基本信息
马慧敏  女  硕导  中国科学院广州地球化学研究所
email: mahuimin@gig.ac.cn
address: 广州市天河区科华街511号有机楼 409
postalCode: 510640

招生信息

   
招生专业
083001-环境科学
招生方向
环境表观遗传学
环境与人体健康

教育背景

2018-12--2019-12   Lancaster University   访问学者
2007-09--2008-09   德国JACOB大学   联合培养博士生
1999-09--2003-06   安徽医科大学   学士学位

工作经历

   
工作简历
2018-12~2019-12,Lancaster University, 访问学者
2007-09~2008-09,德国JACOB大学, 联合培养博士生
2003-05~2009-01,中国科学院广州地球化学研究所, 博士学位
1999-09~2003-06,安徽医科大学, 学士学位
社会兼职
2022-05-01-2024-05-22,中国毒理学会理事, 中国毒理学会 生化与分子毒理专业委员会委员
2019-07-30-2027-12-30,广东省环境诱变剂学会, 副监事长

专利与奖励

   
专利成果
( 1 ) 一组用于检测血铅诱导儿童智力降低的生物标志物及其应用, 2022, 第 1 作者, 专利号: 202211231474.8

出版信息

   
发表论文
(1) Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and in vitro studies, SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 第 2 作者  通讯作者
(2) 某工业区诱导儿童神经损伤的关键重金属及暴露途径, 地球化学, 2024, 第 1 作者  通讯作者
(3) Pollution source and chemicals structure of the water-soluble fractions in PM2.5 that induce apoptosis in China, ENVIRONMENT INTERNATIONAL, 2023, 第 1 作者  通讯作者
(4) Nitroaromatic compounds from secondary nitrate formation and biomass burning are major pro-inflammatory components in organic aerosols in Guangzhou: a bioassay combining high-resolution mass spectrometry analysis, Environmental Science & Technology, 2023, 第 1 作者  通讯作者
(5) Short-term personal PM2.5 exposure and change in DNA methylation of imprinted genes: Panel study of healthy young adults in Guangzhou city, China, ENVIRONMENTAL POLLUTION, 2021, 第 13 作者  通讯作者
(6) DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 12 作者  通讯作者
(7) Identifying bioaccessible suspect toxicants in sediment using adverse outcome pathway directed analysis, JOURNAL OF HAZARDOUS MATERIALS, 2020, 第 3 作者
(8) Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 1 作者
(9) Application of a novel gene encoding bromophenol dehalogenase from Ochrobactrum sp. T in TBBPA degradation, CHEMOSPHERE, 2019, 第 4 作者
(10) Inflammation responses to water-soluble components of fine particular matter (PM2.5) in ten big cities of China during one year: the role of HULIS, Environmental Science & Technology, 2019, 第 1 作者
(11) Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study, LANCET PLANETARY HEALTH, 2018, 第 12 作者
(12) Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China, ENVIRONMENTAL POLLUTION, 2018, 第 12 作者  通讯作者
(13) LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term triclosan exposure: the role of hydroxyl group, TOXICOLOGY IN VITRO, 2016, 第 2 作者  通讯作者
(14) Cl-BDE-208和BDE-209诱导LINE-1基因低甲基化和ESR1基因高甲基化, Cl-BDE-208 and BDE-209 Induce LINE-1 Gene Hypomethylation and ESR1 Gene Hypermethylation, 生态毒理学报, 2016, 第 2 作者
(15) BDE-208和BDE-209诱导了LINE-1基因低甲基化和ESR1基因高甲基化, 生态毒理学报, 2016, 第 1 作者  通讯作者
(16) Triclosan Induce DNA methylation changes in HepG2 cells, The 1st International Conference on Environmental Pollution and Health, 2015, 第 1 作者  通讯作者
(17) 环境相关浓度三氯生对人体肝癌细胞HepG2的甲基化影响, 第二届生态毒理学大会, 2015, 第 1 作者  通讯作者
(18) Effects of Benzene and Its Metabolites on Global DNA Methylation in Human Normal Hepatic L02 Cells, ENVIRONMENTAL TOXICOLOGY, 2014, 第 2 作者  通讯作者
(19) Effects of Long-term Exposure of Low-dose Triclosan on Global DNA Methylation and the Potential Factors, 3rd GIGCAS-HKPOLYU Joint Workshop on Environmental Science and Engineering, 2014, 第 1 作者  通讯作者
(20)  三氯生通过DNMT1MeCP2通路诱导HepG2细胞的全基因组, 2013年中国毒理学大会会议论文, 2013, 第 1 作者  通讯作者
(21) Triclosan reduces the levels of global DNA methylation in HepG2 cells, CHEMOSPHERE, 2013, 第 1 作者  通讯作者
(22) 苯代谢物氢醌对人体肝细胞内DNA甲基转移酶基因和蛋白表达的影响, Effects of Hydroquinone on the Expression of DNA Methyltransferase mRNA and Protein in L02 cells, 昆明理工大学学报:自然科学版, 2013, 
(23) 三氯生诱导HepG2细胞的全基因组DNA甲基化水平, Chemosphere, 2013, 第 1 作者
(24) Simultaneous determination of 8-hydroxy-2 '-deoxyguanosine and 5-methyl-2 '-deoxycytidine in DNA sample by high performance liquid chromatography/positive electrospray ionization tandem mass spectrometry, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2010, 第 3 作者
(25) 苯急性暴露对Sprague-Dawley大鼠全基因组DNA甲基化的影响, Effects of an acute exposure of benzene on DNA methylation in Sprague-Dawley rats, 生态环境学报, 2010, 
(26) 三氯生和三氯卡班对人体肝细胞DNA损伤的研究, The genotoxicity of triclosan and triclocarban in human hepatocyte LO2 cell, 生态环境学报, 2010, 
(27) 人体结肠癌组织样品中基因组DNA甲基化水平的HPLC—ESI MS/MS检测, Determination of the Global DNA Methylation Level in Human Colon Cancer Tissues by High Performance Liquid Chromatography- Tandem Electrospray Ionization Mass Spectrometry, 分析测试学报, 2009, 
(28) Analysis of global DNA methylation levels in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry, EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2009, 第 1 作者
(29) Analysis of global DNA methylation level in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry (HPLC-ESI-MS/MS), European Journal of Mass Spectrometry, 2009, 第 1 作者
(30) DNA片段的质谱试验中各相关因素的影响分析, Analysis of the Impact of Various Correlative Factors in Mass Spectroscopic Experiment of DNA Fragment, 分析测试学报, 2007, 第 1 作者
(31) SNP的电喷雾串联质谱研究, A Study on SNP by Electrospray Ionization Tandem Mass Spectrometry, 分析测试学报, 2007, 第 3 作者
(32) Characterization of activation energy distribution for ultraviolet irradiation of T-rich oligonucleotide using high-performance liquid chromatography electrospray ionization mass spectrometry tandem mass spectrometry, EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2006, 第 5 作者
(33) Characterization of methylated and unmethlyated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry, European Journal of Mass Spectrometry, 2005, 第 1 作者
(34) Pollution source and chemicals structure of the water-soluble fractions in PM2.5 that induce apoptosis in China, ENVIRONMENT INTERNATIONAL, 第 1 作者

