基本信息
刘雅兰  女  硕导  中国科学院武汉病毒研究所
电子邮件: liuyl@wh.iov.cn
通信地址: 武汉市武昌区小洪山中区44号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
包膜病毒与宿主相互作用的分子机制, HSV-2/HIV-1的共感染及抑制

教育背景

2005-09--2010-06   中国科学院武汉病毒研究所   博士学位
1999-09--2003-06   湖北大学   理学学士

工作经历

   
工作简历
2018-09~现在, 中国科学院武汉病毒研究所, 副研究员
2010-07~2018-08,中国科学院武汉病毒研究所, 助理研究员
2005-09~2010-06,中国科学院武汉病毒研究所, 博士学位
2003-08~2005-06,湖北省公安县第一高级中学, 生物教师
1999-09~2003-06,湖北大学, 理学学士

出版信息

   
发表论文
(1) Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22), Frontiers in Immunology, 2022, 通讯作者
(2) A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration, CELL REPORTS, 2021, 通讯作者
(3) Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-kB Activation by Interacting with p65, The Journal of Immunology, 2021, 通讯作者
(4) Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells, FRONTIERS IN MICROBIOLOGY, 2020, 第 7 作者
(5) Self-assembled fluorescent Ce(Ⅲ) coordination polymer as ratiometric probe for HIV antigen detection, Analytica Chimica Acta, 2019, 第 9 作者
(6) Self-assembled fluorescent Ce(III) coordination polymer as ratiometric probe for HIV antigen detection, ANALYTICA CHIMICA ACTA, 2019, 第 9 作者
(7) Hsv-2 glycoprotein j promotes viral protein expression and virus spread, VIROLOGY, 2018, 第 1 作者
(8) Tick-borne encephalitis virus nonstructural protein ns5 induces rantes expression dependent on the rna-dependent rna polymerase activity, JOURNAL OF IMMUNOLOGY, 2018, 通讯作者
(9) Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 + T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4, FRONTIERS IN IMMUNOLOGY, 2018, 其他(合作组作者)
(10) DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses, VIROLOGICA SINICA, 2017, 通讯作者
(11) Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E, VIROLOGY, 2017, 通讯作者
(12) DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein, VIROLOGY, 2016, 第 14 作者
(13) HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway, VIROLOGY JOURNAL, 2016, 通讯作者
(14) HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter, JOURNAL OF IMMUNOLOGY, 2015, 第 2 作者
(15) Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin, JOURNAL OF GENERAL VIROLOGY, 2015, 第 5 作者
(16) Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge, JOURNAL OF IMMUNOLOGY, 2015, 第 10 作者
(17) Inhibition of HIV-1 infection of primary CD4(+) T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9, JOURNAL OF GENERAL VIROLOGY, 2015, 第 6 作者
(18) Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins, VIROLOGY, 2015, 第 1 作者
(19) Sensitivity of transmitted and founder HIV-1 envelopes to carbohydrate binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin, J Gen Virol, 2015, 
(20) HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter, American Association of Immunologists, 2015, 第 2 作者
(21) Contribution of N-linked glycans on HSV-2 gB to cell–cell fusion and viral entry, VIROLOGY, 2015, 第 9 作者
(22) 揭秘病毒与宿主间的博弈——国家“973”计划“重要病毒的入侵机制研究”进展介绍, Uncovering the Battle between Viruses and the Host: Highlights of the National Basic Research Program of China "Entry Mechanisms of Enveloped Viruses", 中国基础科学, 2014, 第 3 作者
(23) Binding of HIV-1 virions to α_4β_7 expressing cells and impact of antagonizing α_4β_7 on HIV-1 infection of primary CD4~+ T cells, Virologica Sinica, 2014, 第 5 作者
(24) Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES, VIRUS RESEARCH, 2012, 第 1 作者
(25) Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4(+) T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-beta Pathway, JOURNAL OF IMMUNOLOGY, 2012, 第 7 作者
(26) 人巨细胞病毒被膜蛋白行为与功能可视化研究, 2010, 第 1 作者
(27) Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci, VIROLOGY, 2009, 第 4 作者
(28) The tegument protein UL94 of human cytomegalovirus as a binding partner for tegument protein pp28 identified by intracellular imaging, VIROLOGY, 2009, 第 1 作者

科研活动

   
科研项目
( 1 ) HSV-2感染对黏膜组织中HIV-1受体表达及易感细胞分布的影响研究 重要新发突发病毒宿主适应与损伤机制研究, 负责人, 国家任务, 2016-01--2019-12
( 2 ) 利用黏膜组织模型研究HSV-2 感染对HIV-1 黏膜入侵的影响, 负责人, 国家任务, 2012-01--2014-12
( 3 ) 重要新发突发病毒宿主适应与损伤机制研究, 参与, 国家任务, 2016-07--2018-12
( 4 ) HSV-2 gJ促进病毒细胞-细胞传播的机制及其对HIV-1黏膜共感染的影响研究, 负责人, 国家任务, 2020-01--2023-12
( 5 ) 抗艾滋病毒抑制剂的研发, 负责人, 企业委托, 2022-05--2028-05
( 6 ) 创新药PLAV001在细胞水平抑制人新型冠状病毒SARS-CoV-2复制的效果研究, 负责人, 企业委托, 2021-11--2025-12