基本信息
徐华强  男  博导  中国科学院上海药物研究所
电子邮件: eric.xu@simm.ac.cn
通信地址: 上海市浦东张江海科路501号1715室
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
100701-药物化学
招生方向
结构生物学
生物物理学

教育背景

1994-11--1996-12   美国麻省理工学院   博士后
1991-01--1994-10   美国德州大学西南医学中心   博士学位
1985-09--1988-12   清华大学   硕士学位
1980-09--1985-07   清华大学   学士学位

工作经历

   
工作简历
2019-09~现在, 中国科学院上海药物研究所, 上海市人才高峰工程获选者
2013-04~2022-12,中国科学院受体结构与功能重点实验室, 创办人,主任
2010-07~现在, 中国科学院上海药物所, 药靶结构与功能中心主任
2010-01~2010-07,美国Van Andel研究所结构科学与药物发现中心, 中心主任
2007-03~2009-12,美国Van Andel研究所结构科学部, 杰出PI/教授
2002-08~2007-03,美国Van Andel研究所结构科学部, 资深PI/教授
2001-08~2002-07,美国格兰素威康研究所结构科学部, 高级研究人员
1999-08~2001-07,美国格兰素威康研究所结构化学系, 二级研究员
1996-12~1999-07,美国格兰素威康研究所结构化学系, 一级研究院
1994-11~1996-12,美国麻省理工学院, 博士后
1994-11~1996-12,美国麻省理工学院, 研究助理
1991-01~1994-10,美国德州大学西南医学中心, 博士学位
1985-09~1988-12,清华大学, 硕士学位
1980-09~1985-07,清华大学, 学士学位
社会兼职
2021-07-31-2025-08-31,中国生物物理学会第十二届理事会 常务理事,
2015-01-01-今,《类固醇》(Steroids), 编委
2014-01-01-今,《基因与发育》(CSHL), 编委
2012-01-01-今,《中国药理学报》(APS), 副主编
2008-06-25-今,美国NIH/NCCAM CERC研究部评委,
2008-02-13-今,美国NIH 分子与细胞内分泌学研究部评委,
2007-07-01-2010-07-31,《分子内分泌学》编委, 编委
2006-01-01-今,美国科学促进会(AAAS), 会员
2004-07-01-今,《核受体信号》编委, 编委
2004-07-01-2010-07-01,美国分子内分泌学协会会员,
2004-01-01-今,美国密西根州中心Life Sciences-CAT synchrotron beam at APS结构生物学管理委员会执行委员会, 成员
1996-07-01-2010-07-31,美国化学协会会员,

专利与奖励

   
奖励信息
(1) “阐明多种药物靶标结构和功能”入选中国科学院上海分院2022年度科技创新“十大进展”(基础研究类), 院级, 2023
(2) 第二十二届吴阶平-保罗杨森医学药学奖(吴杨奖), , 部委级, 2022
(3) 2022年度“中国科学院优秀导师奖”, 院级, 2022
(4) 中国侨联第九届“侨界贡献奖”一等奖, 其他, 2022
(5) 上海市“白玉兰荣誉奖”, 市地级, 2022
(6) 2021年度“中国科学院优秀导师奖”, 院级, 2021
(7) 第十三届“谈家桢生命科学成就奖”, 其他, 2021
(8) “解析蛋白质结构为新药研发提供结构理论基础”入选2019年度中国医学重大进展(药学部), 院级, 2020
(9) 上海市“白玉兰纪念奖”, 市地级, 2020
(10) 2019年度“中国科学院优秀导师奖”, 院级, 2019
(11) 2016年国际蛋白质学会Hans Neurath奖, 其他, 2016
(12) 2016药明康德生命化学杰出成就奖, 特等奖, 其他, 2016
(13) “攻克细胞信号传导重大科学”难题入选两院院士评选2015重大十大科技进展新闻, 国家级, 2015
(14) 阐明独脚金内酯调控水稻分蘖和株型的信号途径荣获2014年度中国科学十大进展, 国家级, 2014
(15) GSK最高杰出研究奖, , 其他, 2001
(16) GSK杰出研究奖, , 其他, 1999
专利成果
( 1 ) HIGHLY POTENT GLUCOCORTICOIDS, 2014, 第 1 作者, 专利号: WO2015/048316A1

