基本信息
信学雷 女 博导 中国科学院新疆理化技术研究所
电子邮件: xinxl@ms.xjb.ac.cn
通信地址: 乌鲁木齐市天山区永和正巷36号
邮政编码: 830011
电子邮件: xinxl@ms.xjb.ac.cn
通信地址: 乌鲁木齐市天山区永和正巷36号
邮政编码: 830011
研究领域
长期致力于维吾尔医常用药材的物质基础及作用机理研究,以期在通过现代技术手段在一定程度上解决维吾尔医药现代化过程中出现的物质基础不清、作用机理不明的问题。
招生信息
招生专业
070303-有机化学
100701-药物化学
100701-药物化学
招生方向
民族药学
天然产物化学
天然产物化学
教育背景
2004-09--2008-07 中国科学院兰州化学物理研究所 理学博士
1988-09--1992-07 新疆大学 理学学士
1988-09--1992-07 新疆大学 理学学士
学历
-- 研究生
学位
-- 博士
工作经历
工作简历
2002-03--今 中国科学院新疆理化技术研究所 高级工程师、副研究员、研究员
1994-04--2002-03 中国科学院新疆化学研究所 助工,工程师,高级工程师
1992-08--1994-04 中国科学院新疆分院毛发公司 技术员,助工
1994-04--2002-03 中国科学院新疆化学研究所 助工,工程师,高级工程师
1992-08--1994-04 中国科学院新疆分院毛发公司 技术员,助工
社会兼职
2015-01-01-2017-12-31,中国医药导报, 编委
专利与奖励
奖励信息
(1) 以毛菊苣为示范的民族药药效物质与标准化关键技术 及其应用, 一等奖, 省级, 2018(2) 第十四届新疆维吾尔自治区优秀论文奖, 二等奖, 省级, 2016(3) 18种新疆特色药用植物化学成分与生物活性研究, 一等奖, 省级, 2015(4) 鹰嘴豆功能因子研究与开发, 二等奖, 省级, 2013(5) 石榴皮多酚泡腾片的研制, 三等奖, 省级, 2011(6) 第十一届自治区优秀论文奖, 二等奖, 省级, 2010(7) 维吾尔药化学样品资源库, 二等奖, 省级, 2008(8) 鹰嘴豆化学成分的研究及营养产品, 二等奖, 省级, 2007
专利成果
[1] 信学雷, 胡苗, 马依努尔·拜克力, 诺莫诺夫·索迪克, 买迪娜, 阿吉艾克拜尔·艾萨. 一种帚枝香青正丁醇提取物的用途. CN: CN112156120A, 2021-01-01.[2] 信学雷, 胡苗, 马依努尔·拜克力, 诺莫诺夫·索迪克, 买迪娜, 阿吉艾克拜尔·艾萨. 一种凤尾蓍乙酸乙酯提取物的用途. CN: CN112121072A, 2020-12-25.[3] 阿吉艾克拜尔·艾萨, 李颖, 帕孜莱提·艾尼瓦尔, 臧登, 信学雷, 希尔艾力. 生物碱香草木宁碱和大叶桉亭在制备治疗白癜风的药物中的用途. CN: CN111956648A, 2020-11-20.[4] 陈丽, 信学雷, 阿吉艾克拜尔·艾萨. 一种预防和治疗酒精性肝损伤的中药复方制剂及其制备方法和用途. CN: CN111821343A, 2020-10-27.[5] 阿吉艾克拜尔·艾萨, 李泽慧, 买吾兰江·买提努尔, 罗玉琴, 信学雷. 一种小裂叶荆芥精油和石榴皮有效组分组合物的用途. CN: CN110755477A, 2020-02-07.[6] 阿吉艾克拜尔·艾萨, 刘晓燕, 罗玉琴, 贺飞, 信学雷, 彭军, 吴涛. 一种具有人醛糖还原酶抑制剂作用的复方制剂的制备方法和用途. CN: CN110721259A, 2020-01-24.[7] 信学雷, 彭军, 刘晓燕, 贺飞, 阿吉艾克拜尔·艾萨. 一种罗布麻叶多酚的用途. CN: CN110693928A, 2020-01-17.[8] 信学雷, 崔靖雪, 段晓梅, 阿吉艾克拜尔·艾萨. 一种大籽蒿有效部位的制备方法及其用途. CN: CN110496145A, 2019-11-26.[9] 阿吉艾克拜尔·艾萨, 祖力皮牙·买买提, 阿不拉江·图拉克, 信学雷. 驱虫斑鸠菊中分离的倍半萜类化合物在制备治疗白癜风的药物中的用途. CN: CN109939106A, 2019-06-28.[10] 李俊, 阿布杜巴克耶夫·萨德尔别克, 赵海清, 信学雷, 阿吉艾克拜尔·艾萨. 一种荜茇酰胺类生物碱的降糖用途. CN: CN109381462A, 2019-02-26.[11] 李俊, 阿布杜巴克耶夫·萨德尔别克, 赵海清, 信学雷, 阿吉艾克拜尔·艾萨. 一种荜茇酰胺生物碱的降糖用途. CN: CN109350614A, 2019-02-19.