基本信息
吕雪梅  女  博导  中国科学院昆明动物研究所
电子邮件: xuemeilu@mail.kiz.ac.cn
通信地址: 云南省昆明市五华区教场东路32号
邮政编码: 650223

研究领域

复杂性状和肿瘤的进化基因组学

招生信息

博士生、硕士生

招生专业
071022-基因组学
071021-生物信息学
071007-遗传学
招生方向
进化基因组学
肿瘤基因组学
分子进化

教育背景

1997-09--2000-06   中国科学院昆明动物研究所   博士
1994-09--1997-06   华南农业大学   硕士
学历

研究生

学位

博士

工作经历

   
工作简历
2009-06~现在, 中国科学院北京基因组研究所, 研究员
2005-09~2009-05,中山大学, 副教授
2003-09~2005-07,美国芝加哥大学, 博士后
2002-01~2003-07,美国圣地亚哥野生动物协会濒危动物保护研究中心, 研究助理
2000-07~2001-10,中国科学院昆明动物研究所, 助理研究员

教授课程

群体遗传与分子进化
人类基因组学研究-进展与应用
进化生物学
基因组学前沿

专利与奖励

   
专利成果
( 1 ) 用于恶性肿瘤治疗的组合物及其应用, 发明, 2013, 第 5 作者, 专利号: ZL201210046682.0
( 2 ) 筛选肿瘤早期诊断靶标的Small RNA-seq库的构建方法, 发明, 2013, 第 4 作者, 专利号: ZL201210041472.2
( 3 ) 一种字符串匹配的方法及装置, 发明, 2015, 第 2 作者, 专利号: ZL201210013304.2
( 4 ) 以痕量DNA为基础的二代测序文库构建方法, 发明, 2016, 第 4 作者, 专利号: ZL201410158326.7
( 5 ) 测序文库及其制备和应用, 发明, 2017, 第 3 作者, 专利号: ZL201310651462.5