( 2 ) PPARγ选择性调控剂及其制备方法和用途, 2014, 第 2 作者, 专利号: 201410289010.1

( 3 ) N-(3-氟-4-氯苄基)吲哚衍生物及其用途, 2014, 第 2 作者, 专利号: 201410025241.1

出版信息

   
发表论文
(1) Molecular recognition of itch-associated neuropeptides by bombesin receptors, CELL RESEARCH, 2023, 通讯作者
(2) AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors, ACTA PHARMACOLOGICA SINICA, 2023, 通讯作者
(3) Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376, ACTA PHARMACOLOGICA SINICA, 2023, 通讯作者
(4) Structures of the entire human opioid receptor family, CELL, 2023, 
(5) Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2, NATURE COMMUNICATIONS, 2022, 通讯作者
(6) Structural insights into the ligand binding and G(i) coupling of serotonin receptor 5-HT5A, CELL DISCOVERY, 2022, 通讯作者
(7) Hormone- and antibody-mediated activation of the thyrotropin receptor, NATURE, 2022, 通讯作者
(8) Structural basis for the tethered peptide activation of adhesion GPCRs, NATURE, 2022, 通讯作者
(9) Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(10) Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(11) Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, SCIENCE, 2022, 通讯作者
(12) Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor, NATURE COMMUNICATIONS, 2022, 通讯作者
(13) Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor, CELL RESEARCH, 2022, 通讯作者
(14) Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2022, 通讯作者
(15) Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors, NATURE COMMUNICATIONS, 2022, 通讯作者
(16) Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins, CELL RESEARCH, 2022, 通讯作者
(17) Structures of adenosine receptor A(2B)R bound to endogenous and synthetic agonists, CELL DISCOVERY, 2022, 通讯作者
(18) Structural insights into the peptide selectivity and activation of human neuromedin U receptors, NATURE COMMUNICATIONS, 2022, 通讯作者
(19) Structural insights into the lipid and ligand regulation of serotonin receptors, NATURE, 2021, 通讯作者
(20) Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor, Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor, CELL RESEARCH, 2021, 通讯作者
(21) RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 通讯作者
(22) Constitutive signal bias mediated by the human GHRHR splice variant 1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 通讯作者
(23) Structures of the human dopamine D3 receptor-Gi complexes, MOLECULAR CELL, 2021, 通讯作者
(24) Structural insights into the human D1 and D2 dopamine receptor signaling complexes, CELL, 2021, 通讯作者
(25) Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex, NATURE, 2021, 通讯作者
(26) GABAB receptor pas de deux:insights from high-resolution structures, GABA(B) receptor pas de deux: insights from high-resolution structures, CELL RESEARCH, 2020, 通讯作者
(27) Structural basis for activation of the growth hormone-releasing hormone receptor, NATURE COMMUNICATIONS, 2020, 
(28) Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B, NATURE, 2020, 通讯作者
(29) Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy, NATURE COMMUNICATIONS, 2020, 
(30) Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir, SCIENCE, 2020, 通讯作者
(31) Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery, CHEMICAL SCIENCE, 2020, 通讯作者
(32) Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, MOLECULAR CELL, 2020, 通讯作者
(33) Crystal structure of heliorhodopsin 48C12, Crystal structure of heliorhodopsin 48C12, CELL RESEARCH, 2020, 第11作者
(34) Structural basis of Fusarium myosin I inhibition by phenamacril, PLOS PATHOGENS, 2020, 第 7 作者
(35) Structure of formylpeptide receptor 2-G i complex reveals insights into ligand recognition and signaling, NATURE COMMUNICATIONS, 2020, 
(36) Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins, NATURE COMMUNICATIONS, 2020, 
(37) Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex, CELL, 2020, 通讯作者
(38) Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM, STRUCTURE, 2019, 第 10 作者
(39) Development of highly potent glucocorticoids for steroid-resistant severe asthma, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 通讯作者
(40) C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels, ACTA PHARMACOLOGICA SINICA, 2019, 
(41) Ligand-induced activation of ERK1/2 signaling by constitutively active Gs-coupled 5-HT receptors, ACTA PHARMACOLOGICA SINICA, 2019, 通讯作者
(42) Structure and dynamics of the active human parathyroid hormone receptor-1, SCIENCE, 2019, 通讯作者
(43) Structural biology of G protein-coupled receptor signaling complexes, PROTEIN SCIENCE, 2019, 通讯作者
(44) A complex structure of arrestin-2 bound to a G protein-coupled receptor, A complex structure of arrestin-2 bound to a G protein-coupled receptor, CELL RESEARCH, 2019, 
(45) Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 9 作者
(46) Cryo-EM structure of human rhodopsin bound to an inhibitory G protein, NATURE, 2018, 通讯作者
(47) Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK), JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 7 作者
(48) Crystal structure of the Frizzled 4 receptor in a ligand-free state, NATURE, 2018, 第 20 作者
(49) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, CELL DISCOVERY, 2018, 通讯作者
