基本信息
郑平  女  博导  中国科学院天津工业生物技术研究所
电子邮件: zheng_p@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码: 300308

研究领域

长期从事细菌的代谢工程改造和系统生物学研究。目前主要研究方向为:在系统生物学分析和关键基因功能解析的基础上,通过代谢工程改造工业微生物的核心代谢途径及关键酶,生产大宗化学品和高附加值精细化学品。


招生信息

   
招生专业
071005-微生物学
招生方向
工业微生物功能基因分析及代谢工程改造

教育背景

2001-10--2006-06   德国不伦瑞克工业大学/德国国家生物工程中心   博士
1993-09--1996-06   山东大学   硕士
1989-09--1993-06   山东大学   学士

工作经历

   
工作简历
2014-04~现在, 中科院天津工业生物技术研究所, 研究员
2008-07~2014-04,中科院天津工业生物技术研究所, 副研究员
2007-09~2008-06,德国赫尔姆霍茨传染病研究中心, 博士后
2000-10~2001-09,德国国家工程中心, 研究助理
1996-09~2000-07,山东轻工业学院, 讲师

教授课程

工业生物技术前沿
系统生物学

专利与奖励

   
奖励信息
(1) 赖氨酸工业菌种创新, , 部委级, 2014
专利成果
[1] 孙际宾, 陈久洲, 蒲伟, 郑平, 周文娟, 石拓, 蔡柠匀. 高产5-氨基乙酰丙酸的工程菌株及5-氨基乙酰丙酸高产菌株的构建方法. CN115747125A, 2023-03-07.
[2] 郑平. 丙酸诱导型启动子的突变体及其应用. 202211478530.8, 2022-11-23.
[3] 孙际宾, 陈久洲, 李广玉, 郑平, 蔡柠匀, 周文娟, 李德衡, 刘娇, 刘世周, 赵兰坤. 谷氨酸脱氢酶启动子突变体及其应用. 202211146300.1, 2022-09-20.
[4] 郑平, 周文娟, 李广玉, 孙际宾, 蔡柠匀, 陈久洲, 王小平, 刘世周, 赵兰坤. 柠檬酸合酶启动子突变体及其应用. 202211145762.1, 2022-09-20.
[5] 郑平, 陈久洲, 蔡柠匀, 孙际宾, 周文娟, 钟沙沙. 突变型柠檬酸合酶及其应用. 202211146281.2, 2022-09-20.
[6] 郑平, 刘娇, 孙际宾, 周文娟, 刘建行, 孙冠男, 乔倩倩. 一种谷氨酰激酶的表达调控序列及其应用. 202211027795.6, 2022-08-25.
[7] 郑平, 刘娇, 孙际宾, 赵晓佳, 周文娟, 刘欣洋, 孙冠男. 一种人工表达调控元件及其应用. 202210923995.3, 2022-08-02.
[8] 郑平, 王钰, 孙际宾, 张知慧, 周文娟, 凡立稳. 一种提高微生物对甲醛耐受性的方法. 202210923993.4, 2022-08-02.
[9] 郑平, 王钰, 蔡柠匀, 孙际宾, 车斌, 高宁, 周文娟, 陈久洲, 倪晓蒙, 凡立稳. 甲醇耐受性蛋白及提高微生物的甲醇耐受性或利用率的方法. 202210833003.8, 2022-07-14.
[10] 孙际宾, 张伟, 郑平, 刘娇, 周文娟. 一种ramB突变体及其构建赖氨酸生产菌株的方法. CN202210400927.9, 2022-04-18.
[11] 孙际宾, 刘娇, 郑平, 赵晓佳, 王钰, 周文娟. 一种提高微生物对渗透压的耐受性的方法. 202210349424.3, 2022-04-01.
[12] 郑平, 蒲伟, 陈久洲, 孙际宾, 刘娇, 周文娟, 王钰. 一种氨基酸生物传感器及其应用. CN202210195613.X, 2022-03-01.
[13] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 孙冠男, 王钰, 石拓, 郭轩, 马延和. 高产L-脯氨酸的谷氨酸棒杆菌以及高产L-脯氨酸的方法. CN: CN114107141A, 2022-03-01.
