His current research interest focuses on understanding (1) the molecular basis of events in the mosquito reproduction cycle linked to a blood meal and pathogen transmission, (2) the role of melanization response in antifungi defense, (3) the physiological, biochemical and molecular adaptation of parasitoid wasp to it hosts.

2005          Ph.D., Department of Entomology and Plant Pathology, Oklahoma State University

1997          B.E., Department of Biochemical Engineering, East China University of Science and Technology Shanghai, China

2012 – present       Professor, group leader of insect immunity and development, Institute of Zoology, Chinese Academy of Sciences

2010 – 2012          Assistant Researcher (non-tenured faculty position), Department of Entomology, University of California Riverside

2007 – 2010          Postdoctoral Researcher, Department of Entomology, University of California, Riverside

2005 – 2007          Postdoctoral Researcher, Department of Entomology and Plant Pathology, Oklahoma State University

1997 – 2000          Junior Research Assistant, Shanghai Institute of Biochemistry, Chinese Academy of Sciences

Organize graduate-level course: Molecular Entomology and Plant Pathology in University of Chinese Academy of Sciences

1. Saha, T.T. , Shin, S.W., Dou, W., Roy, S., Zhao, B., Hou, Y., Wang, X.L., Zou, Z., Girke, T., Raikhel, A.S.#. (2016) Hairy and Groucho mediate the action of juvenile hormone receptor Methoprene-tolerant in gene repression.Proc Natl Acad Sci USA2016, 113(6):E735-43.
2. Roy, S., Saha, T. T., Johnson, L., Zhao, B., Ha, J., White, K. P., Girke, T., Zou, Z.# and Raikhel, A. S.#, (2015). Regulation of gene expression patterns in mosquito reproduction. PLoS Genet, 11, e1005450.
3. Hou, Y., Wang X.L., Saha, T.T., Roy, S., Zhao, B., Raikhel, A.S.#, Zou Z.# 2015. Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction. PLoS Genetics 11(7): e1005309.
4. Meng, Q., Yu, H.Y.,  Zhang, H., Zhu, W., Wang, M.L., Zhang, J.H., Zhou, G.L., Li, X., Qin, Q.L.#, Hu, S.N.#, Zou, Z.#. 2015. Transcriptomic insight into the immune defenses in the ghost moth, Hepialus xiaojinensis, during an Ophiocordyceps sinensis fungal infection. Insect Biochemistry and Molecular Biology, 64:1-15.
5. Wang, Y.H., Hu, Y., Xing, L.S., Jiang, H., Hu, S.N., Raikhel, A.S. #, Zou, Z.# A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. (2015) PLoS Pathog 11(6):e1004931.
6. Xiong, G.H., Xing, L.S., Lin, Z., Saha, T.T., Wang, C., Jiang, H., Zou, Z. #High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections. (2015) BMC Genomics 16(1):321.
7. Zou, Z.*, Saha, T.T.*, Roy, S.*, Shin, S.W., Backman, T.W., Girke, T., White, K.P., and Raikhel, A.S.Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression.(2013) Proc Natl Acad Sci USA 110(24):E2173-81.
8. Shin, S.W., Zou, Z., Saha, T.T. and Raikhel, A.S. bHLH-PAS heterodimer of methoprene-tolerant and Cycle mediates circadian expression of juvenile hormone-induced mosquito genes(2012)Proc Natl Acad Sci USA 109(41): 16576-16581.
9. Zou, Z.*, Souza-Neto, J.A.*, Xi, Z., Shin, S.W., Alvarez, K.S., Kokoza, K., Dimopoulos, G., Raikhel, A.S. Genome-wide transcriptome analysis of immunity related genes in the mosquito, Aedes aegypti. (2011) PLoS Pathogens, 7, e1002394.
10. Shin, S.W.*, Zou, Z.*, Kokoza, V., Raikhel, A.S. Serine protease lection-2 (SPL2) is a negative modulator of hemolymph melanization and involved in modulation of melanization response to malaria infection in Aedes aegypti. (2011) EMBO Report,12, 938-43.
11. Bartholomay, L.C., Waterhouse, R.M., Mayhew, G.F., Campbell, C.L., Michel, K., Zou, Z. et al. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. (2010) Science, 330, 88-90.
12. Kokoza, V., Ahmed, A., Shin, S.W., Okafor, N., Zou, Z., Raikhel, A.S. Blocking of Plasmodium transmission by synergistic action of Cecropin A and Defensin A in the transgenic mosquito Aedes aegypti. (2010) Proc. Natl. Acad. Sci. USA, 107, 8111-6.
13. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Kokoza, K., Raikhel, A.S. Distinct melanization pathways in the mosquito Aedes aegypti (2010) Immunity, 32, 41-53.
14. Zou, Z., Zhao, P., Weng, H., Mita, K., Jiang, H. A comparative analysis of serpin genes in the silkworm genome. (2009) Genomics, 93, 367-75.
15. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Bian, G., Kokoza, K., Raikhel, A.S.Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection. (2008) Proc. Natl. Acad. Sci. USA, 105, 18454-9.
16. Zou, Z., Najar, F., Wang, Y., Roe, B., Jiang, H. Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. (2008) Insect Biochem. Mol. Biol., 38, 677-82.
17. Tribolium Genome Sequencing Consortium, The first genome sequence of a beetle, Tribolium castaneum, a model for insect development and pest biology. (2008) Nature,452, 949-55. Immunity group: Zou, Z., Evans, J., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark, D., and Jiang, H.
18. Zou, Z., Evans, J., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark D., Jiang H. (2007) Comparative genomic analysis of the Tribolium immune system. Genome Biology, 8, R177.
19. Waterhouse, R.M., Kriventseva, E.V., Meister, S., Xi, Z., Alvarez, K.S., Bartholomay, L.C., Barillas-Mury, C., Bian, G., Blandin, S., Christensen, B.M., Dong, Y., Jiang, H., Kanost, M.R., Koutsos, A.C., Levashina, E.A., Li, J., Ligoxygakis, P., Maccallum, R.M., Mayhew, G.F., Mendes, A., Michel, K., Osta, M.A., Paskewitz, S., Shin, S.W., Vlachou, D., Wang, L., Wei, W., Zheng, L., Zou, Z., Severson, D.W., Raikhel, A.S., Kafatos, F.C., Dimopoulos, G., Zdobnov, E.M., Christophides, G.K. (2007) Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science, 316, 1738-43.
20. Honeybee Genome Sequencing Consortium. Insights into social insects from the genome of the honeybee Apis mellifera. (2006) Nature, 443, 931-49. Coauthor in Haobo Jiang’s laboratory: Jiang, H. and Zou, Z.
21. Zou, Z., Lopez, D., Kanost, M.R., Evans, J.D., Jiang, H. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvements in embryonic development and innate immunity. (2006) Insect Mol. Biol., 15, 603-14.
22. Wang, Y.*, Zou, Z.*, Jiang, H. An expansion of the dual clip-domain serine proteinase family in Manduca sexta: gene organization, expression, and evolution of prophenoloxidase-activating proteinase-2, hemolymph proteinase 12, and other related proteinases. (2006) Genomics, 87, 399-409.
23. Pelte, N.*, Robertson, S.A.*, Zou, Z.*, Belorgey, D., Dafforn, R.T., Jiang, H., Lomas, D., Reichhart, J-M., Gubb, D. (2006) Immune challenge induces N-terminal cleavage of the Drosophila Necrotic serpin. Insect Biochem. Mol. Biol., 36, 37-46.
24. Zou, Z., Jiang, H. Manduca sexta serpin-6: a natural regulator of immune serine proteinases PAP-3 and HP8: cDNA cloning, protein expression, inhibition kinetics and function elucidation. (2005) J. Biol. Chem., 280, 14341-8.
25. Zou, Z., Jiang, H. (2005) Gene structure and transcriptional regulation of Manduca sexta prophenoloxidase-activating proteinase-3 (PAP-3), an immune protein containing two clip domains. Insect Mol. Biol.,14, 433-42.
26. Zou, Z., Wang, Y and Jiang, H. (2005) Manduca sexta prophenoloxidase activating proteinase-1 (PAP-1) gene: organization, expression, and regulation by immune and hormonal signals. (2005) Insect Biochem. Mol. Biol., 35, 627-36.

已指导学生

后源  博士研究生  0710Z1-基因组学  

熊光华  博士研究生  0710Z1-基因组学  

金桥  硕士研究生  071010-生物化学与分子生物学  

邢龙生  博士研究生  0710Z1-基因组学  

王雪丽  博士研究生  0710Z1-基因组学  

张伟  博士研究生  0710Z1-基因组学  

程阳  博士研究生  0710Z1-基因组学  

裴高峰  硕士研究生  0710Z1-基因组学  

杜捷  博士研究生  0710Z1-基因组学  

吉雁南  硕士研究生  0710Z1-基因组学  

现指导学生

施佐堃  博士研究生  0710Z1-基因组学  

常蒙蒙  博士研究生  0710Z1-基因组学  

吕向阳  博士研究生  0710Z1-基因组学  

孙晓梅  博士研究生  0710Z1-基因组学  

陆腾飞  博士研究生  0710Z1-基因组学  

王毛  博士研究生  0710Z1-基因组学  

卢浩然  硕士研究生  0710Z1-基因组学  

曾铄程  博士研究生  0710Z1-基因组学  

李珊  博士研究生  0710Z1-基因组学  

吉雁南  博士研究生  0710Z1-基因组学  

耿丹倩  博士研究生  0710Z1-基因组学