长期致力于维吾尔医常用药材的物质基础及作用机理研究，以期在通过现代技术手段在一定程度上解决维吾尔医药现代化过程中出现的物质基础不清、作用机理不明的问题。

   

070303-有机化学
100701-药物化学

民族药学
天然产物化学

2004-09--2008-07 中国科学院兰州化学物理研究所 理学博士
1988-09--1992-07 新疆大学 理学学士

-- 研究生

-- 博士

   

2002-03--今 中国科学院新疆理化技术研究所 高级工程师、副研究员、研究员
1994-04--2002-03 中国科学院新疆化学研究所 助工，工程师，高级工程师
1992-08--1994-04 中国科学院新疆分院毛发公司 技术员，助工

2015-01-01-2017-12-31,中国医药导报, 编委

   

（1） 以毛菊苣为示范的民族药药效物质与标准化关键技术 及其应用, 一等奖, 省级, 2018
（2） 第十四届新疆维吾尔自治区优秀论文奖, 二等奖, 省级, 2016
（3） 18种新疆特色药用植物化学成分与生物活性研究, 一等奖, 省级, 2015
（4） 鹰嘴豆功能因子研究与开发, 二等奖, 省级, 2013
（5） 石榴皮多酚泡腾片的研制, 三等奖, 省级, 2011
（6） 第十一届自治区优秀论文奖, 二等奖, 省级, 2010
（7） 维吾尔药化学样品资源库, 二等奖, 省级, 2008
（8） 鹰嘴豆化学成分的研究及营养产品, 二等奖, 省级, 2007

[1] 信学雷, 胡苗, 马依努尔·拜克力, 诺莫诺夫·索迪克, 买迪娜, 阿吉艾克拜尔·艾萨. 一种帚枝香青正丁醇提取物的用途. CN: CN112156120A, 2021-01-01.

[2] 信学雷, 胡苗, 马依努尔·拜克力, 诺莫诺夫·索迪克, 买迪娜, 阿吉艾克拜尔·艾萨. 一种凤尾蓍乙酸乙酯提取物的用途. CN: CN112121072A, 2020-12-25.

[3] 阿吉艾克拜尔·艾萨, 李颖, 帕孜莱提·艾尼瓦尔, 臧登, 信学雷, 希尔艾力. 生物碱香草木宁碱和大叶桉亭在制备治疗白癜风的药物中的用途. CN: CN111956648A, 2020-11-20.

[4] 陈丽, 信学雷, 阿吉艾克拜尔·艾萨. 一种预防和治疗酒精性肝损伤的中药复方制剂及其制备方法和用途. CN: CN111821343A, 2020-10-27.

[5] 阿吉艾克拜尔·艾萨, 李泽慧, 买吾兰江·买提努尔, 罗玉琴, 信学雷. 一种小裂叶荆芥精油和石榴皮有效组分组合物的用途. CN: CN110755477A, 2020-02-07.

[6] 阿吉艾克拜尔·艾萨, 刘晓燕, 罗玉琴, 贺飞, 信学雷, 彭军, 吴涛. 一种具有人醛糖还原酶抑制剂作用的复方制剂的制备方法和用途. CN: CN110721259A, 2020-01-24.

[7] 信学雷, 彭军, 刘晓燕, 贺飞, 阿吉艾克拜尔·艾萨. 一种罗布麻叶多酚的用途. CN: CN110693928A, 2020-01-17.

[8] 信学雷, 崔靖雪, 段晓梅, 阿吉艾克拜尔·艾萨. 一种大籽蒿有效部位的制备方法及其用途. CN: CN110496145A, 2019-11-26.

[9] 阿吉艾克拜尔·艾萨, 祖力皮牙·买买提, 阿不拉江·图拉克, 信学雷. 驱虫斑鸠菊中分离的倍半萜类化合物在制备治疗白癜风的药物中的用途. CN: CN109939106A, 2019-06-28.

[10] 李俊, 阿布杜巴克耶夫·萨德尔别克, 赵海清, 信学雷, 阿吉艾克拜尔·艾萨. 一种荜茇酰胺类生物碱的降糖用途. CN: CN109381462A, 2019-02-26.

[11] 李俊, 阿布杜巴克耶夫·萨德尔别克, 赵海清, 信学雷, 阿吉艾克拜尔·艾萨. 一种荜茇酰胺生物碱的降糖用途. CN: CN109350614A, 2019-02-19.

[12] 阿吉艾克拜尔·艾萨, 黎凌楠, 杨义, 吴桂荣, 信学雷. 一种羟基红花黄色素A的制备方法. CN: CN108395420A, 2018-08-14.