[14] 孙际宾, 刘娇, 王兴初, 周文娟, 郑平, 马延和. 反式-4-羟基-L-脯氨酸的生产菌株及其构建方法和应用. CN: CN111349640B, 2022-03-01.
[15] 孙际宾, 陈久洲, 郑平, 蔡柠匀, 周文娟, 王钰. 一种DNA聚合酶IIIα亚基突变体及其应用. CN202210141981.6, 2022-02-16.
[16] 郑平, 赵晶, 谭子瑊, 陈久洲, 饶德明, 孙际宾, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN114032224A, 2022-02-11.
[17] 孙际宾, 陈久洲, 郑平, 朱成超, 郭轩, 周文娟, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN114032225A, 2022-02-11.
[18] 孙际宾, 刘娇, 郑平, 刘莫识, 王钰, 周文娟, 孙冠男. 具有 L-脯氨酸外排功能的蛋白及其应用. 202110045175.4, 2022-01-13.
[19] 孙际宾, 赵晶, 刘超, 周文娟, 郑平, 郭轩, 刘娇, 马延和. 一种新型的脯氨酸3-羟化酶及其应用. CN: CN110804596B, 2021-12-28.
[20] 郑平, 石拓, 陈久洲, 孙际宾, 周文娟, 蔡柠匀, 刘娇. 氨基酸生产菌株的构建方法及其应用. CN202111600320.7, 2021-12-24.
[21] 孙际宾, 刘娇, 郑平, 石拓, 周文娟, 陈久洲, 郭轩, 马延和. 丙酮酸羧化酶基因启动子的突变体及其应用. CN: CN113755492A, 2021-12-07.
[22] 郑平, 郑小梅, 孙际宾, 陈美玲, 周文娟, 卢玉丹, 马延和. 一种生产柠檬酸的工程菌及其构建方法和应用. CN202111407487.1, 2021-11-24.
[23] 郑平, 郑小梅, 孙际宾, 卢玉丹, 周文娟, 张立辉, 马延和. 一种柠檬酸的生产方法及其应用. CN202111306184.0, 2021-11-05.
[24] 孙际宾, 刘娇, 郑平, 孙冠男, 周文娟, 倪晓蒙, 陈久洲. 基于赖氨酸外排蛋白构建的重组微生物及生产赖氨酸的方法. CN202111283285.0, 2021-11-02.
[25] 孙际宾, 郑小梅, 郑平, 张立辉, 周文娟, 卢玉丹, 马延和. 生产柠檬酸的微生物及其构建方法和应用. CN202111235410.0, 2021-10-22.
[26] 郑平, 张伟, 周文娟, 孙际宾, 刘娇, 郭轩, 马延和. 生产氨基酸的谷氨酸棒杆菌以及利用该谷氨酸棒杆菌生产氨基酸的方法. CN113462583A, 2021-10-01.
[27] 郑平, 陈久洲, 孙际宾, 蒲伟, 蔡柠匀, 周文娟, 刘娇, 马延和. 磷酸烯醇式丙酮酸羧化酶突变体及其应用. CN202111082664.3, 2021-09-15.
[28] 郑平, 蒲伟, 陈久洲, 孙际宾, 蔡柠匀, 王钰, 周文娟, 马延和. 一种转录调控因子 LysG 的突变体及其应用. CN202111028178.3, 2021-09-02.
[29] 郑平, 陈久洲, 孙际宾, 蒲伟, 蔡柠匀, 周文娟, 王钰, 马延和. 一种转录调控因子 LysG 的突变体及其应用. CN202111026806.4, 2021-09-02.
[30] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 石拓, 马延和. 一种突变的高渗诱导型启动子PproP及其应用. CN113278620A, 2021-08-20.
[31] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 孙冠男, 王钰, 石拓, 郭轩, 马延和. 高产L-脯氨酸的谷氨酸棒杆菌以及高产L-脯氨酸的方法. CN202110952846.5, 2021-08-19.
[32] 孙际宾, 郑小梅, 张立辉, 周文娟, 郑平, 马延和. 有机酸产量提高的菌株及其构建方法和应用. CN: CN113265417A, 2021-08-17.
