基本信息
陈玲玲 女 博导 中国科学院分子细胞科学卓越创新中心
电子邮件: linglingchen@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码: 200031
电子邮件: linglingchen@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码: 200031
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
RNA代谢与功能
教育背景
2007-09--2009-05 University of Connecticut 工商管理硕士(MBA)2004-09--2009-02 University of Connecticut 博士2000-09--2003-06 中科院上海药物研究所 硕士1996-09--2000-06 兰州大学 学士
工作经历
工作简历
2023-11~现在, 核糖核酸功能与应用重点实验室, 主任2017-05~2023-10,分子生物学国家重点实验室, 副主任2011-01~现在, 中国科学院分子细胞科学卓越创新中心(原生物化学与细胞生物学研究所), 二级研究员2010-05~2011-01,University of Connecticut Health Center, Assistant Professor2009-04~2010-04,University of Connecticut Health Center, 博士后2007-09~2009-05,University of Connecticut, 工商管理硕士(MBA)2004-09~2009-02,University of Connecticut, 博士2003-07~2004-06,中科院上海药物所国家新药筛选中心, 研究助理2000-09~2003-06,中科院上海药物研究所, 硕士1996-09~2000-06,兰州大学, 学士
社会兼职
2023-10-01-2027-10-01,中国生物化学与分子生物学会第十三届理事会, 常务理事
2023-08-15-2026-08-15,上海引源科技青年发展研究院35U35, 理事长
2022-12-31-2027-12-31,中国科学:生命科学, 编委
2021-10-31-2025-08-30,Acta Biochimica et Biophysica Sinica, 编委
2021-08-01-2025-08-01,中国生物物理学会第十二届理事会, 常务理事
2021-01-01-今,Cell Research, 编委
2021-01-01-今,Fundamental Research, 编委
2021-01-01-今,RNA, Associate Editor
2020-06-01-2024-05-31,生命的化学, 编委
2020-01-01-今,Science, Board of Reviewing Editor
2020-01-01-今,Cell, 编委
2020-01-01-今,Cell Chemical Biology, 编委
2020-01-01-今,Trends in Cell Biology, 编委
2020-01-01-今,Faculty Opinions (The Control of Gene Expression Section), 编委
2020-01-01-今,Trends in Biochemical Sciences, 编委
2020-01-01-今,Molecular Cell, 编委
2019-11-29-2027-12-31,中国生物化学与分子生物学会基因专业分会, 主任
2018-01-01-2022-12-31,RNA Biology, 编委
2018-01-01-2022-12-31,Transcription, 编委
2017-12-31-2020-12-31,RNA, 编委
2017-12-30-2024-05-31,Mobile DNA, 编委
2017-06-30-2022-06-29,Journal of Biological Chemistry, 编委
2017-05-30-今,HGNC基因命名委员会, 专家委员
2016-07-31-2022-07-31,Chinese Biological Investigators Society, 理事
2015-08-31-今,外籍评委, European Research Council Advanced Grant
2015-04-30-今,Trends in Genetics, 编委
2014-12-31-今,上海科技大学, 特聘教授
2014-05-31-今,Genome Biology, 编委
2023-08-15-2026-08-15,上海引源科技青年发展研究院35U35, 理事长
2022-12-31-2027-12-31,中国科学:生命科学, 编委
2021-10-31-2025-08-30,Acta Biochimica et Biophysica Sinica, 编委
2021-08-01-2025-08-01,中国生物物理学会第十二届理事会, 常务理事
2021-01-01-今,Cell Research, 编委
2021-01-01-今,Fundamental Research, 编委
2021-01-01-今,RNA, Associate Editor
2020-06-01-2024-05-31,生命的化学, 编委
2020-01-01-今,Science, Board of Reviewing Editor
2020-01-01-今,Cell, 编委
2020-01-01-今,Cell Chemical Biology, 编委
2020-01-01-今,Trends in Cell Biology, 编委
2020-01-01-今,Faculty Opinions (The Control of Gene Expression Section), 编委
2020-01-01-今,Trends in Biochemical Sciences, 编委
2020-01-01-今,Molecular Cell, 编委
2019-11-29-2027-12-31,中国生物化学与分子生物学会基因专业分会, 主任
2018-01-01-2022-12-31,RNA Biology, 编委
2018-01-01-2022-12-31,Transcription, 编委
2017-12-31-2020-12-31,RNA, 编委
2017-12-30-2024-05-31,Mobile DNA, 编委
