General

Yao Cong,Ph.D.

Professor, Principal Investigator


National Center for Protein Science (Shanghai)

Institute of Biochemistry and Cell Biology, SIBS,

Chinese Academy of Sciences,

Haike Rd #333, B421

Shanghai, China, 201210

Tel: +86-21-2077-8199

Email: cong@sibcb.ac.cn


Research Areas

Structural Biology, Cryo-EM, Biophysics


Education

1995.9-2000.6      Ph.D. in Physical Chemistry, Jilin University, Jilin, China. Advisor: Dr. Zhongzhi Yang, Dr. Aoqing Tang

​1991.9-1995.7      B.S. in Chemistry, Department of Chemistry, Liaoning Normal University, China. 


Experience

   
Work Experience

2011.7-present       Professor, National Protein Science CenterShanghai, Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences, CAS, Shanghai, China.

2010.10-2011.7    Instructor, Laboratory of Dr. Wah Chiu, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX.

2005.6-2010.9     Research Associate, Laboratory of Dr. Wah Chiu, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX.                

2001.11-2005.5   Postdoctoral Research Associate, Laboratory of Dr. Willy Wriggers, The Scripps Research Institute, La Jolla, CA; University of Texas Health Science Center at Houston, Houston, TX.

2000.9-2001.10     Research Associate, Laboratory of Dr. Xinhe Bao, Dalian Institute of Chemical Physics, State Key Laboratory of Catalysis, Chinese Academy of Science, China.       


Teaching Experience

·  Instructor of the Workshop on Single Particle Reconstruction using EMAN, Fifth K. H. Kuo Summer School of Electron Microscopy and Crystallography, Hefei, China, 2012.9

·  Instructor of Introduction to Rosetta in the NCMI Workshop on Single Particle Reconstruction, Validation and Analysis, Houston, TX, 2011

·  Mentor of three graduate students and one summer student, Baylor College of Medicine, SCBMB program, Houston, TX, 2007-2011

·  Co-instructor of the Workshop on Single Particle Reconstruction, Map Interpretation and Visualization, Houston, TX, 2008.12

·  Supervised two graduate students, University of Texas Health Science Center at Houston, Houston, TX, 2004

·  Co-instructor of Correlation Based Fitting in Situs EM/X-tal Fitting and Modeling Workshop, the Scripps Research Institute, San Diego, CA, 2003

·  Co-instructor of the Molecular Modeling graduate student course, University of Texas at Houston, 2003.11, 2005.4.

·  A teaching assistant of Quantum Mechanics course, Jilin University in fall 1998.

·  Supervised two graduate students and one undergraduate student, Jilin University, 1997-2000 