科研活动

   
科研项目
( 1 ) 广州市PM2.5中不同来源的类腐殖酸类化合物对人体肺细胞的毒性贡献, 负责人, 地方任务, 2022-04--2023-05
( 2 ) 大气细颗粒物中类腐殖酸类化合物的有效毒性组分的筛选和鉴定, 负责人, 国家任务, 2021-01--2024-12
( 3 ) 大气颗粒物中多环芳香有机质(POM)化学组成与毒性的分布和演化, 参与, 国家任务, 2021-01--2025-12
( 4 ) 血铅诱导儿童智力降低的DNA甲基化生物标志物的初步鉴定, 负责人, 地方任务, 2019-10--2022-09
( 5 ) 交通源超细颗粒物暴露与神经退行性疾病风险评估的关键技术及应用, 参与, 国家任务, 2019-07--2022-12
( 6 ) 基于生物标志物的交通源超细颗粒物神经毒性通路研究, 负责人, 国家任务, 2019-01--2021-12
( 7 ) 广州不同典型区域大气颗粒物中的毒害有机物及毒性效应, 参与, 国家任务, 2017-09--2020-09
( 8 ) LTQ Fusion高分辨质谱仪在片段基因DNA甲基化检测方面的功能开发, 负责人, 中国科学院计划, 2016-04--2018-12
( 9 ) 有机地球化学国家重点实验室自主课题, 参与, 研究所自主部署, 2015-01--2016-12
( 10 ) 人类活动对环境变化的影响及其调控原理, 参与, 国家任务, 2012-01--2016-12
( 11 ) HPLC-MS/MS内标法研究典型污染物对人体DNA甲基化的影响, 负责人, 国家任务, 2011-01--2013-12
( 12 ) 中国科学院知识创新工程重要方向项目 南亚POPs污染及其跨境迁移趋向 第二课题, 负责人, 中国科学院计划, 2010-01--2012-12
参与会议
(1)三氯生对人体肝细胞的DNA甲基化影响   第三届生态毒理学学术研讨会   马慧敏    2016-04-28
(2)Triclosan Induce DNA methylation changes in HepG2 cells   Liudan Zeng, HuiminMa*, Zhiqiang Yu, Gan Zhang, Guoying Sheng, Jiamo Fu    2015-06-03
(3)环境相关浓度三氯生对人体肝癌细胞HepG2的甲基化影响   环境相关浓度三氯生对人体肝癌细胞HepG2的甲基化影响   曾柳丹,马慧敏*,于志强,盛国英,傅家谟   2015-04-28
(4)Effects of Long-term Exposure of Low-dose Triclosan on Global DNA Methylation and the Potential Factors   Liu Dan, Huimin Ma   2014-11-24
(5)Effects of benzene and /or its metabolites on global DNA methylation levels in L02 cells   Huimin Ma*, Zhiqing Yu, Yuhua Li , Guoying Sheng , Jiamo Fu   2011-12-13