[13] 阿吉艾克拜尔·艾萨, 胡蕊, 高洁, 信学雷. 一种假白榄烷型二萜内酯及制备方法和用途. CN: CN107805238A, 2018-03-16.

[14] 阿吉艾克拜尔·艾萨, 信学雷, 刘喜喜. 瘤果黑种草籽中的酯类化合物及其制备方法和用途. CN: CN107353205A, 2017-11-17.

[15] 信学雷, 武鹤婷, 赛那瓦尔·芒思尔, 阿吉艾克拜尔·艾萨. 一种具有明确谱效关系的红花提取物的用途. CN: CN105920071A, 2016-09-07.

[16] 阿吉艾克拜尔·艾萨, 郭丹, 邹国安, 信学雷. 一种骆驼刺花瓣乙酸乙酯部位的用途. CN: CN105832810A, 2016-08-10.

[17] 阿吉艾克拜尔·艾萨, 蒋岚, 努拉耶夫·玉素甫, 买迪娜, 叶建平, 米热古丽·牙森, 信学雷, 诺莫诺夫·索迪克. 一种治疗糖尿病的复方金鹳草药物及其制备方法. CN: CN105560313A, 2016-05-11.

[18] 阿吉艾克拜尔·艾萨, 李浩榕, 吐鲁洪·卡地尔, 刘永强, 信学雷, 努尔阿米乃·麦麦提. 驱虫斑鸠菊酚酸部位的制备方法及抗炎用途. CN: CN104825518A, 2015-08-12.

[19] 阿吉艾克拜尔·艾萨, 李浩榕, 阿不拉江·图拉克, 买迪娜, 信学雷, 祖力皮牙·买买提. 驱虫斑鸠菊酚酸部位的制备方法及用途. CN: CN104825519A, 2015-08-12.

[20] 汤丹, 赵永昕, 信学雷, 阿吉艾克拜尔·艾萨. 一种石榴花多酚的抗炎用途. CN: CN104825504A, 2015-08-12.

[21] 信学雷, 萨拉麦提·艾迪热斯, 艾级买力汗·艾比布拉, 谢连珍, 阿吉艾克拜尔·艾萨. 红花籽粕降糖有效部位的制备方法及其用途. CN: CN104706702A, 2015-06-17.

[22] 信学雷, 谢连珍, 陈其宾, 阿吉艾克拜尔·艾萨. 一种瘤果黑种草籽乙酸乙酯部位的用途. CN: CN104688843A, 2015-06-10.

[23] 阿吉艾克拜尔·艾萨, 汤丹, 谢连珍, 信学雷. 榅桲子提取物的制备方法及降糖用途. CN: CN104623002A, 2015-05-20.

[24] 阿吉艾克拜尔·艾萨, 刘丛丛, 信学雷, 窦君. 一种鹰嘴豆豆芽提取物的抗炎用途. CN: CN104547002A, 2015-04-29.

[25] 阿吉艾克拜尔·艾萨, 李勋, 信学雷, 谢连珍. 阿尔泰独尾草降血糖有效部位的制备方法及其用途. CN: CN104491322A, 2015-04-08.

[26] 阿吉艾克拜尔·艾萨, 高洁, 信学雷. 粗根大戟中分离的大环二萜类化合物及多药耐药逆转用途. CN: CN104292186A, 2015-01-21.

[27] 信学雷, 阿吉艾克拜尔·艾萨, 蒋岚, 叶建平. 一种菊苣酸的药物用途. CN: CN103877071A, 2014-06-25.

[28] 阿吉艾克拜尔·艾萨, 肖嘉琪, 信学雷, 谢连珍. 异翅独尾草降糖有效部位的制备方法及其用途. CN: CN103599334A, 2014-02-26.

[29] 阿吉艾克拜尔·艾萨, 陈其宾, 信学雷. 瘤果黑种草籽中的生物碱组分及其制备方法和用途. CN: CN103288826A, 2013-09-11.

[30] 信学雷, 阿吉艾克拜尔·艾萨, 陈其宾. 瘤果黑种草籽中具有骨架类型Ⅰ和Ⅱ生物碱的用途. CN: CN103285000A, 2013-09-11.

[31] 信学雷, 阿吉艾克拜尔·艾萨. 一种红花籽粕提取物的降糖用途. CN: CN103271968A, 2013-09-04.

[32] 信学雷, 陈其宾, 阿吉艾克拜尔·艾萨. 瘤果黑种草籽中具有骨架类型2的生物碱及其制备方法. CN: CN103102305A, 2013-05-15.

[33] 信学雷, 陈其宾, 阿吉艾克拜尔·艾萨. 瘤果黑种草籽中具有骨架类型1的生物碱及其制备方法. CN: CN103086967A, 2013-05-08.

