOLECULAR CELL[J]. 2016, 64(1): 79-91, http://dx.doi.org/10.1016/j.molcel.2016.08.022.
[17] 陈宇航. Homology structure of the SLAC1 anion channel for stomata closure in leaves. Nature. 2010, [18] Chen, Yuhang, He, Linling, Buchanan, Douglas R, Zhang, Yun, Fitzmaurice, Aileen, Yang, Jian. Functional dissection of the intramolecular Src homology 3-guanylate kinase domain coupling in voltage-gated Ca2+ channel beta-subunits. FEBS LETTERS[J]. 2009, 583(12): 1969-1975, https://www.webofscience.com/wos/woscc/full-record/WOS:000267797800025.
[19] Giraudo, Claudio G, GarciaDiaz, Alejandro, Eng, William S, Chen, Yuhang, Hendrickson, Wayne A, Melia, Thomas J, Rothman, James E. Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion. SCIENCE[J]. 2009, 323(5913): 512-516, https://www.webofscience.com/wos/woscc/full-record/WOS:000262587900045.
[20] Zhang, Yun, Chen, YuHang, Bangaru, Saroja D, He, Linling, Abele, Kathryn, Tanabe, Shihori, Kozasa, Tohru, Yang, Jian. Origin of the Voltage Dependence of G-Protein Regulation of P/Q-type Ca2+ Channels. JOURNAL OF NEUROSCIENCE[J]. 2008, 28(52): 14176-14188, https://www.webofscience.com/wos/woscc/full-record/WOS:000261985900017.
[21] He, Linling, Zhang, Yun, Chen, Yuhang, Yamada, Yoichi, Yang, Jian. Functional modularity of the beta-subunit of voltage-gated Ca2+ channels. BIOPHYSICAL JOURNAL[J]. 2007, 93(3): 834-845, https://www.webofscience.com/wos/woscc/full-record/WOS:000247851600011.
[22] Chen, YH, Li, MH, Zhang, Y, He, LL, Yamada, Y, Fitzmaurice, A, Shen, Y, Zhang, HL, Tong, L, Yang, J. Structural basis of the alpha(1)-beta subunit interaction of voltage-gated Ca2+ channels. NATURE[J]. 2004, 429(6992): 675-680, https://www.webofscience.com/wos/woscc/full-record/WOS:000221912600045.

   

（ 1 ） 青年****, 负责人, 国家任务, 2013-01--2016-01
（ 2 ） 新型离子通道TehA突变体结构及其新颖门控机制的研究, 负责人, 国家任务, 2015-01--2018-12
（ 3 ） 真核机械力门控Piezo通道结构功能研究, 负责人, 国家任务, 2015-01--2019-12
（ 4 ） 植物结构生物学, 负责人, 国家任务, 2014-01--2016-12
（ 5 ） 细胞胞内生物膜系统物质与能量代谢过程, 负责人, 中国科学院计划, 2014-01--2018-12
（ 6 ） 植物响应非生物逆境和共生固氮蛋白质机器的研究, 参与, 国家任务, 2016-06--2021-05
（ 7 ） 基于结构机理研究的抗除草剂作物设计, 负责人, 中国科学院计划, 2019-11--2024-10
（ 8 ） 染色质高级结构调控的分子机制研究, 负责人, 中国科学院计划, 2020-01--2022-12
（ 9 ） 叶绿体和核糖体调控温度应答的分子机制, 负责人, 国家任务, 2020-12--2025-11

（1）Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a novel class of anion channels   第一届国际植物电生理学与离子转运研讨会   2021-10-22
（2）Structure and Activity of SLAC1 Channels for Stomatal Signaling in Leaves   第四届全国植物逆境生物学研讨会   2021-06-01
（3）Structure and Activity of SLAC1 Channels for Stomatal Signaling in Leaves   2021-05-28
（4）Structural basis for conductance through TRIC cation channels   第6届国际离子通道大会   2017-06-23

已指导学生

尹凤翔  博士研究生  0710J3-生物信息学  

张法本  博士研究生  0710J3-生物信息学  

曾洋  硕士研究生  0710J3-生物信息学  

赵佩  硕士研究生  085238-生物工程  

李阳  博士研究生  071011-生物物理学  

王小慧  博士研究生  071011-生物物理学  

李德林  博士研究生  071011-生物物理学  

邓亚楠  博士研究生  071011-生物物理学  

郭利利  硕士研究生  071006-神经生物学  

秦力  博士研究生  071011-生物物理学  

王梅花  博士研究生  071011-生物物理学  

现指导学生

刘雪磊  博士研究生  071011-生物物理学  

甄广晓  博士研究生  071011-生物物理学  

张纯瑞  博士研究生  071011-生物物理学  

李其玉  博士研究生  071011-生物物理学  

张祥云  博士研究生  071011-生物物理学  

唐凌汇  博士研究生  071011-生物物理学  

王晓萃  博士研究生  071011-生物物理学  

许世敏  博士研究生  071011-生物物理学  

张显慧  博士研究生  071011-生物物理学  

张高华  博士研究生  071011-生物物理学  

王科  硕士研究生  071009-细胞生物学  

聂佳伟  博士研究生  071011-生物物理学  

杭雨墨  博士研究生  071011-生物物理学  

郝宁杰  硕士研究生  071008-发育生物学