070302-分析化学

光学探针制备，生理活性物质检测，细胞及活体荧光成像研究

2001-09--2004-07   中国科学院化学研究所   博士
1995-09--2001-07   西北大学   学士、硕士

   

2008-12~2024-05,中国科学院化学研究所, 副研究员
2008-10~2008-11,中国科学院化学研究所, 助理研究员
2006-10~2008-09,德国雷根斯堡大学, 博士后
2004-12~2006-10,美国埃默里大学, 博士后
2001-09~2004-07,中国科学院化学研究所, 博士
1995-09~2001-07,西北大学, 学士、硕士

   

（1） 生物分子的光学探针与标记分析研究, 二等奖, 省级, 2010

   

（1） Specific Spleen-Accumulated NIR-II Fluorescent Probe for Imaging-Guided Splenic Operation, Adv. Healthcare Mater., 2023, 第 6 作者
（2） Combination of changeable pi-conjugation and hydrophilic groups for developing water-soluble small-molecule NIR-II fluorogenic probes, CHEMICAL SCIENCE, 2023, 第 11 作者
（3） Imaging HOCl Generation during the Mitochondria Peripheral Fission with a Tailor-Made Fluorescent Probe, Analytical Chemistry, 2023, 
（4） An effective approach to develop targetable and responsive fluorescent probes for imaging of organelles based on cresyl violet scaffold, BIOSENSORS & BIOELECTRONICS, 2022, 第 11 作者
（5） Recent advances in fluorescent probes for lipid droplets, CHEMICAL COMMUNICATIONS, 2022, 第 3 作者
（6） New fluorescent probe with recognition moiety of bipiperidinyl reveals the rise of hepatocellular carboxylesterase activity during heat shock, BIOSENSORS & BIOELECTRONICS, 2022, 第 11 作者
（7） New cell-membrane-anchored near-infrared fluorescent probes for viscosity monitoring, CHEMICAL COMMUNICATIONS, 2022, 第 11 作者
（8） Golgi-Targeted Fluorescent Probe for Imaging NO in Alzheimer's Disease, ANALYTICAL CHEMISTRY, 2022, 第 4 作者
（9） New rhodamines with changeable pi-conjugation for lengthening fluorescence wavelengths and imaging peroxynitrite, CHEM, 2022, 第 11 作者
（10） Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe, CHEMICAL COMMUNICATIONS, 2021, 第 4 作者
（11） Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window, CHEMICAL COMMUNICATIONS, 2021, 第 11 作者
（12） Design, synthesis and application of a dual-functional fluorescent probe for reactive oxygen species and viscosity, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 第 11 作者
（13） A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo, CHEMICAL COMMUNICATIONS, 2021, 第 6 作者
（14） Recent advances in fluorescent probes for lipid droplets, CHEMICAL COMMUNICATIONS, 2021, 第 3 作者
（15） Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 第 6 作者
（16） Water-Soluble Near-Infrared Fluorescent Probes for Specific Detection of Monoamine Oxidase A in Living Biosystems, ANALYTICAL CHEMISTRY, 2021, 第 3 作者
（17） An endoplasmic reticulum-targeting fluorescent probe for imaging (OH)-O-center dot in living cells, CHEMICAL COMMUNICATIONS, 2020, 第 5 作者
（18） Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 5 作者
（19） A near-infrared fluorescent probe reveals decreased mitochondrial polarity during mitophagy, CHEMICAL SCIENCE, 2020, 第 11 作者
（20） H2O2-Responsive Organosilica-Doxorubicin Nanoparticles for Targeted Imaging and Killing of Cancer Cells Based on a Synthesized Silane-Borate Precursor, CHEMMEDCHEM, 2019, 第 4 作者
（21） Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes, ACCOUNTS OF CHEMICAL RESEARCH, 2019, 第 3 作者
（22） Reactive oxygen species-triggered off-on fluorescence donor for imaging hydrogen sulfide delivery in living cells, CHEMICAL SCIENCE, 2019, 第 5 作者
（23） Mitochondria-Immobilized Near-Infrared Ratiometric Fluorescent pH Probe To Evaluate Cellular Mitophagy, ANALYTICAL CHEMISTRY, 2019, 第 11 作者
（24） Ferroptosis Accompanied by (OH)-O-center dot Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 11 作者
（25） A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate, CHEMICAL COMMUNICATIONS, 2018, 第 4 作者
