荧光探针，光动力疗法
化学传感器

2003-09--2006-06   中国科学院理化技术研究所   理学博士

   

2010-01~现在, 中国科学院理化技术研究所, 副研究员
2009-07~2009-12,中国科学院理化技术研究所, 助理研究员
2007-09~2009-06,City University of HongKong, Hong Kong, Research Fellow
2006-09~2007-08,Department of Chemistry, Dankook University, Korea, Postdoctoral Fellow
2003-09~2006-06,中国科学院理化技术研究所, 理学博士

   

（1） Photodynamic therapy for hypoxic tumors: Advances and perspectives, COORDINATION CHEMISTRY REVIEWS, 2021, 第 3 作者
（2） Self-assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy, CHEMISTRY-A EUROPEAN JOURNAL, 2021, 第 2 作者  通讯作者
（3） Multifunctional sonosensitizers in sonodynamic cancer therapy, CHEMICAL SOCIETY REVIEWS, 2020, 第 10 作者  通讯作者
（4） Hypocrellin Derivative-Loaded Calcium Phosphate Nanorods as NIR Light-Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy, CHEMMEDCHEM, 2020, 第 8 作者
（5） Near-Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy, CHEMISTRY-AN ASIAN JOURNAL, 2020, 第 3 作者
（6） A two-photon fluorescent probe for sensitive detection and imaging of gamma-glutamyl transpeptidase, CHEMICAL COMMUNICATIONS, 2020, 第 5 作者
（7） Hypocrellin-Based Multifunctional Phototheranostic Agent for NIR-Triggered Targeted Chemo/Photodynamic/Photothermal Synergistic Therapy against Glioblastoma, ACS APPLIED BIO MATERIALS, 2020, 第 2 作者  通讯作者
（8） Natural-Origin Hypocrellin-HSA Assembly for Highly Efficient NIR Light-Responsive Phototheranostics against Hypoxic Tumors, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 2 作者  通讯作者
（9） Pheophytin Derived Near-Infrared-Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy, CHEMISTRY-AN ASIAN JOURNAL, 2019, 第 6 作者
（10） Biodegradable Natural Product-Based Nanoparticles for Near-Infrared Fluorescence Imaging-Guided Sonodynamic Therapy., ACS APPLIED MATERIALS & INTERFACES, 2019, 第 7 作者
（11） Biodegradable hypocrellin derivative nanovesicle as a near-infrared light-driven theranostic for dually photoactive cancer imaging and therapy, BIOMATERIALS, 2018, 第 3 作者
（12） Coumarin/fluorescein-fused fluorescent dyes for rapidly monitoring mitochondrial pH changes in living cells, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2018, 第 6 作者
（13） New detection method for nucleoside triphosphates based on carbon dots: The distance-dependent singlet oxygen trapping, ANALYTICA CHIMICA ACTA, 2018, 第 6 作者
（14） A colorimetric and ratiometric fluorescent probe for highly selective detection of glutathione in the mitochondria of living cells, SENSORS AND ACTUATORS: B. CHEMICAL, 2018, 第 4 作者
（15） High sensitivity gram-negative bacteria biosensor based on a small-molecule modified surface plasmon resonance chip studied using a laser scanning confocal imaging-surface plasmon resonance system, SENSORS & ACTUATORS: B. CHEMICAL, 2018, 第 6 作者
（16） Red emissive fluorescent probe for the rapid detection of selenocysteine, SENSORS AND ACTUATORS B-CHEMICAL, 2018, 第 7 作者
（17） Red emissive fluorescent probe for the rapid detection of selenocysteine, SENSORS & ACTUATORS: B. CHEMICAL, 2018, 第 7 作者
（18） Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 第 9 作者
（19） High sensitivity gram-negative bacteria biosensor based on a small-molecule modified surface plasmon resonance chip studied using a laser scanning confocal imaging-surface plasmon resonance system, SENSORS AND ACTUATORS B-CHEMICAL, 2018, 第 6 作者
