基本信息

李梅 女 博导 中国科学院生物物理研究所
电子邮件: meili@ibp.ac.cn
通信地址: 北京朝阳区大屯路15号3201房间
邮政编码:
电子邮件: meili@ibp.ac.cn
通信地址: 北京朝阳区大屯路15号3201房间
邮政编码:
招生信息
招生专业
071010-生物化学与分子生物学071011-生物物理学
招生方向
光合作用相关(膜)蛋白的结构生物学研究
教育背景
2004-09--2007-06 中国科学院生物物理研究所 博士1999-09--2003-03 中国科学院生物物理研究所 硕士1991-09--1995-06 天津市南开大学 学士
工作经历
工作简历
2016-12~现在, 中国科学院生物物理研究所, 研究员2007-07~现在, 中国科学院生物物理研究所, 副研究员2004-09~2007-06,中国科学院生物物理研究所, 博士2000-04~现在, 中国科学院生物物理研究所, 助理研究员1999-09~2003-03,中国科学院生物物理研究所, 硕士1995-07~现在, 中国科学院生物物理研究所, 研究实习员1991-09~1995-06,天津市南开大学, 学士
专利与奖励
专利成果
( 1 ) 一组拟南芥磷酸核酮糖激酶的突变体, 2020, 第 1 作者, 专利号: CN111172130A( 2 ) 来自赤子爱胜蚓的蚯蚓纤溶酶多种组分的制备方法, 2007, 第 3 作者, 专利号: CN1308446
出版信息
发表论文
(1) Structural insights into photosynthetic cyclic electron transport, MOLECULAR PLANT, 2023, 第 7 作者(2) Structural insights into the assembly and energy transfer of the Lhcb9-dependent photosystem I from moss Physcomitrium patens, NATURE PLANTS, 2023, 第 4 作者 通讯作者(3) Dynamic Regulation of the Light-Harvesting System through State Transitions in Land Plants and Green Algae, PLANTS-BASEL, 2023, 第 2 作者 通讯作者(4) Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH, NATURE PLANTS, 2022, 第 13 作者 通讯作者(5) Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC���LH1 supercomplex, Nature Communications, 2022, 第 10 作者 通讯作者(6) Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana, Molecular Plant, 2022, 第 9 作者 通讯作者(7) Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082, MARINE DRUGS, 2022, 第 8 作者 通讯作者(8) Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC-LH1 supercomplex, NATURE COMMUNICATIONS, 2022, 第 10 作者 通讯作者(9) 高等植物光系统复合物结构生物学研究进展, Advances in structural biology of photosystem complexes in higher plants, 自然杂志, 2021, 第 2 作者 通讯作者(10) Structural basis of LhcbM5-mediated state transitions in green algae, NATURE PLANTS, 2021, 第 10 作者 通讯作者(11) Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase, NATURE COMMUNICATIONS, 2020, 第 10 作者 通讯作者(12) Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle, PLANT CELL, 2020, 第 8 作者 通讯作者(13) Assembly of eukaryotic photosystem II with diverse light-harvesting antennas, CURRENT OPINION IN STRUCTURAL BIOLOGY, 2020, 第 5 作者 通讯作者(14) Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, NATURE COMMUNICATIONS, 2020, 第 8 作者 通讯作者(15) Structural analysis and comparison of light-harvesting complexes I and II, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2020, 第 5 作者 通讯作者(16) Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex., NATURE PLANTS, 2020, 第 9 作者 通讯作者(17) Structural Insights into Substrate Selectivity, Catalytic Mechanism, and Redox Regulation of Rice Photosystem II Core Phosphatase, MOLECULAR PLANT, 2019, 第 4 作者(18) Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex, NATURE PLANTS, 2019, 第 8 作者 通讯作者(19) Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II, SCIENCE, 2018, 第 8 作者 通讯作者(20) Structural roles of lipid molecules in the assembly of plant PSII-2LHCII supercomplex, Biophysics Reports, 2018, 第 4 作者(21) Structural roles of lipid molecules in the assembly of plant PSII-LHCII supercomplex, Structural roles of lipid molecules in the assembly of plant PSII-LHCII supercomplex, 生物物理学报:英文版, 2018, 第 4 作者(22) A possible molecular basis for photoprotection in the minor antenna proteins of plants, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2018, 第 7 作者(23) Structure, assembly and energy transfer of plant photosystem II supercomplex, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2018, 第 6 作者 通讯作者(24) Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex, SCIENCE, 2017, 第 9 作者 通讯作者(25) Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship, BMC BIOTECHNOLOGY, 2017, 第 4 作者(26) Structure of C-terminal Domain of Peptidyl-prolyl cis-trans Isomerase from Pseudomonas syringae pv. Tomato str. DC3000 at 1.6 angstrom Resolution, PROTEIN AND PEPTIDE LETTERS, 2017, 第 4 作者 通讯作者(27) Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana, PLOS ONE, 2016, 第 2 作者 通讯作者(28) Crystal Structures of Arabidopsis thaliana Oxalyl- CoA Synthetase Essential for Oxalate Degradation, Crystal Structures of Arabidopsis thaliana Oxalyl- CoA Synthetase Essential for Oxalate Degradation, 分子植物:英文版, 