基本信息
李于  男  博导  中国科学院上海营养与健康研究所
电子邮件: liyu@sibs.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:

招生信息

   
招生专业
071003-生理学
100104-病理学与病理生理学
086000-生物与医药
招生方向
生理学-营养感应和代谢调控
病理学与病理生理学-营养感应和代谢调控
生物与医药-营养感应和代谢调控

教育背景

2004-04--2008-08   加拿大圭尔夫大学分子及细胞生物系   博士
2000-09--2003-08   天津科技大学生物工程系   硕士
1996-09--2000-08   天津科技大学生物工程系   学士

工作经历

   
工作简历
2017-01~现在, 中国科学院上海营养与健康研究院, 研究员
2013-01~2016-12,中国科学院上海生命科学研究院营养所, 研究员
2009-03~2013-01,美国波士顿大学Whitaker心血管病研究所, 博士后
2008-09~2009-02,加拿大圭尔夫大学分子及细胞生物系, 博士后
2004-07~2008-04,加拿大圭尔夫大学分子及细胞生物系, 助教
2004-04~2008-08,加拿大圭尔夫大学分子及细胞生物系, 博士
2000-09~2003-08,天津科技大学生物工程系, 硕士
1996-09~2000-08,天津科技大学生物工程系, 学士

教授课程

营养与生理学
营养学

专利与奖励

   
奖励信息
(1) 中华医学会医学科学技术奖三等奖, 三等奖, 其他, 2019
专利成果
( 1 ) 玫瑰茄-绿茶组合物在改善饮食诱导的代谢紊乱中的应用, 2020, 第 1 作者, 专利号: ZL201710102761.7