[12] 阿吉艾克拜尔·艾萨, 黎凌楠, 杨义, 吴桂荣, 信学雷. 一种羟基红花黄色素A的制备方法. CN: CN108395420A, 2018-08-14.[13] 阿吉艾克拜尔·艾萨, 胡蕊, 高洁, 信学雷. 一种假白榄烷型二萜内酯及制备方法和用途. CN: CN107805238A, 2018-03-16.[14] 阿吉艾克拜尔·艾萨, 信学雷, 刘喜喜. 瘤果黑种草籽中的酯类化合物及其制备方法和用途. CN: CN107353205A, 2017-11-17.[15] 信学雷, 武鹤婷, 赛那瓦尔·芒思尔, 阿吉艾克拜尔·艾萨. 一种具有明确谱效关系的红花提取物的用途. CN: CN105920071A, 2016-09-07.[16] 阿吉艾克拜尔·艾萨, 郭丹, 邹国安, 信学雷. 一种骆驼刺花瓣乙酸乙酯部位的用途. CN: CN105832810A, 2016-08-10.[17] 阿吉艾克拜尔·艾萨, 蒋岚, 努拉耶夫·玉素甫, 买迪娜, 叶建平, 米热古丽·牙森, 信学雷, 诺莫诺夫·索迪克. 一种治疗糖尿病的复方金鹳草药物及其制备方法. CN: CN105560313A, 2016-05-11.[18] 阿吉艾克拜尔·艾萨, 李浩榕, 吐鲁洪·卡地尔, 刘永强, 信学雷, 努尔阿米乃·麦麦提. 驱虫斑鸠菊酚酸部位的制备方法及抗炎用途. CN: CN104825518A, 2015-08-12.[19] 阿吉艾克拜尔·艾萨, 李浩榕, 阿不拉江·图拉克, 买迪娜, 信学雷, 祖力皮牙·买买提. 驱虫斑鸠菊酚酸部位的制备方法及用途. CN: CN104825519A, 2015-08-12.[20] 汤丹, 赵永昕, 信学雷, 阿吉艾克拜尔·艾萨. 一种石榴花多酚的抗炎用途. CN: CN104825504A, 2015-08-12.[21] 信学雷, 萨拉麦提·艾迪热斯, 艾级买力汗·艾比布拉, 谢连珍, 阿吉艾克拜尔·艾萨. 红花籽粕降糖有效部位的制备方法及其用途. CN: CN104706702A, 2015-06-17.[22] 信学雷, 谢连珍, 陈其宾, 阿吉艾克拜尔·艾萨. 一种瘤果黑种草籽乙酸乙酯部位的用途. CN: CN104688843A, 2015-06-10.[23] 阿吉艾克拜尔·艾萨, 汤丹, 谢连珍, 信学雷. 榅桲子提取物的制备方法及降糖用途. CN: CN104623002A, 2015-05-20.[24] 阿吉艾克拜尔·艾萨, 刘丛丛, 信学雷, 窦君. 一种鹰嘴豆豆芽提取物的抗炎用途. CN: CN104547002A, 2015-04-29.[25] 阿吉艾克拜尔·艾萨, 李勋, 信学雷, 谢连珍. 阿尔泰独尾草降血糖有效部位的制备方法及其用途. CN: CN104491322A, 2015-04-08.[26] 阿吉艾克拜尔·艾萨, 高洁, 信学雷. 粗根大戟中分离的大环二萜类化合物及多药耐药逆转用途. CN: CN104292186A, 2015-01-21.[27] 信学雷, 阿吉艾克拜尔·艾萨, 蒋岚, 叶建平. 一种菊苣酸的药物用途. CN: CN103877071A, 2014-06-25.[28] 阿吉艾克拜尔·艾萨, 肖嘉琪, 信学雷, 谢连珍. 异翅独尾草降糖有效部位的制备方法及其用途. CN: CN103599334A, 2014-02-26.[29] 阿吉艾克拜尔·艾萨, 陈其宾, 信学雷. 瘤果黑种草籽中的生物碱组分及其制备方法和用途. CN: CN103288826A, 2013-09-11.[30] 信学雷, 阿吉艾克拜尔·艾萨, 陈其宾. 瘤果黑种草籽中具有骨架类型Ⅰ和Ⅱ生物碱的用途. CN: CN103285000A, 2013-09-11.[31] 信学雷, 阿吉艾克拜尔·艾萨. 一种红花籽粕提取物的降糖用途. CN: CN103271968A, 2013-09-04.[32] 信学雷, 陈其宾, 阿吉艾克拜尔·艾萨. 瘤果黑种草籽中具有骨架类型2的生物碱及其制备方法. CN: CN103102305A, 2013-05-15.[33] 信学雷, 陈其宾, 阿吉艾克拜尔·艾萨. 瘤果黑种草籽中具有骨架类型1的生物碱及其制备方法. CN: CN103086967A, 2013-05-08.[34] 阿吉艾克拜尔·艾萨, 哈及尼沙, 信学雷, 赵海清, 米热古丽·亚森. 榅桲果实降血糖有效部位的制备方法及其用途. CN: CN102451251A, 2012-05-16.[35] 阿吉艾克拜尔·艾萨, 张尧, 信学雷. 