（26） In vivo tumor imaging by a gamma-glutamyl transpeptidase-activatable near-infrared fluorescent probe, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 第 4 作者
（27） Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 11 作者
（28） Facile and Sensitive Method for Protein Kinase A Activity Assay Based on Fluorescent Off-On PolyU-peptide Assembly, ANALYTICAL CHEMISTRY, 2017, 第 5 作者
（29） A highly sensitive and selective fluorescence off-on probe for the detection of intracellular endogenous tyrosinase activity, CHEMICAL COMMUNICATIONS, 2017, 第 11 作者
（30） Observation of the Generation of ONOO- in Mitochondria under Various Stimuli with a Sensitive Fluorescence Probe, ANALYTICAL CHEMISTRY, 2017, 第 11 作者
（31） Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者
（32） A Strategy for Specific Fluorescence Imaging of Monoamine OxidaseA in Living Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 3 作者
（33） 青霉素G酰化酶的近红外荧光探针及其活体成像, In vivo imaging of penicillin G acylase in mice via a near-infrared fluorescent probe, 中国科学（化学）, 2017, 第 3 作者
（34） In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe, CHEMICAL SCIENCE, 2017, 第 5 作者
（35） A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging, CHEMISTRY-AN ASIAN JOURNAL, 2016, 第 3 作者
（36） A Lysosome-Targeting Fluorescence Off-On Probe for Imaging of Nitroreductase and Hypoxia in Live Cells, CHEMISTRY-AN ASIAN JOURNAL, 2016, 第 6 作者
（37） Monitoring gamma-glutamyl transpeptidase activity and evaluating its inhibitors by a water-soluble near-infrared fluorescent probe, BIOSENSORS & BIOELECTRONICS, 2016, 第 5 作者
（38） Sensitive and Selective Ratiometric Fluorescence Probes for Detection of Intracellular Endogenous Monoamine Oxidase A, ANALYTICAL CHEMISTRY, 2016, 第 5 作者
（39） Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe, ANALYTICAL CHEMISTRY, 2016, 第 6 作者
（40） Monitoring ��-glutamyl transpeptidase activity and evaluating its inhibitors by a water-soluble near-infrared fluorescent probe, BIOSENSORS AND BIOELECTRONICS, 2016, 第 5 作者
（41） HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe, CHEMICAL SCIENCE, 2015, 第 5 作者
（42） An Upconversion Luminescence Nanoprobe for the Ultrasensitive Detection of Hyaluronidase, ANALYTICAL CHEMISTRY, 2015, 第 11 作者
（43） A simple fluorescent off-on probe for the discrimination of cysteine from glutathione, CHEMICAL COMMUNICATIONS, 2015, 第 11 作者
（44） Design strategies for water-soluble small molecular chromogenic and fluorogenic probes., CHEMICAL REVIEWS, 2014, 第 11 作者
（45） Sensitive and Selective Near-Infrared Fluorescent Off-On Probe and Its Application to Imaging Different Levels of beta-Lactamase in Staphylococcus aureus, ANALYTICAL CHEMISTRY, 2014, 第 4 作者
（46） 转动光谱学与微波光谱技术研究进展, Recent Advances on Rotational Spectroscopy and Microwave Spectroscopic Techniques, 分析化学, 2014, 第 3 作者
（47） Recent Advances on Rotational Spectroscopy and Microwave Spectroscopic Techniques, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2014, 第 3 作者
（48） Gold nanoparticles functionalized with cresyl violet and porphyrin via hyaluronic acid for targeted cell imaging and phototherapy, CHEMICAL COMMUNICATIONS, 2014, 第 5 作者
（49） Detection of glucose via enzyme-coupling reaction based on a DT-diaphorase fluorescence probe, TALANTA, 2014, 第 11 作者
（50） A Cresyl Violet-Based Fluorescent Off-On Probe for the Detection and Imaging of Hypoxia and Nitroreductase in Living Organisms, CHEMISTRY-AN ASIAN JOURNAL, 2014, 第 7 作者
（51） Poly(m-phenylenediamine)-Based Fluorescent Nanoprobe for Ultrasensitive Detection of Matrix Metalloproteinase 2, ANALYTICAL CHEMISTRY, 2014, 第 11 作者
（52） Fluorescent probes and nanoparticles for intracellular sensing of pH values, METHODS AND APPLICATIONS IN FLUORESCENCE, 2014, 第 2 作者