2017-06-30-2022-06-29,Journal of Biological Chemistry, 编委
2017-05-30-今,HGNC基因命名委员会, 专家委员
2016-07-31-2022-07-31,Chinese Biological Investigators Society, 理事
2015-08-31-今,外籍评委, European Research Council Advanced Grant
2015-04-30-今,Trends in Genetics, 编委
2014-12-31-今,上海科技大学, 特聘教授
2014-05-31-今,Genome Biology, 编委
教授课程
分子生物学Bio 2000 分子生物学bio2000 分子生物学
专利与奖励
奖励信息
(1) 亚洲及大洋洲生物化学家与分子生物学家联盟FAOBMB卓越研究奖, , 其他, 2024(2) 首届上海杰出人才, 省级, 2023(3) 全国创新争先奖, 部委级, 2023(4) 首届新基石研究员, , 其他, 2022(5) 上海市自然科学奖一等奖, 一等奖, 省级, 2022(6) 中国科学院优秀导师奖, 部委级, 2022(7) 2021年度全国三八红旗手, 国家级, 2022(8) 中国科学院优秀导师奖, , 部委级, 2021(9) 2019-2020年度上海市三八红旗手标兵提名奖, 省级, 2021(10) 国际RNA Society“2021 Mid-Career Research Award”, 其他, 2021(11) 第十六届中国青年科技奖(特别奖), 特等奖, 部委级, 2020(12) 2020年科学探索奖, , 其他, 2020(13) 中国科学院优秀导师奖, 部委级, 2019(14) 上海市三八红旗手, 省级, 2019(15) 中组部国家“万人计划”科技创新领军人才, 国家级, 2018(16) 中国科学院青年科学家奖, 部委级, 2018(17) 谈家桢生命科学创新奖, 其他, 2017(18) 中科院优秀导师奖, 部委级, 2017(19) 普洛麦格创新奖, , 其他, 2017(20) 霍华德•休斯国际研究员 (HHMI International Research Scholar), , 其他, 2017(21) 上海市科技系统三八红旗手, , 省级, 2017(22) 科技部创新人才推进计划中青年科技创新领军人才, , 部委级, 2017(23) 第十三届中国青年女科学家奖, , 国家级, 2017(24) 华人生物学家协会杰出青年研究员奖 (CBIS Young Instigator Award), , 其他, 2016(25) A-IMBN Research Young Investigator/Ken-ichi Arai Award, , 其他, 2016(26) 中国细胞生物学学会干细胞青年研究员奖, 其他, 2016(27) 第八届上海青年科技英才奖, , 省级, 2016(28) 第十五届李汝祺动物遗传奖, , 其他, 2015(29) 基金委国家优秀青年, 国家级, 2013(30) 中科院上海生科院特别人才, 院级, 2012(31) 中组部万人计划青年拔尖人才, 国家级, 2012(32) 干细胞研究重点项目(Connecticut Stem Cell Seed Award), , 省级, 2009(33) Gordon 国际学术会议最佳墙报表述奖(Best Poster Presentation), , 国家级, 2009(34) 最佳口头报告奖(Best Oral Presentation), , 国家级, 2009(35) 莙政奖金, , 国家级, 1999
专利成果
( 1 ) 环形RNA在系统性红斑狼疮制备治疗药物中的应用, 2021, 第 1 作者, 专利号: CN113710816A( 2 ) 环形RNA纯化方法, 2021, 第 1 作者, 专利号: CN202111136958.X( 3 ) 改进的环形RNA制备方法, 2021, 第 1 作者, 专利号: CN202111138732.3( 4 ) 改进的环形RNA及其制备方法, 2021, 第 1 作者, 专利号: CN202111131281.0( 5 ) 降低环形RNA水平的方法, 2021, 第 1 作者, 专利号: CN202110532816.9( 6 ) 降低环形RNA免疫原性的方法, 2021, 第 1 作者, 专利号: CN202110389509.X( 7 ) 具有分子伴侣功能的 RNA 及其应用, 2021, 第 1 作者, 专利号: CN202110379536.9( 8 ) 一种分离的Cas13蛋白, 2020, 第 1 作者, 专利号: CN202011193112.5( 9 ) 小胖威利综合征的检测试剂盒及其使用方法, 2020, 第 1 作者, 专利号: CN111041084A( 10 ) 小胖威利综合征的检测试剂盒及其使用方法, 2020, 第 1 作者, 专利号: CN111041083A( 11 ) 小胖威利综合征长非编码RNA标记物及检测试剂, 2020, 第 1 作者, 专利号: CN111041085A( 12 ) 一种分离的Cas13蛋白, 2020, 第 1 作者, 专利号: CN202010136188.8( 13 ) 环形RNAcircPOLR2A在系统性红斑狼疮检测标志物及制备治疗药物中的应用, 2020, 第 1 作者, 专利号: CN110643694A( 14 ) 系统性红斑狼疮环形RNA标记物及检测试剂, 2020, 第 1 作者, 专利号: CN110643695A( 15 ) 用于活细胞RNA标记的融合蛋白及应用, 2019, 第 1 作者, 专利号: CN201911127456.3( 16 ) 一种新型RNA环化表达载体的构建及其应用, 2016, 第 2 作者, 专利号: CN105985978A( 17 ) RNA核滞留载体的构建及应用, 2015, 第 1 作者, 专利号: CN105018508A( 18 ) 一种利用基因组编辑技术实现原位激活基因的表达方法及其应用, 2015, 第 1 作者, 专利号: CN104845994A( 19 ) 一种内含子来源环形RNA分子及其成环关键核酸序列的应用, 2015, 第 1 作者, 专利号: CN104419704A( 20 ) 人源甲硫氨酰氨肽酶1的表达方法及它在寻找抗肿瘤药物中应用, 2005, 第 6 作者, 专利号: CN1609221A
出版信息
发表论文
