基本信息
赵颖  女  博导  国家纳米科学中心
email: zhaoying@nanoctr.cn
address: 北京市中关村北一条11号
postalCode:

招生信息

   
招生专业
070304-物理化学
071011-生物物理学
招生方向
生物纳米材料
生物有机功能纳米材料

教育背景

2007-10--2010-09   名古屋工业大学   博士学位
2003-09--2008-06   北京化工大学   博士学位
1999-09--2003-06   北京化工大学   学士学位

工作经历

   
工作简历
2018-03~现在, 国家纳米科学中心, 研究员
2016-03~2018-02,国家纳米科学中心, 特聘研究员
2011-02~2016-03,国家纳米科学中心, 副研究员
2007-10~2010-09,名古屋工业大学, 博士学位
2003-09~2008-06,北京化工大学, 博士学位
1999-09~2003-06,北京化工大学, 学士学位
社会兼职
2019-11-01-今,中国生物物理学会材料生物学与智能诊疗技术分会专业委员会委员,
2018-10-26-今,中国抗癌协会肿瘤精准治疗专业委员会青年委员会委员, 青年委员会委员
2018-03-26-今,中国化学会会员,
2018-03-23-今,中国药学会高级会员,
2018-03-15-今,中国生物医学工程学会高级会员,
2017-11-09-今,中国抗癌协会高级会员,
2017-10-26-今,北京科技人才研究会会员,
2017-10-20-今,中国生物物理学会会员,
2016-09-05-今,中国毒理学会会员,
2015-11-14-今,中国老年保健医学研究会会员,

教授课程

Bionanomaterials
Cancer Nanotechnology
生物无机材料化学

专利与奖励

   
奖励信息
(1) 第二届全国肿瘤精准治疗大会论文奖, 二等奖, 其他, 2018
(2) 北京市科技新星, 省级, 2017
(3) 中科院青促会会员, 院级, 2017
(4) 中科院青促会学术年会“学科交叉与创新奖”, 院级, 2017
(5) 纳米青年之星奖, 研究所(学校), 2016
(6) 全国优秀博士论文提名, , 部委级, 2011
(7) 教育部自然科学奖, 二等奖, 部委级, 2011
专利成果
( 1 ) 一种可在肿瘤细胞内引发毒性的多肽, 2020, 第 1 作者, 专利号: 201710035980.2

