基本信息
牛忠伟  男  博导  中国科学院理化技术研究所
电子邮件: niu@mail.ipc.ac.cn
通信地址: 北京市中关村北一条2号
邮政编码: 100190

招生信息

   
招生专业
070305-高分子化学与物理
080501-材料物理与化学
招生方向
生物材料、组织工程、抗菌材料
功能高分子材料

教育背景

2000-09--2003-07   中国科学院化学研究所   博士学位
1997-09--2000-04   东北石油大学   硕士学位
1993-09--1997-07   东北石油大学   本科 学士学位

工作经历

   
工作简历
2009-11~现在, 中国科学院理化技术研究所, 研究员
2008-02~2009-11,美国南卡罗来纳大学, 研究助理教授
2005-04~2008-02,美国南卡罗来纳大学, 博士后
2004-04~2005-04,比利时鲁汶大学, 博士后
2003-07~2004-03,北京交通大学, 讲师
2000-09~2003-07,中国科学院化学研究所, 博士学位
1997-09~2000-04,东北石油大学, 硕士学位
1993-09~1997-07,东北石油大学, 本科 学士学位

教授课程

光生物
光功能材料化学(二)
光化学系列讲座

专利与奖励

   
奖励信息
(1) 中国科学院优秀博士论文, 特等奖, 院级, 2004
专利成果
( 1 ) 双功能基团改性壳聚糖衍生物及其制备方法, 2021, 第 1 作者, 专利号: ZL201610048234.2

