基本信息
汪迎春  男  博导  中国科学院遗传与发育生物学研究所
email: ycwang@genetics.ac.cn
address: 北京市北辰西路1号院2号
postalCode: 100101

招生信息

   
招生专业
0710J3-生物信息学
071009-细胞生物学
086000-生物与医药
招生方向
蛋白质组学
细胞迁移
生物信息学

教育背景

1998-07--2003-07   Iowa State University   博士
1994-09--1997-08   中国科学院遗传研究所   硕士
1990-09--1994-06   兰州大学   学士

工作经历

   
工作简历
1998-07~2003-07,Iowa State University, 博士
1994-09~1997-08,中国科学院遗传研究所, 硕士
1990-09~1994-06,兰州大学, 学士
社会兼职
2018-05-01-2025-10-15,中国生物化学与分子生物学会蛋白质组学专业委员会委员, 委员

教授课程

蛋白质组学
多维组学
医学蛋白质组学
蛋白质组学系列讲座
信号转导

出版信息

   
发表论文
(1) Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus, Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus, MOLECULAR PLANT, 2021, 第 20 作者
(2) Slr0320 Is Crucial for Optimal Function of Photosystem II during High Light Acclimation in Synechocystis sp. PCC 6803, LIFE-BASEL, 2021, 第 4 作者
(3) Post-translational Modifications of Serine/Threonine and Histidine Kinases and Their Roles in Signal Transductions in Synechocystis Sp. PCC 6803, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2021, 通讯作者
(4) A Systematic Survey of the Light/Dark-dependent Protein Degradation Events in a Model Cyanobacterium, Molecular & Cellular Proteomics, 2021, 
(5) Metabolomic Changes in the Cerebellum Indicate Activation of Hypothalamocerebellar Connections Driven by Hunger Responses., J Gerontol A Biol Sci Med Sci, 2021, 第 1 作者
(6) Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications, SCIENCE CHINA-LIFE SCIENCES, 2021, 其他(合作组作者)
(7) Plant Phosphopeptides Enrichment by Immobilized Metal Ion Affinity Chromatography, Methods Mol Biol, 2021, 通讯作者
(8) A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules, BLOOD, 2021, 第 9 作者
(9) ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins, PLANT CELL, 2021, 第 13 作者
(10) Slr0320 is Crucial for Optimal Function of Photosystem II during High Light Acclimation in Synechocystis sp. PCC 6803, Life, 2021, 
(11) The Effects of Graded Levels of Calorie Restriction: XVI. Metabolomic Changes in the Cerebellum Indicate Activation of Hypothalamocerebellar Connections Driven by Hunger Responses, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2021, 第 5 作者
(12) Synergistic interplay of ABA and BR signal in regulating plant growth and adaptation, NATURE PLANTS, 2021, 第 13 作者
(13) The Quantitative Proteome Atlas of a Model Cyanobacterium, Journal of Genetics and Genomics, 2021, 通讯作者
(14) Structure and activity of SLAC1 channels for stomatal signaling in leaves, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 13 作者
(15) RNA Kinase CLP1/Cbc Regulates Meiosis Initiation in Spermatogenesis, Hum Mol Genet, 2021, 
(16) A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19, NATURE METABOLISM, 2021, 第 24 作者
(17) The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2020, 第 4 作者
(18) Evaluation of the Potential Risk of Advanced Peak Determination in Distorting Isobaric Labeling-Based Single-Shot Proteome Quantitation, PROTEOMICS, 2020, 通讯作者
(19) The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2020, 第 6 作者
(20) Integration of ovular signals and exocytosis of a Ca2+ channel by MLOs in pollen tube guidance, NATURE PLANTS, 2020, 第 4 作者
(21) CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 10 作者
(22) CDK4/6 regulate lysosome biogenesis through TFEB/TFE3, JOURNAL OF CELL BIOLOGY, 2020, 第11作者
(23) NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level, SCIENCE ADVANCES, 2020, 第 9 作者
(24) A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions, A Kinase–Phosphatase–Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root–Hypocotyl Junctions, MOLECULAR PLANT, 2020, 第 7 作者
(25) Control of Grain Size and Weight by the GSK2-LARGE1/OML4 Pathway in Rice, PLANT CELL, 2020, 第 14 作者
(26) An unreported NB-LRR protein SUT1 is required for the autoimmune response mediated by type one protein phosphatase 4 mutation (topp4-1) in Arabidopsis, PLANT JOURNAL, 2019, 第 10 作者