(1) Unveiling the mystery of nuclear RNA homeostasis, Cell Stem Cell, 2024, (2) Altered nucleocytoplasmic export of adenosine (A)-rich circRNAs by PABPC1 contributes to neuronal function, Molecular Cell, 2024, (3) A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development, Science China Life Sciences, 2024, (4) Therapeutic application of circular RNA aptamers in a mouse model of psoriasis, Nature Biotechnology, 2024, (5) CRISPR array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Nature Methods, 2024, (6) Emerging roles of nuclear bodies in genome spatial organization, Trends in Cell Biology, 2023, (7) A guide to naming eukaryotic circular RNAs, NATURE CELL BIOLOGY, 2023, 第 11 作者(8) Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome-surveillance., Nature, 2023, 第 11 作者(9) Long non-coding RNAs: definitions, functions, challenges and recommendations, NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2023, 第 6 作者(10) CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos, GENOME BIOLOGY, 2023, 第 11 作者(11) Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis., RNA Biology, 2023, (12) Multi-color RNA imaging with CRISPR-Cas13b systems in living cells, CELL INSIGHT, 2022, 第 11 作者(13) Circular RNAs: characterization, cellular roles, and applications, Cell, 2022, 第 11 作者(14) Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function, NATURE METHODS, 2022, 第 11 作者(15) RNA circles with minimized immunogenicity as potent PKR inhibitors, MOLECULAR CELL, 2022, 第 11 作者(16) Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system, NATURE PROTOCOLS, 2022, 第 11 作者(17) Biogenesis and regulatory roles of circular RNAs, Annu Rev Cell Dev Biol, 2022, 第 11 作者(18) 7S RNA is surveilling mitochondrial DNA transcription, Life Metab, 2022, 第 11 作者(19) Understanding lncRNA���protein assemblies with imaging and single-molecule approaches, CURRENT OPINION IN GENETICS & DEVELOPMENT, 2022, 第 11 作者(20) LETN and NPM1 tango in human nucleoli, LETN and NPM1 tango in human nucleoli, CELL RESEARCH, 2021, 第 11 作者(21) Long noncoding RNA and protein abundance in lncRNPs, RNA, 2021, 第 11 作者(22) lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription, SCIENCE, 2021, 第 11 作者(23) RNA structure probing uncovers RNA structure-dependent biological functions, NATURE CHEMICAL BIOLOGY, 2021, 第 11 作者(24) Screening for functional circular RNAs using the CRISPR-Cas13 system, NATURE METHODS, 2021, 第 11 作者(25) Expanded regulation of circular RNA translation, MOLECULAR CELL, 2021, 第 11 作者(26) An optimized fixation method containing glyoxal and paraformaldehyde for imaging nuclear bodies, RNA, 2021, 第 11 作者(27) Linking circular intronic RNA degradation and function in transcription by RNase H1, Linking circular intronic RNA degradation and function in transcription by RNase H1, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 11 作者(28) Gene regulation by long noncoding RNAs and its biological functions, Nat Rev Mol Cell Biol, 2021, 第 11 