基本信息
李于  男  博导  中国科学院上海营养与健康研究所
电子邮件: liyu@sinh.ac.cn
通信地址: 上海市岳阳路320号
邮政编码: 200030

招生信息

   
招生专业
100104-病理学与病理生理学
071003-生理学
招生方向
病理学与病理生理学-营养感应和代谢调控
生理学-营养感应和代谢调控

教育背景

2004-04--2008-08   加拿大圭尔夫大学分子及细胞生物系   博士
2000-09--2003-08   天津科技大学生物工程系   硕士
1996-09--2000-08   天津科技大学生物工程系   学士

工作经历

   
工作简历
2017-01~现在, 中国科学院上海营养与健康研究所, 研究员
2013-01~2016-12,中国科学院上海生命科学研究院营养所, 研究员
2009-03~2013-01,美国波士顿大学Whitaker心血管病研究所, 博士后
2008-09~2009-02,加拿大圭尔夫大学分子及细胞生物系, 博士后
2004-07~2008-04,加拿大圭尔夫大学分子及细胞生物系, 助教
2004-04~2008-08,加拿大圭尔夫大学分子及细胞生物系, 博士
2000-09~2003-08,天津科技大学生物工程系, 硕士
1996-09~2000-08,天津科技大学生物工程系, 学士
社会兼职
2023-01-01-今,中国生物化学与分子生物学会脂质与脂蛋白专业分会, 委员
2022-01-01-今,中国生物化学与分子生物学会代谢专业分会, 副主任委员
2020-07-01-2024-06-30,中华糖尿病杂志, 编委
2019-01-01-2023-12-30,生理学报, 常务编委
2019-01-01-今,中国生物物理学会代谢生物学会, 理事
2019-01-01-今,中华医学会糖尿病学分会糖尿病基础研究与转化医学学组, 委员
2018-01-01-今,Nutrition & Metabolism, 副主编
2018-01-01-今,中国病理生理学会内分泌与代谢专业委员会, 副秘书长

教授课程

营养与生理学
营养学

专利与奖励

   
奖励信息
(1) 教育部高等学校科学研究优秀成果奖(科学技术), 二等奖, 部委级, 2023
(2) 四川省科学技术进步奖, 二等奖, 省级, 2022
(3) 中华医学会医学科学技术奖, 三等奖, 部委级, 2019
专利成果
( 1 ) CREBZF抑制剂的筛选方法及溴隐亭作为CREBZF抑制剂在治疗疾病的应用, 2023, 第 1 作者, 专利号: 申请号202311008969.9

( 2 ) CREBZF抑制剂在制备巨噬细胞相关疾病的药物中的应用, 2023, 第 1 作者, 专利号: 申请号202311011186.6

( 3 ) 小鼠宿醉程度精准检测数学分析模型构建方法及应用, 2023, 第 2 作者, 专利号: 专利申请号2023106770517

( 4 ) 小鼠醉酒程度精准检测数学分析模型构建方法及应用, 2023, 第 2 作者, 专利号: 专利申请号202310677052.1

( 5 ) 人参皂苷或包含人参皂苷的组合物的应用, 2022, 第 3 作者, 专利号: 专利申请号202210320411.3

( 6 ) 玫瑰茄-绿茶组合物在改善饮食诱导的代谢紊乱中的应用, 2020, 第 1 作者, 专利号: ZL201710102761.7

( 7 ) CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: ZL201710423436.5

( 8 ) CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: 专利申请号PCT/CN2017/087688