Publications


Papers

  1. Zhang C, Xu C, Dai W, Wang Y, Liu Z, Zhang X, Wang X, Wang H, Gong S*, Cong Y*, Huang Z*.(2021) Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. Nat Commun, 12:2904.
  2. Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C*, Ding Z*, Cong Y*.(2021) Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ. Nat Commun,12:739.
  3. Zheng W, Li F, Ding Z, Liu H, Zhu L, Xu C, Li J, Gao Q,Wang Y, Fu Z, Peng C, Yan X*, Zhu X*, and Cong Y*.(2021) Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM. Proc Natl Acad Sci,118(4):e2021180118.
  4. Zhang C, Wang YF, Zhu Y, Liu C, Gu C, Xu S, Wang YL, Zhou Y, Wang YX, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q*, Xie Y*Cong Y*, Huang Z*.(2021) Development and structural basis of a two-Mab cocktail for treating SARS-CoV-2 infections. Nat Commun,12:264.
  5. Xu C, Wang YX, Liu C, Zhang C, Han W, Hong X, Wang YF, Hong Q, Wang S, Zhao Q, Wang YL, Yang Y, Chen K, Zheng W, Kong L, Wang F, Zuo Q, Huang Z*, Cong Y*. (2021) Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7(1):eabe5575.
  6. Jin M, Liu C, Han W, Cong Y*. (2020) TRiC/CCT Chaperonin: Structure and Function. Macromolecular Protein Complexes II: Structure and Function, Subcellular Biochemistry, 93:625-654. (Book chapter, Springer Nature) 
  7. Yin W, Li Z, Jin M, Yin YL, Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y*, Zhou XE*, Yu X*, Xu HE*. (2019) A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Research, 29:971–983.
  8. Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y*. (2019) An ensemble of cryo-EM structures of TRiC reveals its conformational landscape and subunit specificity. Proc Natl Acad Sci, 116(39):19513–19522.
  9. Ding Z, Xu C, Sahu I, Wang Y, Fu Z, Huang M, Wong CCL, Glickman MH, and Cong Y*. (2019) Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Molecular Cell, 73:1150-1161.
  10. Chen J, Ye X, Zhang X, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y*and Huang Z*. (2019) Coxsackievirus A10 atomic structure facilitating the discovery of a broadspectrum inhibitor against human enteroviruses. Cell Discovery, 5:4.
  11. Wang Y, Ding Z, Liu X, Bao Y, Huang M, Wong CCL, Hong X, Cong Y*. (2018) Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex. Scientific Reports, 8:17405.
  12. Wang H, Han W, Takagi J*, Cong Y*. (2018) Yeast inner-subunit PA–NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis. Journal of Molecular Biology,430(10):1417-1425.
  13. Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang YX, Cong Y*. (2018) Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT. Scientific Reports, 8(1):2374.
  14. Chen J, Zhang C, Zhou Y, Zhang X, Shen C, Ye X, Jiang W, Huang Z* and Cong Y*.  (2018) A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles. Journal of Virology, 92: e01257-17
  15. Wang X, Ku Z, Zhang X, Ye X, Chen J, Liu Q, Zhang W, Zhang C, Fu Z, Jin X, Cong Y* and Huang Z*. (2018) Structure, Immunogenicity and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid. Journal of Virology, 92:e01330-17.
  16. Jin M, Cong Y. (2017) Identification of an allosteric network that influences assembly and function of group II chaperonins. Nat Struct Mol Biol, 24:683–684.
  17. Fan C, Ye X, Ku Z, Kong L, Liu Q, Xu C, Cong Y*, Huang Z*. (2017) Beta-propiolactone inactivation of coxsackievirus A16 induces structural alteration and surface modification of viral capsids.Journal of Virology, 91:e00038-17.
  18. Ding Z, Fu Z, Xu C, Wang YF, Wang YX, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y*. (2017) High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx. Cell Research, 27:373–385.
  19. Zang Y, Jin M, Wang H, Cui Z, Liu C, Kong L, Cong Y*. (2016) Staggered ATP binding mechanism of eukaryotic chaperonin TRiC(CCT) revealed through high-resolution cryo-EM. Nat Struct Mol Biol, 23(12):1083-1091.
  20. Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X*, Cong Y*, Shen Y*. (2016) Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter. Scientific Reports, 6:34174.
  21. Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, Jiang W, Zhang L, Huang Z*, Cong Y*. (2016) Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody. PLoS Pathogens, 12(3):e1005454.
  22. Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ*. (2016) Architecture of the mitochondrial calcium uniporter. Nature, 533(7602):269-273.
  23. Jin W, Wang Y, Liu CP, Yang N, Jin M, Cong Y, Wang M*, Xu RM*. (2016) Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. Genes & Dev, 30(21):2391-2403.
  24. Cheng H, Fan C, Zhang S, Wu Z, Cui Z, Melcher K, Zhang C, Jiang Y, Cong Y, Xu HE*. (2015) Crystallization scale purification of a7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system. Acta Pharmacol Sin, 36(8):1013-1023.