[33] 郑平, 陈久洲, 孙际宾, 蔡柠匀, 郭轩, 周文娟, 刘坯, 刘娇, 马延和. 丙酮酸脱氢酶的突变体及其用于生产L-氨基酸的方法. CN113249347A, 2021-08-13.
[34] 孙际宾, 刘娇, 郑平, 刘莫识, 孙冠男, 周文娟, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN: CN113201539A, 2021-08-03.
[35] 郑平, 刘娇, 王钰, 周文娟, 孙际宾, 陈久洲, 马延和. 具有天冬氨酸激酶活性的多肽及其在生产氨基酸中的应用. CN: CN113201514A, 2021-08-03.
[36] 郑平, 刘娇, 孙际宾, 周文娟, 石拓, 郭轩, 马延和. 具有启动子活性的多核苷酸及其在生产氨基酸中的应用. CN: CN113201536A, 2021-08-03.
[37] 孙际宾, 刘娇, 郑平, 周文娟, 马延和. 谷氨酸脱氢酶基因启动子的突变体及其应用. CN: CN113201535A, 2021-08-03.
[38] 郑平, 刘娇, 孙际宾, 周文娟, 孙冠男, 赵晓佳, 刘欣洋, 王钰, 倪晓蒙, 马延和. 启动子突变体文库的构建方法及启动子突变体文库. CN202110859066.6, 2021-07-28.
[39] 孙际宾, 刘娇, 郑平, 周文娟, 孙冠男, 陈久洲. 基于 dapB 基因的具有启动子活性的多核苷酸及其用途. CN202110638508.4, 2021-06-08.
[40] 郑平, 刘娇, 孙际宾, 孙冠男, 周文娟, 郭轩. 基于 mdh 基因的具有启动子活性的多核苷酸及其用途. CN202110638496.5, 2021-06-08.
[41] 孙际宾, 陈久洲, 郑平, 周文娟, 郭轩, 马延和. 生产赖氨酸的微生物以及赖氨酸的生产方法. CN: CN112877269A, 2021-06-01.
[42] 孙际宾, 陈久洲, 郑平, 朱成超, 郭轩, 周文娟, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN112831483A, 2021-05-25.
[43] 孙际宾, 陈久洲, 黄婧文, 郑平, 周文娟, 刘娇, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN202110505665.8, 2021-05-10.
[44] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 王钰, 马延和. 具有启动子活性的多核苷酸及其用途和生产目标化合物的方法. CN202110504946.1, 2021-05-10.
[45] 孙际宾, 刘娇, 郑平, 石拓, 周文娟, 马延和. 一种天冬氨酸激酶基因表达调控序列及其应用. CN: CN112695036A, 2021-04-23.
[46] 孙际宾, 王钰, 郑平, 凡立稳, 周文娟, 马延和. 一种提高微生物对甲醇的耐受性和利用率的方法. CN: CN112680389A, 2021-04-20.
[47] 孙际宾, 王钰, 郑平, 凡立稳, 周文娟, 马延和. 一种提高菌株的甲醇生物耐受性和生物转化效率的方法. CN: CN112680468A, 2021-04-20.
[48] 徐庆阳, 孙际宾, 张玉富, 郑平, 李燕军, 张成林, 陈宁. 一种高密度发酵生产L-赖氨酸的培养基及其方法. CN: CN112662713A, 2021-04-16.
[49] 徐庆阳, 孙际宾, 张玉富, 郑平, 李燕军, 张成林, 陈宁. 一种赖氨酸循环发酵方法和应用. CN: CN112646844A, 2021-04-13.
[50] 徐庆阳, 孙际宾, 刘云鹏, 郑平, 李燕军, 周文娟, 张成林. 一种L-赖氨酸的发酵方法. CN: CN112626143A, 2021-04-09.
[51] 郑平, 郑小梅, 孙际宾, 卢玉丹, 周文娟, 张立辉, 马延和. 真菌来源的强启动子及其应用. CN202110268572.8, 2021-03-12.
