基本信息
韩之明  女  硕导  中国科学院动物研究所
电子邮件: hanzm@ioz.ac.cn
通信地址: 北京市朝阳区大屯路甲3号中国科学院动物研究所干细胞与再生医学创新研究院
邮政编码:

招生信息

   
招生专业
071008-发育生物学
招生方向
生殖细胞,受精,胚胎发育,细胞重编程,干细胞

教育背景

1997-09--2002-07   北京师范大学   理学博士
1992-09--1996-07   北京师范大学   理学学士

工作经历

   
工作简历
2005-06~2010-04,Temple University, 副科学家
2002-12~2005-06,Temple University, 博士后
1997-09~2002-07,北京师范大学, 理学博士
1996-07~1997-07,中国科学院动物研究所, 研究助理
1992-09~1996-07,北京师范大学, 理学学士
社会兼职
2023-08-22-2027-08-22,中国动物学会细胞与分子显微技术学分会, 秘书长
2023-07-20-2028-07-20,Journal of Ovarian Research, Associate Editor
2019-08-01-2024-08-01,中国动物学会, 理事

专利与奖励

   
奖励信息
(1) 全国人口和计划生育科技成果奖, 一等奖, 国家级, 2006

出版信息

   
发表论文
(1) Overexpression of let-7a mitigates diploidization in mouse androgenetic haploid embryonic stem cells., iScience, 2024, 
(2) NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition., Advanced Science, 2023, 第 6 作者
(3) Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes., Cell Proliferation, 2023, 第 5 作者
(4) SRSF2 is required for mRNA splicing during spermatogenesis., BMC Biology, 2023, 第 12 作者
(5) SRSF1-mediated alternative splicing is required for spermatogenesis., International Journal of Biological Sciences, 2023, 第 10 作者
(6) A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human., iScience, 2023, 第 10 作者
(7) Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation., JCI Insight, 2023, 第 12 作者
(8) MAPRE2 regulates the first meiotic progression in mouse oocytes., Experimental Cell Research, 2022, 
(9) Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling., Cellular and Molecular Gastroenterology and Hepatology, 2022, 第 12 作者
(10) SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing., eLife, 2022, 第 12 作者
(11) Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation., Zoological Research, 2022, 第 8 作者
(12) Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells., Journal of Cerebral Blood Flow and Metabolism, 2022, 
(13) PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4, JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 第 11 作者
(14) Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting, JCI INSIGHT, 2021, 第 12 作者
(15) NEK家族在细胞周期调控中的作用, 遗传, 2021, 第 11 作者
(16) NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2019, 第 11 作者
(17) Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, STEM CELL REPORTS, 2018, 第 25 作者
(18) Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations, SCIENCE ADVANCES, 2018, 第 11 作者
(19) High Throughput Sequencing Identifies an Imprinted Gene, Grb10, Associated with the Pluripotency State in Nuclear Transfer Embryonic Stem Cells, ONCOTARGET, 2017, 第 11 作者
(20) Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, ONCOTARGET, 2017, 第 7 作者
(21) Is Embryonic Hypothermia Tolerance Common in Birds?, BIOLOGY LETTERS, 2017, 
(22) 小鼠孤雄单倍体胚胎干细胞增殖的研究, 中国细胞生物学学报, 2016, 第 4 作者
(23) 小鼠受精卵雌雄原核重编程能力的不对称性, Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes, 科学新闻, 2015, 第 1 作者
(24) 甲状旁腺激素样激素在胚胎发育中的作用, Role of parathyroid hormone-like hormone during embryonic development, 遗传, 2014, 第 4 作者
(25) Roles of Sphingosine-I-Phosphate in Reproduction, REPRODUCTIVE SCIENCES, 2014, 第 11 作者
(26) DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet-Induced Obesity, ENVIRONMENTAL HEALTH PERSPECTIVES, 2014, 第 8 作者
(27) Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes, CELL REPORTS, 2014, 第 11 作者
(28) Maternal Obesity and Diabetes may Cause DNA Methylation Alteration in the Spermatozoa of Offspring in Mice, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2014, 第 4 作者
