基本信息
慈维敏  女  博导  中国科学院北京基因组研究所
电子邮件: ciwm@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101

研究领域

基因组学

招生信息

   
招生专业
0710Z1-基因组学
招生方向
肿瘤表观基因组学
生物信息学
表观遗传学

教育背景

1999-09--2004-07   中科院生物物理研究所   博士
1995-09--1999-07   北京师范大学   学士

工作经历

   
工作简历
2014-01~2014-06,中国科学院北京基因组研究所, 研究员
2009-08~2013-12,中国科学院北京基因组研究所, 副研究员
2008-03~2009-08,Weill Cornell Medicine College, 博士后
2004-10~2008-03,Albert Einstein College of Medicine, 博士后

教授课程

表观遗传学
精准医学概论
组学当代话题
Omics
表观基因组学
人类基因组学研究-进展与应用
生物适应和基因组变异
基因组学

专利与奖励

   
专利成果
( 1 ) 一种石蜡DNA提纯方法及其在基因组学中的应用, 发明, 2019, 第 2 作者, 专利号: 201510818823.X
( 2 ) 维生素C衍生物在制备抗肿瘤产品中的应用, 发明, 2019, 第 1 作者, 专利号: 201710141994.2
( 3 ) 一种cfDNA分类方法、装置和用途,慈维敏, 实用新型, 2019, 第 1 作者, 专利号: 201910374094.1
( 4 ) 一种尿沉渣基因组DNA的分类方法、装置和用途, 实用新型, 2019, 第 1 作者, 专利号: 201911088433.6