(50) Molecular mechanism of GPCR-mediated arrestin activation, NATURE, 2018, 第 7 作者
(51) Structure and Physiological Regulation of AMPK, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 3 作者
(52) The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, MOLECULAR GENETICS AND METABOLISM REPORTS, 2018, 第 9 作者
(53) Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases, PROTEIN SCIENCE, 2017, 通讯作者
(54) Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases, STRUCTURE, 2017, 通讯作者
(55) Molecular assembly of rhodopsin with G protein-coupled receptor kinases, CELL RESEARCH, 2017, 通讯作者
(56) Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 通讯作者
(57) Functional role of the three conserved cysteines in the N domain of visual arrestin-1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 6 作者
(58) Amyloid beta: structure, biology and structure-based therapeutic development, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(59) Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 通讯作者
(60) Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization, GENES & DEVELOPMENT, 2017, 通讯作者
(61) Structural insights into alternative splicing-mediated desensitization of jasmonate signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 7 作者
(62) Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 13 作者
(63) A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, SCIENCE ADVANCES, 2017, 通讯作者
(64) Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1, SCIENTIFIC REPORTS, 2017, 通讯作者
(65) Structure of the PRC2 complex and application to drug discovery, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(66) Combining chemical and genetic approaches to increase drought resistance in plants, NATURE COMMUNICATIONS, 2017, 
(67) Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro, SCIENTIFIC REPORTS, 2017, 通讯作者
(68) Defining the minimum substrate and charge recognition model of gamma-secretase, Defining the minimum substrate and charge recognition model of gamma-secretase, 中国药理学报:英文版, 2017, 第 4 作者
(69) Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors, CELL, 2017, 通讯作者
(70) Defining the minimum substrate and charge recognition model of gamma-secretase, Defining the minimum substrate and charge recognition model of gamma-secretase, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(71) A structural snapshot of the rhodopsin-arrestin complex, FEBS JOURNAL, 2016, 通讯作者
(72) Tumor Targeting with Novel 6-Substituted Pyrrolo 2,3-d Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis, JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 16 作者
(73) Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 通讯作者
(74) Generation and characterization of a human nanobody against VEGFR-2, ACTA PHARMACOLOGICA SINICA, 2016, 第 9 作者
(75) Discovery of a highly potent glucocorticoid for asthma treatment (vol 1, 15035, 2015), CELL DISCOVERY, 2016, 第 14 作者
(76) Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 通讯作者
(77) An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, CELL DISCOVERY, 2016, 通讯作者
(78) Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio, CELL DISCOVERY, 2016, 通讯作者
(79) FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of beta-Klotho, MOLECULAR ENDOCRINOLOGY, 2016, 第 7 作者
(80) A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4, JOURNAL OF CHEMICAL PHYSICS, 2016, 第 4 作者
(81) The structural basis of the dominant negative phenotype of the G alpha(i1)beta(1)gamma(2) G203A/A326S heterotrimer, ACTA PHARMACOLOGICA SINICA, 2016, 通讯作者
(82) X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, SCIENTIFIC DATA, 2016, 通讯作者
(83) Crystallization scale purification of alpha 7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system, ACTA PHARMACOLOGICA SINICA, 2015, 通讯作者
(84) Rh(III)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using alpha-diazomalonates, CHEMICAL COMMUNICATIONS, 2015, 通讯作者
(85) Family reunion of nuclear hormone receptors: structures, diseases, and drugdiscovery, ACTA PHARMACOLOGICA SINICA, 2015, 通讯作者
(86) Rhodium(III)-catalyzed C-H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles, CHEMICAL COMMUNICATIONS, 2015, 通讯作者
(87) Structural and Functional Study of d-Glucuronyl C5-epimerase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 14 作者
(88) The cryo-electron microscopy structure of gamma-secretase: towards complex assembly, substrate recognition and a catalytic mechanism, NATIONAL SCIENCE REVIEW, 2015, 通讯作者
(89) Androgen receptor: structure, role in prostate cancer and drug discovery, ACTA PHARMACOLOGICA SINICA, 2015, 第 3 作者
(90) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, NATURE, 2015, 通讯作者
(91) Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, CELL RESEARCH, 2015, 通讯作者
(92) One-pot cascade synthesis of N-methoxyisoquinolinediones via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization, CHEMICAL COMMUNICATIONS, 2015, 通讯作者
(93) Mild and Efficient Ir(III)-Catalyzed Direct C-H Alkynylation of N-Phenoxyacetamides with Terminal Alkyne, ACS CATALYSIS, 2015, 第 5 作者
