070302-分析化学
070303-有机化学
0703Z1-化学生物学

光学探针、成像分析
光学成像
生物分析

2005-09--2010-06   中国科学院化学研究所   博士
2001-09--2005-06   武汉大学   学士

   

2019-11~现在, 中国科学院化学研究所, 研究员
2013-07~2019-11,中国科学院化学研究所, 副研究员
2010-07~2013-06,中国科学院化学研究所, 助理研究员
2005-09~2010-06,中国科学院化学研究所, 博士
2001-09~2005-06,武汉大学, 学士

2023-01-01-2025-12-31,中国分析测试协会青年委员会, 委员

单分子与单细胞分析技术
化学与生物传感分析
前沿化学实验

   

（ 1 ） 一种检测丙氨酸氨肽酶的比率型荧光探针及其制备方法与应用, 2017, 第 2 作者, 专利号: CN106831634A

（ 2 ） 一种用于γ-谷氨酰转肽酶检测的荧光探针及其制备方法与应用, 2015, 第 1 作者, 专利号: CN104892541A

（ 3 ） 过氧化苯甲酰快速检测试剂盒, 2012, 第 4 作者, 专利号: CN102532177A

（ 4 ） 一种简便快速检测面粉中过氧化苯甲酰含量的方法, 2011, 第 3 作者, 专利号: CN102253019A

（ 5 ） 一种荧光分析试剂及其制备方法与应用, 2011, 第 3 作者, 专利号: CN102212054A

   