出版信息

   
发表论文
[1] Han, Yang, Li, Xinxin, Zhang, Mingxin, Yang, Yang, Ge, Guangzhe, Wang, Kunxiang, Gong, Yanqing, Liang, Yuan, Niu, Haitao, Ci, Weimin. Enhanced Detection of Genitourinary Cancers Using Fragmentation and Copy Number Profiles Obtained from Urinary Cell-Free DNA. CLINICAL CHEMISTRY[J]. 2021, 67(2): 394-403, https://www.webofscience.com/wos/woscc/full-record/WOS:000614680300010.
[2] Ma, Qin, Wang, Jilu, Qi, Jie, Peng, Ding, Guan, Bao, Zhang, Jianye, Li, Zhongwu, Zhang, Hongxian, Li, Ting, Shi, Yue, Li, Xuesong, Zhou, Liqun, Chen, Ke, Ci, Weimin. Increased chromosomal instability characterizes metastatic renal cell carcinoma. TRANSLATIONAL ONCOLOGY[J]. 2021, 14(1): https://doaj.org/article/3367bb42b11a4f0abf3594d983b546d2.
[3] Guan, Bao, Liang, Yuan, Lu, Huan, Xu, Zhengzheng, Shi, Yue, Li, Juan, Kong, Wenwen, Tian, Chuanyu, Tan, Yezhen, Gong, Yanqing, Liu, Jin, Fang, Dong, Shen, Qi, He, Shiming, Shakeel, Muhammad, Zhang, Zhongyuan, He, Qun, Li, Xuesong, Ci, Weimin, Zhou, Liqun. Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 9: http://dx.doi.org/10.3389/fcell.2021.713499.
[4] Ci Weimin. The RNA N6-methyladenosine methyltransferase METTL3 promotes the progression of kidney cancer via m6A-dependent translational enhancement of ABCD1. Frontiers in Cell and Developmental Biology. 2021, [5] Wu, Zeming, Shi, Yue, Lu, Mingming, Song, Moshi, Yu, Zihui, Wang, Jilu, Wang, Si, Ren, Jie, Yang, YunGui, Liu, GuangHui, Zhang, Weiqi, Ci, Weimin, Qu, Jing. METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(19): 11083-11096, https://www.webofscience.com/wos/woscc/full-record/WOS:000606018400039.
[6] Lu, Huan, Liang, Yuan, Guan, Bao, Shi, Yue, Gong, Yanqing, Li, Juan, Kong, Wenwen, Liu, Jin, Fang, Dong, Liu, Libo, He, Qun, Shakeel, Muhammad, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma. THERANOSTICS[J]. 2020, 10(10): 4323-4333, https://www.webofscience.com/wos/woscc/full-record/WOS:000522665800003.
[7] Ci Weimin. Detection of urothelial carcinoma based on copy number profiles of urinary cell-free DNA using shallow whole-genome sequencing. Clinical Chemistry. 2020, [8] Xu, Zhengzheng, Ge, Guangzhe, Guan, Bao, Lei, Zhentao, Hao, Xueyu, Zhou, Yuanyuan, Shi, Yue, Lu, Huan, Wang, Jilu, Peng, Ding, Wu, XiKang, He, Huiying, Zhang, Bao, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles. EUROPEAN UROLOGYnull. 2020, 77(2): 288-290, http://dx.doi.org/10.1016/j.eururo.2019.11.006.
[9] Ge, Guangzhe, Peng, Ding, Xu, Ziying, Guan, Bao, Xin, Zijuan, He, Qun, Zhou, Yuanyuan, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth. EMBO REPORTS[J]. 2018, 19(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000440648700003.
[10] Peng, Ding, Ge, Guangzhe, Gong, Yanqing, Zhan, Yonghao, He, Shiming, Guan, Bao, Li, Yifan, Xu, Ziying, Hao, Han, He, Zhisong, Xiong, Gengyan, Zhang, Cuijian, Shi, Yue, Zhou, Yuanyuan, Ci, Weimin, Li, Xuesong, Zhou, Liqun. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. CLINICAL EPIGENETICS[J]. 2018, 10(1): https://doaj.org/article/96a52fee9a7147ddb66e2c71cd2d2163.
[11] Peng, Ding, Ge, Guangzhe, Xu, Zhengzheng, Ma, Qin, Shi, Yue, Zhou, Yuanyuan, Gong, Yanqing, Xiong, Gengyan, Zhang, Cuijian, He, Shiming, He, Zhisong, Li, Xuesong, Ci, Weimin, Zhou, Liqun. Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation. EPIGENOMICS[J]. 2018, 10(9): 1189-1199, https://www.webofscience.com/wos/woscc/full-record/WOS:000445188400005.
[12] Valls, Ester, Lobry, Camille, Geng, Huimin, Wang, Ling, Cardenas, Mariano, Rivas, Martin, Cerchietti, Leandro, Oh, Philmo, Yang, Shao Ning, Oswald, Erin, Graham, Camille W, Jiang, Yanwen, Hatzi, Katerina, Agirre, Xabier, Perkey, Eric, Li, Zhuoning, Tam, Wayne, Bhatt, Kamala, Leonard, John P, ZweidlerMcKay, Patrick A, Maillard, Ivan, Elemento, Olivier, Ci, Weimin, Aifantis, Iannis, Melnick, Ari. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. CANCER DISCOVERY[J]. 2017, 7(5): 506-521, https://www.webofscience.com/wos/woscc/full-record/WOS:000400269300022.
[13] Ma, Qin, Lu, Huan, Xu, Ziying, Zhou, Yuanyuan, Ci, Weimin. Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation. EPIGENETICS[J]. 2017, 12(8): 708-714, https://www.webofscience.com/wos/woscc/full-record/WOS:000414572900011.
[14] Chen, Ke, Zhang, Jing, Guo, Zhongqiang, Ma, Qin, Xu, Zhengzheng, Zhou, Yuanyuan, Xu, Ziying, Li, Zhongwu, Liu, Yiqiang, Ye, Xiongjun, Li, Xuesong, Yuan, Bifeng, Ke, Yuwen, He, Chuan, Zhou, Liqun, Liu, Jiang, Ci, Weimin. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. CELL RESEARCH[J]. 2016, 26(1): 103-118, https://www.webofscience.com/wos/woscc/full-record/WOS:000367615200010.
[15] Ci, Weimin, Liu, Jiang. Programming and Inheritance of Parental DNA Methylomes in Vertebrates. PHYSIOLOGYnull. 2015, 30(1): 63-68, https://www.webofscience.com/wos/woscc/full-record/WOS:000347306100009.
[16] Li, Guoqiang, Ci, Weimin, Karmakar, Subhradip, Chen, Ke, Dhar, Ruby, Fan, Zhixiang, Guo, Zhongqiang, Zhang, Jing, Ke, Yuwen, Wang, Lu, Zhuang, Min, Hu, Shengdi, Li, Xuesong, Zhou, Liqun, Li, Xianghong, Calabrese, Matthew F, Watson, Edmond R, Prasad, Sandip M, RinkerSchaeffer, Carrie, Eggener, Scott E, Stricker, Thomas, Tian, Yong, Schulman, Brenda A, Liu, Jiang, White, Kevin P. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer. CANCER CELL[J]. 2014, 25(4): 455-468, http://dx.doi.org/10.1016/j.ccr.2014.02.007.
[17] Jiang, Lan, Zhang, Jing, Wang, JingJing, Wang, Lu, Zhang, Li, Li, Guoqiang, Yang, Xiaodan, Ma, Xin, Sun, Xin, Cai, Jun, Zhang, Jun, Huang, Xingxu, Yu, Miao, Wang, Xuegeng, Liu, Feng, Wu, ChungI, He, Chuan, Zhang, Bo, Ci, Weimin, Liu, Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. CELL[J]. 2013, 153(4): 773-784, http://dx.doi.org/10.1016/j.cell.2013.04.041.
[18] Ci, Weimin, Polo, Jose M, Cerchietti, Leandro, Shaknovich, Rita, Wang, Ling, Yang, Shao Ning, Ye, Kenny, Farinha, Pedro, Horsman, Douglas E, Gascoyne, Randy D, Elemento, Olivier, Melnick, Ari. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. BLOOD[J]. 2009, 113(22): 5536-5548, https://www.webofscience.com/wos/woscc/full-record/WOS:000266634700045.
[19] Polo, Jose M, Ci, Weimin, Licht, Jonathan D, Melnick, Ari. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells. BLOOD[J]. 2008, 112(3): 644-651, https://www.webofscience.com/wos/woscc/full-record/WOS:000258257900031.
[20] Ci, Weimin, Polo, Jose M, Melnick, Ari. B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. CURRENT OPINION IN HEMATOLOGY[J]. 2008, 15(4): 381-390, https://www.webofscience.com/wos/woscc/full-record/WOS:000257379600016.
[21] Weimin Ci, Wenyu Li, Ya Ke, Zhong-Ming Qian, Xun Shen. Intracellular Ca 2+ regulates the cellular iron uptake in K562 cells. Cell Calcium. 2003, 33(4): 257-266, http://dx.doi.org/10.1016/S0143-4160(02)00240-3.

