基本信息
王红艳  女  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: hongyanwang@sibcb.ac.cn
通信地址: 上海徐汇区岳阳路320号生化与细胞所
邮政编码: 200031

研究领域

主要从事巨噬细胞和T细胞调控炎症相关疾病的机制研究,作为通讯或共同通讯作者在
Immunity(2篇)、Nat Neurosci、Nat Microbiol、J Clin Invest、
J Exp Med、EMBO J、EMBO Mol Med、Cell Res、Sci Adv(2篇)、PNAS(2
篇)、Cell Rep(3篇)等期刊上发表约30篇论文。

招生信息

   
招生专业
071009-细胞生物学
100102-免疫学
招生方向
免疫细胞和炎症相关疾病
肿瘤和感染和自身免疫性疾病的免疫应答

教育背景

2003-09--2006-09   Imperial College London, UK   博士

工作经历

   
工作简历
2010-01~现在, 上海生化与细胞所, 研究员
2006-09~2010-01,University of Cambridge, UK, Research Fellow
2001-10~2006-09,Imperial College London, UK, Research Associate
社会兼职
2016-06-29-2020-06-28,JBC编委, 编委
2016-05-29-2020-05-28,Immunology编委, 编委
2013-12-31-今,Cell Biochemistry and Function编委,
2010-12-30-今,中国细胞生物学学报编委,

教授课程

免疫学进展

专利与奖励

   
奖励信息
(1) 中科院优秀研究生指导教师奖, 院级, 2015
(2) 基金委优青, 国家级, 2014
(3) 上海浦江人才计划, 一等奖, 省级, 2011
(4) British Society of Immunology travel grant, 一等奖, 专项, 2009
(5) Keystone meeting travel grant, , 专项, 2008
专利成果
[1] 王红艳, 魏滨, 肖俊, 齐琳琳. 阻断微生物感染、降低胆固醇、防治相关肿瘤的药物及其应用. CN: CN113082208A, 2021-07-09.

[2] 王红艳, 魏滨, 肖俊, 李伟芸. 防治病毒的新型化合物及其应用. CN: CN112691094A, 2021-04-23.