( 2 ) 一种壳聚糖-抗菌性多肽接枝聚合物及其制备方法和应用, 2021, 第 1 作者, 专利号: ZL201910072882.5

( 3 ) 一种具有抗菌功能的生物相容性壳聚糖衍生物及其制备方法, 2021, 第 1 作者, 专利号: ZL201910762351.9

( 4 ) 一种pH响应的抗菌肽及其制备方法和应用, 2021, 第 1 作者, 专利号: ZL201811108055.9

( 5 ) 一种新型水溶性天然多糖抗菌材料及其制备方法, 2021, 第 1 作者, 专利号: ZL201710556550.5

( 6 ) 一种pH响应的抗菌肽及其制备方法和应用, 2021, 第 1 作者, 专利号: ZL201811108055.9

( 7 ) 一种pH 响应的ε-聚赖氨酸及其制备方法和应用, 2021, 第 1 作者, 专利号: ZL201811117709.4

( 8 ) 一种纳米粒子及其在制备灭活细菌的光动力制剂中的应用, 2021, 第 1 作者, 专利号: ZL201910480657.5

( 9 ) 一种表面改性的聚多巴胺纳米粒子Pickering乳液的制备方法, 2016, 第 1 作者, 专利号: 201610250457.7

( 10 ) 一种表面功能化的烟草花叶病毒纳米线复合材料的制备方法, 2015, 第 2 作者, 专利号: 201510696672.5

( 11 ) 一种碳基室温磁制冷复合材料及其制备方法, 2014, 第 2 作者, 专利号: 201410165585.2

( 12 ) 一种镧铁硅基室温磁制冷复合材料及制备方法, 2013, 第 2 作者, 专利号: 201310378863.8

( 13 ) 一种具有取向生长结构细胞的材料的制备方法, 2012, 第 1 作者, 专利号: 201210357110.4


出版信息

   
发表论文
(1) Surface decoration with leucine tetrapeptide: An antibacterial strategy against Gram-negative bacteria, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2023, 第 12 作者  通讯作者
(2) Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano-Assembly to Combat Fungal Keratitis, ADVANCED HEALTHCARE MATERIALS, 2023, 第 8 作者  通讯作者
(3) One-Dimensional Rod-like Tobacco Mosaic Virus Promotes Macrophage Polarization for a Tumor-Suppressive Microenvironment, NANO LETTERS, 2023, 第 12 作者  通讯作者
(4) Guanidinylated/PEGylated chitosan in the bioink promotes the formation of multi-layered keratinocytes in a human skin equivalent, CARBOHYDRATE POLYMERS, 2023, 第 9 作者  通讯作者
(5) 水溶性壳聚糖水凝胶对糖尿病小鼠感染全层皮肤缺损创面的作用及其机制, Effects and mechanism of water-soluble chitosan hydrogel on infected full-thickness skin defect wounds in diabetic mice, 中华烧伤与创面修复杂志, 2022, 第 9 作者
(6) Amino Acid Dependent Performance of Modified Chitosan Against Bacteria and Red Blood Cell, Journal of Nanoscience and Nanotechnology, 2021, 第 1 作者  通讯作者
(7) Conjugating Peptides onto 1D Rodlike Bionanoparticles for Enhanced Activity against Gram-Negative Bacteria, NANOLETTERS, 2021, 第 9 作者  通讯作者
(8) 改性壳聚糖滴眼液对兔白念珠菌性角膜炎的治疗作用及安全性评价, Efficacy and safety of modified chitosan eye drops in the treatment of Candida albicanskeratitis in rabbits, 中华实验眼科杂志, 2020, 第 4 作者
(9) Single-wavelength Excited Ratiometric Fluorescence pH Probe to Image Intracellular Trafficking of Tobacco Mosaic Virus, Single-wavelength Excited Ratiometric Fluorescence pH Probe to Image Intracellular Trafficking of Tobacco Mosaic Virus, CHINESE JOURNAL OF POLYMER SCIENCE, 2020, 第 9 作者  通讯作者
(10) Combating Pseudomonas aeruginosa Biofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure, ACS APPLIED MATERIALS & INTERFACES, 2020, 第 13 作者  通讯作者
(11) 3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking, 3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking, BIOACTIVE MATERIALS, 2020, 第 8 作者  通讯作者
(12) Phenotype Regulation of Smooth Muscle Cells Through Facial Crystallization of Poly(epsilon-Caprolactone), JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2019, 第 6 作者  通讯作者
(13) Membrane intercalation-enhanced photodynamic inactivation of bacteria by a metallacycle and TAT-decorated virus coat protein, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 8 作者
(14) Fluorous interaction induced self-assembly of tobacco mosaic virus coat protein for cisplatin delivery, NANOSCALE, 2018, 第 7 作者  通讯作者
(15) Balancing antimicrobial activity with biological safety: bifunctional chitosan derivative for the repair of wounds with Gram-positive bacterial infections, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 第 9 作者  通讯作者
(16) Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology, NANO LETTERS, 2018, 第 9 作者  通讯作者
(17) Filamentous Virus Oriented Pyrene Excimer Emission and Its Efficient Energy Transfer, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2018, 第 9 作者  通讯作者
(18) Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy, MATERIALS CHEMISTRY FRONTIERS, 2018, 第 4 作者
(19) Programming Self-Assembly of Tobacco Mosaic Virus Coat Proteins at Pickering Emulsion Interfaces for Nanorod-Constructed Capsules, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 6 作者  通讯作者
(20) Mussel-Inspired Polydopamine Coating on Tobacco Mosaic Virus: One-Dimensional Hybrid Nanofibers for Gold Nanoparticle Growth, LANGMUIR, 2017, 第 5 作者  通讯作者
(21) One-Pot Green Synthesis of Nitrogen-Doped Carbon Quantum Dots for Cell Nucleus Labeling and Copper(II) Detection, CHEMISTRY-AN ASIAN JOURNAL, 2017, 第 4 作者  通讯作者