作者(29) CRISPR-Cas13系统可视化活细胞内RNA的动态变化, Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems, 科学新闻, 2020, 第 15 作者(30) Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells, CELL, 2020, 第 11 作者(31) 长非编码RNAs物种特异性的加工定位决定其在干细胞中的差异功能, Altered processing of lncRNAs in stem cells contributes to non-conserved functions, 生命的化学, 2020, 第 4 作者(32) Protocol for Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 System, STAR PROTOCOLS, 2020, 第 3 作者(33) 线粒体定位circRNA调控肝脏免疫代谢性炎症机制, 生命的化学, 2020, 第 3 作者(34) 环形RNA结构与降解调控PKR激活和天然免疫反应, Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity, 科学新闻, 2020, 第 24 作者(35) Mechanisms of Long Noncoding RNA Nuclear Retention, TRENDS IN BIOCHEMICAL SCIENCES, 2020, 第 11 作者(36) The expanding regulatory mechanisms and cellular functions of circular RNAs, NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020, 第 11 作者(37) Organization and function of paraspeckles, SPOTLIGHT ON CHINA: RNA, 2020, 第 11 作者(38) Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells, Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells, 中国科学院院刊:英文版, 2020, 第 1 作者(39) Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems, MOLECULAR CELL, 2019, 第 11 作者(40) Linking RNA processing and function, Cold Spring Harb Symp Quant Biol, 2019, 第 3 作者(41) 非编码RNA研究进展, Progress in non-coding RNA research, 中国科学:生命科学, 2019, 第 1 作者(42) Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity, CELL, 2019, 第 11 作者(43) Cellular functions of long noncoding RNAs, NATURE CELL BIOLOGY, 2019, 第 11 作者(44) Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus, MOLECULAR CELL, 2019, 第 11 作者(45) Processing and roles of snoRNA-ended long noncoding RNAs, CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018, 第 11 作者(46) The Biogenesis, Functions, and Challenges of Circular RNAs, MOLECULAR CELL, 2018, 第 11 作者(47) Genome-wide screening of neat1 regulators reveals cross-regulation between paraspeckles and mitochondria, NATURE CELL BIOLOGY, 2018, 第 11 作者(48) N6-Methyladenosines Modulate A-to-I RNA Editing, MOLECULAR CELL, 2018, 第 11 作者(49) ALUternative Regulation for Gene Expression, TRENDS IN CELL BIOLOGY, 2017, 第 11 作者(50) 小核仁RNA相关的长链非编码RNA家族的发现与功能研究, Long Noncoding RNAs Stabilized by Small Nucleolar RNA-Protein (snoRNP) Ends, 中国细胞生物学学报, 2017, 第 2 作者(51) Extensive translation of circular RNAs driven by N~6-methyladenosine, CELL RESEARCH, 2017, 第 9 作者(52) Enhancing the RNA engineering toolkit, SCIENCE, 2017, 第 2 作者(53) The Diversity of Long Noncoding RNAs and Their Generation, TRENDS IN GENETICS, 2017, 第 11 作者(54) The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting, MOLECULAR CELL, 2017, 第 6 作者(55) Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection, MOLECULAR CELL, 2017, 第 11 作者(56) RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression, CELL DISCOVERY, 2017, 第 6 作者(57) SLERT Regulates DDX21 Rings Associated with Pol I Transcription, CELL, 2017, 第 11 作者(58) Increased