基本信息
孟文翔  男  博导  中国科学院遗传与发育生物学研究所
电子邮件: wxmeng@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路一号院二号楼
邮政编码: 100101

招生信息

   
招生专业
071009-细胞生物学
071006-神经生物学
071008-发育生物学
招生方向
人类与动物细胞生物学
神经细胞功能
人类与动物发育生物学

教育背景

1998-04--2002-03   Osaka University   博士
1989-08--1995-07   北京中医药大学   学士

工作经历

   
工作简历
2010-12~现在, 中国科学院遗传与发育学研究所, 研究员
2004-04~2010-12,RIKEN. Center for Developmental Biology, Research Scientist
2002-04~2004-03, Mie University, Postdoctoral Fellowship
1998-04~2002-03,Osaka University, 博士
1995-08~1997-10,内蒙古中蒙医医院, 住院医师
1989-08~1995-07,北京中医药大学, 学士
社会兼职
2020-08-01-今,北京细胞生物学会, 理事

教授课程

生物影像技术
生物医学系列讲座

专利与奖励

   
奖励信息
(1) 理化学研究所 研究奖励赏, 特等奖, 院级, 2010
(2) 中国留日学者 兵库县知事赏, 一等奖, 市地级, 2009
(3) 中国留日学者“中国, 特等奖, 国家级, 2002

出版信息

   
发表论文
(1) CAMSAP2 and CAMSAP3 localize at microtubule intersections to regulate the spatial distribution of microtubules, J Mol Cell Biol, 2023, 通讯作者
(2) Tetra-color superresolution microscopy based on excitation spectral demixing, Tetra-color superresolution microscopy based on excitation spectral demixing, LIGHT-SCIENCE & APPLICATIONS, 2023, 第 6 作者
(3) CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis, Proceedings of the National Academy of Sciences of the United States of America, 2023, 通讯作者
(4) Fu Fang Gang Liu aqueous extract inhibits the proliferation of HeLa cells by causing deoxyribonucleic acid damage, JOURNAL OF ETHNOPHARMACOLOGY, 2023, 通讯作者
(5) Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria, THERANOSTICS, 2020, 第 9 作者
(6) CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 通讯作者
(7) HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions, HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 8 作者
(8) Paper Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria, THERANOSTICS, 2020, 第 9 作者
(9) Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions, CELL REPORTS, 2020, 第 5 作者
(10) 姜黄素2000-2019年研究趋势——文献计量学分析, Trends of Curcumin Research from 2000 to 2019: A Bibliometric Analysis, 世界科学技术:中医药现代化, 2020, 第 2 作者
(11) Standardized Research of Clinical Diagnosis and Treatment Data of Epilepsy, HUMAN SYSTEMS ENGINEERING AND DESIGN II, 2020, 第 8 作者
(12) WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis, DEVELOPMENT, 2019, 第11作者
(13) CAMSAP3 maintains neuronal polarity through regulation of microtubule stability, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 6 作者
(14) PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration, DEVELOPMENT, 2018, 通讯作者
(15) CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells, JOURNAL OF GENETICS AND GENOMICS, 2017, 通讯作者
(16) CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubule release from the centrosome via katanin, JOURNAL OF CELL SCIENCE, 2017, 通讯作者
(17) Noncentrosomal microtubules regulate autophagosome transport through CAMSAP2-EB1 cross-talk, FEBS LETTERS, 2017, 通讯作者
(18) Apical constriction in distal visceral endoderm cells initiates global, collective cell rearrangement in embryonic visceral endoderm to form anterior visceral endoderm, ACADEMIC PRESS, 2017, 
(19) CAMSAP3-dependent dicrotubuledynamics regulates Golgi assembly in epithelial cells., J. Genet. Genomics, 2017, 通讯作者
(20) CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubules release from the centrosome via katanin., CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubules release from the centrosome via katanin., 2017, 通讯作者
(21) Apical constriction in distal visceral endoderm cells initiates global, collective cell rearrangement in embryonic visceral endoderm to form anterior visceral endoderm, DEVELOPMENTALBIOLOGY, 2017, 第 6 作者
(22) CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 8 作者
(23) The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics, DEVELOPMENTAL CELL, 2016, 通讯作者
(24) The adherens junctions control susceptibility to Staphylococcus aureus α-toxin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 10 作者
(25) The adherens junctions control susceptibility to Staphylococcus aureus alpha-toxin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 10 作者
(26) Minus end–directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions, MOLECULAR BIOLOGY OF THE CELL, 2014, 第 4 作者
(27) Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activity, GENES TO CELLS, 2013, 第 2 作者
(28) Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 2 作者
(29) Nezha, a microtubule minus end-anchoring protein, regulates axon morphogenesis, NEUROSCIENCE RESEARCH, 2010, 第 2 作者
(30) Role of the adherens junction in neurogenesis, MECHANISMS OF DEVELOPMENT, 2009, 
(31) Adherens Junction: Molecular Architecture and Regulation, COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2009, 第 1 作者
(32) Microtubule Minus-End Anchorage to the Adherens Junction for Regulation of Epithelial Cell-Cell Contacts, Cell, 2008, 第 1 作者
(33) DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner, EMBO JOURNAL, 2004, 
(34) The Rho GTPase effector protein, mDia, inhibits the DNA binding ability of the transcription factor Pax6 and changes the pattern of neurite extension in cerebellar granule cells through its binding to Pax6. (vol 277, pg 47686, 2002), JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 
(35) Localization of Cathepsins G and L in Spontaneous Resorption of Intervertebral Discs in a Rat Experimental Model., J Musculoskel Neuron Interact., 2001, 第 1 作者
(36) DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner, THE EMBO JOURNAL, 第 1 作者