( 9 ) 两步发酵法生产酵母胞外海藻糖的方法, 2005, 第 4 作者, 专利号: ZL03129701.3

出版信息

   
发表论文
(1) Xue Y#, Cui A#, Wei S, Ma F, Liu Z, Fang X, Huo S, Sun X, Li W, Hu Z, Liu Y, Cai G, Su W, Zhao J, Yan X, Gao C, Wen J, Zhang H, Li H, Liu Y, Lin X, Xu Y, Fu W*, Fang J*, Li Y*. Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism, Proceedings of the National Academy of Sciences, 2023, 通讯作者
(2) Ma F, Liu Y, Hu Z, Xue Y, Liu Z, Cai G, Su W, Zheng Z, Fang Z, Yan X, Ding D, Sun X, Jiang Y, Wei S, Li W, Zhao J, Zhang H, Li H, Xiao D, Zhang C, Ying H, Qin J, Gao X, Dai X, Fu W, Xu Y*, Li Y*, Cui A*. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression, Hepatology, 2023, 第 2 作者
(3) Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B*, Wang H*. Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic Sirtuin 1-C/EBPα-miRNA-223 axis, Hepatology, 2022, 第 8 作者
(4) MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM, Journal of Hepatology, 2022, 第 13 作者
(5) Zhao J#, Zou H#, Huo Y, Wei X, Li Y*. Emerging Roles of Selenium on Metabolism and Type 2 Diabetes, Frontiers in Nutrition, 2022, 通讯作者
(6) Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs, Redox Biology, 2022, 第 18 作者
(7) Zou H, Zhang M, Zhu X, Zhu L, Chen S, Luo M, Xie Q, Chen Y, Zhang K, Bu Q, Wei Y, Ye T, Li Q, Yan X, Zhou Z, Yang C, Li Y, Zhou H*, Zhang C*, You X*, Zheng G*, Zhao G*. Ginsenoside Rb1 improves metabolic disorder in high-fat diet-induced obese mice associated with modulation of gut microbiota, Frontiers in Microbiology, 2022, 第 17 作者
(8) Cui A, Ding D, Li Y*. Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors, Diabetes, 2021, 通讯作者
(9) Zhao Z, Wang Z, Zhou D, Han Y, Ma F, Hu Z, Xin F, Liu XL, Ren T, Zhang F, Xue Y, Cui A, Liu Z, Bai J, Liu Y, Cai G, Su W, Dai X, Shen F, Pan Q, Li Y*, Fan J*. Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene, Cellular and Molecular Gastroenterology and Hepatology, 2021, 通讯作者
(10) 刘雨笑, 苏维彤, 李于*. CREB/ATF碱性亮氨酸拉链转录因子在代谢和细胞生长中的生物学功能, 生理学报, 2021, 通讯作者
(11) Hou X, Yin S, Ren R, Liu S, Yong L, Liu L, Li Y, Zheng M, Kunos G, Gao B, Wang H*. Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis, Hepatology, 2021, 第 7 作者
(12) Shi D#, Xia X#, Cui A#, Xiong Z, Yan Y, Luo J, Chen G, Zeng Y, Cai D, Hou L, McDermott J, Li Y, Zhang H, Han J*. The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18 (Pten) and independent of daf-16, Nature Communications, 2020, 第 13 作者
(13) Cui A#, Li J#, Ji S#, Ma F, Wang G, Xue Y, Liu Z, Gao J, Han J, Tai P, Wang T, Chen J, Ma X*, Li Y*. The effects of B1344, a novel fibroblast growth factor 21 analog, on nonalcoholic steatohepatitis in nonhuman primates, Diabetes, 2020, 通讯作者
(14) Li M, He X, Guo W, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H*. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways, Nature Cancer, 2020, 第 17 作者
(15) Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*. CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mice., Hepatology, 2020, 通讯作者
(16) Bai J, Xia M, Xue Y, Ma F, Cui A, Sun Y, Han Y, Xu X, Zhang F, Hu Z, Liu Z, Liu Y, Cai G, Su W, Sun X, Wu H, Yan H, Chang X, Hu X, Bian H, Xia P, Gao J, Li Y*, Gao X*. Thrombospondin1 improves hepatic steatosis in diet-induced insulin-resistant mice and are associated with hepatic fat content in humans, EBioMedicine, 2020, 通讯作者
(17) Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals, Molecular Metabolism, 2019, 第 7 作者
(18) 碱性亮氨酸拉链转录因子CREBZF通过STAT3通路调控肝脏组织再生, 临床肝胆病杂志, 2019, 通讯作者
(19) Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3, FASEB Journal, 2019, 第 5 作者