[34] 阿吉艾克拜尔·艾萨, 哈及尼沙, 信学雷, 赵海清, 米热古丽·亚森. 榅桲果实降血糖有效部位的制备方法及其用途. CN: CN102451251A, 2012-05-16.

[35] 阿吉艾克拜尔·艾萨, 张尧, 信学雷. 一种多靶点起效的菊苣降糖有效部位的制备方法及用途. CN: CN102406683A, 2012-04-11.

[36] 信学雷, 张尧, 阿吉艾克拜尔·艾萨, 杨义, 巴杭. 一种山莴苣素和山莴苣苦素的制备方法. CN: CN102351824A, 2012-02-15.

[37] 阿吉艾克拜尔·艾萨, 信学雷, 赵海清, 吴涛, 杨伟俊, 张尧. 菊苣降糖有效部位的制备方法及其用途. CN: CN102078356A, 2011-06-01.

[38] 信学雷, 阿吉艾克拜尔·艾萨, 阿布力米提·伊力, 吴汉夔. 瘤果黑种草籽油的药物用途. CN: CN101129497B, 2010-08-04.

[39] 阿吉艾克拜尔·艾萨, 吕辉, 牟新利, 信学雷. 沙生蜡菊总皂甙在制备药物中的应用. CN: CN1947737B, 2010-04-21.

[40] 阿吉艾克拜尔·艾萨, 信学雷, 杨 义. 异苯并呋喃酮类化合物的制备方法. CN: CN101323605A, 2008-12-17.

[41] 阿吉艾克拜尔·艾萨, 吕俏莹, 阿布力米提·伊力, 程 珍, 高艳华, 马庆玲, 信学雷, 徐家林. 一种鹰嘴豆豆芽汁及制备方法和用途. CN: CN101238909A, 2008-08-13.

[42] 阿吉尔克拜尔·艾萨, 程 珍, 阿不力米提·伊力, 信学雷, 马庆玲, 高艳华. 鹰嘴豆胚芽和豆芽有效部位及其制备方法和应用. CN: CN101199581A, 2008-06-18.

[43] 阿吉艾克拜尔·艾萨, 吴汉夔, 信学雷, 阿不力米提·伊力, 巴杭. 菊苣籽有效部位及其制备方法和用途. CN: CN101167776A, 2008-04-30.

[44] 信学雷, 阿吉艾克拜尔·艾萨. 常春藤皂苷元及其制备方法和用途. CN: CN101125880A, 2008-02-20.

[45] 阿吉艾克拜尔·艾萨, 信学雷, 李勇猛. 山窝苣素及其制备方法和用途. CN: CN101099566A, 2008-01-09.

[46] 信学雷, 李维琪, 陈志慧, 刘云英, 麦迪娜, 张云峰. 用基因靶标筛选具有降低血脂中胆固醇组分的方法. CN: CN1238523C, 2006-01-25.

[47] 信学雷, 李维琪, 张云峰, 杨向明, 刘敏. 大蒜中提取蒜氨酸的方法. CN: CN1412317A, 2003-04-23.

   