( 2 ) 两亲性多肽和杂合脂质体及其制备方法以及载药杂合脂质体及其制备方法, 2019, 第 1 作者, 专利号: 201410743416.2

( 3 ) 一种脂质体 聚合物载药纳米粒子及其制备方法和应用, 2019, 第 4 作者, 专利号: 201610676323.1

( 4 ) 一种双重响应性纳米颗粒及其在肿瘤抑制中的应用, 2018, 第 3 作者, 专利号: 201811157282.0

( 5 ) 酶响应性的两亲性多肽和药物载体及其制备方法, 2018, 第 1 作者, 专利号: 201310468456.6

( 6 ) 多肽和药物组合物及其制备方法, 2017, 第 1 作者, 专利号: 201310450392.7

( 7 ) 一种靶向型多肽纳米基因载体复合物, 2017, 第 1 作者, 专利号: 201710134719.8

( 8 ) 一种可在肿瘤细胞溶酶体内发生形貌转换的多肽脂质体, 2017, 第 1 作者, 专利号: 201710035869.3

( 9 ) 多肽-抗体免疫偶联物及其制备方法, 2017, 第 1 作者, 专利号: 201710005459.4

( 10 ) 特异靶向多肽自组装纳米载体、载药纳米颗粒及制备方法, 2016, 第 2 作者, 专利号: 201611161977.7

( 11 ) 一种抗肿瘤多肽纳米药物及其制备方法和应用, 2015, 第 4 作者, 专利号: 201510334405.3

( 12 ) 一种肿瘤血管阻断剂多肽、基因、表达载体及其应用, 2014, 第 4 作者, 专利号: 201410323457.6

( 13 ) 一种肽及其制备方法和用途以及药物组合物及其制备方法, 2012, 第 1 作者, 专利号: 201210361443.4

( 14 ) 一种纳米凝血酶及其制备方法, 2011, 第 5 作者, 专利号: 201110436302.X

出版信息

   
发表论文
(1) Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti-Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis, ADVANCED MATERIALS, 2023, 通讯作者
(2) Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for breast tumor multi-organ metastasis inhibition, ACTA PHARMACEUTICA SINICA B, 2023, 第11作者
(3) Nanotechnology-based combinational strategies toward the regulation of myofibroblasts and diseased microenvironment in liver fibrosis and hepatic carcinoma, NANO RESEARCH, 2023, 通讯作者
(4) The Combination of Sinusoidal Perfusion Enhancement and Apoptosis Inhibition by Riociguat Plus a Galactose-PEGylated Bilirubin Multiplexing Nanomedicine Ameliorates Liver Fibrosis Progression, NANO LETTERS, 2023, 通讯作者
(5) Stroma-targeted nanoparticles that remodel stromal alignment to enhance drug delivery and improve the antitumor efficacy of Nab-paclitaxel in pancreatic ductal adenocarcinoma models, NANO TODAY, 2022, 通讯作者
(6) Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition, ADVANCED HEALTHCARE MATERIALS, 2021, 通讯作者
(7) Trap and kill strategy for non-BRCA mutant pancreatic cancer by co-delivery of olaparib and JQ1 with plectin-1 targeting peptide nanoparticles, NANO TODAY, 2020, 通讯作者
(8) Peptide self-assembly nanoparticles loaded with panobinostat to activate latent human immunodeficiency virus, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2019, 第 8 作者
(9) Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability, NANO LETTERS, 2019, 第 6 作者
(10) Engineering Biomimetic Platesomes for pH-Responsive Drug Delivery and Enhanced Antitumor Activity, ADVANCED MATERIALS, 2019, 第 9 作者
(11) Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy, ACS NANO, 2019, 通讯作者
(12) In Situ Self-Assembled Nanofibers Precisely Target Cancer-Associated Fibroblasts for Improved Tumor Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 3 作者
(13) Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide Assembly-Based Nanosystem, ACS NANO, 2019, 通讯作者
(14) Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes, ADVANCED MATERIALS, 2019, 通讯作者
(15) Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1 alpha Inhibitor Impairs Pancreatic Tumor Growth, ACS NANO, 2019, 第 4 作者
(16) Sequentially responsive therapeutic peptide assembling nanoparticles for dual-targeted cancer immunotherapy, NANO LETTERS, 2018, 第 3 作者
(17) Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis., ACS APPLIED MATERIALS & INTERFACES, 2018, 第 10 作者