（53） Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-(5-Nitrofuran-2-yl)methoxy-3H-phenoxazin-3-one, ANALYTICAL CHEMISTRY, 2013, 第 11 作者
（54） Distinguishing Folate-Receptor-Positive Cells from Folate-Receptor-Negative Cells Using a Fluorescence Off-On Nanoprobe, ANALYTICAL CHEMISTRY, 2013, 第 4 作者
（55） 7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase, CHEMICAL COMMUNICATIONS, 2013, 第 4 作者
（56） Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells as well as green gram sprouts, TALANTA, 2013, 第 4 作者
（57） Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells Cas well as green gram sprouts, TALANTA, 2013, 第 4 作者
（58） Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal, SCIENTIFIC REPORTS, 2013, 第 3 作者
（59） 3, 4-Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S-Transferase in Living Cells, CHINESE JOURNAL OF CHEMISTRY, 2013, 第 4 作者
（60） Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells., J. MATER. CHEM., 2012, 第 4 作者
（61） Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 4 作者
（62） A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen., MOL. BIOSYST., 2012, 第 4 作者
（63） A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen, MOLECULARBIOSYSTEMS, 2012, 第 11 作者
（64） A long-wavelength fluorescent probe for imaging reduced glutathione in live cells, SENSORS AND ACTUATORS B-CHEMICAL, 2012, 第 4 作者
（65） A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 第 2 作者
（66） A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells., ANGEW. CHEM. INT. ED., 2012, 第 2 作者
（67） A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging., ANALYST, 2012, 第 5 作者
（68） A long-wavelength fluorescent probe for imaging reduced glutathione in live cells, SENS. ACTUATORS B: CHEM., 2012, 第 4 作者
（69） Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG, NATURE COMMUNICATIONS, 2012, 第 1 作者
（70） Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe, TALANTA, 2011, 第 6 作者
（71） A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2, CHEMICAL COMMUNICATIONS, 2011, 第 5 作者
（72） Click Chemistry Based Method for the Preparation of Maleinimide-Type Thiol-Reactive Labels, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 2 作者
（73） Imaging Different Interactions of Mercury and Silver with Live Cells by a Designed Fluorescence Probe Rhodamine B Selenolactone, INORGANIC CHEMISTRY, 2010, 第 3 作者
（74） A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, CHEM. COMMUN., 2010, 第 4 作者
（75） Rhodamine B Piperazinoacetohydrazine: AWater-Soluble Spectroscopic Reagent for Pyruvic Acid Labeling, CHEM-EUR J, 2010, 第 5 作者
（76） Imaging Different Interactions of Mercury and Silver with Live Cells by a Designed Fluorescence Probe Rhodamine B Selenolactone, INORG. CHEM., 2010, 第 3 作者
（77） Rhodamine B Piperazinoacetohydrazine: A Water-Soluble Spectroscopic Reagent for Pyruvic Acid Labeling, CHEMISTRY-A EUROPEAN JOURNAL, 2010, 第 5 作者
（78） A near-infrared fluorescent probe for monitoring tyrosinase activity, CHEMICAL COMMUNICATIONS, 2010, 第 11 作者
（79） A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles, CHEMICAL COMMUNICATIONS, 2010, 第 4 作者
（80） A near-infrared fluorescent probe for monitoring tyrosinase activity, CHEM. COMMUN., 2010, 第 1 作者
（81） Clickable fluorophores for biological labeling-with or without copper, ORGANICBIOMOLECULARCHEMISTRY, 2009, 第 2 作者
（82） 含“点击”反应基团的苯并恶嗪类长波长光学探针的合成及其生物分析应用, 分析化学, 2009, 第 1 作者
（83） New Approach for Local Structure Analysis of the Tyrosine Domain in Proteins by Using a Site-Specific and Polarity-Sensitive Fluorescent Probe, CHEMBIOCHEM, 2009, 第 2 作者

   

（ 1 ） 荧光探针的设计及其用于细胞铁死亡过程荧光成像的研究, 负责人, 国家任务, 2022-01--2025-12