（1） Specific Spleen-Accumulated NIR-II Fluorescent Probe for Imaging-Guided Splenic Operation, Adv. Healthcare Mater., 2023, 第 11 作者
（2） Cuproptosis accompanied by obvious ���OH generation revealed with an ultrasensitive NIR fluorescence probe, Chemical Engineering Journal, 2023, 
（3） Combination of changeable pi-conjugation and hydrophilic groups for developing water-soluble small-molecule NIR-II fluorogenic probes, CHEMICAL SCIENCE, 2023, 第 5 作者
（4） An effective approach to develop targetable and responsive fluorescent probes for imaging of organelles based on cresyl violet scaffold, BIOSENSORS & BIOELECTRONICS, 2022, 第 4 作者
（5） Recent advances in fluorescent probes for lipid droplets, CHEMICAL COMMUNICATIONS, 2022, 第 11 作者
（6） An Oxazine-Based Fluorogenic Probe with Changeable pi-Conjugation to Eliminate False-Positive Interference of Albumin and Its Application to Sensing Aminopeptidase N, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 11 作者
（7） Golgi-Targeted Fluorescent Probe for Imaging NO in Alzheimer's Disease, ANALYTICAL CHEMISTRY, 2022, 第 11 作者
（8） New rhodamines with changeable pi-conjugation for lengthening fluorescence wavelengths and imaging peroxynitrite, CHEM, 2022, 第 11 作者
（9） Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe, CHEMICAL COMMUNICATIONS, 2021, 第 11 作者
（10） Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window, CHEMICAL COMMUNICATIONS, 2021, 第 3 作者
（11） A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo, CHEMICAL COMMUNICATIONS, 2021, 第 11 作者
（12） Recent advances in fluorescent probes for lipid droplets, CHEMICAL COMMUNICATIONS, 2021, 第 11 作者
（13） Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 第 11 作者
（14） Water-Soluble Near-Infrared Fluorescent Probes for Specific Detection of Monoamine Oxidase A in Living Biosystems, ANALYTICAL CHEMISTRY, 2021, 第 11 作者
（15） An endoplasmic reticulum-targeting fluorescent probe for imaging (OH)-O-center dot in living cells, CHEMICAL COMMUNICATIONS, 2020, 第 11 作者
（16） A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo, CHEMICAL SCIENCE, 2020, 第 11 作者
（17） Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 11 作者
（18） H2O2-Responsive Organosilica-Doxorubicin Nanoparticles for Targeted Imaging and Killing of Cancer Cells Based on a Synthesized Silane-Borate Precursor, CHEMMEDCHEM, 2019, 第 11 作者
（19） Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes, ACCOUNTS OF CHEMICAL RESEARCH, 2019, 第 2 作者
（20） Reactive oxygen species-triggered off-on fluorescence donor for imaging hydrogen sulfide delivery in living cells, CHEMICAL SCIENCE, 2019, 第 4 作者
（21） Ferroptosis Accompanied by (OH)-O-center dot Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 11 作者
（22） A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate, CHEMICAL COMMUNICATIONS, 2018, 第 2 作者
（23） In vivo tumor imaging by a gamma-glutamyl transpeptidase-activatable near-infrared fluorescent probe, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 第 11 作者
（24） Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 11 作者
（25） Facile and Sensitive Method for Protein Kinase A Activity Assay Based on Fluorescent Off-On PolyU-peptide Assembly, ANALYTICAL CHEMISTRY, 2017, 第 11 作者
（26） Ultrasensitive Detection of Aminopeptidase N Activity in Urine and Cells with a Ratiometric Fluorescence Probe, ANALYTICAL CHEMISTRY, 2017, 第 11 作者
（27） A highly sensitive and selective fluorescence off-on probe for the detection of intracellular endogenous tyrosinase activity, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者
（28） Observation of the Generation of ONOO- in Mitochondria under Various Stimuli with a Sensitive Fluorescence Probe, ANALYTICAL CHEMISTRY, 2017, 第 4 作者
（29） Ratiometric Fluorescent Probe for Imaging of Pantetheinase in Living Cells, ANALYTICAL CHEMISTRY, 2017, 第 11 作者
（30） Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N, CHEMICAL COMMUNICATIONS, 2017, 第 11 作者
（31） A Strategy for Specific Fluorescence Imaging of Monoamine OxidaseA in Living Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 2 作者
（32） 青霉素G酰化酶的近红外荧光探针及其活体成像, In vivo imaging of penicillin G acylase in mice via a near-infrared fluorescent probe, 中国科学（化学）, 2017, 第 4 作者
（33） A near-infrared fluorescence off-on probe for sensitive imaging of hydrogen polysulfides in living cells and mice in vivo, CHEMICAL COMMUNICATIONS, 2017, 第 3 作者