（20） A colorimetric and ratiometric fluorescent probe for highly selective detection of glutathione in the mitochondria of living cells, SENSORS AND ACTUATORS B-CHEMICAL, 2018, 第 4 作者
（21） Near-Infrared Probe Based on Rhodamine Derivative for Highly Sensitive and Selective Lysosomal pH Tracking, ANALYTICAL CHEMISTRY, 2017, 第 6 作者
（22） A fluorescent probe for the efficient discrimination of Cys, Hey and GSH based on different cascade reactions, BIOSENSORS & BIOELECTRONICS, 2017, 第 5 作者
（23） Coumarin-Based Boron Complexes with Aggregation-Induced Emission, JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 7 作者
（24） Dual-Emission Channels for Simultaneous Sensing of Cysteine and Homocysteine in Living Cells, CHEMISTRY-AN ASIAN JOURNAL, 2017, 第 5 作者
（25） Efficient non-doped deep-blue electroluminescence devices based on unsymmetrical and highly twisted pyrene derivatives, NEW JOURNAL OF CHEMISTRY, 2017, 第 5 作者  通讯作者
（26） Surface-enhanced Raman scattering substrate based on cysteamine-modified gold nanoparticle aggregation for highly sensitive pentachlorophenol detection, RSC ADVANCES, 2016, 第 5 作者
（27） Keto-benzoh-Coumarin-Based Near-Infrared Dyes with Large Stokes Shifts for Bioimaging Applications, CHEMISTRY-AN ASIAN JOURNAL, 2016, 第 8 作者
（28） Investigation of biological cell-small molecule interactions with a gold surface plasmon resonance sensor using a laser scanning confocal imaging-surface plasmon resonance system, RSC ADVANCES, 2016, 第 7 作者
（29） Deep-red to near-infrared fluorescent dyes: Synthesis, photophysical properties, and application in cell imaging, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2016, 第 3 作者
（30） Deep-red and near-infrared xanthene dyes for rapid live cell imaging, JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 6 作者
（31） A ratiometric fluorescent probe for quantification of alkaline phosphatase in living cells, RSC ADVANCES, 2016, 第 2 作者  通讯作者
（32） Deep-red to near-infrared fluorescent dyes: Synthesis, photophysical properties, and application in cell imaging, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2016, 第 3 作者
（33） Imaging of nucleolar RNA in living cells using a highly photostable deep-red fluorescent probe, BIOSENSORS & BIOELECTRONICS, 2015, 第 4 作者
（34） Chromogenic/Fluorogenic Ensemble Chemosensing Systems, CHEMICAL REVIEWS, 2015, 第 1 作者
（35） Imaging of nucleolar RNA in living cells using a highly photostable deep-red fluorescent probe, BIOSENSORS AND BIOELECTRONICS, 2015, 第 4 作者
（36） A selective fluorescent and colorimetric dual-responses chemosensor for streptomycin based on polythiophene derivative, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 第 4 作者
（37） Aminobenzofuran-Fused Rhodamine Dyes with Deep-Red to Near-Infrared Emission for Biological Applications, JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 3 作者
（38） A new coumarin-derived fluorescent sensor with red-emission for Zn2+ in aqueous solution, SENSORS AND ACTUATORS B-CHEMICAL, 2014, 第 3 作者  通讯作者
（39） 基于分子内电荷转移机制的巯基荧光比色化学传感器, A Thiol-selective Colorimetric and Fluorescent Sensor Based on Intramolecular Electron Transfer, 影像科学与光化学, 2014, 第 3 作者
（40） Coumarin- and Rhodamine-Fused Deep Red Fluorescent Dyes: Synthesis, Photophysical Properties, and Bioimaging in Vitro, JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 6 作者