(27) Sequences, Domain Architectures, and Biological Functions of the Serine/Threonine and Histidine Kinases in Synechocystis sp. PCC 6803, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2019, 通讯作者
(28) mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ, mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ, 分子植物:英文版, 2019, 第 8 作者
(29) Tyrosine nitration of human ERK1 introduces an intra-hydrogen bond by molecular dynamics simulations, STRUCTURAL CHEMISTRY, 2019, 通讯作者
(30) Nitrate-NRT1.1B-SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants, NATURE PLANTS, 2019, 第 18 作者
(31) mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ, MOLECULAR PLANT, 2019, 第 8 作者
(32) The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2019, 第 5 作者
(33) Ca 2+ -stimulated AMPK-dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection, MOLECULAR CELL, 2019, 第 8 作者
(34) Nitration-induced ubiquitination and degradation control quality of ERK1, BIOCHEMICAL JOURNAL, 2019, 通讯作者
(35) Extensive protein S -nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis, CELL DEATH & DISEASE, 2019, 第 9 作者
(36) Overdosage of Balanced Protein Complexes Reduces Proliferation Rate in Aneuploid Cells, CELL SYSTEMS, 2019, 第 8 作者
(37) 大规模膜蛋白质组鉴定技术进展, Advances of the technologies in large-scale membrane proteome identification, 遗传, 2019, 第 5 作者
(38) The beta 5 subunit is essential for intact 26S proteasome assembly to specifically promote plant autotrophic growth under salt stress, NEW PHYTOLOGIST, 2019, 第 7 作者
(39) Phosphorylation of serine/arginine-rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia, CANCER SCIENCE, 2018, 第 7 作者
(40) Activation of the Oxidative Pentose Phosphate Pathway is Critical for Photomixotrophic Growth of a hik33-Deletion Mutant of Synechocystis sp PCC 6803, PROTEOMICS, 2018, 通讯作者
(41) PPAR gamma maintains the metabolic heterogeneity and homeostasis of renal tubules, EBIOMEDICINE, 2018, 第 7 作者
(42) Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture., PLoS ONE, 2018, 第11作者
(43) cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 15 作者
(44) BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis, PLANT PHYSIOLOGY, 2018, 
(45) The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2018, 第 4 作者
(46) Systematic identification of light-regulated cold-responsive proteome in a model cyanobacterium, JOURNAL OF PROTEOMICS, 2018, 通讯作者
(47) BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis, NATURE COMMUNICATIONS, 2018, 第 10 作者
(48) Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism, EMBO JOURNAL, 2018, 第 7 作者
(49) Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish, DEVELOPMENT, 2017, 第 9 作者
(50) Translating Divergent Environmental Stresses into a Common Proteome Response through the Histidine Kinase 33 (Hik33) in a Model Cyanobacterium *, Molecular & Cellular Proteomics : MCP, 2017, 
(51) Ubiquitination of non-lysine residues in the retroviral integrase, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 第 3 作者
(52) Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light- Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803, Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light- Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803, 分子植物:英文版, 2017, 第 9 作者
(53) The effects of graded levels of calorie restriction: VIII. Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse, ONCOTARGET, 2017, 第 7 作者
(54) The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome, AGING-US, 2017, 第 5 作者
(55) Trophic Mode-Dependent Proteomic Analysis Reveals Functional Significance of Light-Independent Chlorophyll Synthesis in Synechocystis sp. PCC 6803, MOLECULAR PLANT, 2017, 通讯作者
(56) Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory, ELIFE, 2017, 第 10 作者
(57) The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice, AGING CELL, 2017, 第 4 作者