(29) Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2013, 第 5 作者
(30) Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes, BIOLOGY OF REPRODUCTION, 2013, 第 8 作者
(31) The Outcome of Different Post-Thawed Culture Period in Frozen-Thawed Embryo Transfer Cycle, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2013, 第 7 作者
(32) Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes, BIOLOGY OF REPRODUCTION, 2013, 第 6 作者
(33) The Roles of Parathyroid Hormone-Like Hormone during Mouse Preimplantation Embryonic Development, PLOS ONE, 2012, 第 12 作者
(34) The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation, MOLECULAR HUMAN REPRODUCTION, 2011, 第 5 作者
(35) Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes, FERTILITY AND STERILITY, 2011, 第 5 作者
(36) DNA甲基化和组蛋白修饰在克隆动物发育过程中的作用, Effect of DNA methylation and histone modification during the development of cloned animals, 遗传, 2010, 第 3 作者
(37) The histone demethylase jmjd2c is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development, BIOLOGY OF REPRODUCTION, 2010, 第 5 作者
(38) Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos, JOURNAL OF PROTEOME RESEARCH, 2010, 第 1 作者
(39) Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 第 1 作者
(40) Chapter 10 - Nuclear Transfer in Mouse Oocytes and Embryos, Methods in Enzymology, 2010, 
(41) 哺乳动物的受精, 生物学通报, 2010, 第 1 作者
(42) Effects of ooplasm transfer on paternal genome function in mice, HUMAN REPRODUCTION, 2009, 第 2 作者
(43) Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in Mice, BIOLOGY OF REPRODUCTION, 2009, 第 6 作者
(44) The Unfolded Protein Response Contributes to Preimplantation Mouse Embryo Death in the DDK Syndrome, BIOLOGY OF REPRODUCTION, 2009, 第 4 作者
(45) Role of glucose in cloned mouse embryo development, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 第 1 作者
(46) Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype, BIOLOGY OF REPRODUCTION, 2008, 第 1 作者
(47) The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues, GENE EXPRESSION PATTERNS, 2008, 
(48) Trichostatin a and nuclear reprogramming of cloned rabbit embryos, JOURNAL OF ANIMAL SCIENCE, 2008, 
(49) Trichostatin a (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos, DEVELOPMENTAL DYNAMICS, 2008, 第 7 作者
(50) Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2007, 第 2 作者
(51) Tough beginnings: Alterations in the transcriptome of cloned embryos during the first two cell cycles, DEVELOPMENTAL BIOLOGY, 2007, 
(52) Therapeutic cloning: Status and prospects, CURRENT OPINION IN MOLECULAR THERAPEUTICS, 2007, 
(53) Somatic cell nuclei in cloning: Strangers traveling in a foreign land, Advances in experimental medicine and biology, 2007, 第 3 作者
(54) Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones, DEVELOPMENTAL BIOLOGY, 2006, 
(55) Maternal factors controlling blastomere fragmentation in early mouse embryos, BIOLOGY OF REPRODUCTION, 2005, 
(56) X chromosome reactivation and regulation in cloned embryos, DEVELOPMENTAL BIOLOGY, 2005, 
(57) Differential In Vivo Binding Dynamics of Somatic and Oocyte-specific Linker Histones in Oocytes and During ES Cell Nuclear Transfer, MOLECULAR BIOLOGY OF THE CELL, 2005, 
(58) Maternal Transmission Ratio Distortion at the Mouse Om Locus Results From Meiotic Drive at the Second Meiotic Division, GENETICS, 2005, 
(59) Protease inhibitor MG132 in cloning: no end to the nightmare, TRENDS IN BIOTECHNOLOGY, 2005, 