（34） In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe, CHEMICAL SCIENCE, 2017, 第 11 作者
（35） Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe, CHEMICAL SCIENCE, 2016, 第 2 作者
（36） A Lysosome-Targeting Fluorescence Off-On Probe for Imaging of Nitroreductase and Hypoxia in Live Cells, CHEMISTRY-AN ASIAN JOURNAL, 2016, 第 2 作者
（37） Monitoring gamma-glutamyl transpeptidase activity and evaluating its inhibitors by a water-soluble near-infrared fluorescent probe, BIOSENSORS & BIOELECTRONICS, 2016, 第 11 作者
（38） Near-Infrared Fluorescent Probe with New Recognition Moiety for Specific Detection of Tyrosinase Activity: Design, Synthesis, and Application in Living Cells and Zebrafish, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 3 作者
（39） Sensitive and Selective Ratiometric Fluorescence Probes for Detection of Intracellular Endogenous Monoamine Oxidase A, ANALYTICAL CHEMISTRY, 2016, 第 3 作者
（40） Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe, ANALYTICAL CHEMISTRY, 2016, 第 11 作者
（41） Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe, CHEMICAL COMMUNICATIONS, 2016, 第 11 作者
（42） Ultrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells, ANALYTICAL CHEMISTRY, 2016, 第 2 作者
（43） HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe, CHEMICAL SCIENCE, 2015, 第 11 作者
（44） in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off���on probe, BIOSENSORS AND BIOELECTRONICS, 2015, 第 5 作者
（45） A Specific Nucleophilic Ring-Opening Reaction of Aziridines as a Unique Platform for the Construction of Hydrogen Polysulfides Sensors, ORGANIC LETTERS, 2015, 第 4 作者
（46） in vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off-on probe, BIOSENSORS & BIOELECTRONICS, 2015, 第 5 作者
（47） Sensitive Fluorescence Probe with Long Analytical Wavelengths for gamma-Glutamyl Transpeptidase Detection in Human Serum and Living Cells, ANALYTICAL CHEMISTRY, 2015, 第 11 作者
（48） An Upconversion Luminescence Nanoprobe for the Ultrasensitive Detection of Hyaluronidase, ANALYTICAL CHEMISTRY, 2015, 第 5 作者
（49） RationalDesign and Bioimaging Applications of HighlySelective Fluorescence Probes for Hydrogen Polysulfides, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 3 作者
（50） Poly(m-phenylenediamine)-Based Fluorescent Nanoprobe for Ultrasensitive Detection of Matrix Metalloproteinase 2, ANALYTICAL CHEMISTRY, 2014, 第 5 作者
（51） Fluorescent probes and nanoparticles for intracellular sensing of pH values, METHODS AND APPLICATIONS IN FLUORESCENCE, 2014, 第 11 作者
（52） Design strategies for water-soluble small molecular chromogenic and fluorogenic probes., CHEMICAL REVIEWS, 2014, 第 3 作者
（53） Sensitive and Selective Near-Infrared Fluorescent Off-On Probe and Its Application to Imaging Different Levels of beta-Lactamase in Staphylococcus aureus, ANALYTICAL CHEMISTRY, 2014, 第 11 作者
（54） Lysosomal pH Rise during Heat Shock Monitored by a Lysosome-Targeting Near-Infrared Ratiometric Fluorescent Probe, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 第 3 作者
（55） Gold nanoparticles functionalized with cresyl violet and porphyrin via hyaluronic acid for targeted cell imaging and phototherapy, CHEMICAL COMMUNICATIONS, 2014, 第 4 作者
（56） 纳米材料在生物分析应用中存在的若干问题, Some Problems of Nanomaterials in Bioanalytical Applications, ACTA CHIMICA SINICA, 2013, 第 4 作者
（57） Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-(5-Nitrofuran-2-yl)methoxy-3H-phenoxazin-3-one, ANALYTICAL CHEMISTRY, 2013, 第 5 作者
（58） Distinguishing Folate-Receptor-Positive Cells from Folate-Receptor-Negative Cells Using a Fluorescence Off-On Nanoprobe, ANALYTICAL CHEMISTRY, 2013, 第 3 作者
（59） Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells as well as green gram sprouts, TALANTA, 2013, 第 3 作者
（60） Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells Cas well as green gram sprouts, TALANTA, 2013, 第 3 作者
（61） 7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase, CHEMICAL COMMUNICATIONS, 2013, 第 3 作者
（62） Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal, SCIENTIFIC REPORTS, 2013, 第 2 作者
（63） 3, 4-Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S-Transferase in Living Cells, CHINESE JOURNAL OF CHEMISTRY, 2013, 第 11 作者
（64） 纳米材料在生物分析应用中存在的若干问题, Some Problems of Nanomaterials in Bioanalytical Applications, ACTA CHIMICA SINICA, 2013, 第 4 作者
（65） Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells., J. MATER. CHEM., 2012, 第 2 作者
