100706-药理学

代谢性疾病药物药理

2004-09--2007-07   中国科学院上海药物研究所   博士
1999-09--2002-07   北京师范大学   硕士

   

2016-10~现在, 中国科学院上海药物研究所, 研究员
2009-10~2016-10,中国科学院上海药物研究所, 副研究员
2005-06~2009-10,中国科学院上海药物研究所, 助理研究员
2004-09~2007-07,中国科学院上海药物研究所, 博士
2002-07~2005-06,中国科学院上海药物研究所, 研究实习员
1999-09~2002-07,北京师范大学, 硕士

2024-03-01-今,上海市毒理学会第二届理事会, 理事
2022-07-01-今,中华中医药学会方药量效研究分会第三届委员会, 委员

高等药理学

   

（1） 浦东新区科技进步奖, 二等奖, 市地级, 2018

（ 1 ） 一种防治肺纤维化的中药成分组合物及其用途, 2022, 第 4 作者, 专利号: 202211429313.X

（ 2 ） 一种与代谢相关脂肪性肝病发生发展关联的生物标志物, 2022, 第 3 作者, 专利号: CN114196747A

（ 3 ） 雷帕霉素在治疗渐冻症和额颞叶痴呆中的应用, 2022, 第 5 作者, 专利号: 202210168293.9

（ 4 ） miRNA552簇的微小RNA在治疗糖脂代谢病中的应用, 2021, 第 2 作者, 专利号: CN113713107A

（ 5 ） 雷藤舒在制备用于治疗非酒精性脂肪性肝病的药物中的应用, 2021, 第 3 作者, 专利号: CN111821308B

（ 6 ） 靶向PCSK9的microRNA在治疗LDLC相关代谢性疾病中的应用, 2021, 第 3 作者, 专利号: CN113116918A

（ 7 ） miRNA552簇的微小RNA在治疗LDLC相关代谢性疾病中的应用, 2019, 第 3 作者, 专利号: CN110384801A

（ 8 ） 靶向PCSK9的microRNA在治疗LDLC相关代谢性疾病中的应用, 2019, 第 3 作者, 专利号: CN109985243A

（ 9 ） microRNA‑1254及其种子基序和非种子序列在抑制肿瘤恶性增殖中的应用, 2017, 第 5 作者, 专利号: CN107456582A

（ 10 ） 硝唑尼特及其药学上可接受的盐在制备用于治疗阿尔茨海默病的药物中的应用, 2017, 第 5 作者, 专利号: CN107375280A

（ 11 ） N‑取代‑3,5‑二取代苯甲酰胺类化合物及其制备方法和应用, 2017, 第 3 作者, 专利号: CN107108656A

（ 12 ） N-取代-3,5-二取代苯甲酰胺类化合物及其制备方法和应用, 2016, 第 3 作者, 专利号: CN105837599A

（ 13 ） 聚甲酚磺醛在制备用于治疗登革病毒感染所致疾病的药物中的用途, 2016, 第 2 作者, 专利号: CN105748508A

（ 14 ） 原花青素在制备用于治疗登革病毒感染所致疾病的药物中的用途, 2016, 第 2 作者, 专利号: CN105748462A

（ 15 ） 一类牛蒡子苷元氨基甲酸酯衍生物在制备用于治疗阿尔茨海默病的药物中的用途, 2016, 第 6 作者, 专利号: CN105616400A

（ 16 ） 一类反式-1-(吲哚-3-基)-2-(喹啉-4-基)-乙烯衍生物的用途及组合物, 2015, 第 4 作者, 专利号: CN104840461A

（ 17 ） 一类二芳酰胺类衍生物及其制备方法、药物组合物及用途, 2015, 第 6 作者, 专利号: CN104341316A

（ 18 ） 用于制备新木榄二硫醇的中间体、其合成方法、中间体和用途, 2014, 第 4 作者, 专利号: CN104140412A

（ 19 ） PPARγ:RXRα异源二聚体激动剂在缓解拉坦前列腺素在临床上的副作用中的应用, 2014, 第 2 作者, 专利号: CN104096232A

（ 20 ） 一种用于治疗阿尔茨海默病的制剂及其制备方法, 2014, 第 6 作者, 专利号: CN104069263A

（ 21 ） 1,8-二羟基蒽醌在制备治疗糖尿病及其并发症的药物中的用途, 2014, 第 2 作者, 专利号: CN104013607A

（ 22 ） 缩酚酸衍生物的用途, 2014, 第 5 作者, 专利号: CN103664623A

（ 23 ） 牛蒡子苷元碳酰胺衍生物及其制备方法、包含该衍生物的组合物、及其用途, 2013, 第 5 作者, 专利号: CN103467417A

（ 24 ） 化合物SC-51089 在制备治疗糖尿病及并发症的药物中的用途, 2013, 第 3 作者, 专利号: CN103381161A

（ 25 ） 拉坦前列腺素在制备用于治疗糖尿病和/或高甘油三酯血症及其并发症的药物中的应用, 2013, 第 2 作者, 专利号: CN103316018A

（ 26 ） 文朵灵衍生物的医药用途, 2013, 第 5 作者, 专利号: CN103304565A

（ 27 ） 牛蒡子苷元及其衍生物在制备药物中的用途, 2012, 第 4 作者, 专利号: CN102342929A

（ 28 ） 达玛烷三萜类衍生物的用途及包含该衍生物的药物组合物, 2009, 第 5 作者, 专利号: CN101530419A

（ 29 ） 3－(2－羧基苯甲酰基)－齐墩果酸、其药物组合物及其用于治疗糖尿病和/或肥胖症的用途, 2009, 第 1 作者, 专利号: CN101525366A

（ 30 ） 四氢喹啉类化合物、其制备方法及药物组合物, 2008, 第 6 作者, 专利号: CN101245062A

（ 31 ） SARS冠状病毒3CL蛋白酶三维结构模型与抗SARS药物, 2006, 第 11 作者, 专利号: CN1237185C

（ 32 ） 抗SARS－CoV药物作用靶标、药物筛选方法及抗SARS药物, 2006, 第 12 作者, 专利号: CN1237184C

（ 33 ） 一类2,3,5－三取代－4－噻唑烷酮化合物及其药理用途, 2005, 第 7 作者, 专利号: CN1699354A

（ 34 ） 一类2，3，5－三取代－4－噻唑烷酮化合物及其药理用途, 2005, 第 7 作者, 专利号: CN1699355A

（ 35 ） 过氧化物酶体增长因子活化受体拮抗剂和激动剂的筛选方法, 2005, 第 5 作者, 专利号: CN1629310A

（ 36 ） 可溶性SARS病毒3CL蛋白酶的表达和纯化, 2005, 第 4 作者, 专利号: CN1187449C

（ 37 ） 可溶性SARS病毒核衣壳蛋白的表达和纯化, 2004, 第 4 作者, 专利号: CN1472318

   