科研活动

   
科研项目
( 1 ) 生命科学领域优秀青年科技专项, 主持, 部委级, 2011-01--2013-12
( 2 ) 自然科学基金面上项目, 主持, 国家级, 2012-01--2015-12
( 3 ) 肿瘤转移过程中基因突变和表观遗传变异协同性进化的规律, 主持, 国家级, 2013-05--2015-12
( 4 ) DNA甲基化/去甲基化重编程在泌尿系统上皮细胞分化、恶性转化、侵袭转移中的作用机理研究, 主持, 国家级, 2016-01--2016-12
( 5 ) 肿瘤表观基因组学, 主持, 国家级, 2015-01--2017-12
( 6 ) 肿瘤转移模式和表观遗传驱动力的识别, 主持, 部委级, 2016-08--2020-12
( 7 ) 中国女性患者上尿路上皮癌复发的多基因机制研究, 主持, 国家级, 2017-01--2020-12
( 8 ) 表观基因组学检测技术研发与临床应用, 参与, 国家级, 2016-07--2018-12
( 9 ) 恶性肿瘤的基因组演化和精准医学研究, 参与, 部委级, 2016-01--2018-12
( 10 ) 王宽诚率先人才计划“卢嘉锡国际团队项目”, 主持, 部委级, 2018-01--2020-12
( 11 ) 器官再生机制及调控研究, 主持, 部委级, 2017-12--2022-12
( 12 ) 增龄相关健康减损的生物学标志物研究, 主持, 国家级, 2018-12--2022-12
参与会议
(1)Large scale genomic aberrations characterize metastatic renal cell carcinoma evolution   2018-11-01
(2)人类衰老干细胞m6A表观转录组重编程图谱和生物学功能   衰老生物学分会成立大会   2018-09-12
(3)尿路上皮癌的基因组特征及潜在治疗靶点   2018全国微创泌尿外科年会(18th)   2018-05-12
(4)SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer   Guoqiang Li#, Weimin Ci#, Subhradip Karmakar#, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman,    2015-11-10
(5)A “survival of the Fittest” mechanism for weeding out potentially lymphomagenic B-cells during germinal center B-cell differentiation   第49界美国血液学年会   Ci, W. Polo, J.M. Ranuncolo, S.M. Melnick, A.    2007-12-08

指导学生

已指导学生

许争争  硕士研究生  085238-生物工程  

郝雪玉  硕士研究生  0710Z1-基因组学  

马琴  博士研究生  071007-遗传学  

徐子瑛  博士研究生  0710J3-生物信息学  

葛广哲  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

现指导学生

许争争  博士研究生  0710Z1-基因组学  

鲁欢  博士研究生  0710Z1-基因组学  

齐杰  博士研究生  0710Z1-基因组学  

樊健  博士研究生  0710Z1-基因组学  

王基陆  博士研究生  0710Z1-基因组学  

田创宇  硕士研究生  0710Z1-基因组学  

孔雯雯  硕士研究生  0710Z1-基因组学  

于子惠  博士研究生  0710Z1-基因组学  

谭耶真  硕士研究生  0710Z1-基因组学  

张琪  硕士研究生  0710Z1-基因组学  

邹道嘉  硕士研究生  1001Z1-精准医学  

韩漾  博士研究生  0710J3-生物信息学  

李娟  博士研究生  0710J3-生物信息学