一种多靶点起效的菊苣降糖有效部位的制备方法及用途. CN: CN102406683A, 2012-04-11.[36] 信学雷, 张尧, 阿吉艾克拜尔·艾萨, 杨义, 巴杭. 一种山莴苣素和山莴苣苦素的制备方法. CN: CN102351824A, 2012-02-15.[37] 阿吉艾克拜尔·艾萨, 信学雷, 赵海清, 吴涛, 杨伟俊, 张尧. 菊苣降糖有效部位的制备方法及其用途. CN: CN102078356A, 2011-06-01.[38] 信学雷, 阿吉艾克拜尔·艾萨, 阿布力米提·伊力, 吴汉夔. 瘤果黑种草籽油的药物用途. CN: CN101129497B, 2010-08-04.[39] 阿吉艾克拜尔·艾萨, 吕辉, 牟新利, 信学雷. 沙生蜡菊总皂甙在制备药物中的应用. CN: CN1947737B, 2010-04-21.[40] 阿吉艾克拜尔·艾萨, 信学雷, 杨 义. 异苯并呋喃酮类化合物的制备方法. CN: CN101323605A, 2008-12-17.[41] 阿吉艾克拜尔·艾萨, 吕俏莹, 阿布力米提·伊力, 程 珍, 高艳华, 马庆玲, 信学雷, 徐家林. 一种鹰嘴豆豆芽汁及制备方法和用途. CN: CN101238909A, 2008-08-13.[42] 阿吉尔克拜尔·艾萨, 程 珍, 阿不力米提·伊力, 信学雷, 马庆玲, 高艳华. 鹰嘴豆胚芽和豆芽有效部位及其制备方法和应用. CN: CN101199581A, 2008-06-18.[43] 阿吉艾克拜尔·艾萨, 吴汉夔, 信学雷, 阿不力米提·伊力, 巴杭. 菊苣籽有效部位及其制备方法和用途. CN: CN101167776A, 2008-04-30.[44] 信学雷, 阿吉艾克拜尔·艾萨. 常春藤皂苷元及其制备方法和用途. CN: CN101125880A, 2008-02-20.[45] 阿吉艾克拜尔·艾萨, 信学雷, 李勇猛. 山窝苣素及其制备方法和用途. CN: CN101099566A, 2008-01-09.[46] 信学雷, 李维琪, 陈志慧, 刘云英, 麦迪娜, 张云峰. 用基因靶标筛选具有降低血脂中胆固醇组分的方法. CN: CN1238523C, 2006-01-25.[47] 信学雷, 李维琪, 张云峰, 杨向明, 刘敏. 大蒜中提取蒜氨酸的方法. CN: CN1412317A, 2003-04-23.
出版信息
发表论文
[1] Peng, Jun, Abdulla, Rahima, Li, Yi, Liu, Xiaoyan, He, Fei, Xin, Xuelei, Aisa, Haji Akber. Potential anti-diabetic components of Apocynum venetum L. flowers: Optimization, chemical characterization and quality evaluation. JOURNAL OF FOOD COMPOSITION AND ANALYSIS[J]. 2023, 115: http://dx.doi.org/10.1016/j.jfca.2022.104930.[2] 张柏生, 热依木古丽阿布都拉, 信学雷, 范芳芳, 李茜. 洋甘菊中2种咖啡酰基奎宁酸大孔树脂纯化工艺的优化. 食品与药品. 2023, 25(2): I0014-I0019, http://lib.cqvip.com/Qikan/Article/Detail?id=7109498621.[3] Li, Qian, Abdulla, Rahima, Xin, Xuelei, Xue, Guipeng, Kang, Xiaolong, Zhao, Feicui, Asia, Haji Akber. Profiling of chemical constituents of Matricarla chamomilla L. by UHPLC-Q-Orbitrap-HRMS and in vivo evaluation its anti-asthmatic activity. HELIYON[J]. 2023, 9(5): http://dx.doi.org/10.1016/j.heliyon.2023.e15470.[4] 薛桂蓬, 热依木古丽阿布都拉, 信学雷, 阿吉艾克拜尔艾萨, 李茜. 不同产地洋甘菊HPLC指纹图谱分析. 中华中医药杂志[J]. 2023, 38(8): 3786-3790, http://lib.cqvip.com/Qikan/Article/Detail?id=7110371968.