(18) Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation, ACS NANO, 2018, 通讯作者
(19) Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(20) Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression, BIOMATERIALS, 2018, 第 7 作者
(21) Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment, BIOMATERIALS, 2018, 其他(合作组作者)
(22) Nanoparticle-enabled local depletion of tumor-associated platelets enhances anti-tumor efficacy of chemotherapeutics, Nature Biomedical Engineering, 2017, 
(23) Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours., NATURE BIOMEDICAL ENGINEERING, 2017, 第 4 作者
(24) Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy, ACS NANO, 2017, 通讯作者
(25) Tumor Microenvironment Targeting and Responsive Peptide-Based Nanoformulations for Improved Tumor Therapy, MOLECULAR PHARMACOLOGY, 2017, 第 4 作者
(26) Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation, ANGEWANDTE CHEMIE INTERNATIONAL EDITION, 2016, 
(27) An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer, ACS APPLIED MATERIALS & INTERFACES, 2016, 通讯作者
(28) Improvement of stability and efficacy of c16y therapeutic peptide via molecular self-assembly into tumor-responsive nanoformulation, MOLECULAR CANCER THERAPEUTICS, 2015, 第 3 作者
(29) Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery, ADVANCED MATERIALS, 2015, 通讯作者
(30) pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth, ONCOTARGET, 2015, 第 3 作者
(31) Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging, JOURNAL OF CONTROLLED RELEASE, 2014, 
(32) Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications, ADVANCED MATERIALS, 2013, 第 2 作者
(33) Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage‐Based Optical Probe for Tumor Microenvironment Imaging, SMALL, 2013, 
(34) Co-delivery Strategies Based on Multifunctional Nanocarriers for Cancer Therapy, CURRENT DRUG METABOLISM, 2012, 第 2 作者
(35) Self-assembled Gels of Amphiphilic Sequential Peptide in Water and Organic Solvents, CHEMISTRYLETTERS, 2011, 第 2 作者
(36) Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials, SMALL, 2011, 
(37) Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles, BIOMATERIALS, 2011, 第 2 作者
(38) Self-assembling peptide nanofiber scaffolds for controlled release governed by gelator design and guest size, JOURNAL OF CONTROLLED RELEASE, 2010, 第 1 作者
(39) Nanofibrous scaffold from self-assembly of beta-sheet peptides containing phenylalanine for controlled release, JOURNAL OF CONTROLLED RELEASE, 2010, 第 1 作者
(40) Swelling Kinetics of Poly(aspartic acid)/Poly(acrylic acid) Semi-Interpenetrating Polymer Network Hydrogels in Urea Solutions, JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2010, 第 1 作者
(41) Gelation Behavior of β-Sheet Peptide RADA16 Coexisting with Synthetic Polymers, Transactions of the Materials Research Society of Japan, 2010, 第 1 作者
(42) Controlled release and interaction of protein using self-assembling peptide RATEA16 nanofiber hydrogels, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 第 1 作者
(43) Optimization of the preparation of a poly(aspartic acid) superabsorbent resin with response surface methodology, JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 第 1 作者
(44) 聚天门冬氨酸高吸水性树脂吸水率测定方法的研究, Measurement of water absorption capacity of polyaspartic acid resin and its properties, 北京化工大学学报:自然科学版, 2005, 第 1 作者