（41） 1,4-Diazobicyclo(2,2,2)octane-modified multi-ammonium derivatives as ratiometric fluorescent sensors for lipopolysaccharide, SUPRAMOLECULAR CHEMISTRY, 2013, 第 2 作者
（42） Copolythiophene-derived colorimetric and fluorometric sensor for lysophosphatidic acid based on multipoint interactions., ACS APPLIED MATERIALS & INTERFACES, 2013, 第 5 作者
（43） A red fluorescent probe for thiols based on 3-hydroxyflavone and its application in living cell imaging, RSC ADVANCES, 2013, 第 5 作者
（44） Turn-on fluorescence sensor based on the aggregation of pyrazolo3,4-bpyridine-based coumarin chromophores induced by Hg2+, TETRAHEDRON LETTERS, 2013, 第 5 作者
（45） Ultrasensitive and selective gold film-based detection of mercury (II) in tap water using a laser scanning confocal imaging-surface plasmon resonance system in real time, BIOSENSORS & BIOELECTRONICS, 2013, 第 6 作者
（46） COLORIMETRIC DETECTION OF CARBENICILLIN USING CATIONIC POLYTHIOPHENE DERIVATIVES, CHINESE JOURNAL OF POLYMER SCIENCE, 2013, 第 4 作者
（47） Thiol-selective sensor based on intramolecular energy transfer between a bichromophoric system, TETRAHEDRON, 2013, 第 2 作者  通讯作者
（48） A polythiophene-derived ratiometric fluorescent sensor for highly sensitive determination of carbenicillin in aqueous solution, CHEMICAL COMMUNICATIONS, 2012, 第 4 作者
（49） Copolythiophene-derived colorimetric and fluorometric sensor for visually supersensitive determination of lipopolysaccharide., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 2 作者
（50） Synthesis and Properties of Fluorescence Dyes: Tetracyclic Pyrazolo3,4-bPyridine-Based Coumarin Chromophores with Intramolecular Charge Transfer Character, JOURNAL OF ORGANIC CHEMISTRY, 2012, 第 5 作者
（51） A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid, ANALYST, 2012, 第 6 作者
（52） Fluorescent sensors based on controllable conformational change fordiscrimination of Zn2+ over Cd2+, TETRAHEDRON, 2012, 第 1 作者
（53） Reversible "off���on" fluorescent chemosensor for Hg 2+ based on rhodamine derivative, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 第 4 作者
（54） Ruthenium(II) complex-based fluorescent sensor for peroxynitrite, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 第 2 作者  通讯作者
（55） A novel fluoride ion colorimetric chemosensor based on coumarin, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 第 3 作者
（56） Ratiometric Fluorescence Sensor Based on a Pyrene Derivative and Quantification Detection of Heparin in Aqueous Solution and Serum, ANALYTICAL CHEMISTRY, 2011, 第 4 作者
（57） Reversible Fluorescent Probe for Highly Selective and Sensitive Detection of Mercapto Biomolecules, INORGANIC CHEMISTRY, 2011, 第 1 作者
（58） Rhodamine-derived Schiff base for the selective determination of mercuric ions in water media, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 第 2 作者
（59） Aggregation-induced emission enhancement materials with large red shifts and their self-assembled crystal microstructures, CRYSTENGCOMM, 2011, 第 5 作者
（60） Highly sensitive fluorescent probe for thiols based on combination of PET and ESIPT mechanisms, SENSORS AND ACTUATORS B-CHEMICAL, 2011, 第 2 作者
（61） A colorimetric chemosensor for fast detection of thiols based on intramolecular charge transfer, TETRAHEDRON LETTERS, 2011, 第 3 作者
（62） Highly sensitive fluorescent probe for thiols based on combination of PET and ESIPT mechanisms, SENSORS & ACTUATORS: B. CHEMICAL, 2011, 第 2 作者
