基本信息
胡国宏 男 博导 中国科学院上海营养与健康研究所
email: ghhu@sibs.ac.cn
address: 上海岳阳路320号生命科学实验大楼A1503
postalCode: 200031
email: ghhu@sibs.ac.cn
address: 上海岳阳路320号生命科学实验大楼A1503
postalCode: 200031
招生信息
招生专业
071009-细胞生物学100104-病理学与病理生理学086000-生物与医药
招生方向
细胞生物学-肿瘤转移与微环境调控病理学与病理生理学-肿瘤转移与微环境调控生物与医药-肿瘤转移与微环境调控
教育背景
2000-09--2005-05 Rutgers University 分子遗传学博士1996-09--2000-07 清华大学 生物科学与技术系学士
工作经历
工作简历
2009-08~现在, 中国科学院上海营养与健康研究所, 副所长/研究员/研究组长2005-08~2009-08,Princeton University, 博士后/Associate Research Scholar2000-09~2005-05,Rutgers University, 分子遗传学博士1996-09~2000-07,清华大学, 生物科学与技术系学士
教授课程
文献导读
专利与奖励
奖励信息
(1) 中国科学院优秀导师奖, 院级, 2019(2) 中国侨界创新人才贡献奖, 部委级, 2014(3) 明治生命科学奖, 部委级, 2013
专利成果
( 1 ) 组织蛋白酶C 抑制剂在治疗肿瘤转移中的应用, 2020, 第 1 作者, 专利号: 202010955820.1( 2 ) Methods of identifying and treating poor-prognosis cancers, 2019, 第 2 作者, 专利号: US 10,202605 B2( 3 ) 一种抑制肿瘤转移及骨肿瘤的多肽及其应用, 2019, 第 1 作者, 专利号: 201910044856.1( 4 ) 转移性乳腺癌标记物及其在诊断和治疗中的应用, 2017, 第 1 作者, 专利号: 201710283739.1( 5 ) JNK and TGFβ 抑制剂的联用, 2017, 第 1 作者, 专利号: 201710283740.4( 6 ) Method for high-throughput gene expression profile analysis. , 2009, 第 2 作者, 专利号: US 2010/0297622 A1( 7 ) Methods of identifying and treating poor-prognosis cancers., 2008, 第 2 作者, 专利号: 12/215,998
出版信息
发表论文
(1) MTSS1 suppresses expansion and activity of mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination, Nat Cancer, 2020, 通讯作者(2) SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, Nat Commun, 2020, 通讯作者(3) Cathepsin C Promotes Breast Cancer Lung Metastasis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation, Cancer Cell, 2020, 通讯作者(4) Cancer and Microenvironment plasticity: double-edged swords in metastasis, Trends Pharmacol Sci, 2019, 通讯作者(5) Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1, Nat Cell Biol, 2017, 通讯作者(6) A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity, Cell Death Dis, 2017, 通讯作者(7) The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis, Oncogene, 2017, 通讯作者(8) The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis, Oncogene, 2016, 通讯作者(9) MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells, Nat Commun, 2016, 通讯作者(10) Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer, Cancer Research, 2015, 通讯作者(11) Roles of miR-182 in sensory organ development and cancer, Thoracic Cancer, 2015, 通讯作者(12) Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis, Oncogene, 2014, 通讯作者(13) DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis, J Clin Invest, 2014, 通讯作者(14) Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort, PLoS One, 2014, 通讯作者(15) Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis., Cancer Research, 2014, 第 2 作者(16) The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL in breast cancer, J Biol Chem, 2013, 通讯作者(17) Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis, Cell Research, 2012, 通讯作者(18) Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis, J Biol Chem, 2012, 通讯作者(19) Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region., BMC Genomics, 2011, 第 4 作者(20) PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenyl porphine (TPP) for photodynamic therapy, Advanced Functional Materials, 2011, 第 1 作者(21) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization, Nature Medicine, 2011, 第 4 作者(22) MTDH: An emerging key regulator of malignant progression in multiple cancers, Thoracic Cancer, 2011, 通讯作者(23) PEGylated Composite Nanoparticles Containing Upconverting phosphors and meso-tetraphenyl porphine (TPP) for Photodynamic Therapy., Advanced Functional Materials, 2011, 第 3 作者(24) In Vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer., Cancer Research, 2010, 第 4 作者(25) MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer, Cancer Cell, 2009, 第 1 作者(26) The multifaceted role of MTDH/AEG-1 in cancer progression., Clinical Cancer Research, 2009, 第 1 作者(27) From breast to the brain: unraveling the puzzle of metastasis organotropism., J Mol Cell Biol, 2009, 第 1 作者(28) Metadherin as a link between metastasis and chemoresistance., Cell Cycle, 2009, 第 2 作者(29) ADAMTS1 and MMP1 proteolytically engage EGF-like growth factors in an osteolytic paracrine signaling cascade to promote breast cancer bone metastasis., Genes and Development, 2009, 第 3 作者(30) Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression., BMC Genomics, 2008, 通讯作者(31) A highly sensitive and specific system for large-scale gene expression profiling, BMC Genomics, 2008, 第 1 作者(32) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. , J Biol Chem., 2008, 第 3 作者(33) AccuTyping: New algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays, Nucleic Acids Research, 2006, 第 1 作者(34) Determination of haplotype organization of human IGHV region on single chromosomes by multiplex PCR and microarray analysis of single sperm. , Genes and Immunity, 2005, 第 3 作者(35) Production of poly-3-hydroxybutyrate by Bacillus sp. JMa5 cultivated in molasses media., Antonie Van Leeuwenhoek, 2001, 第 3 作者
发表著作
( 1 ) 新研究:基因沉默, Gene Silencing: New Research, Nova Science Publishers, 2006-01, 第 1 作者Biomarker Studies in Early Detection and Prognosis of Breast Cancer, Springer, 2017-01, 第 3 作者
科研活动
科研项目
( 1 ) 表观遗传在肺癌转移中的作用及机制, 负责人, 国家任务, 2011-01--2012-08( 2 ) microRNA在乳腺癌远处转移过程中的作用和机制, 负责人, 国家任务, 2011-01--2013-12( 3 ) 乳腺癌转移的表观遗传调控, 负责人, 地方任务, 2010-01--2012-12( 4 ) 中国科学院上海生命科学院****(自筹)项目, 负责人, 中国科学院计划, 2009-09--2011-12( 5 ) WNT信号介导的肿瘤微环境调控在乳腺癌器官特异性转移中的作用和机制, 负责人, 国家任务, 2015-01--2019-12( 6 ) 乳腺癌骨转移靶向药物的成药性研究, 负责人, 地方任务, 2014-07--2017-09( 7 ) CST6在乳腺癌骨转移中的作用机制研究, 负责人, 国家任务, 2014-01--2017-12( 8 ) 乳腺癌转移过程中癌细胞休眠及苏醒的调控机制, 负责人, 中国科学院计划, 2016-08--2020-12( 9 ) 三阴型乳腺癌化疗耐受机制和靶向药物筛选, 负责人, 国家任务, 2016-10--2019-09( 10 ) 乳腺癌转移与肿瘤微环境, 负责人, 国家任务, 2018-01--2022-12( 11 ) 组织干细胞突变的形成和演化规律研究, 参与, 国家任务, 2017-07--2021-12( 12 ) 组织蛋白酶C(CTSC)在乳腺癌肺转移微环境调控中的作用与机制, 负责人, 国家任务, 2019-01--2022-12( 13 ) 乳腺癌转移微环境调控机制研究, 负责人, 地方任务, 2019-05--2022-04( 14 ) 骨巨细胞瘤中组蛋白突变的功能与机制研究, 负责人, 地方任务, 2020-05--2022-06( 15 ) 微环境对乳腺(癌)干细胞上皮间质相互转换的调控, 负责人, 国家任务, 2020-10--2024-12
参与会议
(1)Regulation of breast metastasis organotropism 2018-08-01(2)he Role of Small RhoGTPase Inhibitor DLC1 in Breast Cancer Bone Metastasis 2016-08-10