  25. Wu Z, Cui Z, Cheng H, Fan C, Melcher K, Jiang Y, Zhang C, Jiang H, Cong Y, Liu Q*, Xu HE*. (2015) High yield and efficient expression and purification of the human 5-HT3A receptor. Acta Pharmacol Sin, 36(8):1024-1032.
  26. Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y*. (2015) Structural Insight into Autoinhibition and Histone H3-induced Activation of DNMT3A. Nature, 517(7536):640-644.
  27. Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z*. (2014) Chimeric virus-like particle vaccines displaying conservedenterovirus 71epitopes elicit protective neutralizing antibodies in mice through divergentmechanisms. Journal of Virology, 88(1):72-81.
  28. Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W*. (2013) TRiC’s tricks inhibit huntingtin aggregation. eLife, 2:e00710.
  29. Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W*. (2013) Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism. Structure, 21(4):604-613.
  30. Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, Shi Z, Greene MI, Cong Y*, Zhou Z*. (2013) Structural and biochemical studies of RIG-I antiviral signaling. Protein Cell, 4(2):142-154.
  31. Leitner A, Joachimiak LA, Bracher A, M?nkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R*, Frydman J*. (2012) The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure, 20(5):814-825.
  32. Cong Y, Schr?der GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W*. (2012) Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO Journal, 31(3):720-730.
  33. Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W*. (2011) 4.4 ? cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO Journal, 30(18):3854-3863.
  34. Cong Y, Ludtke SL. (2010) Single Particle Analysis at High Resolution. Methods in Enzymology, 482:211-235.
  35. Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, Ludtke SJ, Frydman J, Chiu W*. (2010) 4.0 ? Resolution Cryo-EM Structure of the Mammalian Chaperonin TRiC/CCT Reveals its Unique Subunit Arrangement. Proc Natl Acad Sci, 107(11):4967-4972.
  36. Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W*, Decker H*. (2009) Structural Mechanism of SDS-induced Enzyme Activity of Scorpion Hemocyanin Revealed by Electron Cryo-Microscopy. Structure, 17(5):749-758.
  37. Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W*, Frydman J*. (2008) Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol, 15(7):746-753.
  38. Cong Y, Topf M, Sali A, Matsudaira P, Dougherty M, Chiu W, Schmid MF*. (2008) Crystallographic conformers of actin in a biologically active bundle of filaments. J Mol Biol, 375(2):331-336.
  39. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W*. (2008) Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci, 105(28):9610-9615.
  40. Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W *. (2005) Fast rotational matching of single-particle images. J Struct Biol, 152(2):104-112.
  41. Cong Y, Kovacs JA, Wriggers W. (2003) 2D fast rotational matching for image processing of biophysical data. J Struct Biol, 144(1-2):51-60.
  42. Kovacs JA, Chacón P, Cong Y, Metwally E, Wriggers W*. (2003) Fast rotational matching of rigid bodies by fast Fourier transform acceleration of five degrees of freedom. Acta Crystallogr D Biol Crystallogr, 59(8):1371-1376.
  43. Yang Z*, Cong Y, Zhao D, Wang C, Bao XH. (2003) Sigma Pi Scheme in Atom-Bond Electronegativity Equalization Method. J Chin Chem Soc-Taipei, 50:785-794.
  44. Sun R*, Liu Y, Sun Y, Cong Y, Zhang Z. (2003) Theoretical studies of Si6H3 Si5H6 Si5Li3 and Si5Na3 cluster. J Mol Sci, 19:103-108.
  45. Cong Y*, Yang Z, Wang C, Liu X, Bao X. (2002) Investigation of the regio- and stereo-selectivity of Diels-Alder reactions by the newly developed ABEEMσπ model on the basis of local HSAB principle and maximum hardness principle. Chem Phys Lett, 357:59-64.
  46. Cong Y, Yang Z. (2000) General atom-bond electronegativity equalization method and its application in prediction of charge distributions in polypeptide. Chem Phys Lett, 316:324-329.
  47. Niu S, Jin J, Jin X, Cong Y, Yang Z*. (2000) Crystal structure and magnetism of the binuclear Gd(III) complex Gd2(C12H8N2)2(C6H5COO)6Chin Sci Bull, 45(8):706-711.
  48. Yang Z*, Cong Y, Wang C. (1999) Sigma pi model in the atom-bond electronegativity equalization method and its applications. Chem J Chin Univ, 20:1781-1783.
  49. Li S, Wang M, Cong Y, Yang Z*. (1998) Energy transfer of Excited Normal Modes in H2X(X=OS). Chem J Chin Univ, 19:950-954.
  50. Wang C, Sun R, Cong Y, Yang Z. (1997) A Theoretical Study of PdCONaOH Complex as a Sample Model of Promoted Catalysis. J Inorg Chem, 13:301-305. 