（1） Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism., Liver Int., 2024, 
（2） Arctigenin induces activated HSCs quiescence via AMPK-PPAR�� pathway to ameliorate liver fibrosis in mice., Eur J Pharmacol., 2024, 
（3） MiR-337-3p improves metabolic associated fatty liver disease through regulation of glycolipid metabolism., iScience., 2023, 
（4） MiR-552-3p Regulates Multiple Fibrotic and Inflammatory Genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes., Int J Biol Sci., 2023, 
（5） Identification of 3H-benzo[b] [1,4] diazepine derivatives as PPAR�� agonists by in silico studies and biochemical evaluation., J Biomol Struct Dyn., 2023, 
（6） MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis, MOLECULAR BIOMEDICINE, 2022, 第 8 作者  通讯作者
（7） Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-alpha, TOXICOLOGY, 2022, 第 9 作者  通讯作者
（8） Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment, MOLECULAR BIOLOGY REPORTS, 2022, 第 2 作者  通讯作者
（9） miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder, JOURNAL OF HEPATOLOGY, 2021, 第 11 作者  通讯作者
（10） MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice, METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 第 7 作者  通讯作者
（11） Role of microRNAs in the process of metformin treating multiple diseases, FRIGID ZONE MEDICINE, 2021, 第 2 作者  通讯作者
（12） GADD45�� stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation, PHARMACOLOGICAL RESEARCH, 2021, 第 8 作者  通讯作者
（13） New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice, PHARMACOLOGICAL RESEARCH, 2021, 第 6 作者  通讯作者
（14） 热休克蛋白HSP72与非酒精性脂肪性肝病关系的研究进展, The research progress of heat shock protein 72 and nonalcoholic fatty liver disease, 生命科学, 2020, 第 2 作者
（15） PCSK9与多种代谢相关疾病发生发展关系的研究进展, Research advances in the relationship between PCSK9 and the occurrence and development of various metabolic diseases, 中国新药杂志, 2020, 第 2 作者
（16） Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 7 作者
（17） MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability, ONCOGENE, 2020, 第 11 作者
（18） Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2019, 第 9 作者  通讯作者
（19） Nitazoxanide,an anti-parasitic drug,efficiently ameliorates learning and memory impairments in AD model mice, Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice, ACTA PHARMACOLOGICA SINICA, 2019, 第 10 作者
（20） Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression, CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 第 2 作者
（21） Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice, Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice, ACTA PHARMACOLOGICA SINICA, 2019, 第 15 作者  通讯作者
（22） (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice, LIFE SCIENCES, 2019, 第 7 作者  通讯作者
（23） 新型非酒精性脂肪性肝炎小鼠模型的建立, Establishment of a new model of non-alcoholic steatohepatitis in mice, 中国兽医杂志, 2019, 第 2 作者
（24） ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 第 6 作者  通讯作者
（25） Discovery and structure-activity relationships study of thieno2,3-bpyridine analogues as hepatic gluconeogenesis inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 5 作者
（26） TSPA as a novel ATF6 alpha translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 8 作者  通讯作者
（27） The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma, The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2018, 第 2 作者
（28） 非酒精性脂肪肝病的易感基因及与2型糖尿病相关性的研究进展, Research advances in susceptibility genes of non-alcoholic fatty liver disease and its association with type 2 diabetes, 中国药科大学学报, 2018, 第 2 作者
（29） MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth, PLOS GENETICS, 2017, 第 4 作者
（30） Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 第 8 作者  通讯作者
（31） Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187, PHYTOCHEMISTRY LETTERS, 2017, 第 7 作者
（32） DMT efficiently inhibits hepatic gluconeogenesis by regulating the G alpha q signaling pathway, JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2017, 第 11 作者  通讯作者
（33） Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 9 作者  通讯作者
（34） The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma, CANCER LETTERS, 2017, 第 3 作者