出版信息

   
发表论文
[1] Wang, MingShan, Zhang, JinJin, Guo, Xing, Li, Ming, Meyer, Rachel, Ashari, Hidayat, Zheng, ZhuQing, Wang, Sheng, Peng, MinSheng, Jiang, Yu, Thakur, Mukesh, Suwannapoom, Chatmongkon, Esmailizadeh, Ali, Hirimuthugoda, Nalini Yasoda, Zein, Moch Syamsul Arifin, Kusza, Szilvia, KharratiKoopaee, Hamed, Zeng, Lin, Wang, YunMei, Yin, TingTing, Yang, MinMin, Li, MingLi, Lu, XueMei, Lasagna, Emiliano, Ceccobelli, Simone, Gunwardana, Humpita Gamaralalage Thilini Nisanka, Senasig, Thilina Madusanka, Feng, ShaoHong, Zhang, Hao, Bhuiyan, Abul Kashem Fazlul Haque, Khan, Muhammad Sajjad, Silva, Gamamada Liyanage Lalanie Pradeepa, Le Thi Thuy, Mwai, Okeyo A, Ibrahim, Mohamed Nawaz Mohamed, Zhang, Guojie, Qu, KaiXing, Hanotte, Olivier, Shapiro, Beth, Bosse, Mirte, Wu, DongDong, Han, JianLin, Zhang, YaPing. Large-scale genomic analysis reveals the genetic cost of chicken domestication. BMC BIOLOGY[J]. 2021, 19(1): http://dx.doi.org/10.1186/s12915-021-01052-x.
[2] Chunyan Li, Melisa Olave, Yali Hou, Geng Qin, Ralf F Schneider, Zexia Gao, Xiaolong Tu, Xin Wang, Furong Qi, Alexander Nater, Andreas F Kautt, Shiming Wan, Yanhong Zhang, Yali Liu, Huixian Zhang, Bo Zhang, Hao Zhang, Meng Qu, Shuaishuai Liu, Zeyu Chen, Jia Zhong, He Zhang, Lingfeng Meng, Kai Wang, Jianping Yin, Liangmin Huang, Byrappa Venkatesh, Axel Meyer, Xuemei Lu, Qiang Lin. Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000621232800013.
[3] Tang, Xiaolu, Ying, Ruochen, Yao, Xinmin, Li, Guanghao, Wu, Changcheng, Tang, Yiyuli, Li, Zhida, Kuang, Bishan, Wu, Feng, Chi, Changsheng, Du, Xiaoman, Qin, Yi, Gao, Shenghan, Hu, Songnian, Ma, Juncai, Liu, Tiangang, Pang, Xinghuo, Wang, Jianwei, Zhao, Guoping, Tan, Wenjie, Zhang, Yaping, Lu, Xuemei, Lu, Jian. Evolutionary analysis and lineage designation of SARS-CoV-2 genomes. SCIENCE BULLETIN[J]. 2021, 66(22): 2297-2311, http://dx.doi.org/10.1016/j.scib.2021.02.012.
[4] Li, Tao, Liu, Jialin, Feng, Jing, Liu, Zhenzhen, Liu, Sixue, Zhang, Minjie, Zhang, Yuezheng, Hou, Yali, Wu, Dafei, Li, Chunyan, Chen, Yongbin, Chen, Hua, Lu, Xuemei. Variation in the life history strategy underlies functional diversity of tumors. NATIONAL SCIENCE REVIEW[J]. 2021, 8(2): 27-37, http://lib.cqvip.com/Qikan/Article/Detail?id=7104077534.
[5] Ruan, Yongsen, Luo, Zhida, Tang, Xiaolu, Li, Guanghao, Wen, Haijun, He, Xionglei, Lu, Xuemei, Lu, Jian, Wu, Chung, I. On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all?. NATIONAL SCIENCE REVIEW[J]. 2021, 8(1): http://lib.cqvip.com/Qikan/Article/Detail?id=7103950082.
[6] Ma, Fuqiang, Lu, GuangAn, Chen, Qingjian, Ruan, Yongsen, Li, Xin, Lu, Xuemei, Li, Chunyan. Dynamic global analysis of transcription reveals the role of miRNAs in synergistic stabilization of gene expression. SCIENCE BULLETIN[J]. 2020, 65(24): 2130-2140, http://dx.doi.org/10.1016/j.scib.2020.08.011.
[7] Tao Li, Jialin Liu, Jing Feng, Zhenzhen Liu, Sixue Liu, Minjie Zhang, Yuezheng Zhang, Yali Hou, Dafei Wu, Chunyan Li, Yongbin Chen, Hua Chen, Xuemei Lu. Variation in the life history strategy underlies functional diversity of tumors. National Science Review. 2020, 8(2): [8] Luo, Jing, Chai, Jing, Wen, Yanling, Tao, Min, Lin, Guoliang, Liu, Xiaochuan, Ren, Li, Chen, Zeyu, Wu, Shigang, Li, Shengnan, Wang, Yude, Qin, Qinbo, Wang, Shi, Gao, Yun, Huang, Feng, Wang, Lu, Ai, Cheng, Wang, Xiaobo, Li, Lianwei, Ye, Chengxi, Yang, Huimin, Luo, Mi, Chen, Jie, Hu, Hong, Yuan, Liujiao, Zhong, Li, Wang, Jing, Xu, Jian, Du, Zhenglin, Ma, Zhanshan Sam, Murphy, Robert W, Meyer, Axel, Gui, Jianfang, Xu, Peng, Ruan, Jue, Chen, Z Jeffrey, Liu, Shaojun, Lu, Xuemei, Zhang, Yaping. From asymmetrical to balanced genomic diversification during rediploidization: Subgenomic evolution in allotetraploid fish. SCIENCE ADVANCES[J]. 2020, 6(22): http://dx.doi.org/10.1126/sciadv.aaz7677.