[5] Abdurehman, Dilinare, Guoruoluo, Yindengzhi, Lu, Xueying, Li, Jun, Abudulla, Rahima, Liu, Geyu, Xin, Xuelei, Aisa, Haji Akber. Optimization of preparation method of hepatoprotective active components from Coreopsis tinctoria Nutt. and its action mechanism in vivo. BIOMEDICINE & PHARMACOTHERAPY[J]. 2023, 167: http://dx.doi.org/10.1016/j.biopha.2023.115590.[6] Li, Hongliang, Liu, Liu, Gou, Guanghui, Xin, Xuelei, Li, Jun, Aisa, Haji Akber. Guaianolides from Achillea millefolium L. and their anti-inflammatory activity. PHYTOCHEMISTRY[J]. 2023, 210: http://dx.doi.org/10.1016/j.phytochem.2023.113647.[7] Tuohongerbieke, Amanguli, Liu, Liu, Li, Jun, Xin, Xuelei, Aisa, Haji Akber. Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway. BIOORGANIC CHEMISTRY[J]. 2023, 132: http://dx.doi.org/10.1016/j.bioorg.2023.106348.[8] Gou, GuangHui, Liu, Liu, Abdubakiev, Sardorbek, Xin, XueLei, Akber Aisa, Haji, Li, Jun. Anti-Diabetic Effects and Molecular Mechanisms of Amide Alkaloids from Piper longum Based on Network Pharmacology Integrated with Cellular Assays. CHEMISTRY & BIODIVERSITY[J]. 2023, 20(1): [9] Yin, Qiang, Abdulla, Rahima, Kahar, Gulmira, Aisa, Haji Akber, Li, Chunting, Xin, Xuelei. Mass Defect Filtering-Oriented Identification of Resin Glycosides from Root of Convolvulus scammonia Based on Quadrupole-Orbitrap Mass Spectrometer. MOLECULES[J]. 2022, 27(11): http://dx.doi.org/10.3390/molecules27113638.[10] Duan, Xiaomei, Li, Jun, Cui, Jingxue, Wen, Huizheng, Xin, Xuelei, Aisa, Haji Akber. A network pharmacology strategy combined with in vitro experiments to investigate the potential anti-inflammatory mechanism of Prunus cerasifera Ehrhart. JOURNAL OF FOOD BIOCHEMISTRY[J]. 2022, 46(12): http://dx.doi.org/10.1111/jfbc.14396.[11] Duan, Xiaomei, Li, Jun, Cui, Jingxue, Dong, Yuwei, Xin, Xuelei, Aisa, Haji Akber. Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-?B signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2022, 286: http://dx.doi.org/10.1016/j.jep.2021.114899.