基本信息
谢群慧  女  硕导  中国科学院生态环境研究中心
电子邮件: qhxie@rcees.ac.cn
通信地址: 北京市海淀区双清路18号环境科学楼605
邮政编码:

招生信息

   
招生专业
083001-环境科学
071010-生物化学与分子生物学
071006-神经生物学
招生方向
二恶英,持久性有机污染物,神经毒理
信号通路,二恶英受体
乙酰胆碱酯酶,胆碱能神经传导,神经肌肉接头

教育背景

2002-09--2006-12   香港科技大学   理学博士
1995-09--2002-07   北京大学医学部   临床医学学士及硕士

工作经历

   
工作简历
2008-01~2008-07,法国巴黎高师, 博士后
2007-03~2010-03,香港科技大学, 高级研究助理
2002-09~2006-12,香港科技大学, 理学博士
1995-09~2002-07,北京大学医学部, 临床医学学士及硕士
社会兼职
2018-07-02-2019-12-31,中华预防医学会卫生毒理分会青年委员会委员,

教授课程

环境分子毒理学
环境毒理学研究方法
现代生物学技术在环境健康研究中的应用

专利与奖励

   
奖励信息
(1) 环境化学与生态毒理学“青年创新奖”, , 其他, 2011
(2) Biochemical Journal Young Investigator Award, , 其他, 2009
专利成果
( 1 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410099507.7