complexity of circRNA expression during species evolution, RNA BIOLOGY, 2017, 第 11 作者(59) Characterization of circular RNAs in human, mouse and rat hearts, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, (60) The Biogenesis of Nascent Circular RNAs, CELLREPORTS, 2016, 第 11 作者(61) CircRNA-derived pseudogenes, CELL RESEARCH, 2016, 第 5 作者(62) Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins, MOLECULAR CELL, 2016, 第 11 作者(63) Linking Long Noncoding RNA Localization and Function, TRENDS IN BIOCHEMICAL SCIENCES, 2016, 第 11 作者(64) A two-fold challenge: the experience of women of color in genomics, GENOME BIOLOGY, 2016, 第 11 作者(65) Research Progress of Long Noncoding RNA in China, IUBMB LIFE, 2016, 第 11 作者(66) The biogenesis and emerging roles of circular RNAs, NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 第 11 作者(67) Ling-Ling Chen: Linking Long Noncoding RNA Processing and Function to RNA Biology, TRENDS IN BIOCHEMICAL SCIENCES, 2016, 第 11 作者(68) Diverse alternative back-splicing and alternative splicing landscape of circular RNAs, GENOME RESEARCH, 2016, 第 11 作者(69) ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner, CELL RESEARCH, 2015, 第 12 作者(70) Fractionation of non-polyadenylated and ribosomal-free RNAs from mammalian cells, Methods Mol Biol, 2015, 第 1 作者(71) The long noncoding RNA regulation at the MYC locus, CURRENT OPINION IN GENETICS & DEVELOPMENT, 2015, 第 11 作者(72) Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IR Alu s, GENES & DEVELOPMENT, 2015, 第 12 作者(73) SnoVectors for nucelar expression of RNA, Nucleic Acids Res, 2015, 第 11 作者(74) Regulation of circRNA biogenesis, RNA BIOLOGY, 2015, 第 11 作者(75) Gear Up in Circles, MOLECULAR CELL, 2015, 第 11 作者(76) Gene expression profiling of non-polyadenylated RNA-seq across species, GENOMICS DATA, 2014, 第 3 作者(77) Species-specific alternative splicing leads to unique expression of sno-lncRNAs, BMC GENOMICS, 2014, 第 11 作者(78) Scientific migration of junior scientists to China, GENOME BIOLOGY, 2014, 第 11 作者(79) Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus, CELL RESEARCH, 2014, 第 11 作者(80) Competition of RNA splicing: line in or circle up, SCIENCE CHINA-LIFE SCIENCES, 2014, 第 2 作者(81) Life without A tail: New formats of long noncoding RNAs, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2014, 第 11 作者(82) Functional analysis of long noncoding RNAs in development and diseases, Adv Exp Med Biol, 2014, 第 11 作者(83) Complementary Sequence-Mediated Exon Circularization, CELL, 2014, 第 11 作者(84) Microexons Go Big, CELL, 2014, 第 2 作者(85) Circular Intronic Long Noncoding RNAs, MOLECULAR CELL, 2013, 第 9 作者(86) Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences, BMC GENOMICS, 2013, 第 11 作者(87) Nuclear Editing of mRNA 3 '-UTRs, ADENOSINEDEAMINASESACTINGONRNAADARSANDATOIEDITING, 2012, 第 11 作者(88) Long Noncoding RNAs with snoRNA Ends, MOLECULAR CELL, 2012, 第 7 