基本信息
周虎  男  博导  中国科学院上海药物研究所
email: zhouhu@simm.ac.cn
address: 上海市祖冲之路555号3107室
postalCode: 201203

招生信息

   
招生专业
100706-药理学
招生方向
质谱方法学; 有机小分子和生物大分子相互作用
药物蛋白质组学
人类重大疾病相关的转化蛋白质组学

教育背景

2001-09--2007-06   中国科学院上海生命科学研究院生物化学与细胞生物学研究所   生物化学与分子生物学博士
1997-09--2001-07   南开大学   生物学学士

工作经历

   
工作简历
2012-03~现在, 中国科学院上海药物研究所, 研究员/课题组长
2008-03~2012-03,加拿大渥太华大学, 博士后兼质谱实验室主管
2006-10~2008-01,中国科学院上海生命科学研究院, 助理研究员
2001-09~2007-06,中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 生物化学与分子生物学博士
1997-09~2001-07,南开大学, 生物学学士

专利与奖励

   
奖励信息
(1) Outreach scholarship in CIHR Training Program, , 其他, 2011
(2) Conference travel award of CIHR Training Program, , 其他, 2010
(3) 加拿大健康研究院(CIHR)神经退行性脂组学博士后基金, , 其他, 2010
(4) 第21届国际生物化学与分子生物学联盟学术大会青年科学家论坛(IUBMB YSP), , 其他, 2009
专利成果
( 1 ) 布比卡因氮氧化物杂质的单晶制备方法及其表征, 2022, 第 1 作者, 专利号: CN114014797A