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[17] 李茜, 信学雷, 阿吉艾克拜尔艾萨. 洋甘菊总黄酮提取工艺研究. 中华中医药杂志[J]. 2021, 36(4): 2342-2344, http://lib.cqvip.com/Qikan/Article/Detail?id=7104589746.
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[19] 王乾毅, 信学雷, 卢崇道. 三氟甲磺酸铜催化二取代烯酮与吡咯的傅克酰基化反应. 化学世界[J]. 2021, 62(8): 459-465, http://lib.cqvip.com/Qikan/Article/Detail?id=7105442678.
[20] Chen, J, Nuerxiati, R, Yili, A, Mirzaakhmedov, Sh Ya, Aisa, H A, Xin, X. Chemical Properties and Antioxidant Activity of Polysaccharides from Orchis mascula. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2021, 57(6): 996-999, http://dx.doi.org/10.1007/s10600-021-03536-2.
[21] Tuohongerbieke, Amanguli, Li, Jun, Sabir, Gulnar, Xin, Xuelei, Hu, Miao, Duan, Xiaomei, Liu, Liu, Tang, Dan, Zhu, Jun, Aisa, Haji Akber. Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities. PHYTOCHEMISTRY[J]. 2021, 184(4): http://dx.doi.org/10.1016/j.phytochem.2020.112648.
[22] Ma, Ye, Li, Jun, Tong, Fei, Xin, XueLei, Aisa, Haji Akber. Optimization of microwave-assisted extraction using response surface methodology and the potential anti-diabetic efficacy of Nigella glandulifera Freyn determined using the spectrum-effect relationship. INDUSTRIAL CROPS AND PRODUCTS[J]. 2020, 153(10): http://dx.doi.org/10.1016/j.indcrop.2020.112592.
[23] Cui, J, Nuermaimaiti, M, Zou, G, Xin, X. Chemical Composition of Artemisia sieversiana. CHEMISTRYOFNATURALCOMPOUNDS[J]. 2020, 56(6): 1120-1121, https://doi.org/10.1007/s10600-020-03241-6.
[24] Li Chen, Liu Liu, Rahima Abdulla, Xirali Tursun, Xuelei Xin, Haji Akber Aisa. Chemical Components and Hepatoprotective Mechanism of Xwak Granule in Mice Treated with Acute Alcohol. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2020, 2020(9): https://doaj.org/article/216f5be386bf4a4cbcb21a26829837ba.
[25] Haji Akber Aisa, Xuelei Xin, Dan Tang. Chemical constituents and their pharmacological activities of plants from Cichorium genus. 中草药:英文版[J]. 2020, 224-236, http://lib.cqvip.com/Qikan/Article/Detail?id=7103319986.
[26] Li, Qian, Zhao, Shengjun, Lu, Jun, Kang, Xiaolong, Zhang, Gang, Zhao, Feicui, Nie, Jihong, Yang, Xiaomi, Xin, Xuelei, Zhang, Hongping, Aisa, Haji Akber. Quantitative proteomics analysis of the treatment of asthma rats with total flavonoid extract from chamomile. BIOTECHNOLOGY LETTERS[J]. 2020, 42(6): 905-916, https://www.webofscience.com/wos/woscc/full-record/WOS:000516065700002.
[27] 武鹤婷, 赛那瓦尔芒思尔, 高彦华, 信学雷, 宁慧霞. 红花降糖活性成分谱效关系研究. 天然产物研究与开发[J]. 2020, 33(2): 188-197+255, http://lib.cqvip.com/Qikan/Article/Detail?id=7103985293.
[28] Wang, Guoping, Yalikun, Nuerbiya, Mamat, Xamxikamar, Li, Yongtao, Hu, Xun, Wang, Ping, Xin, Xuelei, Hu, Guangzhi. Highly Sensitive Electrochemical Sensor for the Detection of Chloramphenicol Based on Biomass Derived Porous Carbon. SCIENCE OF ADVANCED MATERIALS[J]. 2020, 12(3): 376-382, http://ir.xjipc.cas.cn/handle/365002/7179, http://www.irgrid.ac.cn/handle/1471x/6897254, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000495050800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[29] 田华, 信学雷, 郭芳, 阿吉艾克拜尔艾萨. 红花籽粕不同极性部位体外抗氧化活性研究. 职业与健康[J]. 2019, 35(2): 185-188+192, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2019&filename=ZYJK201902011&v=MTg2MDRaYkc0SDlqTXJZOUVaWVI4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjd1ZlkrZHJGeURrVUx2SVB6VEI=.
[30] Talifu, Ainiwaer, Saimaiti, Refuhati, Maitinuer, Yusufu, Liu, Geyu, Abudureyimu, Miernisha, Xin, Xuelei. Multiomics analysis profile acute liver injury module clusters to compare the therapeutic efficacy of bifendate and muaddil sapra. SCIENTIFIC REPORTS[J]. 2019, 9(1): http://ir.xjipc.cas.cn/handle/365002/5709.
[31] Toshmatov, Zokir O, Li, Jun, Eshbakova, Komila A, Tang, Dan, Xin, Xuelei, Aisa, Haji Akber. New monoterpene glucosides from Dracocephalum komarovi and their anti-inflammatory activity. PHYTOCHEMISTRY LETTERS[J]. 2019, 33: 102-105, http://dx.doi.org/10.1016/j.phytol.2019.08.005.