[52] 郑平, 刘娇, 王钰, 孙际宾, 刘莫识, 周文娟, 郭轩, 马延和. γ-谷氨酰激酶突变体及其应用. CN: CN112111469B, 2021-02-26.
[53] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 马延和. 生产L-脯氨酸的菌株及其构建方法和应用. CN202110161475.9, 2021-02-05.
[54] 郑平, 郑小梅, 孙际宾, 周文娟, 张立辉, 马延和. 葡萄糖转运蛋白及其在提高有机酸生产中的应用. CN: CN112250740A, 2021-01-22.
[55] 孙际宾, 李庆刚, 郑平, 王晓玮, 周文娟, 陈久洲, 王钰, 马延和. 一种赖氨酸生产菌株的构建方法和应用. CN: CN112251391A, 2021-01-22.
[56] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN202110036121.1, 2021-01-12.
[57] 郑平, 郭轩, 陈久洲, 周文娟, 孙际宾, 马延和. 一种从发酵液中制备5-氨基乙酰丙酸的方法及其应用. CN: CN111838421A, 2020-10-30.
[58] 孙际宾, 李庆刚, 周文娟, 郑平, 马延和. L-赖氨酸高产菌株及其构建方法和应用. CN: CN111635879A, 2020-09-08.
[59] 郑平, 郭轩, 陈久洲, 周文娟, 孙际宾. 一种从发酵液中制备5-氨基乙酰丙酸盐酸盐的生产工艺及其应用. CN: CN111517973A, 2020-08-11.
[60] 孙际宾, 刘娇, 王兴初, 郭轩, 周文娟, 郑平, 马延和. 反式-L-羟脯氨酸的生产菌株及其构建方法和应用. CN: CN111484997A, 2020-08-04.
[61] 郑平, 陈久洲, 周文娟, 孙际宾, 马延和. 5-氨基乙酰丙酸生产菌株及其构建方法和应用. CN: CN110862952B, 2020-06-09.
[62] 孙际宾, 陈久洲, 郑平, 饶德明, 王钰, 周文娟, 郭轩, 马延和. 5-氨基乙酰丙酸生产菌株及其构建方法和应用. CN: CN110862952B, 2020-06-09.
[63] 孙际宾, 赵晶, 刘超, 周文娟, 郑平, 马延和. 新型脯氨酸4-羟化酶及其应用. CN: CN110804595A, 2020-02-18.
[64] 郑平, 王钰, 孙际宾, 凡立稳, T·菲利伯特, 马延和. 甲醇生物转化菌株的构建方法以及构建的菌株和应用. CN: CN110760536A, 2020-02-07.
[65] 孙际宾, 李庆刚, 周文娟, 德莱奥西班乔·泰沃, 郑平, 马延和. MviN蛋白突变体、含有该突变体的表达载体和宿主细胞及其应用. CN: CN110283796A, 2019-09-27.
[66] 孙际宾, 李庆刚, 郑平, 周文娟, 张晓立, 德莱奥西班乔·泰沃, 马延和. 活性提高的磷酸转酮酶及在生产代谢物中的应用. CN: CN110218710A, 2019-09-10.
[67] 孙际宾, 李庆刚, 郑平, 王晓玮, 周文娟, 陈久洲, 王钰, 马延和. 赖氨酸生产菌株的构建方法和应用. CN: CN110129247A, 2019-08-16.
[68] 孙际宾, 李庆刚, 杨静, 周文娟, 赵晶, 郑平, 马延和. 高丝氨酸乙酰基转移酶突变体及其宿主细胞和应用. CN: CN110129294A, 2019-08-16.
[69] 郑平, 陈久洲, 孙际宾, 饶德明, 朱成超, 潘丹丹, 周文娟, 马延和. 一种5-氨基乙酰丙酸高产菌株及其制备方法与应用. CN: CN109722459A, 2019-05-07.
[70] 李德衡, 赵兰坤, 徐庆阳, 马延和, 孙际宾, 刘元涛, 许传高, 户红通, 郑平, 高翠娟, 赵凤良, 孙钦波, 范婷婷, 贾召鹏. 谷氨酸的绿色清洁发酵工艺. CN: CN109652478A, 2019-04-19.