(22) 烟草花叶病毒的特定位点改性及应用, Site-specific Modification of Tobacco Mosaic Virus and Its Applications, 影像科学与光化学, 2017, 第 3 作者
(23) Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 第 8 作者  通讯作者
(24) A perspective on general direction and challenges facing antimicrobial peptides, CHINESE CHEMICAL LETTERS, 2017, 第 3 作者  通讯作者
(25) Rod-like plant virus: Functionalization, self-assembly, and bioapplications, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 1 作者
(26) Integrating a dna strand displacement reaction with a whispering gallery mode sensor for label-free mercury (ii) ion detection, SENSORS, 2016, 第 3 作者
(27) Into the polymer brush regime through the "grafting-to'' method: densely polymer-grafted rodlike viruses with an unusual nematic liquid crystal behavior, SOFT MATTER, 2016, 第 7 作者  通讯作者
(28) Tobacco Mosaic Virus-Based 1D Nanorod-Drug Carrier via the Integrin-Mediated Endocytosis Pathway, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 8 作者  通讯作者
(29) Conjugated oligomer-based nanocarrier for chemotherapy agents delivery, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 3 作者
(30) Size Dependent Cellular Uptake of Rod-like Bionanoparticles with Different Aspect Ratios, SCIENTIFIC REPORTS, 2016, 第 7 作者  通讯作者
(31) Hierarchical Self-Assembly of Responsive Organoplatinum(II) Metallacycle-TMV Complexes with Turn-On Fluorescence, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 4 作者  通讯作者
(32) Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H2O2 in living cells, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者  通讯作者
(33) 一维棒状烟草花叶病毒的自组装及其应用, One-Dimensional Rod-Like Tobacco Mosaic Virus: Self-Assembly and Applications, PROGRESS IN CHEMISTRY, 2015, 第 5 作者  通讯作者
(34) Probing the Endocytic Pathways of the Filamentous Bacteriophage in Live Cells Using Ratiometric pH Fluorescent Indicator, ADVANCED HEALTHCARE MATERIALS, 2015, 第 6 作者  通讯作者
(35) Confined chromophores in tobacco mosaic virus to mimic green fluorescent protein, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者  通讯作者
(36) 一维棒状烟草花叶病毒的自组装及其应用, One-Dimensional Rod-Like Tobacco Mosaic Virus: Self-Assembly and Applications, PROGRESS IN CHEMISTRY, 2015, 第 5 作者  通讯作者
(37) 烟草花叶病毒介导合成三角形金纳米片, Synthesis of Triangular Gold Nanoplates Mediated by Tobacco Mosaic Virus, 影像科学与光化学, 2014, 第 6 作者
(38) Multi-enzyme co-embedded organic-inorganic hybrid nanoflowers: synthesis and application as a colorimetric sensor, NANOSCALE, 2014, 第 8 作者
(39) Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth, ACS APPLIED MATERIALS & INTERFACES, 2014, 第 8 作者
(40) Bioactive Nanoparticle-Gelatin Composite Scaffold with Mechanical Performance Comparable to Cancellous Bones, ACS APPLIED MATERIALS & INTERFACES, 2014, 第 7 作者
(41) Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles, CHEMICAL COMMUNICATIONS, 2014, 
(42) Temperature Responsive 3D Structure of Rod-like Bionanoparticles Induced by Depletion Interaction, CHINESE JOURNAL OF POLYMER SCIENCE, 2014, 第 2 作者  通讯作者
(43) Polymeric Supra-amphiphiles Based on Terminal Group Electrostatic Interactions: Fabrication of Micelles with Modifiable Surfaces, LANGMUIR, 2014, 第 5 作者  通讯作者
(44) Biobehavior in Normal and Tumor-Bearing Mice of Tobacco Mosaic Virus, BIOMACROMOLECULES, 2013, 第 6 作者
(45) Enhanced orientation of PEO polymer chains induced by nanoclays in electrospun PEO/clay composite nanofibers, COLLOID AND POLYMER SCIENCE, 2013, 第 9 作者  通讯作者
(46) Hetero-epitaxy of anisotropic polycaprolactone films for the guidance of smooth muscle cell growth, CHEMICAL COMMUNICATIONS, 2013, 第 8 作者  通讯作者
(47) Edge-modified amphiphilic Laponite nano-discs for stabilizing Pickering emulsions, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2013, 第 6 作者
(48) Facile Preparation Route toward Speckled Colloids via Seeded Polymerization, LANGMUIR, 2013, 第 3 作者
(49) 基于两亲性锂藻土的Pickering乳液, Pickering Emulsion Based on Amphiphilic Laponite, 纳米科技, 2012, 第 3 作者
(50) Nonionic Block Copolymers Assemble on the Surface of Protein Bionanoparticle, LANGMUIR, 2012, 第 7 作者  通讯作者
(51) Natural supramolecular building blocks: from virus coat proteins to viral nanoparticles, CHEMICAL SOCIETY REVIEWS, 2012, 第 3 作者  通讯作者
(52) Self-assembly of viral particles, CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2011, 第 2 作者