（63） A novel fluorogenic hybrid material for selective sensing of thiophenols, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 4 作者
（64） Reversibly Fluorescent Probe for Highly Selective and Sensitive Detection of Mercapto Biomolecules, Inorg. Chem., 2011, 50, 6543-6551., 2011, 第 1 作者
（65） Rationally designed fluorescence 'turn-on' sensor for Cu2+, CHEMICAL COMMUNICATIONS, 2011, 第 2 作者
（66） New sensing mechanisms for design of fluorescent chemosensors emerging in recent years., CHEMICAL SOCIETY REVIEWS, 2011, 第 1 作者
（67） A highly selective fluorescent sensor for fluoride in aqueous solution based on the inhibition of excited-state intramolecular proton transfer, SENSORS & ACTUATORS: B. CHEMICAL, 2010, 第 2 作者
（68） Enzyme sensing based on a controllable oxidation reaction, BIOSENSORS & BIOELECTRONICS, 2010, 第 5 作者
（69） Synthesis, Crystal Structures, and Photophysical Properties of Triphenylamine-Based Multicyano Derivatives, JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 3 作者
（70） Highly selective recognition of carbenicillin via concerted interactions in 100% aqueous solution, CHEMICAL COMMUNICATIONS, 2010, 第 4 作者
（71） A highly selective fluorescent sensor for fluoride in aqueous solution based on the inhibition of excited-state intramolecular proton transfer, SENSORS AND ACTUATORS B-CHEMICAL, 2010, 第 2 作者
（72） Sensing of Bacterial Endotoxin in Aqueous Solution by Supramolecular Assembly of Pyrene Derivative, ORGANIC LETTERS, 2010, 第 2 作者
（73） An efficient chloride-selective fluorescent chemosensor based on 2,9-bis(4���-hydroxyphenyl)phenanthroline Cu(II) complex, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2007, 第 1 作者
（74） Highly sensitive and selective chemosensor for Hg2+ based on the rhodamine fluorophore, ORGANIC LETTERS, 2007, 第 2 作者
（75） Rhodamine-based Hg2+-selective chemodosimeter in aqueous solution: Fluorescent OFF-ON, ORGANIC LETTERS, 2007, 第 1 作者
（76） Fluorescence turn on of coumarin derivatives by metal cations: a new signaling mechanism based on c=n isomerization, ORGANIC LETTERS, 2007, 第 1 作者
（77） Anion Triggered Ring-opening of Fluorescein Spirolactam: Fluorescence OFF-ON, TETRAHEDRONLETT20074831593162, 2007, 第 1 作者
（78） Novel fluorescent sensor for detection of Cu(II) in aqueous solution, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2006, 第 1 作者
（79） N，N-双（α-萘基-苯基）-4，4＇-联苯二胺纳米管的制备及其光谱行为, Preparation and Spectral Behavior of N,N-Bis(��-naphthylphenyl)-4,4'-biphenyldiamine Nanotubes, 高等学校化学学报, 2005, 第 3 作者
（80） New fluorescent chemosensor based on exciplex signaling mechanism, ORGANIC LETTERS, 2005, 
（81） 一种能选择性识别磷酸根离子的金属配合物化学敏感器, Metal-containing Chemosensor for Selective Recognition of Phosphate Anion in Water, 化学学报, 2004, 第 2 作者

   

（ 1 ） 用于高灵敏检测磷酸水解酶的新型荧光探针的设计, 负责人, 国家任务, 2012-01--2015-12
（ 2 ） 高效荧光和磷光杂化机制的白光OLED材料和器件结构的研究, 参与, 地方任务, 2011-01--2013-12
（ 3 ） 用于检测谷胱甘肽还原酶的荧光传感分子的设计, 负责人, 国家任务, 2010-01--2010-12
（ 4 ） 太阳能行动计划, 参与, 中国科学院计划, 2009-07--2011-06

（1）Controllable C=N Isomerization for Rational Design of Fluorescent Sensors   Jiasheng Wu, Ruilong Sheng, Weimin Liu, and Pengfei Wang*   2011-09-11
（2）Coumarin-Based Fluorescence Turn-on Probe for Zn2+ with Longer Emission Wavelength   Jiasheng Wu, Ruilong Sheng, Weimin Liu, and Pengfei Wang*   2011-08-07