(58) A Light Harvesting Complex-Like Protein in Maintenance of Photosynthetic Components in Chlamydomonas, PLANT PHYSIOLOGY, 2017, 其他(合作组作者)
(59) Translating Divergent Environmental Stresses into a Common Proteome Response through the Histidine Kinase 33 (Hik33) in a Model Cyanobacterium *, MOLECULAR & CELLULAR PROTEOMICS, 2017, 通讯作者
(60) Bidirectional factors impact the migration of nk cells to draining lymph node in aged mice during influenza virus infection, EXPERIMENTAL GERONTOLOGY, 2017, 第 8 作者
(61) Quantitative profiling of spreading-coupled protein tyrosine phosphorylation in migratory cells, SCIENTIFIC REPORTS, 2016, 通讯作者
(62) The calponin family member chdp-1 interacts with rac/ced-10 to promote cell protrusions, PLOS GENETICS, 2016, 第 5 作者
(63) SCF SAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana, NATURE COMMUNICATIONS, 2016, 第 6 作者
(64) A receptor heteromer mediates the male perception of female attractants in plants, NATURE, 2016, 第 7 作者
(65) The proteome and phosphoproteome of maize pollen uncovers fertility candidate proteins, PLANT MOLECULAR BIOLOGY, 2016, 第 6 作者
(66) Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics, JOURNAL OF PROTEOMICS, 2016, 第 4 作者
(67) Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis, PLoS Biology, 2016, 第11作者
(68) Protein kinase C controls lysosome biogenesis independently of mTORC1, NATURE CELL BIOLOGY, 2016, 第 17 作者
(69) Mea6 Controls VLDL Transport Through the Coordinated Regulation of COPII Assembly, CELL RESEARCH, 2016, 其他(合作组作者)
(70) Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3, PLoS Biology, 2016, 第 10 作者
(71) Large-scale comparative phosphoprotein analysis of maize seedling leaves during greening, PLANTA, 2016, 第 8 作者
(72) The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics, DEVELOPMENTAL CELL, 2016, 第 7 作者
(73) The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways, AGING-US, 2016, 第 6 作者
(74) The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks, AGING-US, 2016, 第 4 作者
(75) The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse, ONCOTARGET, 2016, 第 6 作者
(76) The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction, SCIENTIFIC REPORTS, 2015, 第 8 作者
(77) The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse, ONCOTARGET, 2015, 第 8 作者
(78) Site-Specific Nitrosoproteomic Identification of Endogenously S-Nitrosylated Proteins in Arabidopsis, PLANT PHYSIOLOGY, 2015, 第 7 作者
(79) Protomer Roles in Chloroplast Chaperonin Assembly and Function, Protomer Roles in Chloroplast Chaperonin Assembly and Function, 分子植物:英文版, 2015, 第 8 作者
(80) Protomer Roles in Chloroplast Chaperonin Assembly and Function, MOLECULAR PLANT, 2015, 第 8 作者
(81) Toward the complete proteome of Synechocystis sp PCC 6803, PHOTOSYNTHESIS RESEARCH, 2015, 通讯作者
(82) The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse, ONCOTARGET, 2015, 第 13 作者
(83) The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice, ONCOTARGET, 2015, 第 9 作者
(84) Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin, HUMAN MOLECULAR GENETICS, 2015, 其他(合作组作者)
(85) Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Proteins (PMPs), MOLECULAR & CELLULAR PROTEOMICS, 2015, 通讯作者
(86) Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Protein, Mol Cell Proteomics, 2015, 通讯作者
(87) Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis sp. PCC 6803, MOLECULAR & CELLULAR PROTEOMICS, 2014, 第 9 作者
(88) Functional Proteomic Discovery of Slr0110 as a Central Regulator of Carbohydrate Metabolism in Synechocystis Species PCC6803, MOLECULAR & CELLULAR PROTEOMICS, 2014, 通讯作者
(89) Evaluation of empirical rule of linearly correlated peptide selection (ERLPS) for proteotypic peptide-based quantitative proteomics, PROTEOMICS, 2014, 第 5 作者
(90) Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA, CELL METABOLISM, 2014, 