( 2 ) CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: ZL201710423436.5

( 3 ) CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: PCT/CN2017/087688

( 4 ) 两步发酵法生产酵母胞外海藻糖的方法, 2005, 第 4 作者, 专利号: ZL03129701.3

出版信息

   
发表论文
(1) Cui A, Ding D, Li Y*. Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors, Diabetes, 2021, 通讯作者
(2) CREB/ATF碱性亮氨酸拉链转录因子在代谢和细胞生长中的生物学功能, 生理学报, 2021, 通讯作者
(3) Zhao Z, Wang Z, Zhou D, Han Y, Ma F, Hu Z, Xin F, Liu XL, Ren T, Zhang F, Xue Y, Cui A, Liu Z, Bai J, Liu Y, Cai G, Su W, Dai X, Shen F, Pan Q, Li Y*, Fan J*. Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene, Cellular and Molecular Gastroenterology and Hepatology, 2021, 通讯作者
(4) Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B*, Wang H*. Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic Sirtuin 1-C/EBPα-miRNA-223 axis, Hepatology, 2021, 第 8 作者
(5) Hou X, Yin S, Ren R, Liu S, Yong L, Liu L, Li Y, Zheng M, Kunos G, Gao B, Wang H*. Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis, Hepatology, 2021, 第 7 作者
(6) Lin Q, Huang Z, Cai G, Fan X, Yan X, Liu Z, Zhao Z, Li J, Li J, Shi H, Kong M, Zheng M, Conklin D, Epstein P, Wintergerst K, Mohammadi M, Cai L, Li X, Li Y, Tan Y*. Activating AMP-activated protein kinase mediates fibroblast growth factor 1 protection from nonalcoholic fatty liver disease in mice, Hepatology, 2021, 第 19 作者
(7) Shi D#, Xia X#, Cui A#, Xiong Z, Yan Y, Luo J, Chen G, Zeng Y, Cai D, Hou L, McDermott J, Li Y, Zhang H, Han J*. The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18 (Pten) and independent of daf-16, Nature Communications, 2020, 第 13 作者
(8) Li M, He X, Guo W, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H*. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways, Nature Cancer, 2020, 第 17 作者
(9) Cui A#, Li J#, Ji S#, Ma F, Wang G, Xue Y, Liu Z, Gao J, Han J, Tai P, Wang T, Chen J, Ma X*, Li Y*. The effects of B1344, a novel fibroblast growth factor 21 analog, on nonalcoholic steatohepatitis in nonhuman primates, Diabetes, 2020, 通讯作者
(10) Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*. CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mice., Hepatology, 2020, 通讯作者
(11) Bai J, Xia M, Xue Y, Ma F, Cui A, Sun Y, Han Y, Xu X, Zhang F, Hu Z, Liu Z, Liu Y, Cai G, Su W, Sun X, Wu H, Yan H, Chang X, Hu X, Bian H, Xia P, Gao J, Li Y*, Gao X*. Thrombospondin1 improves hepatic steatosis in diet-induced insulin-resistant mice and are associated with hepatic fat content in humans, EBioMedicine, 2020, 通讯作者
(12) 碱性亮氨酸拉链转录因子CREBZF通过STAT3通路调控肝脏组织再生, 临床肝胆病杂志, 2019, 通讯作者
(13) Yang Y#, Ma F#, Liu Z, Su Q, Liu Y, Liu Z, Li Y*. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3, Journal of Biological Chemistry, 2019, 通讯作者
(14) Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex, Cell Metabolism, 2019, 第 7 作者
(15) Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway, Free Radic Biol Med, 2019, 第 10 作者
(16) Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats, EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, 通讯作者
(17) Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene, Nature Communications, 2019, 通讯作者
(18) Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang J, Chen S, Ye RD, Li Y, and Le Y*. Fpr2 deficiency alleviates diet-induced insulin resistance through reducing body weight gain and inhibiting inflammation mediated by macrophage chemotaxis and M1 polarization, Diabetes, 2019, 第11作者
(19) Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin X-M*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply, Autophagy, 2018, 第 9 作者
(20) Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M. DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease, Hepatology, 2018, 第 5 作者
(21) Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice, Hepatology, 2018, 通讯作者
(22) 刘雨笑,张菲菲,李于*.肝脏CREBZF通过抑制Insig活性促进胰岛素诱导的脂质合成并加重饮食诱导的胰岛素抵抗小鼠的肝脏脂质沉积, 临床肝胆病杂志, 2018, 通讯作者
(23) Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X*. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21, British Journal of Pharmacology, 2018, 通讯作者
(24) Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y. Fasting-induced hormonal regulation of lysosomal function, Cell Res, 2017, 第 7 作者
(25) Sun Y, Yuan X, Zhang F, Han Y, Chang X, Xu X, Li Y, and Gao X. Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells, Scientific Reports, 2017, 第 7 作者
(26) 崔奥媛, 李于*. 成纤维细胞生长因子21的前世今生:胰岛素增敏机制与临床研究, 中华糖尿病杂志, 2017, 通讯作者
(27) Cui A, Hu Z, Han Y, Yang Y, Li Y*. Optimized Analysis Of In Vivo and In Vitro Hepatic Steatosis, Journal of Visualized Experiments, 2017, 通讯作者
(28) Zhuo S, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y. Microrna-451 negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase mediated gluconeogenesis, Diabetes, 2016, 第11作者
(29) Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice through Peroxisome Proliferator-Activated Receptor Alpha, Diabetes, 2016, 通讯作者
(30) Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1, Hepatology, 2016, 通讯作者
(31) 龚琦, 张菲菲, 韩亚美, 李于*. FGF21的代谢调控及临床应用, 中国细胞生物学学报, 2015, 通讯作者
(32) Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*, Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21, Gastroenterology, 2014, 通讯作者
(33) DenBoer LM, Iyer A, McCluggage ARR, Li Y, Martyn AC, Lu R. JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation, Biochim Biophys Acta, 2013, 第 4 作者
(34) Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs, PLoS ONE, 2013, 第 1 作者
(35) Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice, Journal of Biological Chemistry, 2013, 通讯作者
(36) Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, and Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in Diet-Induced insulin-resistant mice, Cell Metabolism, 2011, 第 1 作者
(37) Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver, FASEB Journal, 2011, 第 1 作者
(38) Audas TE, Li Y, Liang G, and Lu R. A novel protein, Luman/CREB3 recruitment factor (LRF), inhibits Luman activation of the unfolded protein response, Molecular and Cellular Biology, 2008, 第 2 作者
(39) Liang G, Audas TE, Li Y, Cockram GP, Dean JD, Martyn AC, Kokame K, and Lu R. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element, Molecular and Cellular Biology, 2006, 第 3 作者