[12] Aihaiti, Kariyemu, Li, Jun, Yaermaimaiti, Saimijiang, Liu, Liu, Xin, Xuelei, Aisa, Haji Akber. Non-volatile compounds of Hyssopus cuspidatus Boriss and their antioxidant and antimicrobial activities. FOOD CHEMISTRY[J]. 2022, 374: http://dx.doi.org/10.1016/j.foodchem.2021.131638.[13] Liu, Xiao Yan, Peng, Jun, He, Fei, Tursun, Xirali, Li, Shu Ping, Xin, Xue Lei, Aisa, Haji Akber. 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Journal of Chromatograph A. 2009, [83] 信学雷, 薛慧清, 阿吉艾克拜尔·艾萨, 汪汉卿. 黑种草属植物研究进展. 时珍国医国药[J]. 2008, 19(6): 1514-1517, http://lib.cqvip.com/Qikan/Article/Detail?id=27566376.[84] 信学雷. 瘤果黑种草籽中黄铜和分类物质的研究. Chemistry of natural compound. 2008, [85] 信学雷. 瘤果黑种草籽中的三萜类成分研究. 2008, [86] 李兰松, 李维琪, 信学雷, 曹旭. 大鼠SR-BI胞外域与ApoA-Ⅰ蛋白相互作用的确认. 微生物学通报[J]. 2006, 33(2): 68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=21720352.[87] 信学雷, 阿吉艾克拜尔·艾萨, 汪汉卿. 维药黑种草籽降脂活性的初步研究. 中国科协第六届青年学术年会卫星会议-新疆第六届青年学术年会暨首届博士生论坛null. 2006, 1273-1277, http://ir.xjipc.cas.cn/handle/365002/3625.[88] 李兰松, 李维琪, 信学雷, 曹旭. SR-BI的分子结构及其表达调控. 中国生物工程杂志[J]. 2005, 25(4): 14-17, http://lib.cqvip.com/Qikan/Article/Detail?id=15446861.[89] 信学雷, 李兰松, 阿吉艾克拜尔艾萨, 茹仙古丽莎吾尔, 李维琪, 阿力木江阿布地热力木. 2种维药复方对apo-AI和SR-BI之间相互作用的影响. 中国中药杂志[J]. 2005, 30(13): 1041-1043, http://lib.cqvip.com/Qikan/Article/Detail?id=16152793.[90] 信学雷, 陈志慧, 李维琪, 刘云英, 麦迪娜, 张云峰. 用酵母双杂交系统研究载脂蛋白AI(apoAI)和清道夫受体BI(SR-BI)间的相互作用. 中国生物工程杂志[J]. 2005, 25(5): 80-84, http://lib.cqvip.com/Qikan/Article/Detail?id=15949513.[91] Hongliang Li, Liu Liu, Guanghui Gou, Xuelei Xin, Jun Li, Haji Akber Aisa. Guaianolides from Achillea millefolium L. and their anti-inflammatory activity. PHYTOCHEMISTRY. http://dx.doi.org/10.1016/j.phytochem.2023.113647.[92] Edirs Salamet, Turak Ablajan, Numonov Sodik, Xin Xuelei, Aisa Haji Akber. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM. 2017: https://doaj.org/article/d517b1243cd64996ac83c17e93a45d17.