[9] 麻富强, 陆广安, 陈青建, 阮永森, 李欣, 吕雪梅, 李春燕. 通过对基因转录的动态和全局分析揭示miRNAs协同稳定基因表达的作用. 科学通报:英文版. 2020, 65(24): 2130-2140, http://lib.cqvip.com/Qikan/Article/Detail?id=7104014150.
[10] Yin, Liduo, Banerjee, Sharmi, Fan, Jiayi, He, Jianlin, Lu, Xuemei, Xie, Hehuang. Epigenetic regulation of neuronal cell specification inferred with single cell "Omics" data. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2020, 18: 942-952, http://dx.doi.org/10.1016/j.csbj.2020.04.007.
[11] 吕雪梅. The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2, 2020. Science China_Life Sciences. 2020, [12] Liu, Qingyun, Wei, Jianhao, Li, Yawei, Wang, Mei, Su, Jun, Lu, Yonghui, Lopez, Mariana G, Qian, Xueqin, Zhu, Zhaoqin, Wang, Haiying, Gan, Mingyun, Jiang, Qi, Fu, YunXin, Takiff, Howard, Comas, Inaki, Li, Feng, Lu, Xuemei, Fortune, Sarah M, Gao, Qian. Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments. SCIENCE ADVANCES[J]. 2020, 6(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000537238200044.
[13] Hou, Yali, Qi, Furong, Bai, Xue, Ren, Tong, Shen, Xu, Chu, Qin, Zhang, Xiquan, Lu, Xuemei. Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals. BMC GENOMICS[J]. 2020, 21(1): https://doaj.org/article/314610e6c7de4c4bb6f6a174d798387d.
[14] Liu, Sixue, Yang, Zuyu, Li, Guanghao, Li, Chunyan, Luo, Yanting, Gong, Qiang, Wu, Xin, Li, Tao, Zhang, Zhiqian, Xing, Baocai, Xu, Xiaolan, Lu, Xuemei. Multi-omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratumoral Phenotypic Diversity. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2019, 17(6): 576-589, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP167DO3JP1MFR.
[15] Xue Bai, Zhenzhen Liu, Xiaojian Shao, Di Wang, Encheng Dong, Yan Wang, ChungI Wu, Yunfei Yuan, Xuemei Lu, Chunyan Li. The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma.. PLoS ONE[J]. 2019, 14(2): https://doaj.org/article/bfcf09939b094b4b878960136a9ced81.
[16] Zhang, Yuezheng, Li, Yawei, Li, Tao, Shen, Xu, Zhu, Tianqi, Tao, Yong, Li, Xueying, Wang, Di, Ma, Qin, Hu, Zheng, Liu, Jialin, Ruan, Jue, Cai, Jun, Wang, HurngYi, Lu, Xuemei. Genetic Load and Potential Mutational Meltdown in Cancer Cell Populations. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2019, 36(3): 541-552, http://ir.amss.ac.cn/handle/2S8OKBNM/34334, http://www.irgrid.ac.cn/handle/1471x/6869268, http://ir.amss.ac.cn/handle/2S8OKBNM/34335, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000462585100009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[17] Qi, Furong, Yang, Airong, Ambreen, Sadaf, Bai, Xue, Hou, Yali, Lu, Xuemei. Birth and death of Mx genes and the presence/absence of genes regulating Mx transcription are correlated with the diversity of anti-pathogenicity in vertebrate species. MOLECULAR GENETICS AND GENOMICS[J]. 2019, 294(1): 121-133, https://www.webofscience.com/wos/woscc/full-record/WOS:000457456800011.
[18] Yin, Liduo, Luo, Yanting, Xu, Xiguang, Wen, Shiyu, Wu, Xiaowei, Lu, Xuemei, Xie, Hehuang. Virtual methylome dissection facilitated by single-cell analyses. EPIGENETICS & CHROMATIN[J]. 2019, 12(1): http://dx.doi.org/10.1186/s13072-019-0310-9.