[71] 郑平, 陈久洲, 孙际宾, 周文娟, 孙村民, 郭轩, 马延和. 5-氨基乙酰丙酸高产菌株及其制备方法和应用. CN: CN108517327A, 2018-09-11.
[72] 岳国君, 孙际宾, 郑平, 刘娇, 李庆刚, 夏令和, 周永生, 罗虎, 周勇, 满云, 卢宗梅, 马延和. 天冬氨酸激酶III突变体及其宿主细胞和应用. CN: CN108486082A, 2018-09-04.
[73] 孙际宾, 刘娇, 郑平, 王兴初, 马延和. 一种生产反式‑4‑羟基‑L‑脯氨酸的方法. CN: CN107674864A, 2018-02-09.
[74] 孙际宾, 刘娇, 郑平, 王兴初, 周文娟, 马延和. 一种生产反式‑4‑羟基‑L‑脯氨酸的方法. CN: CN107674863A, 2018-02-09.
[75] 孙际宾, 刘娇, 赵晶, 寇风雨, 郑平, 马延和. 新的赖氨酸脱羧酶及其应用. CN: CN107177641A, 2017-09-19.
[76] 孙际宾, 赵晶, 刘娇, 孙村民, 郑平, 马延和. 新的赖氨酸脱羧酶突变体及其应用. CN: CN107164352A, 2017-09-15.
[77] 孙际宾, 赵晶, 刘娇, 孙村民, 郑平, 马延和. 新的赖氨酸脱羧酶突变体及其应用. 中国: CN107164352A, 2017-09-15.
[78] 孙际宾, 郑小梅, 郑平, 马延和. 一种新型向导RNA表达盒及在CRISPR/Cas系统中的应用. CN: CN107164375A, 2017-09-15.
[79] 孙际宾, 李澎鹏, 郑平, 马延和. 一种基因组测序数据序列组装方法. CN: CN104751015B, 2017-08-29.
[80] 孙际宾, 毕振华, 曹国强, 郑平, 马延和. 天冬氨酸激酶/高丝氨酸脱氢酶突变体及其应用. CN: CN106978405A, 2017-07-25.
[81] 孙际宾, 李庆刚, 刘亚男, 郑平, 刘永飞, 张大伟, 马延和. 新型的L-苏氨酸-诱导型启动子及其应用. CN: CN106148336A, 2016-11-23.
[82] 姜文侠, 张笑然, 郑平, 曹国强, 周文娟. 一种发酵产苏氨酸的方法及发酵系统. CN: CN105734088A, 2016-07-06.
[83] 孙际宾, 郑平, 刘娇, 王兴初, 彭久合, 马延和. 一种L-脯氨酸-4-羟基化酶及其应用. CN: CN105713883A, 2016-06-29.
[84] 郑平, 曹国强, 马红武, 张彦飞, 孙际宾, 马延和. 一种提高L-苏氨酸转化率的方法及其应用. CN: CN105505969A, 2016-04-20.
[85] 郑平, 毕振华, 曹国强, 孙际宾, 马延和. 天冬氨酸激酶/高丝氨酸脱氢酶突变体及其应用. CN: CN105505894A, 2016-04-20.
[86] 孙际宾, 李澎鹏, 郑平, 马延和. 一种基因组测序数据序列组装方法. CN: CN104750765A, 2015-07-01.
[87] 郑平, 陈久洲, 蒲伟, 孙际宾, 马延和. 5-氨基乙酰丙酸高产菌株及其制备方法和应用. CN: CN103981203A, 2014-08-13.
[88] 岳国君, 孙际宾, 郑平, 刘娇, 李庆刚, 夏令和, 周永生, 罗虎, 周勇, 满云, 卢宗梅, 马延和. 天冬氨酸激酶III突变体及其宿主细胞和应用. CN: CN103773745A, 2014-05-07.
[89] 郑平, 陈久洲, 蒲伟, 孙际宾, 马延和. 一种5-氨基乙酰丙酸产生菌株及其制备方法与应用. CN: CN103710374A, 2014-04-09.
[90] 郑平, 陈久洲, 潘丹丹, 郭小飞, 蒲伟, 孙村民, 孙际宾, 马延和. 通过弱化5-氨基乙酰丙酸脱水酶活性获得5-氨基乙酰丙酸高产菌株及其应用. CN: CN103695364A, 2014-04-02.
[91] 孙际宾, 刘娇, 郑平. 苹果酸酶突变体及其应用. CN: CN102311943A, 2012-01-11.
[92] 孙际宾, 刘娇, 郑平, 孙村民. 琥珀酸高产菌株及其应用. CN: CN102286415A, 2011-12-21.