科研活动

   
科研项目
( 1 ) 以成纤维细胞激活蛋白α为肿瘤治疗靶点的环境响应型多肽纳米载体抗肿瘤疗效的研究, 负责人, 国家任务, 2012-01--2015-12
( 2 ) 基于调控肿瘤微环境的两亲性多肽自组装纳米药物载体的抗肿瘤机制研究, 负责人, 国家任务, 2013-01--2015-12
( 3 ) pH响应性多肽自组装纳米结构的组装规律及抗肿瘤作用机制研究, 负责人, 国家任务, 2014-01--2017-12
( 4 ) 基于肿瘤微环境调控的抗肿瘤纳米材料设计和机制研究, 参与, 国家任务, 2012-01--2016-08
( 5 ) 生物医用纳米材料的代谢过程及其分析方法研究, 参与, 国家任务, 2013-01--2017-08
( 6 ) 抗BRCA突变型胰腺癌的多肽纳米载体的设计和功能研究, 参与, 地方任务, 2016-01--2018-12
( 7 ) 调控肿瘤相关成纤维细胞的多肽自组装纳米载体的设计及抗肿瘤机制研究, 负责人, 国家任务, 2017-01--2020-12
( 8 ) 调控肿瘤微环境细胞外基质的新型纳米药物的设计及抗肿瘤机制研究, 负责人, 地方任务, 2017-01--2019-12
( 9 ) 北京市科技新星, 负责人, 地方任务, 2017-01--2019-12
( 10 ) 中国科学院青年创新促进会人才项目, 负责人, 中国科学院计划, 2017-01--2020-12
( 11 ) 基于先进集成技术的纳米生物效应与纳米药物研究, 参与, 中国科学院计划, 2016-08--2020-12
( 12 ) 高性能材料的结构设计、制备与应用探索, 参与, 中国科学院计划, 2014-01--2015-12
( 13 ) 生物材料(抗肿瘤纳米药物), 负责人, 国家任务, 2018-01--2020-12
( 14 ) 自组装生物纳米材料调控肿瘤基质微环境及肿瘤治疗研究, 负责人, 国家任务, 2018-05--2023-04
( 15 ) 靶向Tie2的多肽纳米药物设计及变构增效肿瘤治疗研究, 负责人, 国家任务, 2019-01--2022-12
( 16 ) 新型多功能核壳杂化纳米材料的生物安全性评价及其在肿瘤治疗上的应用, 负责人, 国家任务, 2019-01--2021-12
( 17 ) 中国科学院王宽诚率先人才计划“卢嘉锡国际团队”,微环境调控型抗肿瘤纳米药物, 参与, 中国科学院计划, 2019-01--2021-12
( 18 ) 调控肿瘤微环境的新型纳米药物增敏肝癌消 融治疗的研究, 负责人, 地方任务, 2019-11--2021-10
( 19 ) 调控肝窦内皮细胞窗孔结构提高多肽纳米药物的靶向递送及增效肝纤维化治疗的研究, 负责人, 国家任务, 2022-01--2025-12
( 20 ) 中科院青促会优秀会员项目, 负责人, 中国科学院计划, 2022-01--2024-12
参与会议
(1)多肽纳米药物调控肿瘤基质微环境   天津工业大学多学科交叉学术交流会   2020-11-27
(2)纳米药物调控肿瘤微环境   第三届全国肿瘤精准治疗大会   2019-12-14
(3)Using Peptide-based Nanoformulations to Target and Regulate Cancer-associated Fibroblasts for Improved Tumor Therapy   2019-08-15
(4)变构增效纳米药物瘤内渗透研究   2019年生物医用高分子材料学术大会   2019-04-19
(5)变构增效纳米药物瘤内渗透研究   第二届全国肿瘤精准治疗大会   2018-10-26
(6)纳米药物调控肿瘤相关成纤维细胞增效肿瘤治疗研究   第三届青年纳米论坛   2018-10-11
(7)多肽组装变构在肿瘤 微环境中的生物效应   中国化学会第31届学术年会   2018-05-05
(8)多肽纳米药物靶向及调控 肿瘤相关成纤维细胞   中科院青促会2017年学术年会   2017-11-05
(9)变构增效纳米药物瘤内递送研究   第十五次中国暨国际生物物理大会   2017-11-03
(10)纳米药物调控肿瘤微环境   2017(第二届)癌症、炎症与免疫研讨会   2017-09-22
(11)Using Peptide-based Nanoformulations to Target and Regulate Cancer-associated fibroblasts for Improved Tumor Therapy   2017-02-27
(12)Self-assembled Peptide Nanoparticles as Tumor Microenvironment Activatable Probes for Tumor Targeting and Imaging   2014-08-24
(13)A Specific Bio-Imaging Nanoprobe Responding to the Tumor Microenvironment via Fibroblast Activation Protein-alpha   2013-06-22
(14)Self-assembled Peptide Nanoparticles as Tumor Microenvironment Activatable Probes for Tumor Targeting and Imaging   2012-09-04
(15)Construction of nanoarchitecture for scaffold by self-assembly of -sheet peptides containing phenylalanine   2010-01-26
(16)Preparation and Characterization of Self-Assembled pH-Responsive Hydrogels Composed of the RATEA16 Peptide   2009-10-20
(17)In Vitro Controlled Release for Drug Delivery: Interactions of D- or L-Amino Acids with Nanofibers in Self-Assembling Peptide RATEA16 Hydrogels   2008-12-09
(18)Controlled release from self-assembling pH-responsive hydrogels based on peptide RATEA16   2007-10-22
(19)pH-Responsive Nanofiber Hydrogels Composed of Peptide RATEA16 through Self-Assembly   2007-10-20