[19] Xiang, Ying, Yan, Kai, Zheng, Qian, Ke, Haiqiang, Cheng, Jie, Xiong, Wenjun, Shi, Xin, Wei, Lei, Zhao, Min, Yang, Fei, Wang, Ping, Lu, Xing, Fu, Li, Lu, Xuemei, Li, Feng. Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1. CANCER RESEARCH[J]. 2019, 79(1): 86-98, [20] 吕雪梅. Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1 (LINE-1). Cancer Research. 2019, [21] Li, Juan, Jiang, Lan, Wu, ChungI, Lu, Xuemei, Fang, Shu, Ting, ChauTi. Small Segmental Duplications in DrosophilaHigh Rate of Emergence and Elimination. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 11(2): 486-496, https://www.webofscience.com/wos/woscc/full-record/WOS:000467953500012.
[22] Wang Hurngyi, Chen Yuxin, Tong Ding, Ling Shaoping, Hu Zheng, Tao Yong, Lu Xuemei, Wu Chung I. Is the evolution in tumors Darwinian or non-Darwinian?. 国家科学评论:英文版[J]. 2018, 5(1): 15-17, http://lib.cqvip.com/Qikan/Article/Detail?id=675485904.
[23] Ma, Fuqiang, Lin, Pei, Chen, Qingjian, Lu, Xuemei, Zhang, Yong E, Wu, Chung, I. Direct measurement of pervasive weak repression by microRNAs and their role at the network level. BMC GENOMICS[J]. 2018, 19(1): https://doaj.org/article/96454d5da11940a4a0f9d147c446e69c.
[24] Wang, HurngYi, Chen, Yuxin, Tong, Ding, Ling, Shaoping, Hu, Zheng, Tao, Yong, Lu, Xuemei, Wu, ChungI. Is the evolution in tumors Darwinian or non-Darwinian?. NATIONAL SCIENCE REVIEWnull. 2018, 5(1): 15-17, http://lib.cqvip.com/Qikan/Article/Detail?id=675485904.
[25] Liu, Sixue, Yang, Zuyu, Li, Guanghao, Luo, Yanting, Gong, Qiang, Wu, Xin, Li, Tao, Zhang, Zhiqian, Xing, Baocai, Xu, Xiaolan, Lu, Xuemei. Multi-omics analysis in primary cell cultures reveals the genomic basis of phenotypic diversity within tumors. CANCER RESEARCHnull. 2018, 78(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000468818901278.
[26] Luo, Yanting, He, Jianlin, Xu, Xiguang, Sun, Mingan, Wu, Xiaowei, Lu, Xuemei, Xie, Hehuang. Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells. PLOS COMPUTATIONAL BIOLOGY[J]. 2018, 14(3): https://doaj.org/article/742e328decb843cbb1fb60a92fc9806e.
[27] 吕雪梅. Multi-omics analysis in primary cell cultures reveal the genomic basis of phenotypic diversity within tumor. Genomics, Proteomics & Bioinformatics. 2018, [28] Ye, Wen, Ling, Shaoping, Liu, RanYi, Pan, ZhiZhong, Wang, Gaoyuan, Gao, Shijuan, Wu, Jiangxue, Cao, Lihua, Dong, Lili, Li, Yingchang, Zhou, Yi, Du, Wuying, Meng, Xiangqi, Chen, Jinna, Guan, Xinyuan, He, Yulong, Pan, Changchuan, Zheng, X F Steven, Lu, Xuemei, Chen, Shuai, Huang, Wenlin. Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. JOURNAL OF PATHOLOGY[J]. 2018, 245(2): 222-234, https://www.webofscience.com/wos/woscc/full-record/WOS:000432035600011.
[29] Li, Chunyan, Hou, Yali, Xu, Jin, Zhang, Aiqun, Liu, Zhenzhen, Qi, Furong, Yang, Zuyu, Chen, Ke, Liu, Sixue, Huang, Huanwei, Wang, Qianfei, Dong, Jiahong, Wu, ChungI, Lu, Xuemei. A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(7): 1730-1742, https://www.webofscience.com/wos/woscc/full-record/WOS:000402754400016.
[30] Lin, YouYu, Hsieh, ChiaHung, Chen, JiunHong, Lu, Xuemei, Kao, JiaHorng, Chen, PeiJer, Chen, DingShinn, Wang, HurngYi. De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline. BMC BIOINFORMATICS[J]. 2017, 18(1): http://dx.doi.org/10.1186/s12859-017-1630-z.
[31] Xu, Jin, Peng, Xinxin, Chen, Yuxin, Zhang, Yuezheng, Ma, Qin, Liang, Liang, Carter, Ava C, Lu, Xuemei, Wu, ChungI. Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularit. ELIFE[J]. 2017, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000418225200001.
[32] Kaile Wang, Shujuan Lai, Xiaoxu Yang, Tianqi Zhu, Xuemei Lu, ChungI Wu, Jue Ruan. Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/6fd788ebdd2d4aa9a1ab98de73353467.