作者(89) Genome-Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells, STEM CELLS, 2011, 第 2 作者(90) Genomewide characterization of non-polyadenylated RNAs, GENOME BIOLOGY, 2011, 第 11 作者(91) Decoding the function of nuclear long non-coding RNAs, CURRENT OPINION IN CELL BIOLOGY, 2010, 第 11 作者(92) Long noncoding RNAs in mammalian cells: what, where, and why?, WILEY INTERDISCIPLINARY REVIEWS-RNA, 2010, 第 11 作者(93) Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells, CELL CYCLE, 2010, 第 11 作者(94) Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA, MOLECULAR CELL, 2009, 第 1 作者(95) Gene regulation by SINES and inosines Biological consequences of A-to-I editing of Alu element inverted repeats, CELL CYCLE, 2008, 第 1 作者(96) On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin, RNA, 2008, 第 3 作者(97) Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, (98) Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, (99) Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, (100) Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, (101) Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes, BIOORGANIC & MEDICINAL CHEMISTRY, 2004, (102) Characterization of full length and truncated type I hMetAP expressed from E. coli, Biochemistry, 2004, 第 1 作者(103) Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity, JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, (104) Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening, ACTA PHARMACOLOGICA SINICA, 2004, (105) Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae, JOURNAL OF MEDICINAL CHEMISTRY, 2003, (106) Specificity for inhibitors of metal-substituted methionine aminopeptidase, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, (107) Studies on the apoptosis of retinal neurons following optic nerve injure in Zebrafish (Brachydanio rerio), J Lanzhou University, 2001, 第 1 作者(108) 视神经损伤引起斑马鱼视网膜神经细胞凋亡的研究, 兰州大学学报:自然科学版, 2001, 第 1 作者(109) Alu element-mediated gene silencing, THE EMBO JOURNAL, 第 1 作者(110) Shedding light on paraspeckle structure by super-resolution microscopy, THE JOURNAL OF CELL BIOLOGY, 第 3 作者
科研活动
科研项目
( 1 ) 环形RNA动态折叠的模拟及功能验证, 负责人, 地方任务, 2023-12--2026-11( 2 ) 核糖核酸高效使能的基础与应用研究, 负责人, 中国科学院计划, 2023-10--2028-09( 3 ) 新基石科学基金会新基石研究员项目, 负责人, 其他国际合作项目, 2023-01--2027-12( 4 ) 环形RNA生成代谢的调控与功能, 负责人, 国家任务, 2021-12--2026-11( 5 ) 细胞核亚结构域长非编码RNA图谱(LAND)解码及功能研究, 负责人, 中国科学院计划, 2021-06--2026-05( 6 ) 细胞核亚结构域长非编码RNA(LAND)图谱绘制及功能研究, 负责人, 地方任务, 2020-10--2023-09( 7 ) 非编码RNA代谢与功能, 负责人, 国家任务, 2020-01--2022-12( 8 ) 人类细胞中长RNA分子转录后命运决定机制, 负责人, 国家任务, 2019-01--2021-12( 9 ) 小核仁RNA加工来源的两类新型长非编码RNAs的代谢和功能研究, 负责人, 国家任务, 2019-01--2023-12( 10 ) 长非编码RNA的代谢与功能, 负责人, 国家任务, 2018-01--2022-12( 11 ) 霍华德•休斯医学研究所国际科学家支持计划 (HHMI International Research Scholar Program), 负责人, 其他国际合作项目, 2017-09--2022-08( 12 ) 非编码RNA调控细胞增殖与分化的转换与维持, 负责人, 中国科学院计划, 2016-07--2020-12( 13 ) 非编码RNA 介导的染色质高级结构动态变化对细胞命运决定的调控作用及分子机制, 参与, 国家任务, 2016-07--2020-12( 