科研活动

   
科研项目
( 1 ) 国家自然科学基金委_面上项目 核受体RARβ调控肝脏脂质沉积和胰岛素抵抗的机制研究, 负责人, 国家任务, 2017-01--2020-12
( 2 ) 国家自然科学基金委_面上项目 转录因子CREBZF调节肝脏糖异生和控制糖代谢平衡的机制研究, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 国家自然科学基金委_面上项目 肝脏SIRT1通过FGF21调节酮体生成和能量代谢的机制研究, 负责人, 国家任务, 2013-01--2016-12
( 4 ) 中国科学院计划_战略性先导科技专项 基于新型代谢因子CREBZF的抗糖尿病药物新靶标的研究, 负责人, 中国科学院计划, 2019-01--2020-09
( 5 ) 国家科技部_重点研发计划 糖尿病发病机理及代谢异常生物标志物与个体化诊疗研究, 参与, 国家任务, 2017-09--2019-12
( 6 ) 上海市科学技术委员会_科技创新行动计划项目 肝脏再生及重建小鼠模型的建立及应用, 负责人, 地方任务, 2019-05--2022-04
( 7 ) 国家自然科学基金委_重点项目 CREB/ATF碱性亮氨酸拉链转录因子调节肝脏稳态与NASH发生发展的机制研究, 负责人, 国家任务, 2022-01--2026-12
( 8 ) 国家自然科学基金委_杰出青年科学基金 肝脏营养感应与代谢调控, 负责人, 国家任务, 2020-01--2024-12
( 9 ) 国家科技部_重点研发计划 生长发育期营养失衡对代谢性疾病的影响及其机制, 参与, 国家任务, 2020-01--2024-12
参与会议
(1)Pharmacological inhibition of CREBZF improves insulin resistance by altering activation of macrophage in adipose tissue of diet-induced obese mice. American Diabetes Association 81th Scientific Sessions, Oral presentation, June 25-29, 2021. Virtual.   2021-06-25
(2)Hydroxylation regulation of hepatic gluconeogenesis via prolyl-hydroxylase 3 in mice. American Diabetes Association 81th Scientific Sessions, Oral presentation, June 25-29, 2021. Virtual.   2021-06-25
(3)Hormonal regulation of hepatic metabolism and nonalcoholic fatty liver disease in nonhuman primates. Chinese Diabetes Association (CDS)’s 24th scientific meeting,Invited Speaker, November 26, 2020,Suzhou.   2020-11-26
(4)Nutrient sensing and metabolic regulation in the liver. American Diabetes Association 80th Scientific Sessions, Invited Speaker, Chinese diabetes society symposium-Novel antidiabetic approaches and potential targets, June 15, 2020, Chicago, IL.   2020-06-15
(5)A novel genetic modified and PEGylated FGF21 analog for the treatment of nonalcoholic steatohepatitis in nonhuman primates. American Diabetes Association 80th Scientific Sessions, Poster presentation, June 12-16, 2020, Chicago, IL.   2020-06-12
(6)CREBZF acetylation at Lys126 couples glucose to white adipose tissue browning. American Diabetes Association 80th Scientific Sessions, Poster presentation, June 12-16, 2020, Chicago, IL.    2020-06-12
(7)CREBZF as a novel target of glucose sensing signaling in the control of adaptive thermogenesis in the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California.   2019-06-07
(8)Myeloid CREBZF couples inflammatory signals to systemic insulin resistance by regulating immune response of the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California   2019-06-07
(9)A Novel Metabolic Regulator CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig. 9th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, June 20-22, 2018, Orlando, Florida   2018-06-20
(10)Molecular Controls of Lipid Metabolism and Nonalcoholic Fatty Liver Disease. 2018 Queenstown Molecular Biology Meetings in Shanghai   2018-03-22
(11)bZIP Transcription Factor CREBZF Functions as a Novel Metabolic Regulator in the Control of Hepatic Steatosis in Diet-Induced Insulin Resistant Mice. American Diabetes Association 77th Scientific Sessions, Oral presentation, San Diego, California.   2017-06-09
(12)Hepatic SIRT1 Deficiency Abolishes Berberine-Mediated Augmentation of Autophagy and Reduction of Hepatic Steatosis in Diet-Induced Obesity Mice. American Diabetes Association 77th Scientific Sessions, Poster presentation, San Diego, California.   2017-06-09
(13)Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, February 15-19, 2017, Shanghai, China.   2017-02-19
(14)Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, Shanghai, China.   2017-02-15
(15)A novel mechanism for fibroblast growth factor 21 to regulate hepatic insulin sensitivity via inhibiting mammalian target of rapamycin complex 1. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.   2016-06-10
(16) ATF6 directly increases peroxisome proliferator-activated receptor alpha activity to reduce hepatic steatosis in mice. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.   2016-06-10
(17)FGF21 in Control of Hepatic Insulin Sensitivity. 7th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, New Orleans, Louisiana.   2016-06-09
(18)Fibroblast growth factor 21 improves hepatic insulin sensitivity and controls glucose homeostasis. New Advances in Metabolism Research Symposium, Duke-NUS Medical School, Invited Speaker, Singapore.   2016-04-20
(19) Hepatic SIRT1 Stimulates Fibroblast Growth Factor 21 to Improve Hepatic Insulin Sensitivity and Control Glucose Homeostasis. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.   2015-06-05
(20) The Unfolded Protein Response Regulates Hepatic Fatty Acid Metabolism and Hepatic Steatosis through Peroxisome Proliferator-Activated Receptor Alpha. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.   2015-06-05
(21) mTOR mediates metabolic effects of FGF21 on insulin sensitivity in mice. American Diabetes Association 74th Scientific Sessions, Oral Presentation, San Francisco, California.   2014-06-13
(22)RARβ functions as a novel downstream regulator of SIRT1 that protects against metabolic disorders in diet-induced obesity mice. American Diabetes Association 73th Scientific Sessions, Oral Presentation, Chicago, Illinois.   2013-06-21
(23)Transcriptional Regulation of Fasting Inducible Hormone FGF21 by Retinoic Acid Receptor β in the Liver. American Diabetes Association 72nd Scientific Sessions, Oral Presentation, Philadelphia, Pennsylvania.   2012-06-08
(24)Loss of SIRT1 in Liver Suppresses FGF21 Expression and Inhibits Fatty Acid Oxidation and Ketogenesis, Leading to Decreased Energy Expenditure and Increased Susceptibility of Obesity in Mice. American Diabetes Association 72nd Scientific Sessions, Poster Presentation, Philadelphia, Pennsylvania.   2012-06-08