发表著作
( 1 ) 饮食中药:第80章 菊苣, Dietary Chinese Herbs: Chapter 80 Cichorium glandulosum Bioss. Et Huet, Springer, 2015-08, 第 2 作者
科研活动
科研项目
( 1 ) 国家杰出青年科学基金, 参与, 国家级, 2010-01--2013-12( 2 ) 干旱区可食植物资源及活性成分研究国际合作伙伴计划项目, 参与, 国家级, 2008-08--2012-09( 3 ) 西北区域黄芪、红花、沙棘等大宗中药材质量标准提高及其综合利用研究-红花质量标准提高及其综合利用研究 , 主持, 国家级, 2011-07--2015-06( 4 ) 维药瘤果黑种草籽改善胰岛素抵抗活性成分及作用机理研究, 主持, 国家级, 2012-01--2015-12( 5 ) 两种新疆道地药材降糖活性成分及作用机理研究, 主持, 省级, 2013-01--2015-12
参与会议
(1)Spectrum-effect Relationship in Protein Tyrosine Phosphatase (PTP1B) Inhibition Effect of Carthamus tinctorius L. 第十一届天然化合物化学国际研讨会 Wu Heting1,2,3, Sanawear Mansur1,2,3, Gao Yanhua1,2 , Zhao Haiqing1,2, Xin Xuelei1,2*, Haji Akber Aisa1,2*, 2015-10-01(2)The ameliorating effect and mechanism on insulin resistence of Nigella Glandulifera Freyn Seeds. 2015 年传统与民族医药国际研讨会 信学雷,谢连珍、汤丹 2015-06-12(3)Bioactivities of some compounds and components from two kinds of edible plant in Xinjiang, P. R. China 第四届可食植物及其活性成分国际研讨会 信学雷 2014-07-25(4)Study on Chemical consistent and bioactivities of Cichorium glandulosum 第四届澳大利亚-中国科技、教育联合研讨会 信学雷 2012-12-16
指导学生
已指导学生
张尧 硕士研究生 070303-有机化学
陈其宾 硕士研究生 070303-有机化学
蒋岚 博士研究生 070303-有机化学
谢连珍 硕士研究生 070303-有机化学
武鹤婷 硕士研究生 070303-有机化学
现指导学生
刘柳 硕士研究生 070303-有机化学
刘喜喜 硕士研究生 070303-有机化学
买吐送居买 博士研究生 070303-有机化学
阿卜力克木·奥布力 博士研究生 070303-有机化学
康喜亮 博士研究生 070303-有机化学
马冶 硕士研究生 070303-有机化学
阿提坎·吾布力喀斯木 博士研究生 070303-有机化学
李泽慧 博士研究生 070303-有机化学
麦麦提艾力·奥布力 博士研究生 070303-有机化学
再乃普古丽·伊斯马伊力 博士研究生 070303-有机化学
祖克拉·肉孜 博士研究生 070303-有机化学
刘昌华 博士研究生 070303-有机化学