科研活动

   
科研项目
( 1 ) 中科院 ****, 负责人, 中国科学院计划, 2011-01--2012-12
( 2 ) 中国科学院 创新项目, 负责人, 研究所自主部署, 2010-12--2013-12
( 3 ) “神经元迁移、形态发生和微环路形成的调控机”课题二---神经元形态发生的调控机理, 参与, 国家任务, 2014-05--2018-12
( 4 ) Nezha调控纺锤体组装和功能分子机制的研究, 负责人, 国家任务, 2016-01--2019-12
( 5 ) 非中心体微管自身调控机制以及其调控胞内细胞器定位的分子机制的研究, 负责人, 国家任务, 2013-01--2016-12
( 6 ) “脊椎动物第四胚层发育的调控”课题二---囊泡运输在发育过程中调控细胞迁移的机制, 负责人, 中国科学院计划, 2013-01--2015-12
( 7 ) 中国科学院科学事业单位修缮购置专项资金-超高分辨率观测平台项目, 负责人, 中国科学院计划, 2012-01--2012-12
( 8 ) 非中心体微管调控功能分子机制的研究, 负责人, 研究所自主部署, 2012-01--2016-12
( 9 ) 细胞运动中微管网络有序分布的调控机制, 负责人, 国家任务, 2020-01--2024-12
( 10 ) 非中心体微管负端蛋白CAMSAPs在神经元极性建立以及迁移的过程中的作用机制研究, 负责人, 国家任务, 2019-01--2022-12
参与会议
(1)ACF7/Nezha complex anchors non-centrosomal microtubules at the actin filaments   2014-10-20
(2)ACF7/Nezha complex anchors non-centrosomal microtubules at the actin filaments   第二届全国发育生物学大会   2014-10-16
(3)Nezha is Anchored the Non-Centrosomal Microtubules in Cytoplasm   2012-09-18
(4)Nezha Regulates Golgi Assembly through Stabilization of Non-Centrosomal Microtubule Minus-Ends   北京细胞生物学会2011年学术年会暨第三次会员代表大会   2011-12-10