2016, 第 3 作者(29) Structure-oriented substrate specificity engineering of aldehyde-deformylating oxygenase towards aldehydes carbon chain length, BIOTECHNOLOGY FOR BIOFUELS, 2016, 第 4 作者(30) Structure of spinach photosystem II-LHCII supercomplex at 3.2 angstrom resolution, NATURE, 2016, 第 6 作者 通讯作者(31) Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, 蛋白质与细胞:英文版, 2015, 第 2 作者(32) Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese- Induced Conformational Change, Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese- Induced Conformational Change, 分子植物:英文版, 2015, 第 3 作者(33) Crystal structures of the PsbS protein essential for photoprotection in plants, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, (34) Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, 蛋白质与细胞:英文版, 2015, 第 2 作者(35) Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, PROTEIN CELL, 2015, (36) Structural mechanism underlying the specific recognition between the arabidopsis state-transition phosphatase tap38/pph1 and phosphorylated light-harvesting complex protein lhcb1, PLANT CELL, 2015, 第 3 作者(37) Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, PROTEIN & CELL, 2015, 第 2 作者 通讯作者(38) Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese-Induced Conformational Change, MOLECULAR PLANT, 2015, (39) Crystal Structure of a Multilayer Packed Major Light-Harvesting Complex: Implications for Grana Stacking in Higher Plants, MOLECULAR PLANT, 2014, 第 2 作者 通讯作者(40) Structure of 2-haloacid dehalogenase from Pseudomonas syringae pv. tomato DC3000, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2013, 第 3 作者 通讯作者(41) Spectroscopic Study of the Light-Harvesting CP29 Antenna Complex of Photosystem II-Part I, JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 第 3 作者(42) Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae, PROTEIN & CELL, 2013, 第 3 作者(43) Recombinant hemangiopoietin promotes cell adhesion and binds heparin in its multimeric form, MOLECULAR MEDICINE REPORTS, 2013, 第 3 作者(44) Architecture and function of plant light-harvesting complexes II, CURRENT OPINION IN STRUCTURAL BIOLOGY, 2013, 第 3 作者(45) 杜氏盐藻类驱动蛋白钙调素结合蛋白马达区的表达与纯化, Expression and purification of KCBP motor domain from Dunaliella salina, 郑州大学学报:医学版, 2011, 第 6 作者(46) Structural insights into energy regulation of light-harvesting complex CP29 from spinach, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, (47) Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 6 作者(48) Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P(8)' Residue in the Potato Inhibitor I Family, PLOS ONE, 2011, 第 3 作者(49) Crystal structures of SULT1A2 and SULT1A1*3: Insights into the substrate inhibition and the role of Tyr149 in SULT1A2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 第 4 作者(50) Crystal structure of the PSPTO-PSP protein from Pseudomonas syringae pv. tomato str. DC3000 in complex with D-glucose, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 第 3 作者(51) Crystal structures of Pseudomonas syringae pv. tomato DC3000 quinone oxidoreductase and its complex with NADPH, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 第 4 作者(52) Protein crystallization, PHOTOSYNTHESIS RESEARCH, 2009, 第 1 作者(53) 决明子中一种新的降脂蛋白的纯化与生化特性, 中国科学:C辑, 2008, 第 2 作者(54) Purification and characterization of a novel cholesterol-lowering protein from the seeds of Senna obtusifolia, SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2008, 第 2 作者(55) Crystal structure studies on sulfur oxygenase reductase from Acidianus tengchongensis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 第 1 作者(56) 决明子中一种新的降脂蛋白的纯化与生化特性, 中国科学:C辑, 2008, 第 2 作者(57) Purification and characterization of a novel cholesterol-lowering protein from the seeds of Senna obtusifolia, SCIENCEINCHINASERIESCLIFESCIENCES, 2008, 第 2 作者(58) Crystal structure study on human s100a13 at 2.0 angstrom resolution, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 第 1 作者 通讯作者(59) B链羧端去三肽(B28-B30)与去四肽(B27-B30)胰岛素的制备及去三肽胰岛素的初步晶体学研究, 自然科学进展, 1999, 第 2 作者
科研活动
科研项目
( 1 ) 光系统I及相关膜蛋白复合物的结构、组装及动态调控, 负责人, 国家任务, 2020-01--2024-12( 2 ) 光合作用能量转换及动态调控的结构基础, 负责人, 中国科学院计划, 2018-08--2023-07