基本信息
魏刚 男 博导 中国科学院上海营养与健康研究所
电子邮件： weigang@picb.ac.cn
通信地址： 岳阳路320号
邮政编码：
电子邮件： weigang@picb.ac.cn
通信地址： 岳阳路320号
邮政编码：
招生信息
招生专业
0710Z2-计算生物学
招生方向
计算生物学-发育和疾病的表观遗传调控
教育背景
2000-09--2005-07 北京大学 博士
1996-09--2000-07 北京大学 学士
1996-09--2000-07 北京大学 学士
工作经历
工作简历
2012-01~现在, 中科院上海生命科学研究院计算生物学研究所, 研究员
2005-09~2011-12,美国国立健康研究院, 博士后研究助理
2000-09~2005-07,北京大学, 博士
1996-09~2000-07,北京大学, 学士
2005-09~2011-12,美国国立健康研究院, 博士后研究助理
2000-09~2005-07,北京大学, 博士
1996-09~2000-07,北京大学, 学士
出版信息
发表论文
（1） PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum, MICROBIOLOGY SPECTRUM, 2023, 第 11 作者
（2） The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression, CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 第 11 作者
（3） Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 第 11 作者
（4） Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging, DEVELOPMENTAL CELL, 2022, 第 18 作者
（5） Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma, ENDOCRINE, 2022, 第 11 作者
（6） Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, NATIONAL SCIENCE REVIEW, 2022, 第 11 作者
（7） Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 11 作者
（8） The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum, MBIO, 2021, 第 11 作者
（9） Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, SCIENCE ADVANCES, 2020, 第 11 作者
（10） Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling, CELL DEATH AND DIFFERENTIATION, 2020, 第 9 作者
（11） The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, MOLECULAR CELL, 2020, 第 0 作者
（12） Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites, MBIO, 2020, 第 16 作者
（13） Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, CELL RESEARCH, 2020, 第 23 作者
（14） SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, NATURE COMMUNICATIONS, 2020, 第 10 作者
（15） Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, SCIENCE, 2020, 第 12 作者
（16） Establishment and Investigation of a Multiple Gene Expression Signature to Predict Long-Term Survival in Pancreatic Cancer, BIOMED RESEARCH INTERNATIONAL, 2020, 第 11 作者
（17） Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis, CELL DEATH AND DIFFERENTIATION, 2019, 第 11 作者
（18） SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes, STEM CELLS, 2019, 第 11 作者
（19） Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, NATURE COMMUNICATIONS, 2019, 第 26 作者
（20） MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes, CANCER LETTERS, 2018, 第 7 作者
（21） Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., PROTEIN & CELL, 2018, 第 5 作者
（22） Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, ELIFE,6,(2017-10-12), 2017, 第 2 作者
（23） Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway, DIABETES, 2017, 第 12 作者
（24） SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing, NUCLEIC ACIDS RESEARCH, 2017, 第 9 作者
（25） Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, STEM CELL REPORTS, 2017, 第 11 作者
（26） Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation, EPIGENOMICS, 2017, 第 11 作者
（27） Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 第 11 作者
（28） USP21 prevents the generation of T-helper-1-like Treg cells, NATURE COMMUNICATIONS, 2016, 第 10 作者
（29） A positive role for polycomb in transcriptional regulation via H4K20me1, CELL RESEARCH, 2016, 第 11 作者
（30） Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, CLINICAL EPIGENETICS, 2016, 第 11 作者
（31） GFR��2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer, CANCER LETTERS, 2016, 第 12 作者
（32） Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, DEVELOPMENT, 2016, 第 4 作者
（33） Foxp1/2/4 regulate endochondral ossification as a suppresser complex, DEVELOPMENTAL BIOLOGY, 2015, 第 0 作者
（34） Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development, PLOSGENETICS, 2014, 第 5 作者
（35） Critical role of histone demethylase Jmjd3 in the regulation of CD4 + T cell differentiation, NATURE COMMUNICATIONS, 2014, 第 8 作者
（36） Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 5 作者
（37） Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 4 作者
（38） PARP-1 regulates expression of TGF-�� receptors in T cells, BLOOD, 2013, 第 9 作者
（39） Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, SCIENCE CHINA-LIFE SCIENCES, 2013, 第 2 作者
（40） c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells, CELL, 2012, 第 3 作者
（41） The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, IMMUNITY, 2012, 第 4 作者
（42） Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, NUCLEOSOMES, HISTONES & CHROMATIN, PT B, 2012, 第 1 作者
（43） Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, CELL RESEARCH, 2012, 第 2 作者
（44） Chapter Thirteen - Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, METHODSINENZYMOLOGY, 2012, 第 1 作者
（45） Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types, IMMUNITY, 2011, 第 1 作者
（46） Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 第 2 作者
（47） GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice, JOURNAL OF CLINICAL INVESTIGATION, 2011, 第 13 作者
（48） Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, CELL RESEARCH, 2010, 第 3 作者
（49） The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, IMMUNITY, 2010, 第 3 作者
（50） IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 第 2 作者
（51） Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103(+) inducible regulatory T cells, JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 第 3 作者
（52） H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, NATURE GENETICS, 2009, 第 3 作者
（53） Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, NUCLEIC ACIDS RESEARCH, 2009, 第 2 作者
（54） Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4 + T Cells, IMMUNITY, 2009, 第 1 作者
（55） Dynamic Regulation of Nucleosome Positioning in the Human Genome, CELL, 2008, 第 7 作者