[32] Liu, Xixi, Aisa, Haji Akber, Xin, Xuelei. A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity. NATURAL PRODUCT RESEARCH[J]. 2019, 33(4): 472-476, https://www.webofscience.com/wos/woscc/full-record/WOS:000465153400003.
[33] Dan Tang, Liu Liu, Dildar Ajiakber, Jianping Ye, Jianjun Xu, Xuelei Xin, Haji Akber Aisa. Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways. FRONTIERS IN ENDOCRINOLOGY[J]. 2018, 9: https://doaj.org/article/d0d59578974a42b29dde977703682bc3.
[34] Liu, Liu, Yasen, Mireguli, Tang, Dan, Ye, Jianping, Aisa, Haji Akber, Xin, Xuelei. Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway. BIOMEDICINE & PHARMACOTHERAPY[J]. 2018, 100(4): 29-35, http://dx.doi.org/10.1016/j.biopha.2018.01.143.
[35] 信学雷. The pomegranate peel extract ameliorates inflammation via Akt/GSK-3β and NF-κB pathway in LPS-induced RAW 264.7 cells. Res. J. Biotech. 2018, [36] Edirs, Salamet, Jiang, Lan, Xin, XueLei, Aisa, Haji Akber. Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells. JOURNAL OF PHARMACOLOGICAL SCIENCES[J]. 2018, 137(2): 212-219, http://dx.doi.org/10.1016/j.jphs.2018.06.011.
[37] Chen, QiBin, Gao, Jie, Zou, GuoAn, Xin, XueLei, Aisa, Haji Akber. Piperidine Alkaloids with Diverse Skeletons from Anacyclus pyrethrum. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(6): 1474-1482, https://doi.org/10.1021/acs.jnatprod.8b00239.
[38] Chen, QiBin, Xin, XueLei, Aisa, Haji Akber. Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity. PHYTOCHEMISTRY LETTERS[J]. 2017, 19(3): 168-171, http://dx.doi.org/10.1016/j.phytol.2016.12.024.
[39] Tang, Dan, Chen, QiBin, Xin, XueLei, Aisa, HajiAkber. Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway. BIOMEDICINE & PHARMACOTHERAPY[J]. 2017, 87: 145-152, http://dx.doi.org/10.1016/j.biopha.2016.12.058.
[40] Edirs, Salamet, Turak, Ablajan, Numonov, Sodik, Xin, Xuelei, Aisa, Haji Akber. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2017, 2017: https://doaj.org/article/d517b1243cd64996ac83c17e93a45d17.
[41] Liu Liu, Tang Dan, Zhao Haiqing, Xin Xuelei, Aisa Haji Akber. Hypoglycemic effect of the polyphenols rich extract from Rose rugosa Thunb on high fat diet and STZ induced diabetic rats. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2017, [42] Liu, Liu, Tang, Dan, Zhao, Haiqing, Xin, Xuelei, Aisa, Haji Akber. Hypoglycemic effect of the polyphenols rich extract from Rose rugosa Thunb on high fat diet and STZ induced diabetic rats. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2017, 200(3): 174-181, http://ir.xjipc.cas.cn/handle/365002/4777.
[43] 信学雷. A new fatty acid ester from Nigella sativa var.hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity. Natural Product Research. 2017, [44] 谢连珍, 肖佳琪, 李勋, 信学雷, 阿吉艾克拜尔艾萨. 阿尔泰独尾草和异翅独尾草提取物PTP1B抑制作用及动力学研究. 天然产物研究与开发[J]. 2017, 29(1): 1-6, http://www.irgrid.ac.cn/handle/1471x/1178300.
[45] 萨拉麦提·艾迪热斯, 武鹤婷, 阿不拉江·图拉克, 田华, 信学雷, 阿吉艾克拜尔·艾萨. 红花籽粕降糖有效部位的纯化工艺. 中国医药导报[J]. 2016, 13(21): 16-20, http://lib.cqvip.com/Qikan/Article/Detail?id=669641446.
[46] 张晓翠, 汤丹, 窦君, 张富春, 信学雷, 陈君, 阿吉艾克拜尔·艾萨. 新疆玫瑰花提取物体外降糖活性. 医药导报[J]. 2016, 35(7): 693-697, http://lib.cqvip.com/Qikan/Article/Detail?id=669460027.
[47] 信学雷. Anti-Diabetic Action of Cydonia oblonga Seed Extract: Improvement of Glucose Metabolism via Activation of PI3K/AKT Signaling Pathway. Journal of Pharmacognosy and Phytochemistry. 2016, [48] Gao, Jie, Chen, QiBin, Liu, YongQiang, Xin, XueLei, Yili, Ablimiti, Aisa, Haji Akber. Diterpenoid constituents of Euphorbia macrorrhiza. PHYTOCHEMISTRY[J]. 2016, 122(2): 246-253, http://dx.doi.org/10.1016/j.phytochem.2015.12.003.