[33] Yang, Zuyu, Jia, Mingming, Liu, Guojing, Hao, Huaining, Chen, Li, Li, Guanghao, Liu, Sixue, Li, Yawei, Wu, ChungI, Lu, Xuemei, Wang, Shengdian. Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model. PLOS ONE[J]. 2017, 12(11): https://doaj.org/article/3feae3bf3f434306a27008679c2ae64e.
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[36] Shen, Xu, Bai, Xue, Xu, Jin, Zhou, Min, Xu, Haipin, Nie, Qinghua, Lu, Xuemei, Zhang, Xiquan. Transcriptome sequencing reveals genetic mechanisms underlying the transition between the laying and brooding phases and gene expression changes associated with divergent reproductive phenotypes in chickens. MOLECULAR BIOLOGY REPORTS[J]. 2016, 43(9): 977-989, https://www.webofscience.com/wos/woscc/full-record/WOS:000382144400010.
[37] Wang, Kaile, Ma, Xiaolu, Zhang, Xue, Wu, Dafei, Sun, Chenyi, Sun, Yazhou, Lu, Xuemei, Wu, ChungI, Guo, Caixia, Ruan, Jue. Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000374949400001.
[38] Wu, ChungI, Wang, HurngYi, Ling, Shaoping, Lu, Xuemei, Bonini, NM. The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process. ANNUAL REVIEW OF GENETICS, VOL 50null. 2016, 50: 347-369, https://www.webofscience.com/wos/woscc/full-record/WOS:000389584800016.
[39] Wang, Kaile, Ma, Qin, Jiang, Lan, Lai, Shujuan, Lu, Xuemei, Hou, Yali, Wu, ChungI, Ruan, Jue. Ultra-precise detection of mutations by droplet-based amplification of circularized DNA. BMC GENOMICS[J]. 2016, 17(1): http://www.corc.org.cn/handle/1471x/2374305.
[40] Liu, Shaojun, Luo, Jing, Chai, Jing, Ren, Li, Zhou, Yi, Huang, Feng, Liu, Xiaochuan, Chen, Yubao, Zhang, Chun, Tao, Min, Lu, Bin, Zhou, Wei, Lin, Guoliang, Mai, Chao, Yuan, Shuo, Wang, Jun, Li, Tao, Qin, Qinbo, Feng, Hao, Luo, Kaikun, Xiao, Jun, Zhong, Huan, Zhao, Rurong, Duan, Wei, Song, Zhenyan, Wang, Yanqin, Wang, Jing, Zhong, Li, Wang, Lu, Ding, Zhaoli, Du, Zhenglin, Lu, Xuemei, Gao, Yun, Murphy, Robert W, Liu, Yun, Meyer, Axel, Zhang, YaPing. Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(5): 1327-1332, https://www.webofscience.com/wos/woscc/full-record/WOS:000369085100068.
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[44] Li, Chunyan, Liu, Zhenzhen, Yang, Fang, Liu, Wensheng, Wang, Di, Dong, Encheng, Wang, Yu, Wu, ChungI, Lu, Xuemei. siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells. ONCOTARGET[J]. 2015, 6(25): 21603-21613, https://www.webofscience.com/wos/woscc/full-record/WOS:000360969200070.
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[47] Liu, Guojing, Zhang, Rui, Xu, Jin, Wu, ChungI, Lu, Xuemei. Functional Conservation of Both CDS- and 3'-UTR-Located MicroRNA Binding Sites between Species. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2015, 32(3): 623-628, https://www.webofscience.com/wos/woscc/full-record/WOS:000350908500006.
[48] Shao, Xiaojian, Zhang, Cuiyun, Sun, MingAn, Lu, Xuemei, Xie, Hehuang. Deciphering the heterogeneity in DNA methylation patterns during stem cell differentiation and reprogramming. BMC GENOMICS[J]. 2014, 15(1): http://dx.doi.org/10.1186/1471-2164-15-978.
[49] Cui, Xiaogang, Hou, Yali, Yang, Shaohua, Xie, Yan, Zhang, Shengli, Zhang, Yuan, Zhang, Qin, Lu, Xuemei, Liu, George E, Sun, Dongxiao. Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC GENOMICS[J]. 2014, 15(1): 226-226, http://dx.doi.org/10.1186/1471-2164-15-226.