（56） High-Resolution Profiling of Histone Methylations in the Human Genome, CELL, 2007, 第 7 作者
（57） Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns, GENOME RESEARCH, 2007, 第 2 作者
（58） The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 6 作者
（2） The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression, CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 第 11 作者
（3） Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 第 11 作者
（4） Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging, DEVELOPMENTAL CELL, 2022, 第 18 作者
（5） Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma, ENDOCRINE, 2022, 第 11 作者
（6） Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, NATIONAL SCIENCE REVIEW, 2022, 第 11 作者
（7） Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 11 作者
（8） The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum, MBIO, 2021, 第 11 作者
（9） Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, SCIENCE ADVANCES, 2020, 第 11 作者
（10） Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling, CELL DEATH AND DIFFERENTIATION, 2020, 第 9 作者
（11） The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, MOLECULAR CELL, 2020, 第 0 作者
（12） Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites, MBIO, 2020, 第 16 作者
（13） Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, CELL RESEARCH, 2020, 第 23 作者
（14） SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, NATURE COMMUNICATIONS, 2020, 第 10 作者
（15） Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, SCIENCE, 2020, 第 12 作者
（16） Establishment and Investigation of a Multiple Gene Expression Signature to Predict Long-Term Survival in Pancreatic Cancer, BIOMED RESEARCH INTERNATIONAL, 2020, 第 11 作者
（17） Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis, CELL DEATH AND DIFFERENTIATION, 2019, 第 11 作者
（18） SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes, STEM CELLS, 2019, 第 11 作者
（19） Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, NATURE COMMUNICATIONS, 2019, 第 26 作者
（20） MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes, CANCER LETTERS, 2018, 第 7 作者
（21） Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., PROTEIN & CELL, 2018, 第 5 作者
（22） Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, ELIFE,6,(2017-10-12), 2017, 第 2 作者
（23） Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway, DIABETES, 2017, 第 12 作者
（24） SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing, NUCLEIC ACIDS RESEARCH, 2017, 第 9 作者
（25） Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, STEM CELL REPORTS, 2017, 第 11 作者
（26） Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation, EPIGENOMICS, 2017, 第 11 作者
（27） Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 第 11 作者
（28） USP21 prevents the generation of T-helper-1-like Treg cells, NATURE COMMUNICATIONS, 2016, 第 10 作者
（29） A positive role for polycomb in transcriptional regulation via H4K20me1, CELL RESEARCH, 2016, 第 11 作者
（30） Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, CLINICAL EPIGENETICS, 2016, 第 11 作者
（31） GFR��2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer, CANCER LETTERS, 2016, 第 12 作者
（32） Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, DEVELOPMENT, 2016, 第 4 作者
（33） Foxp1/2/4 regulate endochondral ossification as a suppresser complex, DEVELOPMENTAL BIOLOGY, 2015, 第 0 作者
（34） Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development, PLOSGENETICS, 2014, 第 5 作者
（35） Critical role of histone demethylase Jmjd3 in the regulation of CD4 + T cell differentiation, NATURE COMMUNICATIONS, 2014, 第 8 作者
（36） Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 5 作者
（37） Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 4 作者
（38） PARP-1 regulates expression of TGF-�� receptors in T cells, BLOOD, 2013, 第 9 作者
（39） Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, SCIENCE CHINA-LIFE SCIENCES, 2013, 第 2 作者
（40） c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells, CELL, 2012, 第 3 作者
（41） The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, IMMUNITY, 2012, 第 4 作者
（42） Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, NUCLEOSOMES, HISTONES & CHROMATIN, PT B, 2012, 第 1 作者
（43） Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, CELL RESEARCH, 2012, 第 2 作者
（44） Chapter Thirteen - Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, METHODSINENZYMOLOGY, 2012, 第 1 作者
（45） Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types, IMMUNITY, 2011, 第 1 作者
（46） Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 第 2 作者
（47） GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice, JOURNAL OF CLINICAL INVESTIGATION, 2011, 第 13 作者
（48） Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, CELL RESEARCH, 2010, 第 3 作者
（49） The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, IMMUNITY, 2010, 第 3 作者
（50） IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 第 2 作者
（51） Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103(+) inducible regulatory T cells, JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 第 3 作者
（52） H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, NATURE GENETICS, 2009, 第 3 作者
（53） Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, NUCLEIC ACIDS RESEARCH, 2009, 第 2 作者
（54） Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4 + T Cells, IMMUNITY, 2009, 第 1 作者
（55） Dynamic Regulation of Nucleosome Positioning in the Human Genome, CELL, 2008, 第 7 作者
（56） High-Resolution Profiling of Histone Methylations in the Human Genome, CELL, 2007, 第 7 作者
（57） Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns, GENOME RESEARCH, 2007, 第 2 作者
（58） The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 6 作者
科研活动
科研项目
（ 1 ） 生死细胞互作青年交叉团队, 参与, 中国科学院计划, 2024-01--2026-12