( 2 ) 布比卡因氮氧化物杂质的分离纯化及单晶制备方法, 2022, 第 1 作者, 专利号: CN113979924A

( 3 ) 微型固相萃取支架, 2021, 第 1 作者, 专利号: CN214551350U

( 4 ) 多通道毛细管色谱柱电喷雾离子源装置, 2021, 第 1 作者, 专利号: CN113514593A

( 5 ) 一种色谱阀联动的移动式电喷雾离子源精准定位装置, 2021, 第 1 作者, 专利号: CN113514592A

( 6 ) 一种色谱仪和质谱仪的连接装置, 2021, 第 1 作者, 专利号: CN213337500U

( 7 ) 多通道毛细管色谱柱控温加电装置, 2020, 第 1 作者, 专利号: CN211825882U

( 8 ) 一种中草药抗衰老物质及其筛选方法, 2018, 第 6 作者, 专利号: CN108279308A

( 9 ) 一种电喷雾离子源的背景降噪装置, 2018, 第 1 作者, 专利号: CN207074640U

出版信息

   
发表论文
(1) Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma, CANCER CELL, 2022, 第 11 作者
(2) S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis, CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 第 6 作者
(3) Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36�� signaling pathway, PHARMACOLOGICAL RESEARCH, 2021, 第 11 作者
(4) USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines, FEBS JOURNAL, 2021, 第 11 作者
(5) Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity, MOLECULAR PSYCHIATRY, 2021, 第 8 作者
(6) The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties, The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 16 作者
(7) Quantitative Proteomics Reveals the Protective Effects of Huangqi Decoction Against Acute Cholestatic Liver Injury by Inhibiting the NF-kappa B/IL-6/STAT3 Signaling Pathway, JOURNAL OF PROTEOME RESEARCH, 2020, 第 11 作者
(8) Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota, JOURNAL OF PROTEOMICS, 2020, 第 11 作者
(9) Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 9 作者
(10) MSpectraAI: a powerful platform for deciphering proteome profiling of multi-tumor mass spectrometry data by using deep neural networks, BMC BIOINFORMATICS, 2020, 第 3 作者
(11) Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer, CANCER LETTERS, 2020, 第 11 作者
(12) Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone, ISCIENCE, 2020, 第 0 作者
(13) Allosteric Regulation of Hsp90�����s Activity by Small Molecules Targeting the Middle Domain of the Chaperone, ISCIENCE, 2020, 第 0 作者
(14) Author Correction: Solution structure of extracellular loop of human ��4 subunit of BK channel and its biological implication on ChTX sensitivity, SCIENTIFIC REPORTS, 2020, 第 9 作者
(15) Helix Matrix Transformation Combined With Convolutional Neural Network Algorithm for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Bacterial Identification, FRONTIERS IN MICROBIOLOGY, 2020, 第 6 作者
(16) The Active Constituent From Gynostemma Pentaphyllum Prevents Liver Fibrosis Through Regulation of the TGF-beta 1/NDRG2/MAPK Axis, FRONTIERS IN GENETICS, 2020, 第 5 作者
(17) Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis, JOURNAL OF PROTEOMICS, 2020, 第 11 作者
(18) Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent, ACTA PHARMACEUTICA SINICA B, 2020, 第 11 作者
(19) Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA (vol 26, pg 2329, 2019), CELL DEATH AND DIFFERENTIATION, 2020, 第 12 作者
(20) LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2, CELL DEATH AND DIFFERENTIATION, 2020, 第 5 作者
(21) 乙肝病毒相关肝细胞癌的整合蛋白基因组学特征性研究, Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma, 科学新闻, 2020, 第 51 作者
(22) Isoform���resolved correlation analysis between mRNA abundance regulation and protein level degradation, MOLECULAR SYSTEMS BIOLOGY, 2020, 第 9 作者
(23) Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies, NATURE COMMUNICATIONS, 2020, 第 25 作者
(24) Selective N-glycan editing on living cell surfaces to probe glycoconjugate function, NATURE CHEMICAL BIOLOGY, 2020, 第 14 作者
(25) Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma, JOURNAL OF HEPATOLOGY, 2020, 第 20 作者
(26) Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia, CANCER CELL, 2019, 第 21 作者
(27) Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis, identificationofglutaminylcyclaseisoenzymeisoqcasaregulatorofsirpcd47axis, 细胞研究:英文版, 2019, 第 0 作者
(28) Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma, CELL, 2019, 第 11 作者
(29) Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRP alpha-CD47 axis, CELL RESEARCH, 2019, 第 0 作者
(30) DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism, EPIGENETICS & CHROMATIN, 2019, 第 0 作者
(31) Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA, CELL DEATH AND DIFFERENTIATION, 2019, 第 12 作者
(32) TGF-��1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM, EBIOMEDICINE, 2019, 第 11 作者
(33) A novel short-term high-lactose culture approach combined with a matrix-assisted laser desorption ionization-time of flight mass spectrometry assay for differentiating Escherichia coli and Shigella species using artificial neural networks, PLOS ONE, 2019, 第 8 作者
(34) Palladium-Promoted DNA-Compatible Heck Reaction, ORGANIC LETTERS, 2019, 第 6 作者
(35) Multi-omic measurements of heterogeneity in HeLa cells across laboratories, NATURE BIOTECHNOLOGY, 2019, 第 17 作者
(36) Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics, JOURNAL OF PROTEOME RESEARCH, 2019, 第 11 作者
(37) GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH, ONCOGENE, 2019, 第 14 作者
(38) TGF-beta 1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM, EBIOMEDICINE, 2019, 第 11 作者
(39) ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response, NUCLEIC ACIDS RESEARCH, 2019, 第 3 作者
(40) Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 11 作者
(41) Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal ��-actinin-4 expression and stabilizing integrin-cytoskeleton linkage, ARTHRITIS RESEARCH & THERAPY, 2019, 第 11 作者
(42) YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression, NATURE COMMUNICATIONS, 2019, 第 15 作者
(43) A complex structure of arrestin-2 bound to a G protein-coupled receptor, A complex structure of arrestin-2 bound to a G protein-coupled receptor, CELL RESEARCH, 2019, 第 13 作者
(44) Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids, ORGANIC LETTERS, 2018, 第 6 作者
(45) Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 9 作者
(46) Wnt7a promotes bladder cancer cell invasion via canonical Wnt/beta-Catenin signaling, CANCER RESEARCH, 2018, 第 6 作者
(47) Solution structure of extracellular loop of human beta 4 subunit of BK channel and its biological implication on ChTX sensitivity, SCIENTIFIC REPORTS, 2018, 第 9 作者
(48) A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer., THERANOSTICS, 2018, 第 11 作者
(49) Label-free quantitative proteomic analysis identifies CTNNB1 as a direct target of FOXP3 in gastric cancer cells, ONCOLOGY LETTERS, 2018, 第 8 作者
(50) The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 第 9 作者
(51) Enhancing Membrane Protein Identification Using a Simplified Centrifugation and Detergent-Based Membrane Extraction Approach, ANALYTICAL CHEMISTRY, 2018, 第 11 作者
(52) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, 中国科学:化学英文版, 2018, 第 5 作者
(53) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, SCIENCE CHINA-CHEMISTRY, 2018, 第 5 作者