(20) The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3, Journal of Biological Chemistry, 2019, 通讯作者
(21) Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex, Cell Metabolism, 2019, 第 7 作者
(22) Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway, Free Radic Biol Med, 2019, 第 10 作者
(23) Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats, Experimental and Molecular Medicine, 2019, 通讯作者
(24) Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene, Nature Communications, 2019, 通讯作者
(25) Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang J, Chen S, Ye RD, Li Y, and Le Y*. Fpr2 deficiency alleviates diet-induced insulin resistance through reducing body weight gain and inhibiting inflammation mediated by macrophage chemotaxis and M1 polarization, Diabetes, 2019, 第11作者
(26) Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin X-M*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply, Autophagy, 2018, 第 9 作者
(27) Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M. DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease, Hepatology, 2018, 第 5 作者
(28) Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice, Hepatology, 2018, 通讯作者
(29) 刘雨笑,张菲菲,李于*.肝脏CREBZF通过抑制Insig活性促进胰岛素诱导的脂质合成并加重饮食诱导的胰岛素抵抗小鼠的肝脏脂质沉积, 临床肝胆病杂志, 2018, 通讯作者
(30) Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X*. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21, British Journal of Pharmacology, 2018, 通讯作者
(31) Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y. Fasting-induced hormonal regulation of lysosomal function, Cell Res, 2017, 第 7 作者
(32) Sun Y, Yuan X, Zhang F, Han Y, Chang X, Xu X, Li Y, and Gao X. Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells, Scientific Reports, 2017, 第 7 作者
(33) 崔奥媛, 李于*. 成纤维细胞生长因子21的前世今生:胰岛素增敏机制与临床研究, 中华糖尿病杂志, 2017, 通讯作者
(34) Cui A, Hu Z, Han Y, Yang Y, Li Y*. Optimized Analysis Of In Vivo and In Vitro Hepatic Steatosis, Journal of Visualized Experiments, 2017, 通讯作者
(35) Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice through Peroxisome Proliferator-Activated Receptor Alpha, Diabetes, 2016, 通讯作者
(36) Zhuo S, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y. Microrna-451 negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase mediated gluconeogenesis, Diabetes, 2016, 第11作者
(37) Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1, Hepatology, 2016, 通讯作者
(38) 龚琦, 张菲菲, 韩亚美, 李于*. FGF21的代谢调控及临床应用, 中国细胞生物学学报, 2015, 通讯作者
(39) Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*, Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21, Gastroenterology, 2014, 通讯作者
(40) DenBoer LM, Iyer A, McCluggage ARR, Li Y, Martyn AC, Lu R. JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation, Biochim Biophys Acta, 2013, 第 4 作者
(41) Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs, PLoS ONE, 2013, 第 1 作者
(42) Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice, Journal of Biological Chemistry, 2013, 通讯作者
(43) Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, and Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in Diet-Induced insulin-resistant mice, Cell Metabolism, 2011, 第 1 作者
(44) Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver, FASEB Journal, 2011, 第 1 作者
(45) Audas TE, Li Y, Liang G, and Lu R. A novel protein, Luman/CREB3 recruitment factor (LRF), inhibits Luman activation of the unfolded protein response, Molecular and Cellular Biology, 2008, 第 2 作者
(46) Liang G, Audas TE, Li Y, Cockram GP, Dean JD, Martyn AC, Kokame K, and Lu R. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element, Molecular and Cellular Biology, 2006, 第 3 作者