Research Interests

Cryo-EM based structural and functional study on macromolecular complexes including protein quality control macromolecular machines and epigenetic related complexes; cryo-EM 2D image alignment method development 


Conferences

1)  Proteasome in Action Revealed by Near-atomic Resolution Cryo-EM, 16th Conference of the Asian Crystallographic Association, Singapore, December 2019

2) Mechanisms of Proteasome Regulation and Assembly Revealed by Cryo-EM, Southern University of Science and Technology, Shenzhen, China, December 2019  

3) An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity, 16th Chinese Microscopy Society Meeting, Hefei, October 2019 (Session Chair)

4) Protein Quality Control Machines in Action Revealed by High-resolution Cryo-EM, 18th Cross-Strait Symposium on Biomedical Research、16th Symposium of the Frontiers of Biomedical Science, Taiwan, China, September 2019

5) Protein Quality Control Machines in Action Revealed by Cryo-EM, The 6th Chinese Cryo-EM Society Meeting, Miyun, China, June 2019

6) Protein Folding Nanomachine TRiC in Action Revealed by Cryo-EM, The Chinese University of Hong Kong, Hong Kong, China, June 2019

7)  Atomic-resolution Cryo-EM Structure Based Vaccine and Drug Discovery against Enterovirus, Zhangjiang Cryo-EM Workshop 2019 Spring –Cryo-EM Structural Based Vaccine and Drug Development, Shanghai, China, May 2019

8) Atomic-resolution Cryo-EM Structure Based Vaccine and Drug Discovery against Enterovirus, Queenstown Meeting, Shanghai, China, 2019

9) Protein Quality Control Nanomachines in Action Revealed by Cryo-EM, MRC Laboratory of Molecular Biology, Cambridge, UK, 2019

10) Protein Quality Control Nanomachine in Action Revealed by Near-atomic Resolution Cryo-EM, The Chinese Society of Biochemistry and Molecular Biology Meeting, Chongqing, China, 2018

11) Protein Quality Control Nanomachine in Action Revealed by Near-atomic Resolution Cryo-EM, 16th Chinese Biophysics Society Meeting, Chengdu, China, 2018

12) Protein Quality Control Nanomachine in Action Revealed by Near-atomic Resolution Cryo-EM, 2018 Chinese EM Society Meeting, Chengdu, China, 2018 (Keynote Talk)

13) Proteasome in Action Revealed by Near-atomic Resolution Cryo-EM, 2018 Kuo Symposium on 3D-EM of Macromolecules and Cells, Hangzhou, China, 2018

14) Protein Folding Nanomachine TRiC/CCT in Action Revealed by Near-atomic Resolution Cryo-EM, Institute of Genetics and Developmental Biology, CAS, Beijing, China, 2018

15) Protein Quality Control Nanomachines in Action Revealed by Near-atomic Resolution Cryo-EM, University of Massachusetts Medical School, Worcester, USA, 2018

16) Protein Quality Control Nanomachines in Action Revealed by Near-atomic Resolution Cryo-EM, National University of Singapore, Singapore, 2018

17) Protein Quality Control Nanomachines in Action Revealed by Near-atomic Resolution Cryo-EM, Frontiers of Multiscale Structural Biology, IPR, Osaka University, Japan, 2018

18) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM, 22th Biophysics Conference in Taiwan, KaohSiung, 2017 (Plenary Talk)

19) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM, 2017 Gordon Research Conferences in 3DEM, Switzerland, 2017 (Keynote Talk)

20) Macromolecular Machines in Action Revealed by Cryo-EM, Institute of Microbiology, CAS, Beijing, China, 2017

21) ATP Triggered Opposite Modes of Action of the ATPases in Protein Quality Control Revealed by Cryo-EM, The Third Trilateral Workshop for Frontier Protein Studies, Shanghai, China, 2017

22) ATP Triggered Opposite Modes of Action of the ATPases in Protein Quality Control Revealed by Cryo-EM, The 5th National Symposium of cryo-EM, Shanghai, China, 2017

23) Macromolecular Machines in Action Revealed by Cryo-EM, Zhejiang University, China, 2017

24) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM, The 2016 Kuo Symposium on 3D Cryo-EM Molecular Imaging, Beijing, China, 2016

25) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM, The Second Trilateral Workshop for Frontier Protein Studies, Osaka, Japan, 2016

26) Cryo-EM visualization of antibody-virus complex, IPR/CRED/PDIS Joint Seminar on Drug Development "From protein structural science to development of therapeutics", Hokkaido, Japan, 2016