(54) mouseembryonicstemcellshaveincreasedcapacityforreplicationforkrestartdrivenbythespecificfiliaflopedproteincomplex, CELL RESEARCH, 2018, 第 8 作者
(55) SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2018, 第 9 作者
(56) A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53, CANCER RESEARCH, 2018, 第 15 作者
(57) Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons, JOURNAL OF NEUROCHEMISTRY, 2018, 第 11 作者
(58) The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 11 作者
(59) Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury, JOURNAL OF PROTEOME RESEARCH, 2018, 第 11 作者
(60) Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance, CELL DEATH & DISEASE, 2018, 第 20 作者
(61) Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose, SCIENTIFIC REPORTS, 2017, 第 3 作者
(62) Discovery of a Potential Plasma Protein Biomarker Panel for Acute-on-Chronic Liver Failure Induced by Hepatitis B Virus, FRONTIERS IN PHYSIOLOGY, 2017, 第 11 作者
(63) Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control, SCIENTIFIC REPORTS, 2017, 第 5 作者
(64) Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 第 5 作者
(65) Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis, ADDICTION BIOLOGY, 2017, 第 11 作者
(66) Quantitative proteomic Analysis Reveals up-regulation of caveolin-1 in FOXP3-overexpressed human gastric cancer cells, SCIENTIFIC REPORTS, 2017, 第 11 作者
(67) 基于质谱的药物蛋白质组学研究, 生命的化学, 2017, 第 3 作者
(68) Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis, HEPATOLOGY, 2017, 第 10 作者
(69) Comparative evaluation of small molecular additives and their effects on peptide/protein identification, ANALYTICAL CHEMISTRY, 2017, 第 11 作者
(70) 铁过载对神经元功能的调控作用研究, 神经药理学报, 2017, 第 4 作者
(71) EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes, THERANOSTICS, 2017, 第 0 作者
(72) Development of Online pH Gradient-Eluted Strong Cation Exchange Nanoelectrospray-Tandem Mass Spectrometry for Proteomic Analysis Facilitating Basic and Histidine-Containing Peptides Identification, ANALYTICAL CHEMISTRY, 2016, 第 7 作者
(73) An intramolecular disulfide bond designed in myoglobin fine-tunes both protein structure and peroxidase activity, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2016, 第 3 作者
(74) A redox mechanism underlying nucleolar stress sensing by nucleophosmin, NATURE COMMUNICATIONS, 2016, 第 9 作者
(75) Gsy, a novel glucansucrase from Leuconostoc mesenteroides , mediates the formation of cell aggregates in response to oxidative stress, SCIENTIFIC REPORTS, 2016, 第 9 作者
(76) Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway, ONCOLOGY REPORTS, 2016, 
(77) 翻译后修饰蛋白质组学分离方法的研究进展, Recent advances in separation methods for post-translational modification proteomics, 色谱, 2016, 第 3 作者
(78) pVHL mediates K63-linked ubiquitination of IKK beta, leading to IKK beta inactivation, CANCER LETTERS, 2016, 第 6 作者
(79) Altered intestinal microbiota���host mitochondria crosstalk in new onset Crohn's disease, NATURE COMMUNICATIONS, 2016, 第 9 作者
(80) Identification of a Novel Function of Adipocyte Plasma Membrane Associated Protein (APMAP) in Gestational Diabetes Mellitus by Proteomic Analysis of Omental Adipose Tissue, JOURNAL OF PROTEOME RESEARCH, 2016, 第 11 作者
(81) Proteomic analysis of minute amount of colonic biopsies by enteroscopy sampling, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 第 11 作者
(82) Structural basis of rifampin inactivation by rifampin phosphotransferase, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 8 作者
(83) Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2016, 第 11 作者
(84) Characterization of gain-of-function mutant provides new insights into clpp structure, ACS CHEMICAL BIOLOGY, 2016, 第 15 作者
(85) Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization, BBA - PROTEINS AND PROTEOMICS, 2016, 第 6 作者
(86) Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells, FRONTIERS IN PHYSIOLOGY, 2016, 第 11 作者
(87) Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44, MOLECULAR CANCER THERAPEUTICS, 2016, 第 4 作者
(88) ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer, CELL RESEARCH, 2015, 第 6 作者
(89) Label-Free Proteomics Uncovers Energy Metabolism and Focal Adhesion Regulations Responsive for Endometrium Receptivity, JOURNAL OF PROTEOME RESEARCH, 2015, 第 7 作者
(90) Conformational states of the full-length glucagon receptor, NATURE COMMUNICATIONS, 2015, 
(91) Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5, NUCLEIC ACIDS RESEARCH, 2015, 第 6 作者
(92) Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells, PROTEOMICS, 2013, 第 7 作者
(93) Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion, CURRENT OPINION IN LIPIDOLOGY, 2013, 第 2 作者
(94) The Liver Connexin32 Interactome Is a Novel PlasmaMembrane-Mitochondrial Signaling Nexus, JOURNAL OF PROTEOME RESEARCH, 2013, 第 3 作者
(95) Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy, FEBS JOURNAL, 2013, 第 4 作者
(96) Advancements in Top-Down Proteomics, ANALYTICAL CHEMISTRY, 2012, 第 1 作者
(97) Combination of online enzyme digestion with stable isotope labeling for high-throughput quantitative proteome analysis, PROTEOMICS, 2012, 第 3 作者
(98) Lyso-form fragment ions facilitate the determination of stereospecificity of diacyl glycerophospholipids, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2011, 第 2 作者
(99) egulation of Septin Dynamics by the Saccharomyces cerevisiae Lysine Acetyltransferase NuA4, PLoS One, 2011, 第 1 作者
(100) Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins: EVIDENCE THAT ApoC-III PLAYS A MAJOR ROLE IN THE FORMATION OF LIPID PRECURSORS WITHIN THE MICROSOMAL LUMEN, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 4 作者
(101) Analytical Aspects of Proteomics: 2009-2010, ANALYTICAL CHEMISTRY, 2011, 第 2 作者
(102) Improved Recovery and Identification of Membrane Proteins from Rat Hepatic Cells using a Centrifugal Proteomic Reactor, MOLECULAR & CELLULAR PROTEOMICS, 2011, 第 1 作者
(103) Proteomic reactors and their applications in biology, FEBS JOURNAL, 2011, 第 1 作者
(104) LIPIDOMICS ERA: ACCOMPLISHMENTS AND CHALLENGES, MASS SPECTROMETRY REVIEWS, 2010, 第 3 作者
(105) Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia, JOURNAL OF LIPID RESEARCH, 2010, 第 4 作者
(106) New ammunition for the proteomic reactor: strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 第 1 作者
(107) Analysis of low-abundance proteins using the proteomic reactor with pH fractionation, TALANTA, 2010, 第 1 作者
(108) Nonsynonymous Mutations within APOB in Human Familial Hypobetalipoproteinemia: EVIDENCE FOR FEEDBACK INHIBITION OF LIPOGENESIS AND POSTENDOPLASMIC RETICULUM DEGRADATION OF APOLIPOPROTEIN B, JOURNALOFBIOLOGICALCHEMISTRY, 2010, 第 4 作者
(109) Glycoproteomic Reactor for Human Plasma, JOURNAL OF PROTEOME RESEARCH, 2009, 第 1 作者
(110) Quantitative Analysis of Secretomes from Adipocytes Regulated by Insulin, 2009, 第 1 作者
(111) Triptolide analogue LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36�� signaling pathway, PHARMACOLOGICAL RESEARCH, 第 11 作者