出版信息

   
发表论文
[1] Zheng, Xin, Xiao, Jun, Jiang, Qi, Zheng, Lingming, Liu, Chang, Dong, Chen, Zheng, Yuxiao, Ni, Peili, Zhang, Chi, Zhang, Fang, Zhong, Ruiyue, Ding, Huihua, Wang, Qiong, Qiu, Ying, Gao, Minxia, Ding, Jianping, Shen, Nan, Wei, Bin, Wang, Hongyan. AKT2 reduces IFN beta 1 production to modulate antiviral responses and systemic lupus erythematosus. EMBO JOURNAL[J]. 2022, 41(6): [2] Wanghongyan. Meningeal lymphatic vessels mediate the drainage of virus from the central nervous system and protect against neurotropic virus infection.. NATURE NEUROSCIENCE[J]. 2022, 25(5): 577-587, [3] Ma, Li, Li, Weiyun, Zhang, Yanbo, Qi, Linlin, Zhao, Qi, Li, Na, Lu, Yao, Zhang, Luqing, Zhou, Fei, Wu, Yichun, He, Yongning, Yu, Hongxiu, He, Yulong, Wei, Bin, Wang, Hongyan. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. AUTOPHAGY. 2021, http://dx.doi.org/10.1080/15548627.2021.1985338.
[4] Zhiqi Li, Jun Xiao, Xiaoyan Xu, Weiyun Li, Ruiyue Zhong, Linlin Qi, Jiehui Chen, Guizhong Cui, Shuang Wang, Yuxiao Zheng, Ying Qiu, Sheng Li, Xin Zhou, Yao Lu, Jiaying Lyu, Bin Zhou, Jiawei Zhou, Naihe Jing, Bin Wei, Jin Hu, Hongyan Wang. M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery. Science Advances[J]. 2021, 7(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954455/.
[5] Fang Zhang, Linlin Qi, Qiuyun Feng, Baokai Zhang, Xiangyue Li, Chang Liu, Weiyun Li, Qiaojie Liu, Dan Yang, Yue Yin, Chao Peng, Han Wu, ZhaoHui Tang, Xi Zhou, Zou Xiang, Zhijiang Zhang, Hongyan Wang, Bin Wei. HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis. Proceedings of the National Academy of Sciences of the United States of America[J]. 2021, 118(28): [6] Zhang, Chi, Li, Weiyun, Lei, Xiaobo, Xie, Zhenfei, Qi, Linlin, Wang, Hui, Xiao, Xia, Xiao, Jun, Zheng, Yuxiao, Dong, Chen, Zheng, Xin, Chen, Shiyang, Chen, Jianfeng, Sun, Bing, Qin, Jun, Zhai, Qiwei, Li, Jinsong, Wei, Bin, Wang, Jianwei, Wang, Hongyan. Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity. SCIENCE ADVANCES[J]. 2021, 7(38): http://dx.doi.org/10.1126/sciadv.abb5933.
[7] Xiao, Jun, Li, Weiyun, Zheng, Xin, Qi, Linlin, Wang, Hui, Zhang, Chi, Wan, Xiaopeng, Zheng, Yuxiao, Zhong, Ruiyue, Zhou, Xin, Lu, Yao, Li, Zhiqi, Qiu, Ying, Liu, Chang, Zhang, Fang, Zhang, Yanbo, Xu, Xiaoyan, Yang, Zhongzhou, Chen, Hualan, Zhai, Qiwei, Wei, Bin, Wang, Hongyan. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. IMMUNITY[J]. 2020, 52(1): 109-+, http://dx.doi.org/10.1016/j.immuni.2019.11.015.
[8] Wang, Qiong, Zhou, Xin, Yang, Long, Zhao, Yongjian, Chew, Zhihuan, Xiao, Jun, Liu, Chang, Zheng, Xin, Zheng, Yuxiao, Shi, Qi, Liang, Qianqian, Wang, Yongjun, Wang, Hongyan. The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis (vol 32, 108158-16.e1, 2020). CELL REPORTS[J]. 2020, 33(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000593108100022.
[9] Liu, Chang, Xu, Xiaoyan, Han, Lei, Wan, Xiaopeng, Zheng, Lingming, Li, Chunyang, Liao, Zhaohui, Xiao, Jun, Zhong, Ruiyue, Zheng, Xin, Wang, Qiong, Li, Zonghai, Chen, Hualan, Wei, Bin, Wang, Hongyan. LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(32): 19388-19398, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431024/.
[10] Lu, Yao, Qiu, Ying, Chen, Peng, Chang, Haishuang, Guo, Luqiang, Zhang, Fang, Ma, Li, Zhang, Chi, Zheng, Xin, Xiao, Jun, Zhong, Ruiyue, Han, Lei, Xu, Xiaoyan, Zhang, Yanbo, Li, Dangsheng, Zhong, Guisheng, Boyton, Rosemary, Huang, Ying, He, Yongning, Hu, Ronggui, Wei, Bin, Wang, Hongyan. ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. NATURE MICROBIOLOGY[J]. 2019, 4(12): 2331-2346, http://dx.doi.org/10.1038/s41564-019-0542-2.
[11] Zhou, Xin, Li, Weiyun, Wang, Shuang, Zhang, Panli, Wang, Qiong, Xiao, Jun, Zhang, Chi, Zheng, Xin, Xu, Xiaoyan, Xue, Shengjie, Hui, Lijian, Ji, Hongbin, Wei, Bin, Wang, Hongyan. YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis. CELL REPORTS[J]. 2019, 27(4): 1176-+, http://dx.doi.org/10.1016/j.celrep.2019.03.028.
[12] Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang. Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ. EBioMedicine. 2018, 31: 217-225, http://dx.doi.org/10.1016/j.ebiom.2018.04.023.
[13] Qiong Wang, Xin Zhou, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Yongjun Wang, Hongyan Wang, Qianqian Liang. Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway. Frontiers in Immunology[J]. 2018, 9: https://doaj.org/article/071f6a9aa08947668d8bed2d0368e1e0.
[14] Wang Hongyan. TET3 inhibits IFN-I production independent of DNA demethylation. Cell Reports. 2016, [15] Wang Hongyan. The immune adaptor ADAP regulates reciprocal TGF-1-integrin crosstalk to protect from H5N1 influenza virus infection. PLoS Pathogens. 2015, [16] Li, Chunyang, Li, Weiyun, Xiao, Jun, Jiao, Shaozhuo, Teng, Fei, Xue, Shengjie, Zhang, Chi, Sheng, Chun, Leng, Qibin, Rudd, Christopher E, Wei, Bin, Wang, Hongyan. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8(+) cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO MOLECULAR MEDICINE[J]. 2015, 7(6): 754-769, http://dx.doi.org/10.15252/emmm.201404578.
[17] Wang Hongyan. Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro.. Cell Research. 2015, [18] Huang, Ying, Jiao, Shaozhuo, Tao, Xiaoyan, Tang, Qing, Jiao, Wentao, Xiao, Jun, Xu, Xiaoyan, Zhang, Yanbo, Liang, Guodong, Wang, Hongyan. Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. JOURNAL OF NEUROINFLAMMATION[J]. 2014, 11(1): http://dx.doi.org/10.1186/s12974-014-0146-y.
[19] Wei, Bin, Han, Lei, Abbink, Truus E M, Groppelli, Elisabetta, Lim, Daina, Thaker, Youg Raj, Gao, Wei, Zhai, Rongrong, Wang, Jianhua, Lever, Andrew, Jolly, Clare, Wang, Hongyan, Rudd, Christopher E. Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. RETROVIROLOGY[J]. 2013, 10(1): 101-101, http://dx.doi.org/10.1186/1742-4690-10-101.
[20] Wang Hongyan. Integrin signaling and function in immune cells. Immunology. 2012, [21] Wang Hongyan. Integrin signaling and immunopathology. Seminars in Immunopathology. 2010, [22] Wang Hongyan. SKAP1 is dispensable for chemokine induced T-cell migration. Immunol Letters. 2010, [23] Raab, Monika, Wang, Hongyan, Lu, Yuning, Smith, Xin, Wu, Zhonglin, Strebhardt, Klaus, Ladbury, John E, Rudd, Christopher E. T Cell Receptor "Inside-Out" Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes. IMMUNITY[J]. 2010, 32(4): 541-556, http://dx.doi.org/10.1016/j.immuni.2010.03.007.
[24] Wang, Hongyan, Wei, Bin, Bismuth, Georges, Rudd, Christopher E. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 106(30): 12436-12441, https://www.webofscience.com/wos/woscc/full-record/WOS:000268440200043.
[25] Helga Schneider, Hongyan Wang, Monika Raab, Elke Valk, Xin Smith, Matt Lovatt, Zhonglin Wu, Braudel MaqueiraIglesias, Klaus Strebhardt, Christopher E Rudd. Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.. PLoS ONE[J]. 2008, 3(3): https://doaj.org/article/37259dd77d584d01acbbb8de150e22af.
[26] Wang, Hongyan, Rudd, Christopher E. SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. TRENDS IN CELL BIOLOGYnull. 2008, 18(10): 486-493, http://dx.doi.org/10.1016/j.tcb.2008.07.005.
[27] Silvy da Rocha Dias, Christopher E Rudd, Bin Wei, Hongyan Wang. CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase. American Association of Immunologists. 2007, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902020982859ZK.
[28] Wang, Hongyan, Liu, Hebin, Lu, Yuning, Lovatt, Matt, Wei, Bin, Rudd, Christopher E. Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. MOLECULAR AND CELLULAR BIOLOGY[J]. 2007, 27(19): 6863-6875, https://www.webofscience.com/wos/woscc/full-record/WOS:000249642600024.
[29] Jo, EK, Wang, HY, Rudd, CE. An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2005, 201(11): 1733-1739, https://www.webofscience.com/wos/woscc/full-record/WOS:000229600300006.
[30] Wang Hongyan. ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation.. J. Exp. Med.. 2004, [31] Wang Hongyan. Positive and negative adaptors in T cell signaling. Immunology. 2004, [32] Rudd, CE, Wang, HY. Hematopoietic adaptors in T-cell signaling: Potential applications to transplantation. AMERICAN JOURNAL OF TRANSPLANTATIONnull. 2003, 3(10): 1204-1210, https://www.webofscience.com/wos/woscc/full-record/WOS:000185899900006.
[33] Wang, HY, Moon, EY, Azouz, A, Wu, X, Smith, A, Schneider, H, Hogg, N, Rudd, CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. NATURE IMMUNOLOGY[J]. 2003, 4(4): 366-374, https://www.webofscience.com/wos/woscc/full-record/WOS:000181987700017.
[34] Weiyun Li, Jun Xiao, Xin Zhou, Ming Xu, Chaobo Hu, Xiaoyan Xu, Yao Lu, Chang Liu, Shengjie Xue, Lei Nie, Haibin Zhang, Zhiqi Li, Yanbo Zhang, Fu Ji, Lijian Hui, Wufan Tao, Bin Wei, Hongyan Wang. STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma. The Journal of Clinical Investigation. 125(11): 4239-4254, https://www.webofscience.com/wos/woscc/full-record/WOS:000364110000025.

