100104-病理学与病理生理学
071009-细胞生物学

病理学与病理生理学-细胞死亡与免疫代谢
细胞生物学-细胞死亡与免疫代谢

2000-09--2005-07   中科院上海生科院   博士学位
1993-09--1997-07   山东大学生命科学学院   学士学位

   

2013-04~现在, 中国科学院上海营养与健康研究所, 研究员/课题组长
2012-04~2013-04,Children's Hospital of Philadelphia, 博士后
2006-02~2012-03,Thomas Jefferson University, 博士后
2000-09~2005-07,中科院上海生科院, 博士学位
1993-09~1997-07,山东大学生命科学学院, 学士学位

   

（ 1 ） sgRNA筛选系统和方法, 2020, 第 1 作者, 专利号: CN106636154B

   

（1） ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression, ADVANCED SCIENCE, 2023, 第 21 作者  通讯作者
（2） A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis, BLOOD, 2023, 第 30 作者
（3） Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia, CELL DEATH AND DIFFERENTIATION, 2022, 第 19 作者  通讯作者
（4） Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development, CELL DEATH AND DIFFERENTIATION, 2022, 第 26 作者  通讯作者
（5） Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease, CELL REPORTS, 2020, 第 12 作者  通讯作者
（6） Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 第 8 作者
（7） Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, JOURNAL OF CLINICAL INVESTIGATION, 2020, 第 23 作者
（8） A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression, CELL DEATH & DISEASE, 2020, 第 8 作者
（9） Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation, CELL DEATH & DISEASE, 2020, 第 7 作者  通讯作者
（10） Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3, British Journal of Pharmacology, 2019, 第 11 作者
（11） MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses, CANCER LETTERS, 2019, 第 11 作者  通讯作者
（12） Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis, NATURE COMMUNICATIONS, 2019, 第 14 作者  通讯作者
（13） Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption, Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption, PROTEIN & CELL, 2019, 第 7 作者
（14） Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity, PLOS BIOLOGY, 2018, 第 12 作者
（15） Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, SCIENCE CHINA-LIFE SCIENCES, 2018, 第 2 作者  通讯作者
（16） Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis, JOURNAL OF IMMUNOLOGY, 2018, 第 6 作者  通讯作者
（17） Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, 中国科学：生命科学英文版, 2018, 第 2 作者
（18） RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice, CELL REPORTS, 2017, 第 10 作者  通讯作者
（19） RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, CELL DEATH AND DIFFERENTIATION, 2017, 第 15 作者  通讯作者
（20） RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, CELL DEATH AND DIFFERENTIATION, 2017, 第 11 作者
（21） Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation, ONCOTARGET, 2017, 第 11 作者  通讯作者
（22） 3. A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells, Biochem Biophys Res Commun, 2016, 第 1 作者  通讯作者
（23） MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome, Cell Reports, 2016, 第 1 作者  通讯作者
（24） 1. Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-��B and MAPK in macrophages, Acta Biochim Biophys Sin, 2016, 第 1 作者  通讯作者
（25） Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-kappa B and MAPK in macrophages, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2016, 第 11 作者  通讯作者
（26） MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome, CELL REPORTS, 2016, 第 11 作者  通讯作者
（27） Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality, CELL DEATH & DISEASE, 2016, 第 7 作者  通讯作者

   

（ 1 ） CYLD剪切调控细 胞死亡与炎症的作用机制研究, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 构建基于基因组标签的重要器官精准蛋白质图谱, 参与, 地方任务, 2023-01--2027-12
（ 3 ） 组织器官发育与稳态维持的关键脂质代谢物及其调控网络, 参与, 国家任务, 2022-12--2027-11
（ 4 ） 不同细胞死亡方式互作机制及协同调控组织微环境的作用机理研 究, 负责人, 地方任务, 2022-06--2025-05
（ 5 ） Caspase8和RIP3调控细胞程序性坏死的关键机制研究, 负责人, 国家任务, 2020-01--2023-12
（ 6 ） 蛋白激酶RIP1泛素化修饰调控胚胎发育与免疫炎症的机制 研究, 负责人, 国家任务, 2018-01--2021-12
（ 7 ） 环境与遗传致病因素导致2型糖尿病发生发展的机制研究, 参与, 国家任务, 2016-09--2020-12
（ 8 ） RIPK3/MLKL介导细胞程序性坏死的分子机制及其在肠道炎症中的作用机理研究, 负责人, 国家任务, 2016-01--2019-12

（1）MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating the NLRP3 Inflammasome   冷泉港亚洲会议-细胞死亡与疾病   2015-11-10