( 2 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410100554.9

( 3 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410100654.1

( 4 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410099508.1

( 5 ) 用于二恶英类物质生物检测的重组载体, 2014, 第 3 作者, 专利号: 201410100210.8

( 6 ) 用于二恶英类物质生物检测的重组载体和细胞, 2014, 第 3 作者, 专利号: 201410099506.2

出版信息

   
发表论文
(1) Effects of perinatal TCDD exposure on colonic microbiota and metabolism in offspring and mother mice, Science of the Total Environment, 2022, 
(2) 芳香烃受体与慢性肾病发生发展关系的研究进展, Research progress on relationship between aryl hydrocarbon receptor and occurrence and development of chronic kidney disease, 中国药理学通报, 2021, 第 5 作者
(3) A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation, ENVIRONMENT INTERNATIONAL, 2021, 通讯作者
(4) Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 
(5) Simple and rapid determination of dioxin in fish and sea food using a highly sensitive reporter cell line, CBG 2.8D, JOURNAL OF ENVIRONMENTAL SCIENCES, 2021, 第 5 作者
(6) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and up-regulation of neurofilament expression in neuronal cells: Evaluation of AhR and MAPK pathways, ENVIRONMENT INTERNATIONAL, 2020, 
(7) New perspective on regulation of acetylcholinesterase via aryl hydrocarbon receptor., J. Neurochem., 2020, 第 1 作者
(8) 白细胞介素-6基因-174C/G和-634C/G多态性与尘肺易感性的Meta分析, Meta-analysis on association between interleukin-6-174C/G and-634C/G polymorphisms and pneumoconiosis susceptibility, 卫生研究, 2020, 第 4 作者
(9) Intranasal exposure to ZnO nanoparticles induces alterations in cholinergic neurotransmission in rat brain, NANO TODAY, 2020, 
(10) Regulation of Aryl Hydrocarbon Receptor Signaling Pathway and Dioxin Toxicity by Novel Agonists and Antagonists, CHEMICAL RESEARCH IN TOXICOLOGY, 2020, 
(11) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on spontaneous movement of human neuroblastoma cells, SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 
(12) Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure, CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 
(13) Transcriptomic Analysis of Anabas testudineus and Its Defensive Mechanisms in Response to Persistent Organic Pollutants Exposure, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 
(14) The toxic effects of in situ exposure of a native fish species ( Anabas testudineus ) to electronic waste pollution, Science of the Total Environment, 2019, 
(15) Characterization of the Aryl Hydrocarbon Receptor (AhR) Pathway in Anabas testudineus and Mechanistic Exploration of the Reduced Sensitivity of AhR2a, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 
(16) Aryl hydrocarbon receptor activity of polyhalogenated carbazoles and the molecular mechanism, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 
(17) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells, CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 
(18) Type 3 innate lymphoid cells are altered in colons of C57BL/6 mice with dioxin exposure, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 
(19) Development and Application of a Novel Bioassay System for Dioxin Determination and Aryl Hydrocarbon Receptor Activation Evaluation in Ambient-Air Samples, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 
(20) Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells, JOURNAL OF ENVIRONMENTAL SCIENCES, 2018, 
(21) Dioxins as potential risk factors for autism spectrum disorder, ENVIRONMENT INTERNATIONAL, 2018, 
(22) SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cell, Environmental Pollution, 2018, 
(23) Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 
(24) 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells, ENVIRONMENTAL POLLUTION, 2018, 
(25) Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure, JOURNAL OF ENVIRONMENTAL SCIENCES, 2017, 
(26) CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells, SCIENTIFIC REPORTS, 2017, 
(27) 重金属污染下龟壳攀鲈组织中ACP和AKP的活力比较, Activity Comparision of ACP and AKP in the Tissues of Anabas testudineus from Heavy Metal-polluted Areas, 生态毒理学报, 2016, 第 4 作者
(28) Development and characterization of monoclonal antibodies against human aryl hydrocarbon receptor, JOURNAL OF ENVIRONMENTAL SCIENCES, 2016, 
(29) Effects of Acute Low-Dose Exposure to the Chlorinated Flame Retardant Dechlorane 602 and Th1 and Th2 Immune Responses in Adult Male Mice, ENVIRONMENTAL HEALTH PERSPECTIVES, 2016, 
(30) New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins, CHEMICO-BIOLOGICAL INTERACTIONS, 2016, 
(31) 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells, CHEMICO-BIOLOGICAL INTERACTIONS, 2016, 
(32) 二恶英神经毒理机制研究进展, 中国化学会第30届学术年会摘要集-第二十六分会:环境化学, 2016, 第 3 作者
(33) Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2015, 第 4 作者
(34) The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals and Physiological Functions, Environmental Science and Technology, 2015, 
(35) mircroRNAs在二噁英毒理作用中的调控机制, 中国化学会第29届学术年会——第20分会:环境与健康, 2014, 第 2 作者
(36) Functional Analysis of the Dioxin Response Elements (DREs) of the Murine CYP1A1 Gene Promoter: Beyond the Core DRE Sequence, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 
(37) 用于二噁英类物质检测的高灵敏细胞传感器的构建, 中国化学会第29届学术年会——第20分会:环境与健康, 2014, 第 3 作者
(38) 长期低剂量暴露条件下二噁英免疫毒性的研究, 中国化学会第29届学术年会——第20分会:环境与健康, 2014, 第 3 作者
(39) Dioxin and Dioxin-Like Compounds Suppress Acetylcholinesterase Activity via Transcriptional Downregulations In Vitro, JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 
(40) The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder, mdpi, 2014, 
(41) 二英类污染物生物分析方法研究进展, 环境化学, 2014, 第 3 作者
(42) Characterizations of Cholinesterases in Golden Apple Snail (Pomacea canaliculata), JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 
(43) 二恶英类持久性有机污染物与老年痴呆可能存在相关性, Environmental Health Perspectives (Chinese), 2013, 
(44) Dioxin suppresses the expression of neuronal acetylcholinesterase via aryl hydrocarbon receptor., Environ Health Perspect., 2013, 第 1 作者
(45) 二恶英在转录水平调控乙酰胆碱酯酶的表达, 第七届全国环境化学学术大会, 2013, 第 1 作者
(46) 二恶英类神经毒理作用新机制的研究, 第七次全国分析毒理学大会暨第四届分析毒理专业委员会第二次会议, 2012, 第 2 作者
(47) Immunoanalysis Methods for the Detection of Dioxins and Related Chemicals, Sensors (Basel, Switzerland), 2012, 
(48) 免疫法二恶英生物检测技术展望, 第七次全国分析毒理学大会暨第四届分析毒理专业委员会第二次会议, 2012, 第 1 作者
(49) Expression of the IgSF protein Kirre in the rat central nervous system, LIFE SCIENCES, 2011, 
(50) 人参皂苷Rb2和Rb3的雌激素受体活性研究, 第六届全国环境化学学术大会论文集, 2011, 第 2 作者
(51) 二噁英对免疫系统影响的研究进展, REVIEW:EFFECTS OF DIOXINS ON THE IMMUNE SYSTEM, 环境化学, 2011, 第 2 作者
(52) 福寿螺胆碱酯酶特性的研究及在环境监测中的应用, 第六届全国环境化学学术大会论文集, 2011, 第 1 作者
(53) An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells, CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 
(54) The PRiMA-linked Cholinesterase Tetramers Are Assembled from Homodimers: HYBRID MOLECULES COMPOSED OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE DIMERS ARE UP-REGULATED DURING DEVELOPMENT OF CHICKEN BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 
(55) PRiMA directs a restricted localization of tetrameric AChE at synapses, CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 
(56) 二恶英对免疫系统影响的研究进展, 环境化学, 2010, 第 1 作者
(57) Targeting Acetylcholinesterase to Membrane Rafts: A FUNCTION MEDIATED BY THE PROLINE-RICH MEMBRANE ANCHOR (PRiMA) IN NEURONS*, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 
(58) Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: An inductive effect of neuron differentiation, BRAIN RESEARCH, 2009, 
(59) Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions - contribution and expression from motor neurons, FEBS JOURNAL, 2009, 