[49] Tursun, Xirali, Zhao, Yongxin, Talat, Zulfiya, Xin, Xuelei, AdilaTursun, Abdulla, Rahima, AkberAisa, Haji. Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages. BIOMOLECULES & THERAPEUTICS[J]. 2016, 24(2): 184-190, https://www.webofscience.com/wos/woscc/full-record/WOS:000370892300011.
[50] 信学雷. Novel Design for Centrifugal Counter-Current Chromatography: VI. Ellipsoid Column, 38: 68–73,. Journal of Liquid Chromatography & Related Technologies. 2015, [51] Gu, Dongyu, Yang, Yi, Xin, Xuelei, Aisa, Haji Akber, Ito, Yoichiro. Novel Design for Centrifugal Counter-Current Chromatography: VI. Ellipsoid Column. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES[J]. 2015, 38(1): 68-73, http://dx.doi.org/10.1080/10826076.2014.883533.
[52] Chen, QiBin, Xin, XueLei, Yang, Yi, Lee, ShoeiSheng, Aisa, H A. Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera. JOURNALOFNATURALPRODUCTS[J]. 2014, 77(4): 807-812, http://www.irgrid.ac.cn/handle/1471x/902641.
[53] Begmatov, N B, Bobakulov, Kh M, Xin, Xuelei, Aisa, H A. Low-Molecular-Weight Compounds from Flowers of Apocynum lancifolium. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2014, 50(6): 1116-1117, https://www.webofscience.com/wos/woscc/full-record/WOS:000345771400038.
[54] Bozorov, Khurshed, Ma, HaiRong, Zhao, JiangYu, Zhao, HaiQing, Chen, Hua, Bobakulov, Khayrulla, Xin, XueLei, Elmuradov, Burkhon, Shakhidoyatov, Khusnutdin, Aisa, Haji A. Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 84(9): 739-745, http://dx.doi.org/10.1016/j.ejmech.2014.07.065.
[55] Xin, Xuelei, Yang, Weijun, Yasen, Mireguli, Zhao, Haiqing, Aisa, Haji Akber. The mechanism of hepatoprotective effect of sesquiterpene rich fraction from Cichorum glandulosum Boiss. et Huet on immune reaction-induced liver injury in mice. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 155(2): 1068-1075, http://www.irgrid.ac.cn/handle/1471x/902631.
[56] Yang, Yi, Gu, Dongyu, Chen, Qibin, Xin, Xuelei, Yili, Abulimiti, Aisa, Haji Akber. A sample pretreatment strategy for pH-zone-refining counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2013, 1273(1): 44-48, http://dx.doi.org/10.1016/j.chroma.2012.11.049.
[57] Dan-Dan Zhong, Yan-Ping Huang, Xue-Lei Xin, Zhao-Sheng Liu, Haji Akber Aisa. Preparation of metallic pivot-based imprinted monolith for polar template. JOURNAL OF CHROMATOGRAPHY B. 2013, 934: 109-116, http://dx.doi.org/10.1016/j.jchromb.2013.07.006.
[58] Li, Lingnan, Yang, Yi, Hou, Xueling, Gu, Dongyu, Hang, Ba, Abdulla, Rahima, Wu, Guirong, Xin, Xuelei, Aisa, Haji Akber. Bioassay-guided separation and purification of water-soluble antioxidants from Carthamus tinctorius L. by combination of chromatographic techniques. SEPARATION AND PURIFICATION TECHNOLOGY[J]. 2013, 104(2): 200-207, http://dx.doi.org/10.1016/j.seppur.2012.11.027.
[59] Zhong, DanDan, Huang, YanPing, Xin, XueLei, Liu, ZhaoSheng, Aisa, Haji Akber. Preparation of metallic pivot-based imprinted monolith for polar template. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2013, 934(9): 109-116, http://dx.doi.org/10.1016/j.jchromb.2013.07.006.
[60] Gu, Dongyu, Yang, Yi, Bakri, Mahinur, Chen, Qibin, Xin, Xuelei, Aisa, Haji Akber. A LC/QTOF-MS/MS Application to Investigate Chemical Compositions in a Fraction with Protein Tyrosine Phosphatase 1B Inhibitory Activity from Rosa Rugosa Flowers. PHYTOCHEMICAL ANALYSIS[J]. 2013, 24(6): 661-670, http://www.irgrid.ac.cn/handle/1471x/902111.
[61] 赵海清, 信学雷, 阿吉艾克拜尔艾萨, 魏媛媛, 李潇, 帕尔哈提克热木. 毛菊苣降糖有效部位的筛选研究. 时珍国医国药[J]. 2012, 23(4): 794-797, http://lib.cqvip.com/Qikan/Article/Detail?id=41693991.
[62] 信学雷, 汪汉卿, 阿吉艾克拜尔艾萨. 维药瘤果黑种草籽化学成分研究. 天然产物研究与开发[J]. 2012, 24(7): 892-896, http://lib.cqvip.com/Qikan/Article/Detail?id=42741003.
[63] 阿吉艾克拜尔艾萨, 张尧, 信学雷. 维药毛菊苣降糖有效部位的纯化工艺. 中成药[J]. 2012, 34(12): 2322-2325, http://www.irgrid.ac.cn/handle/1471x/646431.