14 ) 两类环形RNA的生成加工机制研究及其功能探索, 负责人, 国家任务, 2015-01--2018-12( 15 ) 长非编码RNA 的机制与功能研究, 负责人, 国家任务, 2014-01--2016-12( 16 ) 单倍体干细胞表观遗传特性维持的研究, 负责人, 国家任务, 2014-01--2018-08( 17 ) 青年拔尖人才支持计划, 负责人, 国家任务, 2013-01--2015-12( 18 ) 一类内含子来源的长非编码 RNA 的加工成熟机制及功能研究, 负责人, 国家任务, 2013-01--2016-12( 19 ) 中国科学院上海生命科学研究院S类人才计划项目, 负责人, 其他国际合作项目, 2012-07--2015-12( 20 ) 新型内含子来源的长非编码RNA加工成熟机制及功能研究, 负责人, 研究所自主部署, 2012-06--2014-05( 21 ) 非编码RNA在干细胞命运调控中的功能及分子机制, 参与, 国家任务, 2011-01--2015-08( 22 ) 细胞谱系的建立与发育调控, 参与, 中国科学院计划, 2011-01--2015-12
参与会议
(1)Developing effective circular RNA aptamers against PKR-mediated inflammation 2024-02-09(2)Biogenesis, Function and Potential Application of Circular RNAs 2024-01-10(3)Biogenesis, function and potential application of circular RNAs 2023-10-12(4)Biogenesis, Function and Potential Application of Circular RNAs 2023-08-23(5)Linking circular RNA biogenesis and function 2022-10-11(6)Circular RNAs as potent inhibitors of PKR 2022-05-18(7)Circular RNA in innate immunity and its potential application 2022-05-16(8)Unconventional RNA Form & Function and beyond 2018-05-22(9)Unconventional RNA form and function - regulation by Alu elements 2018-02-26(10)The diversity of long noncoding RNAs, their generation and function 2018-02-18(11)AlUternative regulation for gene expression 2018-02-12(12)The diversity of long noncoding RNAs and their generation 谈家桢生命科学奖十周年庆典暨第十届颁奖大会,北京 2017-11-18(13)The long noncoding RNA regulation in the nucleolus 2017-11-04(14)Genome-wide screening of NEAT1 regulators reveals mito-paraspeckle communications 2017-10-21(15)Biogenesis and functional implications of Circular RNAs 2017-09-26(16)Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection 第十二次全国基因功能与表观遗传调控学术研讨会,北京 2017-08-15(17)The Diversity And Function of Long Noncoding RNAs 2017-06-14(18)CircRNAs 2017-06-01(19)SLERT regulates DDX21-rings associated with Pol I transcription RNA加工学术研讨会,镇江 2017-04-23(20)The diversity of sno-processed lncRNAs and their roles in gene regulation 2017-02-08(21)The diversity of long noncoding RNAs - their generation and function 2017-02-01(22)The processing and functional implication of sno-processed long noncoding RNAs 2016年上海科技大学细胞生物学前沿学术研讨会,上海 2016-12-16(23)Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins 2016-11-17(24)Characterization of new long noncoding RNA species 2016年上海科技大学免疫化学国际生物论坛,上海(3rd ShanghaiTech-SIAIS BioForum) 2016-11-08(25)Sno-processed long noncoding RNAs 2016-11-07(26)Discovery, biogenesis and functional implication of new long noncoding RNA species 2016-10-31(27)Characterization of long noncoding RNAs in the Prader-Willi Syndrome deletion region 中国生物化学与分子生物学会2016年全国学术年会,杭州 2016-10-21(28)Unusual processing generates sno-processed long noncoding RNAs 第九届全国核糖核酸 (RNA) 学术讨论会,上海 2016-09-27(29)Circular RNAs 2016-09-12(30)Unusual processing generates long noncoding RNAs with new formats 2016-08-01(31)Unusual processing