(94) Discovery of a highly potent glucocorticoid for asthma treatment, CELL DISCOVERY, 2015, 第 14 作者
(95) One-Pot Synthesis of 3-Iminoisoindolinones by a Rhodium(III)-Catalyzed and Methanol-Assisted C-H Cyanation-Cyclization Cascade with N-Alkoxyl Transfer, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2015, 通讯作者
(96) High yield and efficient expression and purification of the human 5-HT3A receptor., ACTA PHARMACOLOGICA SINICA, 2015, 第11作者
(97) Structural basis of the Norrin-Frizzled 4 interaction, CELL RESEARCH, 2015, 第 8 作者
(98) Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex, CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 第 4 作者
(99) Structural basis of AMPK regulation by adenine nucleotides and glycogen, CELLRESEARCH, 2015, 第 10 作者
(100) Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling, NATURE, 2015, 通讯作者
(101) Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery, ACTA PHARMACOLOGICA SINICA, 2015, 通讯作者
(102) Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors, SCIENCE ADVANCES, 2015, 通讯作者
(103) Structural basis for corepressor assembly by the orphan nuclear receptor TLX, GENES & DEVELOPMENT, 2015, 通讯作者
(104) Rh(III)催化的N-甲氧基苯甲酰胺系列物选择性C-H氰基化反应, Rh(III)-catalyzed direct C–H cyanation of N-methoxybenzamides using N-cyano-N-phenyl-p-toluenesulfonamide, CHINESE JOURNAL OF CATALYSIS, 2015, 第 5 作者
(105) Structural insights into gene repression by the orphan nuclear receptor SHP, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 9 作者
(106) Abscisic acid perception and signaling: structural mechanisms and applications, ACTA PHARMACOLOGICA SINICA, 2014, 第 4 作者
(107) PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis, MOLECULAR AND CELLULAR BIOLOGY, 2014, 第 4 作者
(108) H 2 O 2 Inhibits ABA-Signaling Protein Phosphatase HAB1, PLOS ONE, 2014, 第 5 作者
(109) Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPAR gamma modulator, ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 通讯作者
(110) Structures and mechanism for the design of highly potent glucocorticoids, CELL RESEARCH, 2014, 通讯作者
(111) Rhodium(III)-Catalyzed Regioselective Direct C-2 Alkenylation of Indoles Assisted by the Removable N-(2-Pyrimidyl) Group, ADVANCED SYNTHESIS & CATALYSIS, 2014, 通讯作者
(112) EZH2: biology, disease, and structure-based drug discovery, ACTA PHARMACOLOGICA SINICA, 2014, 第 5 作者
(113) Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis, CELL METABOLISM, 2014, 第 14 作者
(114) Rhodium(III)-catalyzed C2-selective carbenoid functionalization and subsequent C7-alkenylation of indoles, CHEMICAL COMMUNICATIONS, 2014, 通讯作者
(115) DWARF 53 acts as a repressor of strigolactone signalling in rice, NATURE, 2013, 通讯作者
(116) The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation, PLOS ONE, 2013, 
(117) Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C-H/O-H bond functionalization, RSC ADVANCES, 2013, 第 7 作者
(118) Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 10 作者
(119) Structural basis for molecular recognition of folic acid by folate receptors, NATURE, 2013, 第 8 作者
(120) Efficient Synthesis of Functionalized 1-oxo-1-pheny1-2-acetic Acids through Ru(II)-catalyzed Transfer Hydrogenation, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2013, 通讯作者
(121) Structure Modeling Using Genetically Engineered Crosslinking, CELL, 2013, 第 3 作者
(122) Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex, GENES & DEVELOPMENT, 2013, 通讯作者
(123) Structural basis for RNA recognition by a dimeric PPR-protein complex, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 通讯作者
(124) An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants, CELL RESEARCH, 2013, 第 15 作者
(125) Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, CELL RESEARCH, 2013, 通讯作者
(126) Structural Basis for Molecular Recognition at Serotonin Receptors, SCIENCE, 2013, 第 23 作者
(127) Structural Features for Functional Selectivity at Serotonin Receptors, SCIENCE, 2013, 其他(合作组作者)
(128) Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases, SCIENCE, 2012, 第 21 作者
(129) Modulation of beta-Catenin Signaling by Glucagon Receptor Activation, PLOS ONE, 2012, 第 9 作者
(130) A new era for GPCR research: structures, biology and drug discovery, ACTA PHARMACOLOGICA SINICA, 2012, 通讯作者
(131) Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors, ACTA PHARMACOLOGICA SINICA, 2012, 第 3 作者
(132) Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 第 15 作者
(133) Structure and activation of rhodopsin, ACTA PHARMACOLOGICA SINICA, 2012, 第 3 作者
(134) Abscisic Acid Signaling: Thermal Stability Shift Assays as Tool to Analyze Hormone Perception and Signal Transduction, PLOS ONE, 2012, 通讯作者
(135) Couple Dynamics: PPAR gamma and Its Ligand Partners, STRUCTURE, 2012, 通讯作者
(136) Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 通讯作者
(137) Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 第 13 作者
(138) Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response, SCIENCE SIGNALING, 2011, 第 14 作者
(139) 
(140) Structural basis for motilin and erythromycin recognition by motilin receptor, SCIENCE ADVANCES, 