[64] Yang, Chunyan, Yang, Yi, Aisa, Haji Akber, Xin, Xuelei, Ma, Hairong, Yili, Abulimiti, Zhao, Yongxin. Bioassay-guided isolation of antioxidants from Astragalus altaicus by combination of chromatographic techniques. JOURNAL OF SEPARATION SCIENCE[J]. 2012, 35(8): 977-983, http://www.irgrid.ac.cn/handle/1471x/524792.
[65] Li, L, Wang, Q, Yang, Y, Wu, G, Xin, X, Aisa, H A. Chemical Components and Antidiabetic Activity of Essential Oils Obtained by Hydrodistillation and Three Solvent Extraction Methods from Carthamus tinctorius L.. ACTA CHROMATOGRAPHICA[J]. 2012, 24(4): 653-665, http://www.irgrid.ac.cn/handle/1471x/735262.
[66] Yang, WeiJun, Luo, YuQin, Aisa, Haji Akber, Xin, XueLei, Totahon, Z, Mao, Yan, Hu, MengYing, Xu, Lei, Zhang, RuiPing. Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum. CHINESE MEDICINE[J]. 2012, 7(1): 21-21, http://dx.doi.org/10.1186/1749-8546-7-21.
[67] Yang WeiJun, Luo YuQin, Aisa Haji, Xin XueLei, Totahon Z, Mao Yan, Hu MengYing, Xu Lei, Zhang RuiPing. Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum. CHINESE MEDICINE[J]. 2012, 7(1): https://doaj.org/article/8bc74c41736746a4b5c83f2c106a9de4.
[68] 信学雷, 吴汉夔, 吕俏莹, 阿吉艾克拜尔艾萨. 维吾尔药毛菊苣提取物降糖活性的研究. 天然产物研究与开发[J]. 2012, 24(2): 234-238, http://lib.cqvip.com/Qikan/Article/Detail?id=40919693.
[69] 赵永昕, 窦君, 信学雷, 阿吉艾克拜尔艾萨. DPPH法评价草棉花不同提取物体外抗氧化作用. 中成药[J]. 2011, 33(8): 1416-1418, http://lib.cqvip.com/Qikan/Article/Detail?id=39101812.
[70] Wu, H K, Xin, X L, Su, Z, Aisa, H A. 2-ISOPROPYL-6-METHYLPYRIMIDIN-4(3H)-ONE AND TARAXASTEROL FROM THE STEMS OF Cichorium glandulosum. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2011, 47(4): 664-666, http://www.irgrid.ac.cn/handle/1471x/524894.
[71] 刘禾培, 窦君, 马纪, 信学雷, 赵海清, 阿吉艾克拜尔艾萨. 三种维药提取物对蛋白酪氨酸磷酸酶1B抑制作用的研究. 天然产物研究与开发[J]. 2011, 23(1): 142-145, http://lib.cqvip.com/Qikan/Article/Detail?id=36855186.
[72] 信学雷. 瘤果黑种草籽石油醚和正己烷提取物的降糖活性研究. Journal of Food Biochemistry,. 2010, [73] 再娜布吐合达洪, 仲婕, 信学雷, 阿吉艾克拜尔艾萨. 毛菊苣药材不同部位主要活性成分含量. 中国中药杂志[J]. 2010, 1018-1021, http://lib.cqvip.com/Qikan/Article/Detail?id=33664523.
[74] Xin, Xuelei, Wang, Qi, Aisa, Haji Akber, Wang, Hanqing. ANTIDIABETES PROPERTIES OF n-HEXANE AND PETROLEUM ETHER EXTRACTS FROM SEEDS OF NIGELLA GLANDULIFERA FREYN. JOURNAL OF FOOD BIOCHEMISTRY[J]. 2010, 34(4): 811-824, http://www.irgrid.ac.cn/handle/1471x/524978.
[75] 信学雷. 毛菊苣中的两个新的倍半萜和一个三萜的研究. Helvetica Chimica Acta. 2010, [76] Xin, Xuelei, Yang, Yi, Zhong, Jie, Aisa, Haji Akber, Wang, Hanqing. Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration. JOURNAL OF CHROMATOGRAPHY A[J]. 2009, 1216(19): 4258-4262, http://dx.doi.org/10.1016/j.chroma.2009.03.050.
[77] 信学雷. 利用高速逆流色谱及凝胶色谱分离瘤果黑种草籽中的异苯并呋喃酮和三萜类物质. Journal of Chromatograph A. 2009, [78] 信学雷, 薛慧清, 阿吉艾克拜尔·艾萨, 汪汉卿. 黑种草属植物研究进展. 时珍国医国药[J]. 2008, 19(6): 1514-1517, http://lib.cqvip.com/Qikan/Article/Detail?id=27566376.
[79] 信学雷. 瘤果黑种草籽中黄铜和分类物质的研究. Chemistry of natural compound. 2008, [80] 信学雷. 瘤果黑种草籽中的三萜类成分研究. 2008, [81] 李兰松, 李维琪, 信学雷, 曹旭. 大鼠SR-BI胞外域与ApoA-Ⅰ蛋白相互作用的确认. 微生物学通报[J]. 2006, 33(2): 68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=21720352.
[82] 信学雷, 阿吉艾克拜尔·艾萨, 汪汉卿. 维药黑种草籽降脂活性的初步研究. 中国科协第六届青年学术年会卫星会议-新疆第六届青年学术年会暨首届博士生论坛null. 2006, 1273-1277, http://ir.xjipc.cas.cn/handle/365002/3625.
[83] 李兰松, 李维琪, 信学雷, 曹旭. SR-BI的分子结构及其表达调控. 中国生物工程杂志[J]. 2005, 25(4): 14-17, http://lib.cqvip.com/Qikan/Article/Detail?id=15446861.
[84] 信学雷, 李兰松, 阿吉艾克拜尔艾萨, 茹仙古丽莎吾尔, 李维琪, 阿力木江阿布地热力木. 2种维药复方对apo-AI和SR-BI之间相互作用的影响. 中国中药杂志[J]. 2005, 30(13): 1041-1043, http://lib.cqvip.com/Qikan/Article/Detail?id=16152793.
[85] 信学雷, 陈志慧, 李维琪, 刘云英, 麦迪娜, 张云峰. 用酵母双杂交系统研究载脂蛋白AI（apoAI）和清道夫受体BI（SR-BI）间的相互作用. 中国生物工程杂志[J]. 2005, 25(5): 80-84, http://lib.cqvip.com/Qikan/Article/Detail?id=15949513.
[86] Edirs Salamet, Turak Ablajan, Numonov Sodik, Xin Xuelei, Aisa Haji Akber. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM. 2017: https://doaj.org/article/d517b1243cd64996ac83c17e93a45d17.