科研活动

   
科研项目
( 1 ) 二恶英免疫毒理效应的分子作用靶点及机理研究, 参与, 国家任务, 2013-01--2016-12
( 2 ) 超高灵敏二恶英类生物检测方法的开发与应用, 参与, 国家任务, 2013-01--2015-12
( 3 ) 二恶英类污染物神经毒理作用新机制的研究, 参与, 国家任务, 2012-01--2015-12
( 4 ) 生活垃圾焚烧厂排放污染物生物检测传感器及生物活性检测技术, 参与, 国家任务, 2012-01--2014-12
( 5 ) 二恶英类污染物免疫毒性的分子机理研究, 参与, 中国科学院计划, 2011-01--2013-12
( 6 ) 二恶英类污染物对神经胶质细胞分化和功能的影响及相关作用机制, 负责人, 国家任务, 2014-01--2017-12
( 7 ) 典型污染物的生物作用典型污染物导致信号通路扰动与其生物效应的关联机制, 负责人, 中国科学院计划, 2014-07--2019-06
( 8 ) 细颗粒物与生物界面作用机制的系统探索, 参与, 国家任务, 2016-01--2019-12
( 9 ) 二恶英类污染物系统性神经毒理过程与机制研究, 参与, 国家任务, 2019-01--2023-12
( 10 ) 二恶英类污染物对肌肉发育与功能的干扰作用机制与生理代偿机制研究, 负责人, 国家任务, 2020-01--2023-12
( 11 ) 高灵敏环境持久性有毒污染物感知与识别生物系统, 参与, 国家任务, 2019-07--2024-06
参与会议
(1)New perspective on regulation of acetylcholinesterase via aryl hydrocarbon receptor   2020-12-08
(2)Dioxin suppresses AChE expression in neuron and muscle   2018-09-09
(3)A potential role of microRNA in alterations of AChE expression caused by dioxin   2015-09-26
(4)AN ALTERATION IN ENZYMATIC ACTIVITY OF NEURONAL ACETYLCHOLINESTERASE IN RESPONSE TO DIOXIN   Xie HQ, Xu H-M, Hu Q, Tian W-J, Zhao B   2012-08-26
(5)A TRANSCRIPTIONAL REGULATION OF NEURONAL ACETYLCHOLINESTERASE BY DIOXIN   Heidi Qunhui Xie, Bin Zhao   2012-06-04
(6)福寿螺胆碱酯酶特性的研究   中国化学会第27届学术年会   谢群慧, 查广才, 赵斌   2010-06-20