科研活动

   
科研项目
( 1 ) 基于蛋白质结构与功能的药物多靶标作用机制研究, 参与, 中国科学院计划, 2011-01--2013-12
( 2 ) ****启动项目, 负责人, 国家任务, 2010-07--2015-07
( 3 ) 与神经系统疾病相关的离子通道的结构与功能研究, 负责人, 国家任务, 2012-01--2015-12
( 4 ) 组合化学制备化合物研究, 负责人, 中国科学院计划, 2012-01--2012-12
( 5 ) 重要GPCR三维结构解析, 参与, 国家任务, 2012-01--2016-08
( 6 ) 离子通道和膜转运蛋白的结构与功能研究, 负责人, 国家任务, 2013-01--2017-08
( 7 ) 基于GPCR结构与功能的药物发现关键技术发展与平台建设, 负责人, 国家任务, 2012-01--2015-12
( 8 ) 生物膜感受与转导外界信号的过程, 负责人, 中国科学院计划, 2014-01--2018-12
( 9 ) 重要脑认知神经递质受体与配体及下游信号转导蛋白复合物的结构与功能研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 10 ) GPCR激酶调控GPCR介导的细胞信号转导的机制研究, 负责人, 国家任务, 2022-01--2026-12
参与会议
(1)Hormone- and antibody-mediated activation of the thyrotropin receptor   2023-06-09
(2)Cryo-EM Revolution of GPCR Structural Biology   第十五届上海中医药与天然药物国际大会   2022-11-17
(3)From COVID-19 to Omicron: structures, mechanisms, and drug design   2022年中国-新西兰抗传染病国际联合研讨会   2022-07-21
(4)Structural Biology and Drug Discovery of Hormone Receptors   第十九次中国暨国际生物物理大会大会   2021-07-23
(5)/   2019-12-01
(6)A complex structure of β-arrestin bound to a G protein-coupled receptor   第六届药物所—格里菲斯大学双边学术研讨会   2019-10-09
(7)Structure Biology of GPCR Signalling Complexes   2018-11-05
(8)Structures and ligand regulation of orphan nuclear receptor   第八届厦门冬季国际学术会议   2017-12-08
(9)Structure of a GPCR-arrestin complex   H Eric Xu   2016-06-18
(10)Structure of rhodopsin-arrestin complex   H Eric Xu   2016-03-20
(11)X-ray laser Structure of rhodopsin-arrestin complex   H Eric Xu   2015-12-01
(12)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2015-09-24
(13)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2014-08-05
(14)The Rhodopsin-Arrestin Structure by femtosecond X-ray laser   H Eric Xu   2014-06-06
(15)Arrestin coupling to GPCRs: a new paradigm of cell signaling by a molten globule protein   H Eric Xu   2014-03-13
(16)Crystal structure of rhodopsin bound to arrestin determined by free electron X-ray laser diffraction   H Eric Xu   2013-12-05
(17)Structural mechanism of transcriptional repression by orphan nuclear receptors   苏州冷泉港会议   H Eric Xu   2013-11-05
(18)靶向GPCR的药物研发   东方科技论坛第164期学术研讨会   徐华强   2010-11-09