generates long noncoding RNAs with new formats 2016-08-01(32)SPA lncRNAs 2016-06-27(33)Biogenesis and functional studies of lncRNAs with new formats 浙江大学医学院,杭州 2016-04-15(34)Biogenesis of long noncoding RNAs with new formats 2016-03-24(35)Characterization of long noncoding RNAs in the Prader-Willi Syndrome deletion region 2016-03-21(36)The biogenesis of circular RNAs 2016-02-14(37)Biogenesis of different types of new long noncoding RNA species 中国科学技术大学生命科学学院,合肥, 中国 2015-12-16(38)Characterization of new long noncoding RNA species: discovery, biogenesis and functional implication 2015-10-27(39)Biogenesis and functional implication of new long noncoding RNA species 2015-10-25(40)CircRNA biogenesis 2015-10-18(41)CARM1 regulates mRNA nuclear retention in paraspeckles 第十一次全国基因功能与表观遗传调控学术研讨会, 上海, 中国 2015-10-13(42)long noncoding RNA species with new formats: discovery, biogenesis and functional implication 2015-09-13(43)Characterization of new long noncoding RNA species from the Prader-Willi Syndrome deletion region 2015-05-31(44)New long noncoding RNA species in gene regulation 2014-10-11(45)Complementary-sequences mediated exon circularization 2014-09-10(46)Identification and characterization of new long noncoding RNA species 2014-07-07(47)Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus 2014-06-03(48)Characterization of new long noncoding RNA species 2014-06-02(49)Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus 2014-05-05(50)characterization of new long noncoding RNA species 2014-05-01(51)Characterization and functional implications of new long noncoding RNA species 2014-05-01(52)Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus 2014年春RNA研究战略研讨学术研讨会,合肥,中国 2014-04-11(53)Life without A tail: new long noncoding RNAs from excised introns 2013-12-21(54)New formats of long noncoding RNAs from excised introns: mechanisms and functional implications 2013-11-18(55)Gene expression regulation by intronic long noncoding RNAs 2013-11-06(56)Functional noncoding RNAs from excised introns 2013-10-20(57)Functional intronic long noncoding RNAs 2013-10-09(58)Life without (A) tail: new long noncoding RNAs from excised introns 2013-08-28(59)Circular intronic long noncoding RNAs 2013-08-20(60)Circular intronic long noncoding RNAs 第1次非编码RNA研究战略研讨会,北京 2013-04-12(61)Prader-Willi Syndrome associated new long noncoding RNAs in splicing regulation in human embryonic stem cells 2012-12-03(62)A new class of intron-derived long noncoding RNAs with snoRNA ends 2012-10-08(63)New long noncoding RNAs in human embryonic stem cells “非编码RNA在重大生物学过程中功能和机制” 香山科学会议 2012-06-05(64)Long noncoding RNAs with snoRNA ends 2012-04-23(65)Intron-derived long noncoding RNAs in human embryonic stem cells 2011-12-07(66)Altered Nuclear Retention Of MRNAS Containing Inverted Repeats In Human Embryonic Stem Cells: Functional Role Of A Nuclear Noncoding RNA Ling-Ling Chen 2009-10-30