出版信息

   
发表论文
[1] 周文娟, 付刚, 齐显尼, 郑小梅, 房欢, 夏苗苗, 张大伟, 王钦宏, 郑平, 王钰, 孙际宾. 发酵工业菌种的迭代创制. 生物工程学报[J]. 2022, 38(11): 4200-4218, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545592.
[2] Xiaomei Zheng, Timothy Cairns, Ping Zheng, Vera Meyer, Jibin Sun. Protocol for gene characterization in Aspergillus niger using 5S rRNA-CRISPR-Cas9-mediated Tet-on inducible promoter exchange. STAR PROTOCOLS. 2022, 3(4): http://dx.doi.org/10.1016/j.xpro.2022.101838.
[3] Timothy C Cairns, Xiaomei Zheng, Claudia Feurstein, Ping Zheng, Jibin Sun, Vera Meyer. A Library of Aspergillus niger Chassis Strains for Morphology Engineering Connects Strain Fitness and Filamentous Growth With Submerged Macromorphology. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2022, 9: [4] Yudan Lu, Xiaomei Zheng, Yu Wang, Lihui Zhang, Lixian Wang, Yu Lei, Tongcun Zhang, Ping Zheng, Jibin Sun. Evaluation of Aspergillus niger Six Constitutive Strong Promoters by Fluorescent-Auxotrophic Selection Coupled with Flow Cytometry: A Case for Citric Acid Production. JOURNAL OF FUNGI[J]. 2022, 8(568): https://doaj.org/article/af4f7a838ae04e88b4554bb2c01b456c.
[5] 李学朋, 陈久洲, 张东旭, 李树标, 王小平, 吕金东, 周敬, 许志颖, 郑平, 孙际宾. L-谷氨酸生产关键技术创新与产业化应用. 生物工程学报[J]. 2022, 38(11): 4343-4351, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545600.
[6] Jiuzhou Chen, Yu Wang, Ping Zheng, jibin sun. Engineering synthetic auxotrophs for growth-coupled directed protein evolution. Trends in Biotechnology[J]. 2022, [7] Zhang, Tongtong, Chen, Jiuzhou, Zheng, Ping, Gong, Weimin, Sun, Jibin, Liu, Haiping. Crystal structure of 5-Aminolevulinate synthase HemA from Rhodopseudomonas palustris presents multiple conformations. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2022, 609: 100-104, http://dx.doi.org/10.1016/j.bbrc.2022.04.021.
[8] Wang, Yu, Zheng, Ping, Xu, Zhenghong, Kondo, Akihiko, Wittmann, Christoph, Wendisch, Volker F. Editorial: Engineering Corynebacterium glutamicum Chassis for Synthetic Biology, Biomanufacturing, and Bioremediation. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2022, 10: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000814763300001.
[9] Xiaomei Zheng, Timothy Cairns, Ping Zheng, Vera Meyer, Jibin Sun. Protocol for gene characterization in Aspergillus niger using 5S rRNA-CRISPR/Cas9-mediated Tet-on inducible promoter exchange. STAR PROTOCOLS[J]. 2022, 3(4): 101838-, http://dx.doi.org/10.1016/j.xpro.2022.101838.
[10] Timothy Cairns, Xiaomei Zheng, Claudia Feurstein, Ping Zheng, Jibin Sun, Vera Meyer. Quantitative phenotypic screens of Aspergillus niger mutants in solid and liquid culture. STAR PROTOCOLS. 2022, 3(4): http://dx.doi.org/10.1016/j.xpro.2022.101883.
[11] Wang, Yu, Zhao, Dongdong, Sun, Letian, Wang, Jie, Fan, Liwen, Cheng, Guimin, Zhang, Zhihui, Ni, Xiaomeng, Feng, Jinhui, Wang, Meng, Zheng, Ping, Bi, Changhao, Zhang, Xueli, Sun, Jibin. Engineering of the Translesion DNA Synthesis Pathway Enables Controllable C-to-G and C-to-A Base Editing in Corynebacterium glutamicum. ACS SYNTHETIC BIOLOGY[J]. 2022, 11(10): 3368-3378, http://dx.doi.org/10.1021/acssynbio.2c00265.