(53) Visualizing Cell Extracellular Matrix (ECM) Deposited by Cells Cultured on Aligned Bacteriophage M13 Thin Films, LANGMUIR, 2011, 第 3 作者
(54) Electrospinning fabrication, structural and mechanical characterization of rod-like virus-based composite nanofibers, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 4 作者
(55) Fabrication of continuous highly ordered mesoporous silica nanofibre with core/sheath structure and its application as catalyst carrier, NANOSCALE, 2011, 第 4 作者
(56) Self-Assembly of Virus Particles on Flat Surfaces via Controlled Evaporation, LANGMUIR, 2011, 第 6 作者
(57) Polymer-virus core-shell structures prepared via co-assembly and template synthesis methods, SCIENCE CHINA-CHEMISTRY, 2010, 第 2 作者
(58) Chemical Modification of M13 Bacteriophage and Its Application in Cancer Cell Imaging, BIOCONJUGATE CHEMISTRY, 2010, 第 5 作者
(59) Synthesis of Nano/Microstructures at Fluid Interfaces, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 第 1 作者
(60) Self-assembly of rod-like bionanoparticles in capillary tube, Angew Chem Int Ed 2010, 49, 868, 2010, 第 1 作者
(61) Synthesis of nano/micro structure at interfaces, Angew Chem Int Ed 2010, 49, 10052, 2010, 第 1 作者
(62) Controlled Assembly of Protein in Glass Capillary, LANGMUIR, 2010, 第 4 作者  通讯作者
(63) Tobacco mosaic virus based thin film sensor for detection of volatile organic compounds, JOURNAL OF MATERIALS CHEMISTRY, 2010, 第 6 作者  通讯作者
(64) Pulling Genetic RNA out of Tobacco Mosaic Virus Using Single-Molecule Force Spectroscopy, JOURNALOFTHEAMERICANCHEMICALSOCIETY, 2010, 第 5 作者
(65) Structure and interaction in 2D assemblies of tobacco mosaic viruses, SOFT MATTER, 2009, 第 5 作者
(66) The bioconjugation of bionanoparticles, Nano Research, 2009, 2, 349, 2009, 第 1 作者
(67) Tobacco mosaic virus templated synthesis of one dimensional inorganic-polymer hybrid fibres, JOURNAL OF MATERIALS CHEMISTRY, 2009, 第 6 作者  通讯作者
(68) Synthesis and Characterization of Bionanoparticle-Silica Composites and Mesoporous Silica with Large Pores, Synthesis and Characterization of Bionanoparticle-Silica Composites and Mesoporous Silica with Large Pores, NANO RESEARCH, 2009, 第 1 作者
(69) Soft raspberry-like colloids assembled from icosahedral plant virus and polymer, Chem. Mater. 2009, 21, 1046, 2009, 第 1 作者
(70) Self-assembly of tobacco mosaic virus at oil/water interface, Langmuir, 2009, 25, 4979, 2009, 第 1 作者
(71) Nanomechanical characterization of polyaniline coated tobacco mosaic virus nanotubes, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2008, 第 2 作者
(72) Bacteriophage M13 as a Scaffold for Preparing Conductive Polymeric Composite Fibers, Bacteriophage M13 as a Scaffold for Preparing Conductive Polymeric Composite Fibers, NANO RESEARCH, 2008, 第 1 作者
(73) Oriented cells growth on self-assembled bacteriophage M13 thin films, Chem. Commun. 2008, 5185, 2008, 第 1 作者  通讯作者
(74) Layer-by-layer assembly of viral capsid for cellular adhesion, Acta Biomaterials 2008, 4, 838-843, 2008, 第 1 作者
(75) Core-Shell biocomposite from hierarchical assembly of bionanoparticle and polymer, Small 2008, 4, 1624, 2008, 第 1 作者
(76) Assembly of tobacco mosaic virus into fibrous and macroscopic bundled arrays by aniline polymerization on its surface, Langmuir 2007, 23, 6719, 2007, 第 1 作者
(77) Biological templated synthesis of water-soluble conductive polymeric nanowires, NANO LETTERS, 2007, 第 1 作者
(78) Study and characterization of tobacco mosaic virus head-to-tail assembly assisted by aniline polymerization, CHEMICAL COMMUNICATIONS, 2006, 第 1 作者
(79) 模板技术制备介观结构材料, Template-synthesis of Mesostructured Materials, 中国科学院研究生院学报, 2005, 第 1 作者
(80) 模板技术制备介观结构材料, Template-synthesis of Mesostructured Materials, 中国科学院研究生院学报, 2005, 第 1 作者
(81) 模板技术制备-维纳米纤维及其阵列, 物理, 2004, 第 2 作者
(82) 纳米图案化高分子凝胶的制备, SYNTHESIS OF NANOPATTERNED HYDROGELS, 高分子学报, 2004, 第 4 作者
(83) 敏感性有序大孔水凝胶的模板合成与表征, Template-synthesis and Characterization of Responsive Ordered Macroporous Hydrogels, 高等学校化学学报, 2004, 第 3 作者
发表著作
( 1 ) 细胞和生物分子的识别, Cellular and Biomolecular Recognition, Wiley-VCH, Weinheim, 2009-06, 第 1 作者
Viral nanoparticles for diagnostic and therapeutic applications. Nanoparticles for Biotherapeutic Delivery, Future science group, 2015-01, 第 2 作者
Self-assembly of rod-like bionanoparticles at interfaces and in solution, Humana Press, 2018-09, 第 2 作者