科研活动

   
科研项目
( 1 ) 免疫细胞粘附迁移、调控炎症及相关疾病的新型信号传导机制, 主持, 国家级, 2015-01--2017-12
( 2 ) 应激条件下细胞可塑性调控, 主持, 部委级, 2017-01--2017-12
( 3 ) VEGF-C/VEGFR-3信号调控调节性T细胞(Treg)和炎症性肠病(IBD)的新机制, 主持, 国家级, 2016-01--2019-12
( 4 ) 动物流感病毒免疫学研究, 主持, 国家级, 2016-07--2020-12
参与会议
(1)T cell integrin signaling regulates infection and multiple sclerosis   第六届海峡两岸免疫学研讨会   2017-03-18
(2)LRCH1 interferes with DOCK8-Cdc42-induced T cell migration andameliorates EAE    2017-02-15
(3)Identification of Stk4 and VEGFR3 in inflammation-related diseases   2016-05-14
(4) Stk4 regulates inflammation-associated liver cancer   2015-12-07
(5)VEGFR-3 and Stk4 in TLR pathways   2015-10-17
(6)ADAP regulates TGF-beta signaling and H5N1 infection   2015-09-07
(7)VEGFR-3 restricts TLR4 signaling and protects from sepsis   2014-04-15

指导学生

已指导学生

张彦波  01  19182  

韩磊  01  19182  

徐晓燕  01  19182  

李春阳  01  19182  

薛晟杰  01  19182  

李伟芸  01  19182  

现指导学生

路瑶  01  19182  

刘畅  01  19182  

肖俊  01  19182  

周欣  01  19182  

张驰  01  19182  

邱颖  01  19182  

王爽  02  19181  

郑新  01  19182