基本信息
娄晓敏  女  硕导  中国科学院北京基因组研究所(国家生物信息中心)
email: louxm@big.ac.cn
address: 北京市朝阳区北辰西路一号院,中国科学院奥运科技园1-7
postalCode: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
肿瘤标志物的发现及功能研究
肿瘤蛋白质组学

教育背景

2002-09--2007-06   中国科学院北京基因组研究所   博士学位

工作经历

   
工作简历
2009-11~现在, 中国科学院北京基因组研究所, 副研究员
2008-05~2008-11,Institute of Cancer Therapeutics, 访问学者
2007-07~2009-10,中国科学院北京基因组研究所, 助理研究员
2002-09~2007-06,中国科学院北京基因组研究所, 博士学位
社会兼职
2011-08-31-今,中国生物化学与分子生物学会蛋白质组学专业委员会, 理事

教授课程

分析生物化学及样品制备
组学回顾
Analytical Biochemistry and Sample Preparation
Omics Brush-up
蛋白质科学与医学研究
基因组学中的核心技术
组学在疾病与健康中的应用

专利与奖励

   
专利成果
( 1 ) Cathepsin D抗原多肽、自身抗体在制备检测肿瘤试剂盒中的应用及含有该多肽的检测试剂盒, 2010, 第 1 作者, 专利号: 200810227252.2

( 2 ) 检测六项肿瘤标志物的微阵列—酶联免疫检测试剂盒, 2009, 第 5 作者, 专利号: 200810105335.4

出版信息

   
发表论文
(1) Proteomic Profiling of Gastric Signet Ring Cell Carcinoma Tissues Reveals Characteristic Changes of the Complement Cascade Pathway, Mol Cell Proteomics, 2021, 第 7 作者
(2) Pathway attenuation of fatty acid beta-oxidation in the skeletal muscle of a type 2 diabetic mouse model, Rapid Commun Mass Spectrom, 2020, 第 9 作者
(3) Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression, Gene, 2019, 第 7 作者
(4) Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma, Nature, 2019, 其他(合作组作者)
(5) 基因编辑技术及其在基因治疗中的应用, Research advance and application in the gene therapy of gene editing technologies, 遗传, 2019, 第 3 作者
(6) Combination Strategy of Quantitative Proteomics Uncovers the Related Proteins of Colorectal Cancer in the Interstitial Fluid of Colonic Tissue from the AOM-DSS Mouse Model, Methods in Molecular Biology, 2018, 第 3 作者
(7) KLF1 和 KLF9 对 K562 细胞红系分化的协同调控作用, Synergistic regulation of the erythroid differentiation of, 遗传, 2018, 第 4 作者
(8) Proteomic analysis of avian influenza A (H7N9) patients within a family cluster, The Journal of Infectious Diseases, 2018, 第 2 作者
(9) Fungal Immunomodulatory Protein from Nectria haematococca Suppresses Growth of Human Lung Adenocarcinoma by Inhibiting the PI3K/Akt Pathway, International Journal of Molecular Sciences, 2018, 通讯作者
(10) Reagents for Isobaric Labeling Peptides in Quantitative Proteomics, Analytic Chemistry, 2018, 第 7 作者
(11) Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence, Molecular & Cellular Proteomics, 2017, 通讯作者
(12) Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate poorly mimic human colorectal cancer, Scientific Reports, 2017, 第 2 作者
(13) The serum protein responses to treatment with Xiaoke Pill and Glibenclamide in type 2 diabetes patients, Clinical Proteomics, 2017, 第 5 作者
(14) Nuclear phosphoproteomics analysis reveals that CDK1/2 are involved in EGF-regulated constitutive pre-mRNA splicing in MDA-MB-468 cells, Journal of Proteomics, 2016, 通讯作者
(15) The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression, Oncotarget, 2016, 通讯作者
(16) The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate-induced esophageal aquamous cell carcinoma cell death, Oncotarget, 2016, 第 4 作者
(17) mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances, Journal of Proteomics, 2016, 通讯作者
(18) Discovery of potential colorectal cancer serum biomarkers through quantitative proteomics on the colonic tissue interstitial fluids from the AOM-DSS mouse model, Journal of Proteomics, 2016, 通讯作者
(19) Cytokines and chemokines in mild/asymptomatic cases infected with avian influenza A (H7N9) virus., Journal of Medical Microbiology, 2016, 第 2 作者
(20) A Comprehensive Investigation toward the Indicative Proteins of Bladder Cancer in Urine: From Surveying Cell Secretomes to Verifying Urine Proteins, Journal of Proteome Research, 2016, 通讯作者
(21) Peptide Biosynthesis with Stable Isotope Labeling from a Cell-free Expression System for Targeted Proteomics with Absolute Quantification, Molecular & Cellular Proteomics, 2016, 第 4 作者
(22) A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor Associated Macrophages, Journal of Proteome Research, 2015, 通讯作者
(23) Biomarker Discovery and Verification of Esophageal Squamous Cell Carcinoma Using Integration of SWATH/MRM, Journal of Proteome Research, 2015, 第 2 作者
(24) The other side of the coin: The tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis., Cell Cycle, 2014, 第 1 作者
(25) MFAP3L activation promotes colorectal cancer cell invasion and metastasis., BBA - Molecular Basis of Disease, 2014, 第 1 作者
(26) Chromosome-8-Coded Proteome of Chinese Chromosome Proteome Data Set (CCPD) 2.0 with Partial Immunohistochemical Verifications., Journal of Proteome Research, 2014, 通讯作者
(27) Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations., Oncoscience, 2014, 第 2 作者
(28) Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions. , Oncoscience, 2014, 第 2 作者
(29) Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. , Molecular Biology Reports, 2014, 第 4 作者
(30) Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway. , Journal of Biological Chemistry, 2014, 通讯作者
(31) Isoforms of wild type proteins often appear as low molecular weight bands on SDS-PAGE., Biotechnology Journal, 2014, 第 2 作者
(32) A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer., Cancer Letters, 2013, 第 2 作者
(33) Quantitative evaluation towards the expression status of aldo-keto reductase genes in hepatocellular carcinoma (HCC) cell lines., Genomics, Proteomics, Bioinformatics, 2013, 通讯作者
(34) Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle. , Cell Cycle, 2013, 第 2 作者
(35) Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins., PLoS One, 2013, 第 2 作者
(36) BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway. , Cancer Letters, 2012, 第 2 作者
(37) An on-target desalting and concentration sample preparation protocol for MALDI-MS and MS/MS analysis., Methods in Molecular Biology, 2012, 第 3 作者
(38) PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma., Cancer Research, 2009, 第 3 作者
(39) Cathepsin D Is Secreted from M-BE Cells: Its Potential Role as a Biomarker of Lung Cancer, Journal of Proteome Research, 2007, 第 1 作者
发表著作
( 1 ) 肺癌, Lung Cancer, 北京大学医学出版社, 2007-08, 第 5 作者
( 2 ) 心血管蛋白质组学——第七章 功能蛋白质组学研究技术, Cardiovascular Proteomics, 人民卫生出版社, 2010-11, 第 1 作者
( 3 ) 肿瘤学(第3版)——第二十一章第二节 肿瘤基因组学和蛋白质组学研究, Oncology, 人民卫生出版社, 2012-04, 第 3 作者
Methods in Molecular Biology_Combination Strategy of Quantitative Proteomics Uncovers the Related Proteins of Colorectal Cancer in the Interstitial Fluid of Colonic Tissue from the AOM-DSS Mouse Model, Springer, 2017-11, 第 3 作者
( 5 ) 蛋白质组学与精准医学——5 蛋白质组学在结直肠癌研究中的应用, Proteomics and Precision Medicine, 上海交通大学出版社, 2017-12, 第 1 作者
( 6 ) 肿瘤学(第5版), 人民卫生出版社, 2020-11, 第 其他 作者