27) High Resolution Cryo-EM in Structure and Function Studies of Macromolecular Machines, Shanghai Center for Plant Stress Biology, CAS, Shanghai, China, 2016

28) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM, The 5th Chinese Structural Biology Workshop, Shenzhen, China, 2016

29) NCPSS Cryo-EM Facility Setup and Progress Report, Baylor College of Medicine, Houston, USA, 2015

30) Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM, Current Developments in Three-Dimensional Biological EM, Okinawa, Japan, 2015

31) Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM, International Workshop of Advanced Image Processing of Cryo-Electron Microscopy, Beijing, China, 2015

32) Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM, The First Trilateral Workshop for Frontier Protein Studies, Beijing, China, 2015

33) Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM, 9th Asian Biophysics Association Symposium, Hangzhou, China, 2015

34) Cryo-EM of asymmetric and dynamic protein folding nanomachine TRiC, 2014 Kuo International Symposium on 3D Cyro-EM Molecular Imaging, Shanghai, China, 2014

35) Cryo-EM Study on Asymmetric and Dynamic Protein Folding Nanomachine TRiC, Cold Spring Harbor Asia conferences, Suzhou, China, 2014

36) Proteins in disease I, The 4th Asia Pacific Protein Association (APPA2014), Chejudo, Korea, 2014

37) 2D Image Alignment and Classification, International Workshop of Advanced Image Processing of Cryo-Electron Microscopy, Beijing, China, 2013

38) Cryo-EM Study on Asymmetric and Dynamic Macromolecular Machine TRiC, The 4th Xiamen Winter Symposium, Xiamen, China, 2013

39) Cryo-EM Study on Asymmetric and Dynamic Macromolecular Machine TRiC, The First East-Asia Microscopy Conference, Chongqing, China, 2013

40) Symmetry-Free Cryo-EM Structures of the Chaperonin TRiC Along its ATPase-Driven Conformational Cycle, International Workshop of 3D Molecular Imaging by Cryo-Electron Microscopy, Huangshan Mountain, China, 2012

41)Symmetry-Free Cryo-EM Structures of the Chaperonin TRiC Along its ATPase-Driven Conformational Cycle, International Symposium on Advanced Electron Microscopy “Theory and Application”, Beijing, China, 2012

Students

已指导学生

丁占玉  博士研究生  071010-生物化学与分子生物学  

臧云祥  博士研究生  071010-生物化学与分子生物学  

刘向阳  硕士研究生  085238-生物工程  

陈进寰  博士研究生  071010-生物化学与分子生物学  

付政麟  硕士研究生  085238-生物工程  

郑伟  博士研究生  071010-生物化学与分子生物学  

金明梁  博士研究生  071010-生物化学与分子生物学  

王胡萍  硕士研究生  085238-生物工程  

谭静  硕士研究生  085238-生物工程  

张翔  硕士研究生  085238-生物工程  

洪晓喻  硕士研究生  085238-生物工程  

现指导学生

徐聪  博士研究生  071010-生物化学与分子生物学  

刘彩璇  博士研究生  071010-生物化学与分子生物学  

汪一帆  博士研究生  071010-生物化学与分子生物学  

韩文玉  博士研究生  071010-生物化学与分子生物学  

王舒田  硕士研究生  085238-生物工程  

李佳蔚  博士研究生  071010-生物化学与分子生物学  

赵巧钰  硕士研究生  071009-细胞生物学  

陈锴剑  博士研究生  071010-生物化学与分子生物学  

洪琴  博士研究生  071010-生物化学与分子生物学  

李祖洋  硕士研究生  071010-生物化学与分子生物学  

蒙学明  硕士研究生  071010-生物化学与分子生物学  

Honors & Distinctions

·  National Excellent Young Scientists Career Award, National Natural Science Foundation of China, 2013.1-2015.12

·  Hundred Talents Program of Chinese Academy of Sciences, 2012.1-2014.12

·  W. M. Keck Postdoctoral Fellowship, 2004.1-2005.12 (Mentor: Dr. Willy Wriggers, Dr. Wah Chiu)

·  3D Electron Microscopy Gordon Research Conference Travel Award, 2005.6  

·  Outstanding Paper Award, 7th Chinese Quantum Chemistry Conference, Fuzhou, 1999.10 

·  Outstanding Undergraduate Thesis Award, Liaoning Normal University, 1995