科研活动

   
科研项目
( 1 ) 上海市级科技重大专项,“构建基于基因组标签的重要器官精准蛋白质图谱”, 参与, 地方任务, 2023-01--2023-12
( 2 ) “GPCR分子机器调控机制及配体发现”课题2“GPCR的功能调控机制研究”, 参与, 国家任务, 2022-12--2027-11
( 3 ) “重要器官细胞增殖与分化过程中关键蛋白质机器的动态调控网络及机制”课题1“发现调控细胞增殖与分化新因子”, 参与, 国家任务, 2020-11--2025-10
( 4 ) 上海市优秀学术带头人(青年), “肿瘤蛋白基因组学研究”, 负责人, 地方任务, 2020-10--2023-09
( 5 ) 用于蛋白类药物在线快速分析的集成化样品处理系统, 负责人, 中国科学院计划, 2016-01--2017-12
( 6 ) 脂肪细胞膜相关蛋白(APMAP) 作为糖尿病胰岛素抵抗防治新靶标的发现与确证, 负责人, 中国科学院计划, 2016-01--2017-12
( 7 ) 用于膜蛋白质组分析的液相色谱-质谱联用新方法研究, 负责人, 国家任务, 2014-01--2017-12
( 8 ) 用于G蛋白偶联受体膜蛋白质分析的液-质联用方法研究, 负责人, 中国科学院计划, 2013-01--2014-12
( 9 ) 基于GPCR结构与功能的新药创制, 参与, 国家任务, 2013-01--2015-12
( 10 ) 中国科学院****, 负责人, 中国科学院计划, 2012-04--2017-03
参与会议
(1)Improved Recovery and Identification of Membrane Proteins from Rat Hepatic Cells using a Centrifugal Proteomic Reactor   Zhou H. et al   2011-08-29
(2)Development of proteomic reactor and its application in Alzheimer’s disease study.    Zhou H, Ning Z, Bennett SAL, Figeys D.   2011-06-09