（35） Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188, PHYTOCHEMISTRY LETTERS, 2017, 第 6 作者
（36） beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123, TETRAHEDRON, 2016, 第 6 作者
（37） Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening, EUROPEANJOURNALOFMEDICINALCHEMISTRY, 2016, 第 10 作者
（38） SP6616 as a new Kv2.1 channel inhibitor efficiently promotes ��-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways., Cell Death Dis., 2016, 第 13 作者  通讯作者
（39） Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha) in Stabilizing the Homodimerization of the Receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 5 作者
（40） BBT improves glucose homeostasis by ameliorating beta-cell dysfunction in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2015, 第 9 作者
（41） Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells, ACTA PHARMACOLOGICA SINICA, 2015, 第 7 作者
（42） 基于能量代谢调控机制新型运动模拟剂的发现研究, 2015, 第 5 作者
（43） Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways, ACTA PHARMACOLOGICA SINICA, 2014, 第 7 作者  通讯作者
（44） Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 5 作者  通讯作者
（45） Novel approaches to drug discovery for the treatment of type 2 diabetes, EXPERT OPINION ON DRUG DISCOVERY, 2014, 第 5 作者
（46） Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways, Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways, 中国药理学报：英文版, 2014, 第 7 作者
（47） Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice, PHYTOMEDICINE, 2014, 第 4 作者
（48） Regulation of prostaglandin F-2 alpha, against beta amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia, PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2013, 第 5 作者  通讯作者
（49） Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice, DIABETOLOGIA, 2013, 第 7 作者  通讯作者
（50） Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, PLOS ONE, 2013, 第 5 作者
（51） Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance, JOURNAL OF NEUROSCIENCE, 2013, 第 5 作者
（52） Free energy landscape for the binding process of Huperzine A to acetylcholinesterase, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 3 作者
（53） Regulation of prostaglandin F2�� against �� amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia, PROSTAGLANDINS AND OTHER LIPID MEDIATORS, 2013, 第 5 作者
（54） Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability, STEROIDS, 2013, 第 6 作者
（55） Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 5 作者
（56） Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models, JOURNAL OF ETHNOPHARMACOLOGY, 2013, 第 5 作者  通讯作者
（57） Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets, JOURNAL OF PHARMACY AND PHARMACOLOGY, 2013, 第 4 作者
（58） The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 1 作者
（59） Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro, ACTA PHARMACOLOGICA SINICA, 2013, 第 4 作者
（60） L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases beta-amyloid peptide production in HEK293-APPswe cells, ACTA PHARMACOLOGICA SINICA, 2012, 第 4 作者
（61） (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice, PLOS ONE, 2012, 第 5 作者
（62） L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases p-amyloid peptide production in HEK293-APPswe cells, ACTA PHARMACOLOGICA SINICA, 2012, 第 4 作者
（63） 葡萄糖转运蛋白4功能调节信号通路及其在药物研发中的应用, 中国科学化学, 2012, 第 2 作者
（64） Molecular Determinants of Magnolol Targeting Both RXR alpha and PPAR gamma, PLOS ONE, 2011, 第 4 作者
（65） Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 4 作者
（66） Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1, PROTEIN SCIENCE, 2011, 第 3 作者  通讯作者
（67） Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: Inhibition by salvianolic acid B from Salvia miltiorrhiza, PHYTOMEDICINE, 2011, 第 3 作者
（68） Structural Basis for Retinoic X Receptor Repression on the Tetramer, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 3 作者
（69） Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance, PLOS ONE, 2011, 第 3 作者
（70） Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway, ACTA PHARMACOLOGICA SINICA, 2011, 第 3 作者  通讯作者
（71） Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle, BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 第 6 作者  通讯作者