(60) Recapitulation of the Ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos, BIOLOGY OF REPRODUCTION, 2005, 
(61) 用于克隆的猕猴耳成纤维细胞的培养及其有关生物学特性, Culture and Related Characteristics of Macaque Ear FibroblastsUsed for Cloning, 细胞生物学杂志, 2004, 第 3 作者
(62) Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: Correlation with differences in pronuclear epigenetic modification, BIOLOGY OF REPRODUCTION, 2004, 
(63) Mitochondrial DNA heteroplasmy in calves cloned by using adult somatic cell, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2004, 
(64) In vitro development and mitochondrial fate of macaca-rabbit cloned embryos, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2003, 
(65) Rotation of meiotic spindle is controlled by microfilaments in mouse oocytes, BIOLOGY OF REPRODUCTION, 2003, 
(66) Flow cytometric cell-cycle analysis of cultured fibroblasts from the giant panda, Ailuropoda melanoleuca L, CELL BIOLOGY INTERNATIONAL, 2003, 
(67) 体细胞克隆牛:供体细胞和受体的影响, 科学通报, 2003, 第 3 作者
(68) 兔早期胚胎发育过程中线粒体的位置变化, Translocation of active mitochondria during early development of rabbit embryos, 北京师范大学学报:自然科学版, 2002, 第 1 作者
(69) 哺乳动物体细胞克隆遗传物质的检测, 生物化学与生物物理学报:英文版, 2002, 第 1 作者
(70) Interspecies implantation and mitochondria fate of panda-rabbit cloned embryos, BIOLOGY OF REPRODUCTION, 2002, 
(71) Activation of protein kinase C induces mitogen-activated protein kinase dephosphorylation and pronucleus formation in rat oocytes, BIOLOGY OF REPRODUCTION, 2002, 
(72) 应用激光扫描共聚焦显微镜FRAP技术研究兔早期胚胎发育中细胞间隙连接介导通讯, Gap junctional intercellular communication (GJIC) between rabbit blastomeres as revealed by laser scanning confocal microscopy FRAP, 细胞生物学杂志, 2002, 第 7 作者
(73) Rabbit cloning: Improved fusion rates using cytochalasin B in the fusion buffer, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2002, 
(74) 几种因素对电刺激诱导小鼠卵母细胞孤雌活化的影响, Factors affecting the parthenogenetic activation of mouse oocytes with electrical stimulation, 动物学报, 2002, 第 2 作者
(75) 未经休眠处理的体细胞用于异种核移植(简报), Interspecies nuclear transfer using nonquiescent somatic cell, 实验生物学报, 2002, 第 2 作者
(76) 动物克隆, 生物学通报, 2001, 第 1 作者
(77) Phosphorylation of mitogen-activated protein kinase is regulated by protein kinase C, cyclic 3',5'-adenosine monophosphate, and protein phosphatase modulators during meiosis resumption in rat oocytes, BIOLOGY OF REPRODUCTION, 2001, 
(78) 用于核移植的供体细胞的细胞周期研究, 发育与生殖生物学报:英文版, 2001, 第 1 作者
(79) Viable rabbits derived from reconstructed oocytes by germinal vesicle transfer after intracytoplasmic sperm injection (ICSI), MOLECULAR REPRODUCTION AND DEVELOPMENT, 2001, 
(80) The culture of fibroblasts from diaphragm of giant panda, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2001, 
(81) 连续核移植对异种克隆大熊猫胚胎发育的影响, 科学通报, 2001, 第 4 作者
(82) 微卫星DNA分析证明异种克隆大熊猫重构胚的核来自大熊猫供体, 科学通报, 2000, 第 11 作者
(83) 小鼠精子睾丸后成熟过程中单克隆抗体MSH27抗原表位的 …, 中国科学:C辑, 1999, 第 2 作者
(84) 小鼠精子睾丸后成熟过程中单克隆抗体MSH27抗原表位的显露, 中国科学. C辑, 生命科学, 1999, 第 6 作者
(85) 大熊猫供核体细胞在兔卵胞质中可去分化而支持早期重构胚发育, 中国科学C辑:生命科学, 1999, 第 13 作者
(86) 鸟类的婚配制度, 生物学通报, 1999, 第 1 作者
(87) 小鼠精子在附睾成熟过程中质膜糖蛋白的变化, 动物学报, 1999, 第 1 作者
(88) 非休眠期成年牛耳成纤维细胞用于核移植, 科学通报, 1999, 第 6 作者
(89) 抗精子单克隆抗体6B10的免疫定位及其相应抗原分析, 中国科学:C辑, 1998, 第 5 作者

科研活动

   
科研项目
( 1 ) 着床前胚胎细胞命运决定的表观遗传调控机制研究, 参与, 国家任务, 2022-12--2025-11
( 2 ) 母源Grb10在小鼠早期胚胎发育及胚胎干细胞多能性维持中的作用与机制研究, 负责人, 国家任务, 2020-01--2023-12
( 3 ) 染色体倍性改造干细胞的建立与应用, 参与, 国家任务, 2019-10--2023-12
( 4 ) 植入前胚胎发育的调控网络研究, 参与, 国家任务, 2018-12--2021-12
( 5 ) 小鼠受精卵雄原核中组蛋白修饰相关重编程因子的研究, 负责人, 国家任务, 2016-01--2019-12
( 6 ) PTHLH在小鼠着床前胚胎发育中作用机制的研究, 负责人, 国家任务, 2014-01--2017-12