（66） Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 2 作者
（67） Spectroscopic probes with changeable ��-conjugated systems., CHEM. COMMUN., 2012, 第 1 作者
（68） A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen., MOL. BIOSYST., 2012, 第 3 作者
（69） Spectroscopic probes with changeable pi-conjugated systems, CHEMICAL COMMUNICATIONS, 2012, 第 1 作者
（70） A long-wavelength fluorescent probe for imaging reduced glutathione in live cells, SENSORS AND ACTUATORS B-CHEMICAL, 2012, 第 11 作者
（71） A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen, MOLECULARBIOSYSTEMS, 2012, 第 3 作者
（72） A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 第 11 作者
（73） A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells., ANGEW. CHEM. INT. ED., 2012, 第 1 作者
（74） A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation, CHEMICAL COMMUNICATIONS, 2012, 第 3 作者
（75） A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging., ANALYST, 2012, 第 11 作者
（76） A long-wavelength fluorescent probe for imaging reduced glutathione in live cells, SENS. ACTUATORS B: CHEM., 2012, 第 3 作者
（77） Spectroscopic Response of Ferrocene Derivatives Bearing a BODIPY Moiety to Water: A New Dissociation Reaction, CHEMISTRY-A EUROPEAN JOURNAL, 2012, 第 3 作者
（78） Hydrogen Peroxide Vapor Sensing with Organic Core/Sheath Nanowire Optical Waveguides, ADVANCED MATERIALS, 2012, 第 4 作者
（79） A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation., CHEM. COMMUN., 2012, 第 3 作者
（80） Spectroscopic Response of Ferrocene Derivatives Bearing a BODIPY Moiety to Water: A New Dissociation Reaction., CHEM. EUR. J., 2012, 第 3 作者
（81） Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine-6G spirolactam based on consecutive chemical reactions, ANALYTICA CHIMICA ACTA, 2011, 第 2 作者
（82） Application of rhodamine B thiolactone to fluorescence imaging of Hg2+ in Arabidopsis thaliana, SENSORS AND ACTUATORS B: CHEMISTRY, 2011, 第 2 作者
（83） Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe, TALANTA, 2011, 第 5 作者
（84） An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide, CHEMICAL COMMUNICATIONS, 2011, 第 2 作者
（85） Application of rhodamine B thiolactone to fluorescence imaging of Hg2+ in Arabidopsis thaliana, SENSORS AND ACTUATORS B-CHEMICAL, 2011, 第 2 作者
（86） A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2, CHEMICAL COMMUNICATIONS, 2011, 第 4 作者
（87） Imaging Different Interactions of Mercury and Silver with Live Cells by a Designed Fluorescence Probe Rhodamine B Selenolactone, INORGANIC CHEMISTRY, 2010, 第 1 作者
（88） A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, CHEM. COMMUN., 2010, 第 3 作者
（89） Rhodamine B Piperazinoacetohydrazine: AWater-Soluble Spectroscopic Reagent for Pyruvic Acid Labeling, CHEM-EUR J, 2010, 第 3 作者
（90） Enhanced sensitivity in a Hg2+ sensor by photonic crystals, ANALYTICAL METHODS, 2010, 第 2 作者
（91） Imaging Different Interactions of Mercury and Silver with Live Cells by a Designed Fluorescence Probe Rhodamine B Selenolactone, INORG. CHEM., 2010, 第 1 作者
（92） Rhodamine B Piperazinoacetohydrazine: A Water-Soluble Spectroscopic Reagent for Pyruvic Acid Labeling, CHEMISTRY-A EUROPEAN JOURNAL, 2010, 第 3 作者
（93） A near-infrared fluorescent probe for monitoring tyrosinase activity, CHEMICAL COMMUNICATIONS, 2010, 第 2 作者
（94） A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, CHEMICAL COMMUNICATIONS, 2010, 第 3 作者
（95） A near-infrared fluorescent probe for monitoring tyrosinase activity, CHEM. COMMUN., 2010, 第 2 作者
（96） 罗丹明B内硫酯在细胞成像中的应用, 分析化学, 2009, 第 1 作者
（97） Characterization of 2-phenylbenzogquinoxaline derivatives as viscosity-sensitive fluorescent probes, TALANTA, 2009, 第 2 作者
（98） Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2008, 第 3 作者
（99） A highly selective and sensitive fluorescence probe for the hypochlorite anion, CHEMISTRY-A EUROPEAN JOURNAL, 2008, 第 4 作者
（100） Rhodamine B thiolactone: a simple chemosensor for Hg(2+) in aqueous media, CHEMICAL COMMUNICATIONS, 2008, 第 1 作者
（101） Selective modification of Trp19 in beta-lactoglobulin by a new diazo fluorescence probe, JOURNAL OF PROTEOME RESEARCH, 2007, 第 3 作者
（102） 侧链烯丙酯化的生物可降解聚碳酸酯的酶促合成与功能化, Enzyme-Catalyzed Polymerization and Functionalization of Biodegradable Polycarbonates with Pendant Allyl Ester Groups, 武汉大学学报：理学版, 2005, 第 4 作者

   

（ 1 ） 基于氧杂蒽的长波长荧光团设计合成及其在近红外二区荧光成像中的应用, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 光学探针与传感分析, 负责人, 国家任务, 2020-01--2022-12