[50] Zhao, Lei, Sun, Mingan, Li, Zejuan, Bai, Xue, Yu, Miao, Wang, Min, Liang, Liji, Shao, Xiaojian, Arnovitz, Stephen, Wang, Qianfei, He, Chuan, Lu, Xuemei, Chen, Jianjun, Xie, Hehuang. The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation. GENOME RESEARCH[J]. 2014, 24(8): 1296-1307, https://www.webofscience.com/wos/woscc/full-record/WOS:000339860200005.
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[53] Xu, Jin, Zhang, Rui, Shen, Yang, Liu, Guojing, Lu, Xuemei, Wu, ChungI. The evolution of evolvability in microRNA target sites in vertebrates. GENOME RESEARCH[J]. 2013, 23(11): 1810-1816, https://www.webofscience.com/wos/woscc/full-record/WOS:000326642500005.
[54] Gong, Qiang, Tao, Yong, Yang, JianRong, Cai, Jun, Yuan, Yunfei, Ruan, Jue, Yang, Jin, Liu, Hailiang, Li, Wanghua, Lu, Xuemei, Zhuang, ShiMei, Wang, San Ming, Wu, ChungI. Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC GENOMICS[J]. 2013, 14(1): 51-51, http://www.corc.org.cn/handle/1471x/2374295.
[55] Yali Hou, Yachun Wang, Xuemei Lu, Xu Zhang, Qian Zhao, Rory J Todhunter, Zhiwu Zhang. Correction: Monitoring Hip and Elbow Dysplasia Achieved Modest Genetic Improvement of 74 Dog Breeds over 40 Years in USA. PLoS ONE[J]. 2013, 8(10): https://doaj.org/article/6574da6a9e09403e8ec52e0561a1b487.
[56] Chong, Zechen, Zhai, Weiwei, Li, Chunyan, Gao, Min, Gong, Qiang, Ruan, Jue, Li, Juan, Jiang, Lan, Lv, Xuemei, Hungate, Eric, Wu, ChungI. The Evolution of Small Insertions and Deletions in the Coding Genes of Drosophila melanogaster. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2013, 30(12): 2699-2708, https://www.webofscience.com/wos/woscc/full-record/WOS:000327793000015.
[57] Ruan, Jue, Jiang, Lan, Chong, Zechen, Gong, Qiang, Li, Heng, Li, Chunyan, Tao, Yong, Zheng, Caihong, Zhai, Weiwei, Turissini, David, Cannon, Charles H, Lu, Xuemei, Wu, ChungI. Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology. BMC GENOMICS[J]. 2013, 14(711): http://ir.xtbg.org.cn/handle/353005/4786.
[58] Fang, Hongbo, Nie, Linghu, Chi, Zhenfen, Liu, Jing, Guo, Dan, Lu, Xuemei, Hei, Tom K, Balajee, Adayabalam S, Zhao, Yongliang. RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis. PLOS ONE[J]. 2013, 8(7): https://doaj.org/article/dd06aefa62704f38a837eaf5f1054532.
[59] Xu, Jin, Zhang, Rui, Shen, Yang, Liu, Guojing, Lu, Xuemei, Wu, ChungI. The evolution of evolvability in microRNA target sites in vertebrates. GENOME RESEARCH[J]. 2013, 23(11): 1810-1816, https://www.webofscience.com/wos/woscc/full-record/WOS:000326642500005.
[60] 吕雪梅. Sex, sex chromosome and gene expression.. BMC Biology. 2011, [61] Tao, Yong, Ruan, Jue, Yeh, ShiouHwei, Lu, Xuemei, Wang, Yu, Zhai, Weiwei, Cai, Jun, Ling, Shaoping, Gong, Qiang, Chong, Zecheng, Qu, Zhengzhong, Li, Qianqian, Liu, Jiang, Yang, Jin, Zheng, Caihong, Zeng, Changqing, Wang, HurngYi, Zhang, Jing, Wang, ShengHan, Hao, Lingtong, Dong, Lili, Li, Wenjie, Sun, Min, Zou, Wei, Yu, Caixia, Li, Chaohua, Liu, Guojing, Jiang, Lan, Xu, Jin, Huang, Huanwei, Li, Chunyan, Mi, Shuangli, Zhang, Bing, Chen, Baoxian, Zhao, Wenming, Hu, Songnian, Zhuang, ShiMei, Shen, Yang, Shi, Suhua, Brown, Christopher, White, Kevin P, Chen, DingShinn, Chen, PeiJer, Wu, ChungI. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(29): 12042-12047, http://dx.doi.org/10.1073/pnas.1108715108.
[62] He, Ziwen, Zhai, Weiwei, Wen, Haijun, Tang, Tian, Wang, Yu, Lu, Xuemei, Greenberg, Anthony J, Hudson, Richard R, Wu, ChungI, Shi, Suhua. Two Evolutionary Histories in the Genome of Rice: the Roles of Domestication Genes. PLOS GENETICS[J]. 2011, 7(6): https://doaj.org/article/d4f0bb0cb767414abcaff1aa2ea67b20.
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科研活动