科研活动

   
科研项目
( 1 ) 创面和粘膜医疗抗菌应用技术, 负责人, 其他, 2024-03--2029-03
( 2 ) 菌膜诱导组装结构转变的多肽偶联物用于抵抗革兰氏阴性菌生物膜感染研究, 负责人, 国家任务, 2021-01--2024-12
( 3 ) 针对体表慢性难愈合创面的功能性敷料, 负责人, 研究所自主部署, 2021-01--2023-12
( 4 ) 植入材料多物理特性高通量耦合设计计算与构建, 负责人, 国家任务, 2018-09--2021-06
( 5 ) 基于生物材料构建的微环境诱导多种损伤组织同步修复再生的基础科学问题与关键技术研究, 参与, 国家任务, 2017-07--2020-12
( 6 ) 烟草花叶病毒蛋白-高分子生物杂合嵌段共聚物的构筑及其组装, 负责人, 国家任务, 2015-01--2018-12
( 7 ) 重大疾病相关的若干重要难检活性小分子细胞内纳米传感研究, 参与, 国家任务, 2013-01--2017-08
( 8 ) 内壁具有规整纳微取向结构的聚合物微管的制备及其对血 管平滑肌细胞行为的影响, 负责人, 国家任务, 2012-01--2015-12
( 9 ) 生物纳米粒子模板合成一维Janus结构, 负责人, 国家任务, 2011-01--2013-12
( 10 ) 基于生物纳米粒子和嵌段共聚物的可控组装及其生物医用, 负责人, 国家任务, 2011-01--2013-12
( 11 ) 功能高分子材料的生物医用研究, 负责人, 中国科学院计划, 2011-01--2012-12
参与会议
(1)Rod-like Plant Virus: Functionalization, Self-Assembly and Bioapplications   2016-03-13
(2)Rod-like virus: modification, self-assembly, cellular internalization mechanism and biobehavior in normal mice   2015-05-09
(3)Self-assembly of bionanoparticles   牛忠伟   2010-10-30
(4)生物纳米粒子的可控组装   中国化学会第27届学术年会   牛忠伟   2010-06-20