科研活动

   
科研项目
( 1 ) 国家自然科学基金委重点项目_ CREB/ATF碱性亮氨酸拉链转录因子调节肝脏稳态与NASH发生发展的机制研究, 负责人, 国家任务, 2022-01--2026-12
( 2 ) 国家自然科学基金委杰出青年科学基金_肝脏营养感应与代谢调控, 负责人, 国家任务, 2020-01--2024-12
( 3 ) 国家科技部重点研发计划_发育编程及其代谢调节专项, 参与, 国家任务, 2020-01--2024-12
( 4 ) 上海市市级重大专项课题_构建基于基因组标签的重要器官精准蛋白质图谱-子课题, 负责人, 地方任务, 2023-01--2027-12
( 5 ) 国家科技部重点研发计划_糖尿病及其微血管并发症生物标志物与个体化诊疗靶标研究, 负责人, 国家任务, 2017-09--2020-12
( 6 ) 国家自然科学基金面上项目_核受体RARβ调控肝脏脂质沉积和胰岛素抵抗的机制研究, 负责人, 国家任务, 2017-01--2020-12
( 7 ) 中科院战略性先导项目_基于新型代谢因子CREBZF的抗糖尿病药物新靶标的研究, 负责人, 中国科学院计划, 2019-01--2020-09
参与会议
(1)Hepatic PHD3 stimulates gluconeogenesis and aggravates hyperglycemia and type 2 diabetes by hydroxylating CRTC2 at Pro129 and Pro615. American Diabetes Association 83th Scientific Sessions, Poster presentation, June 23-26, 2023, San Diego, CA.   2023-06-23
(2)Pharmacological inhibition of CREBZF improves insulin resistance by altering activation of macrophage in adipose tissue of diet-induced obese mice. American Diabetes Association 81th Scientific Sessions, Oral presentation, June 25-29, 2021. Virtual.   2021-06-25
(3)Hydroxylation regulation of hepatic gluconeogenesis via prolyl-hydroxylase 3 in mice. American Diabetes Association 81th Scientific Sessions, Oral presentation, June 25-29, 2021. Virtual.   2021-06-25
(4)Hormonal regulation of hepatic metabolism and nonalcoholic fatty liver disease in nonhuman primates. Chinese Diabetes Association (CDS)’s 24th scientific meeting,Invited Speaker, November 26, 2020,Suzhou.   2020-11-26
(5)Nutrient sensing and metabolic regulation in the liver. American Diabetes Association 80th Scientific Sessions, Invited Speaker, Chinese diabetes society symposium-Novel antidiabetic approaches and potential targets, June 15, 2020, Chicago, IL.   2020-06-15
(6)A novel genetic modified and PEGylated FGF21 analog for the treatment of nonalcoholic steatohepatitis in nonhuman primates. American Diabetes Association 80th Scientific Sessions, Poster presentation, June 12-16, 2020, Chicago, IL.   2020-06-12
(7)CREBZF acetylation at Lys126 couples glucose to white adipose tissue browning. American Diabetes Association 80th Scientific Sessions, Poster presentation, June 12-16, 2020, Chicago, IL.    2020-06-12
(8)CREBZF as a novel target of glucose sensing signaling in the control of adaptive thermogenesis in the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California.   2019-06-07
(9)Myeloid CREBZF couples inflammatory signals to systemic insulin resistance by regulating immune response of the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California.   2019-06-07
(10)A Novel Metabolic Regulator CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig. 9th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, June 20-22, 2018, Orlando, Florida.   2018-06-20
(11)Molecular Controls of Lipid Metabolism and Nonalcoholic Fatty Liver Disease. 2018 Queenstown Molecular Biology Meetings in Shanghai   2018-03-22
(12)bZIP Transcription Factor CREBZF Functions as a Novel Metabolic Regulator in the Control of Hepatic Steatosis in Diet-Induced Insulin Resistant Mice. American Diabetes Association 77th Scientific Sessions, Oral presentation, San Diego, California.   2017-06-09
(13)Hepatic SIRT1 Deficiency Abolishes Berberine-Mediated Augmentation of Autophagy and Reduction of Hepatic Steatosis in Diet-Induced Obesity Mice. American Diabetes Association 77th Scientific Sessions, Poster presentation, San Diego, California.   2017-06-09
(14)Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, February 15-19, 2017, Shanghai, China.   2017-02-19
(15)Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, Shanghai, China.   2017-02-15
(16)A novel mechanism for fibroblast growth factor 21 to regulate hepatic insulin sensitivity via inhibiting mammalian target of rapamycin complex 1. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.   2016-06-10
(17) ATF6 directly increases peroxisome proliferator-activated receptor alpha activity to reduce hepatic steatosis in mice. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.   2016-06-10
(18)FGF21 in Control of Hepatic Insulin Sensitivity. 7th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, New Orleans, Louisiana.   2016-06-09
(19)Fibroblast growth factor 21 improves hepatic insulin sensitivity and controls glucose homeostasis. New Advances in Metabolism Research Symposium, Duke-NUS Medical School, Invited Speaker, Singapore.   2016-04-20
(20) Hepatic SIRT1 Stimulates Fibroblast Growth Factor 21 to Improve Hepatic Insulin Sensitivity and Control Glucose Homeostasis. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.   2015-06-05
(21) The Unfolded Protein Response Regulates Hepatic Fatty Acid Metabolism and Hepatic Steatosis through Peroxisome Proliferator-Activated Receptor Alpha. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.   2015-06-05
(22) mTOR mediates metabolic effects of FGF21 on insulin sensitivity in mice. American Diabetes Association 74th Scientific Sessions, Oral Presentation, San Francisco, California.   2014-06-13
(23)RARβ functions as a novel downstream regulator of SIRT1 that protects against metabolic disorders in diet-induced obesity mice. American Diabetes Association 73th Scientific Sessions, Oral Presentation, Chicago, Illinois.   2013-06-21
(24)Transcriptional Regulation of Fasting Inducible Hormone FGF21 by Retinoic Acid Receptor β in the Liver. American Diabetes Association 72nd Scientific Sessions, Oral Presentation, Philadelphia, Pennsylvania.   2012-06-08
(25)Loss of SIRT1 in Liver Suppresses FGF21 Expression and Inhibits Fatty Acid Oxidation and Ketogenesis, Leading to Decreased Energy Expenditure and Increased Susceptibility of Obesity in Mice. American Diabetes Association 72nd Scientific Sessions, Poster Presentation, Philadelphia, Pennsylvania.   2012-06-08