（ 1 ） 饮食中药：第80章 菊苣, Dietary Chinese Herbs: Chapter 80 Cichorium glandulosum Bioss. Et Huet, Springer, 2015-08, 第 2 作者

   

（ 1 ） 国家杰出青年科学基金, 参与, 国家级, 2010-01--2013-12
（ 2 ） 干旱区可食植物资源及活性成分研究国际合作伙伴计划项目, 参与, 国家级, 2008-08--2012-09
（ 3 ） 西北区域黄芪、红花、沙棘等大宗中药材质量标准提高及其综合利用研究-红花质量标准提高及其综合利用研究 , 主持, 国家级, 2011-07--2015-06
（ 4 ） 维药瘤果黑种草籽改善胰岛素抵抗活性成分及作用机理研究, 主持, 国家级, 2012-01--2015-12
（ 5 ） 两种新疆道地药材降糖活性成分及作用机理研究, 主持, 省级, 2013-01--2015-12

（1）Spectrum-effect Relationship in Protein Tyrosine Phosphatase (PTP1B) Inhibition Effect of Carthamus tinctorius L.   第十一届天然化合物化学国际研讨会   Wu Heting1,2,3, Sanawear Mansur1,2,3, Gao Yanhua1,2 , Zhao Haiqing1,2, Xin Xuelei1,2*, Haji Akber Aisa1,2*,   2015-10-01
（2）The ameliorating effect and mechanism on insulin resistence of Nigella Glandulifera Freyn Seeds.   2015 年传统与民族医药国际研讨会   信学雷，谢连珍、汤丹   2015-06-12
（3）Bioactivities of some compounds and components from two kinds of edible plant in Xinjiang, P. R. China   第四届可食植物及其活性成分国际研讨会   信学雷   2014-07-25
（4）Study on Chemical consistent and bioactivities of Cichorium glandulosum   第四届澳大利亚-中国科技、教育联合研讨会   信学雷   2012-12-16

已指导学生

张尧  硕士研究生  070303-有机化学  

陈其宾  硕士研究生  070303-有机化学  

蒋岚  博士研究生  070303-有机化学  

谢连珍  硕士研究生  070303-有机化学  

武鹤婷  硕士研究生  070303-有机化学  

现指导学生

刘柳  硕士研究生  070303-有机化学  

刘喜喜  硕士研究生  070303-有机化学  

买吐送居买  博士研究生  070303-有机化学  

阿卜力克木·奥布力  博士研究生  070303-有机化学  

康喜亮  博士研究生  070303-有机化学  

马冶  硕士研究生  070303-有机化学  

阿提坎·吾布力喀斯木  博士研究生  070303-有机化学  

李泽慧  博士研究生  070303-有机化学  

麦麦提艾力·奥布力  博士研究生  070303-有机化学  

再乃普古丽·伊斯马伊力  博士研究生  070303-有机化学  

祖克拉·肉孜  博士研究生  070303-有机化学  

刘昌华  博士研究生  070303-有机化学