生物囊泡创新剂型的创制与转化、免疫治疗

   

081703-生物化工

生物囊泡创新剂型，细胞治疗增效

   

2024-02~现在, 中国科学院过程工程研究所, 青年研究员
2022-10~现在, 中国科学院过程工程研究所, 副研究员
2020-12~2022-09,中国科学院过程工程研究所, 助理研究员
2018-07~2020-12,中国科学院过程工程研究所, 博士后

   

（1） 中国科协青年人才托举工程, 国家级, 2024
（2） 北京市科技新星计划-创新新星, 市地级, 2023
（3） 中国颗粒学会自然科学奖, 一等奖, 省级, 2020

（ 1 ） 一种COVID-19病毒抗体检测微球及其制备方法和含该微球的试剂盒, 发明专利, 2020, 第 15 作者, 专利号: CN111551713A

（ 2 ） 一种基于外泌体的抗肿瘤疫苗, 发明专利, 2020, 第 3 作者, 专利号: CN110846281A

   

（1） Intranasal mask for protecting the respiratory tract against viral aerosols, Nature Communications, 2023, 第 2 作者
（2） Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization, Nature, 2023, 第 19 作者
（3） Nanomaterial's interfacial stimulation of vascular endothelial cells and divergent guidances for nanomedicine treating vasculature-associated diseases, NANO TODAY, 2023, 第 10 作者
（4） Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours, Nature Nanotechnology, 2023, 第 2 作者
（5） Advancement of Engineered Bacteria for Orally Delivered Therapeutics, SMALL, 2023, 第 2 作者
（6） 仿生合成疫苗：从人工颗粒到天然颗粒底盘, 2022生物物理大会摘要集, 2022, 第 3 作者
（7） Advances of bacteria-based delivery systems for modulating tumor microenvironment, ADVANCED DRUG DELIVERY REVIEWS, 2022, 第 3 作者
（8） In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer, ADVANCED FUNCTIONAL MATERIALS, 2022, 第 5 作者
（9） Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma, NATURE COMMUNICATIONS, 2022, 第 4 作者
（10） Construction of gastric cancer patient-derived organoids and their utilization in a comparative study of clinically used paclitaxel nanoformulations, JOURNAL OF NANOBIOTECHNOLOGY, 2022, 第 2 作者
（11） Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects, NATURE NANOTECHNOLOGY, 2021, 第 8 作者
（12） Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor, ADVANCED SCIENCE, 2021, 第 5 作者
（13） Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment, SCIENCE TRANSLATIONAL MEDICINE, 2021, 第 1 作者
（14） Transformable vesicles for cancer immunotherapy, ADVANCED DRUG DELIVERY REVIEWS, 2021, 第 1 作者
（15） Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells, NATURE BIOMEDICAL ENGINEERING, 2021, 第 4 作者
（16） Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen, NATURE BIOMEDICAL ENGINEERING, 2021, 第 8 作者
（17） Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer, SCIENCE ADVANCES, 2021, 第 3 作者
（18） MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload, NATURE COMMUNICATIONS, 2021, 第 5 作者
（19） Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy, ADVANCED MATERIALS, 2020, 第 6 作者
（20） Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors, CHEMICAL ENGINEERING JOURNAL, 2020, 第 5 作者
（21） Recent Advances in Particulate Adjuvants for Cancer Vaccination, ADVANCED THERAPEUTICS, 2020, 第 3 作者
（22） Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy, ADVANCED MATERIALS, 2020, 第 5 作者
（23） Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy, ADVANCED SCIENCE, 2020, 第 2 作者
（24） Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination, SCIENCE ADVANCES, 2020, 第 3 作者
（25） Engineering Magnetosomes for High-Performance CancerVaccination, ACS CENTRAL SCIENCE, 2019, 第 9 作者
（26） Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics, CHEMICAL SCIENCE, 2019, 第 7 作者
（27） Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications, ADVANCED BIOSYSTEMS, 2019, 第 1 作者
（28） Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine, SMALL, 2018, 第 1 作者
（29） Using self-healing microcapsules as antigen arsenal to elicit a prolonged anti-tumor response, JOURNAL OF CONTROLLED RELEASE, 2017, 第 3 作者
（30） Using self-healing microcapsules as antigen arsenal to elicit a prolonged anti-tumor response, MEETING ABSTRACT, 2017, 第 3 作者
（31） CaCO3-based nano-missile potentiates antigen delivery and cross-presentation, MEETING ABSTRACT, 2017, 第 1 作者
（32） PEGylated graphene oxide elicits strong immunological responses despite surface passivation, NATURE COMMUNICATIONS, 2017, 第 3 作者
（33） Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer, ADVANCED SCIENCE, 2017, 第 6 作者
（34） Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells, ADVANCED MATERIALS, 2016, 第 6 作者
（35） Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases, JOURNAL OF MATERIALS CHEMISTRY B, 2016, 第 6 作者
（36） 多佐剂复合型肿瘤全细胞疫苗的构建及应用探索, Nanoparticles-based multi-adjuvant whole cell tumor vaccine forcancer immunotherapy, BIOMATERIALS, 2013, 第 6 作者

   

（ 1 ） Neo淋巴结的创建及其用于肿瘤个体化治疗的研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 工程化溶酶体陷阱“LysoTRAP”用于病毒及变异株的清除, 负责人, 地方任务, 2023-10--2025-10
（ 3 ） 囊泡嵌合型温敏水凝胶喷鼻剂型的创制及其用于病毒气溶胶鼻内防护的研究, 负责人, 研究所自主部署, 2023-01--2025-12
（ 4 ） mRNA/碳酸钙递送载体的构建、优化及其用于工程化外泌体型肿瘤免疫治疗药物的研究, 负责人, 国家任务, 2022-01--2024-12
（ 5 ） 双靶向巨噬-肿瘤杂合外泌体用作肿瘤治疗性疫苗的研究, 负责人, 其他国际合作项目, 2019-07--2020-07