（72） Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway, Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway, 中国药理学报：英文版, 2011, 第 3 作者
（73） Activation of Protein Serine/Threonine Phosphatase PP2C alpha Efficiently Prevents Liver Fibrosis, PLOS ONE, 2010, 第 3 作者
（74） 2,2',4'-Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice, JOURNAL OF NEUROCHEMISTRY, 2010, 第 5 作者
（75） Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways, ACTA PHARMACOLOGICA SINICA, 2010, 第 2 作者
（76） Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure ���, VIROLOGY, 2009, 第 6 作者
（77） Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization, BMC MICROBIOLOGY, 2009, 第 1 作者
（78） 7-Chloroarctinone-b as a new selective PPAR gamma antagonist potently blocks adipocyte differentiation, ACTA PHARMACOLOGICA SINICA, 2009, 第 3 作者  通讯作者
（79） 7-Chloroarctinone-b as a new selective PPAR�� antagonist potently blocks adipocyte differentiation, ACTA PHARMACOLOGICA SINICA, 2009, 第 3 作者
（80） 表皮生长因子受体酪氨酸激酶抑制剂高通量筛选模型的建立, Establishment of high throughput screening model for epidermal growth factor receptor tyrosine kinase inhibitor, 第二军医大学学报, 2009, 第 5 作者
（81） The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation, ACTA PHARMACOLOGICA SINICA, 2009, 第 3 作者  通讯作者
（82） 7-Chloroarctinone-b as a new selective PPARy antagonist potently blocks adipocyte differentiation, 7-Chloroarctinone-b as a new selective PPARy antagonist potently blocks adipocyte differentiation, 中国药理学报英文版, 2009, 第 3 作者
（83） Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E-coli: Enzymatic characterization with crystal structure analysis, PROTEIN SCIENCE, 2008, 第 4 作者
（84） Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 4 作者
（85） 幽门螺旋杆菌氨基庚二酸脱羧酶（HpDAPDC）的酶学性质和晶体结构分析, 2008, 第 4 作者
（86） SARS冠状病毒3CL蛋白酶突变体的结构对其聚合-活性关系的提示, 2008, 第 4 作者
（87） Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2008, 第 6 作者
（88） Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay, PROTEIN SCIENCE, 2008, 第 6 作者
（89） Enzymatic characterization and inhibitor discovery of a new cystathionine gamma-synthase from Helicobacter pylori, JOURNAL OF BIOCHEMISTRY, 2008, 第 5 作者
（90） Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2008, 第 6 作者
（91） The Catalytic Intermediate Stabilized by a "Down" Active Site Loop for Diaminopimelate Decarboxylase from Helicobacter pylori: ENZYMATIC CHARACTERIZATION WITH CRYSTAL STRUCTURE ANALYSIS, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 3 作者
（92） Malonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein, PROTEIN SCIENCE, 2007, 第 5 作者
（93） Helicobacter pylori acyl carrier protein: Expression, purification, and its interaction with beta-hydroxyacyl-ACP dehydratase, PROTEIN EXPRESSION AND PURIFICATION, 2007, 第 4 作者
（94） Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: Self-association analysis and nucleic acid binding characterization, BIOCHEMISTRY, 2006, 第 2 作者
（95） One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation, BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 第 2 作者
（96） Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice, Swietenia mahagony extract shows agonistic activity to PPAR�� and gives ameliorative effects on diabetic db/db mice, 中国药理学报：英文版, 2005, 第 7 作者
（97） 线粒体渗透性转变孔结构和功能的研究进展, Progress in the studies of the structure and function of mitochondria permeability transition pore, 生命科学, 2005, 第 3 作者
（98） Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca^2＋ uptake/ release, Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca^2��� uptake/ release, 中国药理学报英文版, 2005, 第 4 作者
（99） Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique1, ACTA PHARMACOLOGICA SINICA, 2005, 第 4 作者
（100） 可溶性SARS病毒核衣壳蛋白的表达和纯化, 科技开发动态, 2004, 第 4 作者
（101） 基于酵母水平的高通量药物筛选, Yeast-based high-throughput drug screening, 生命科学, 2004, 第 6 作者
（102） 可溶性SARS病毒3CL蛋白酶的表达和纯化, 科技开发动态, 2004, 第 4 作者
（103） 基于生物传感器Biacore S51技术的新药发现与开发, Drug Discovery and Development Based on Biacore S51, 生命的化学, 2004, 第 2 作者
（104） Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1, PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY, 第 3 作者

   

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