(91) The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity, CELL HOST & MICROBE, 2014, 第 10 作者
(92) Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in Caenorhabditis elegans, PLOS GENETICS, 2013, 第 13 作者
(93) Phosphorylation-Coupled Proteolysis of the Transcription Factor MYC2 Is Important for Jasmonate-Signaled Plant Immunity, PLOS GENETICS, 2013, 第 8 作者
(94) Proteomics method for identification of pseudopodium phosphotyrosine proteins, Methods Mol. Biol, 2012, 第 1 作者
(95) KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer, CANCER RESEARCH, 2012, 第 10 作者
(96) Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 1 作者
(97) Mutational Analysis of Photosystem I of Synechocystis sp. PCC 6803: The Role of Four Conserved Aromatic Residues in the j -helix of PsaB, PLOS ONE, 2011, 第 2 作者
(98) Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells, PROTEOMICS, 2011, 
(99) Spatial Phosphoprotein Profiling Reveals a Compartmentalized ERK Switch Governing Neurite Growth and Retraction, J. Biol. Chem, 2011, 第 1 作者
(100) Structures of PHR Domains from Mus musculus Phr1 (Mycbp2) Explain the Loss-of-Function Mutation (Gly1092 → Glu) of the C. elegans Ortholog RPM-1, JOURNAL OF MOLECULAR BIOLOGY, 2010, 第 8 作者
(101) Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression, Proceedings of the National Academy of Sciences of the United States of America, 2010, 
(102) Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation, PLOS ONE, 2010, 第 10 作者
(103) Identification and bioinformatic analysis of the thylakoid membrane proteome of Synechocystis sp. PCC6803, Proteome Science, 2009, 通讯作者
(104) Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid induced chemotaxis using Dual-step 18O Labeling Coupled with Immobilized Metal Affinity Chromatography, J Proteome Res, 2008, 第 1 作者
(105) Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 第 2 作者
(106) PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets, MOLECULAR & CELLULAR PROTEOMICS, 2008, 第 1 作者
(107) Profiling signaling polarity in chemotactic cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 
(108) Biochemical Purification of Pseudopodia from Migratory Cells, Methods Mol Biol, 2007, 第 1 作者
(109) Methods for Pseudopodia Purification and Proteomics Analysis, Sci STKE, 2007, 第 1 作者
(110) Computational methods for comparison of large genomic and proteomic datasets reveals protein markers of metastatic cancer, J Proteome Res, 2006, 第 1 作者
(111) 花药特异嵌合启动子的构建及雄性不育转基因拟南芥的获得, 农业生物技术学报, 2001, 第 3 作者
(112) Thermodynamics of electron transfer in oxygenic photosynthetic reaction center: a photoacoustic study revealed a similarity to bacterial reaction centers on electron transfer in photosystem I in both volume change and entropy, Biochemistry, 2001, 第 1 作者
(113) Proteins of the cyanobacterial photosystem I, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2001, 
(114) Proteomic study of the peripheral proteins from thylakoid membranes of the cyanobacterium Synechocystis sp PCC 6803, ELECTROPHORESIS, 2000, 
(115) 植物花药花粉特异性基因的调控序列, 生物工程进展, 2000, 第 2 作者
(116) TA29—Barnase基因导致抗虫转基因欧洲黑杨雄性不育的研究, 林业科学, 2000, 第 2 作者
(117) 高粱细胞质雄性不育与HSC70mRNA的关系, 科学通报, 1998, 第 4 作者
(118) 嵌合启动子调控Barnase基因花药特异性表达的研究, 1997, 第 1 作者

科研活动

   
科研项目
( 1 ) 干细胞三维培养与自我更新调控网络的研究, 参与, 国家任务, 2011-01--2015-12
( 2 ) 植物表观遗传调控及其在重要发育过程中的作用机制及结构基础研究, 负责人, 国家任务, 2012-01--2016-08
( 3 ) 脊椎动物第四胚层发育的调控, 参与, 中国科学院计划, 2013-01--2015-12
( 4 ) 诺和诺德长城教授奖, 负责人, 其他任务, 2009-08--2012-08
( 5 ) 集胞藻膜蛋白地图集的构建, 负责人, 国家任务, 2017-01--2021-12
( 6 ) 以家犬为模型解析社交与情感的生物学基础, 参与, 国家任务, 2020-01--2024-12
( 7 ) 新型核糖核酸修饰鉴定和代谢及其对脑与胚胎发育的调控, 参与, 国家任务, 2020-01--2024-12
参与会议
(1)A systematic survey of the light-regulated protein degradation events in a model cyanobacterium    第十一届中国蛋白质组学大会   Weiyang Chen   2021-10-13
(2)A systematic survey of the light-regulated protein degradation events in a model cyanobacterium    2021全国光合作用学术研讨会   Weiyang Chen   2021-10-08