   
科研项目
( 1 ) 结合人工诱变和全基因组测序建立复杂性状新型研究模型, 主持, 国家级, 2011-01--2013-12
( 2 ) 肿瘤的个体化RNA干扰治疗, 参与, 国家级, 2012-01--2015-12
( 3 ) 细胞群体的适应性进化规律和进化关键基因的识别, 主持, 国家级, 2012-01--2015-12
( 4 ) 在模式系统中研究复杂性状演化和稳定性的网络调控, 主持, 部委级, 2014-06--2019-05
( 5 ) 肿瘤生长、迁移及其进化驱动力的群体基因组学解析, 主持, 国家级, 2016-01--2018-12
( 6 ) DNA甲基化对高原适应的调控作用, 主持, 部委级, 2017-05--2018-06
( 7 ) 肿瘤细胞群体适应性权衡的生态进化机制, 主持, 国家级, 2018-01--2021-12
( 8 ) 2017年度基因组学、干细胞、组织再生学术研讨会, 主持, 国家级, 2017-08--2017-12
参与会议
(1)Rapid generation of copy number variation may lead to very high mutation load in cancer cell population   2017-08-28
(2)Evolution of cancer cell populations   吕雪梅   2016-04-25
(3)肿瘤内部和之间异质性的演化及其医学意义   2016肿瘤异质性学术研讨会   凌少平、杨芳、杨祖玉、吕雪梅、吴仲义   2016-04-22
(4)细胞分化过程中DNA 甲基化的变异度和保真性的时空动态变化   2015中国遗传学学会大会   赵磊、吕雪梅、谢荷煌等   2015-08-14
(5)Genetic diversity and evolutionary forces within and between tumors    第十二届国际生物信息学论坛(IBW2015)   吕雪梅   2015-07-09
(6)Genetic diversity and evolutionary forces within and between HCC tumors   Xuemei Lu   2015-01-13
(7)r- and K-selection revisited with free-living mammalian cells   Jialin Liu, Tao Li, Yuezheng Zhang   2014-10-08

指导学生

已指导学生

刘珍珍  硕士研究生  085238-生物工程  

戚甫荣  硕士研究生  085211-计算机技术  

张翠云  硕士研究生  071021-生物信息学  

任通  硕士研究生  0710Z1-基因组学  

邓强  硕士研究生  085211-计算机技术  

吴欣  硕士研究生  085238-生物工程  

李雪凝  硕士研究生  085238-生物工程  

现指导学生

李涛  博士研究生  0710Z1-基因组学  

李亚威  博士研究生  071007-遗传学  

罗燕婷  博士研究生  0710J3-生物信息学  

戚甫荣  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

胡振宇  硕士研究生  0710Z1-基因组学  

殷利夺  博士研究生  0710Z1-基因组学  

魏昀旸  硕士研究生  0710Z1-基因组学  

夏瑞燕  硕士研究生  0710Z1-基因组学  

钱雨   博士研究生  0710Z1-基因组学  

冯璥  博士研究生  0710Z1-基因组学