科研活动

   
科研项目
( 1 ) 实体肿瘤的微环境蛋白质组研究, 参与, 国家任务, 2011-01--2015-08
( 2 ) 天冬氨酸组织蛋白酶D与细胞衰老的关系研究, 负责人, 国家任务, 2009-01--2011-12
( 3 ) 肿瘤蛋白质分子标志物的研究与开发, 参与, 国家任务, 2012-01--2015-12
( 4 ) 人体消化道蛋白质组表达谱, 参与, 国家任务, 2014-01--2018-08
( 5 ) 精准医学大数据的有效挖掘与关键信息技术研发, 参与, 国家任务, 2018-08--2020-12
参与会议
(1)Exosomal membrane proteomes of murine normal macrophages and tumor associated macrophages   第十届中国蛋白质组学大会   2018-11-15
(2)Quantitative Evaluation towards the Glutathione S-Transferases in Human Plasma Using Affinity coupling with LC-MS/MS   第十六届国际蛋白质组学年会   2017-09-17
(3)Discovery of potential colorectal cancer serum biomarkers through quantitative proteomics on the colonic tissue interstitial fluids from two mouse models   第十五届国际蛋白质组学年会   2016-09-13
(4)Quantitative Evaluation towards the Glutathione S-Transferases in Human Plasma Using Affinity coupling with LC-MS/MS   2016-06-05
(5)The abundance of serine proteases in colon tissue interstitial fluid and serum serves as an indicator for colorectal cancer progression   第九届中国蛋白质组学会议   谢莹莹   2016-05-22
(6)Proteomics Analysis of Exosome Released from Tumor Associated Macrophages Reveals a Cell-Dependent Protein Signature   第十四届国际蛋白质组学年会   祝颖慧   2015-09-27
(7)A quantitative proteomics towards the tissue interstitial fluid from AOM-DSS mouse model of colorectal cancer   第十三届国际蛋白质组学年会   王杨   2014-10-02
(8)MFAP3L as a nuclear kinase promotes invasion and metastasis of colorectal cancer   第八届中国蛋白质组学大会   Xiaomin Lou   2013-09-07