基本信息
马东媛 女 硕导 中国科学院动物研究所
电子邮件: madongyuan@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院中国科学院动物研究所
邮政编码:
电子邮件: madongyuan@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院中国科学院动物研究所
邮政编码:
招生信息
招生专业
071008-发育生物学
招生方向
再生医学、发育生物学
教育背景
2004-09--2009-06 中国农业大学 博士2000-09--2004-06 河北大学 学士
工作经历
工作简历
2013-01~现在, 中国科学院动物研究所, 副研究员2009-07~2012-12,中国科学院动物研究所, 助理研究员2004-09~2009-06,中国农业大学, 博士2000-09~2004-06,河北大学, 学士
专利与奖励
专利成果
( 1 ) 一种构建荧光血栓斑马鱼模型的方法、应用及治疗血栓的药物, 2023, 第 3 作者, 专利号: CN115960957A( 2 ) 一种水生生物精准控温养殖系统, 2021, 第 2 作者, 专利号: CN113835452A
出版信息
发表论文
(1) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis, Proc Natl Acad Sci U S A., 2023, 第 5 作者(2) Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity., Cell Res, 2023, 第 6 作者(3) Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics, Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics, CELL RESEARCH, 2022, 第 7 作者(4) A SINGLE-CELL RESOLUTION DEVELOPMENTAL ATLAS OF HEMATOPOIETIC STEM AND PROGENITOR CELL EXPANSION IN ZEBRAFISH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 9 作者(5) SMARCA5-MEDIATED EPIGENETIC PROGRAMMING FACILITATES FETAL HSPC DEVELOPMENT IN VERTEBRATES, BLOOD, 2021, 第 3 作者(6) De novo generation of macrophage from placenta-derived hemogenic endothelium, DEVELOPMENTAL CELL, 2021, 第 8 作者(7) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells, STEM CELL REPORTS, 2020, 第 2 作者(8) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling, PLOS BIOLOGY, 2020, 第 6 作者(9) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish, NATURE COMMUNICATIONS, 2019, 第 5 作者(10) Essential Role for SUN5 in Anchoring Sperm Head to the Tail, ELIFE, 2017, 第 9 作者(11) 胚胎期造血干细胞发育的分子调控, Molecular Regulation of Hematopoietic Stem Cell during Embryogenesis, 中国细胞生物学学报, 2017, 第 2 作者(12) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b, DEVELOPMENTAL CELL, 2017, 第 5 作者(13) m(6)A modulates haematopoietic stem and progenitor cell specification, NATURE, 2017, 第 6 作者(14) Epigenetic Regulation of Left-Right Asymmetry by DNA Methylation, EMBO JOURNAL, 2017, 第 4 作者(15) The rising zebrafish research in China:Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society, 遗传学报(英文版), 2016, 第 1 作者(16) Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis, DEVELOPMENTAL CELL, 2015, 第 3 作者(17) Genome Editing and Its Applications in Model Organisms, Genome Editing and Its Applications in Model Organisms, GENOMICS PROTEOMICS & BIOINFORMATICS, 2015, 第 1 作者(18) Inflammatory Signaling Regulates Hematopoietic Stem and Progenitor Cell Emergence in Vertebrates, BLOOD, 2015, 第 5 作者(19) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition., CELL RESEARCH, 2015, 第 7 作者(20) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notchl inhibition, CELL RESEARCH, 2015, 第 7 作者(21) Genome Editing and Its Applications in Model Organisms, Genome Editing and Its Applications in Model Organisms, 基因组蛋白质组与生物信息学报:英文版, 2015, 第 1 作者(22) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish., BLOOD, 2014, 第 2 作者(23) Regulatory mechanisms of thymus and T cell development, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 第 1 作者(24) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 1 作者(25) 烟草转酮醇酶基因(NtTK)的克隆与表达, Cloning and Expression of Transketolase Gene (NtTK)in Tobacco, 河南农业大学学报, 2008, 第 2 作者
科研活动
科研项目
( 1 ) 造血系统发育过程中细胞类群动态变化及互作研究, 参与, 国家任务, 2023-12--2028-11( 2 ) 血液发育相关转录因子突变体系统研制, 参与, 国家任务, 2019-09--2024-08( 3 ) Foxn1及其下游基因调控斑马鱼胸腺和T细胞发育分子机制的研究, 负责人, 国家任务, 2014-01--2017-12( 4 ) Foxn1调控斑马鱼胸腺及T细胞发育分子机制的初步研究, 负责人, 国家任务, 2011-01--2013-12