[12] Wei Pu, Jiuzhou Chen, Liu, Pi, Jie Shen, Ningyun Cai, Baoyan Liu, Yu Lei, Lixian Wang, Xiaomeng Ni, Jie Zhang, Jiao Liu, Yingyu Zhou, Wenjuan Zhou, Hongwu Ma, Yu Wang, ping zheng, Jibin Sun. Directed evolution of linker helix as an efficient strategy for engineering LysR-type transcriptional regulators as whole-cell biosensors. Biosensors and Bioelectronics[J]. 2022, 222: [13] Xiaomei Zheng, Timothy C Cairns, Xiaomei Ni, Lihui Zhang, Huanhuan Zhai, Vera Meyer, Ping Zheng, Jibin Sun. Comprehensively dissecting the hub regulation of PkaC on high-productivity and pellet macromorphology in citric acid producing Aspergillus niger. Microbial Biotechnology[J]. 2022, [14] Liu Jiao, Liu Moshi, Tuo Shi, Guannan Sun, Ning Gao, Xiaojia Zhao, Xuan Guo, Xiaomeng Ni, Qianqian Yuan, Jinhui Feng, Zhemin Liu, Yanmei Guo, Jiuzhou Chen, Yu Wang, Ping Zheng, Jibin Sun. CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction. Nature Communication[J]. 2022, 13(891): [15] Cairns Timothy, Xiaomei Zheng, Claudia Feurstein, Ping Zheng, Jibin Sun, Vera Meyer. Quantitative phenotypic screens of Aspergillus niger mutants in solid and liquid culture. STAR PROTOCOLS[J]. 2022, 3(4): 101883-, http://dx.doi.org/10.1016/j.xpro.2022.101883.
[16] Sun, Xue, Li, Qinggang, Wang, Yu, Zhou, Wenjuan, Guo, Yanmei, Chen, Jiuzhou, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Isoleucyl-tRNA synthetase mutant based whole-cell biosensor for high-throughput selection of isoleucine overproducers. BIOSENSORS & BIOELECTRONICS[J]. 2021, 172: http://dx.doi.org/10.1016/j.bios.2020.112783.
[17] Huang, Jingwen, Chen, Jiuzhou, Wang, Yu, Shi, Tuo, Ni, Xiaomeng, Pu, Wei, Liu, Jiao, Zhou, Yingyu, Cai, Ningyun, Han, Shuangyan, Zheng, Ping, Sun, Jibin. Development of a Hyperosmotic Stress Inducible Gene Expression System by Engineering the MtrA/MtrB-Dependent NCgl1418 Promoter in Corynebacterium glutamicum. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.718511.
[18] Nie, Zhihua, Liu,Pi, Zheng, Ping, Zhu, Leilei. Directed evolution and rational design of mechanosensitive channel MscCG2 for improved glutamate excretion efficiency. Journal of Agricultural and Food Chemistry[J]. 2021, [19] Fan, Liwen, Wang, Yu, Qian, Jin, Gao, Ning, Zhang, Zhihui, Ni, Xiaomeng, Sun, Letian, Yuan, Qianqian, Zheng, Ping, Sun, Jibin. Transcriptome analysis reveals the roles of nitrogen metabolism and sedoheptulose bisphosphatase pathway in methanol-dependent growth of Corynebacterium glutamicum. MICROBIAL BIOTECHNOLOGY[J]. 2021, 14(4): 1797-1808, http://dx.doi.org/10.1111/1751-7915.13863.
[20] 凡立稳, 王钰, 郑平, 孙际宾. 一碳代谢关键酶——甲醇脱氢酶的研究进展与展望. 生物工程学报[J]. 2021, 37(2): 530-540, http://lib.cqvip.com/Qikan/Article/Detail?id=7104000438.
[21] Cairns, Timothy C, Zheng, Xiaomei, Zheng, Ping, Sun, Jibin, Meyer, Vera. Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic. JOURNAL OF FUNGI[J]. 2021, 7(7): http://dx.doi.org/10.3390/jof7070535.
[22] Yu Wang, Haijiao Cheng, Yang Liu, Ye Liu, Xiao Wen, Kun Zhang, Xiaomeng Ni, Ning Gao, Liwen Fan, Zhihui Zhang, Jiao Liu, Jiuzhou Chen, Lixian Wang, Yanmei Guo, Ping Zheng, Meng Wang, Jibin Sun, Yanhe Ma. In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-21003-y.
[23] Zhang, Zhihui, Wang, Yu, Zheng, Ping, Sun, Jibin. Promoting Lignin Valorization by Coping with Toxic C1 Byproducts. TRENDS IN BIOTECHNOLOGY. 2021, 39(4): 331-335, http://dx.doi.org/10.1016/j.tibtech.2020.09.005.
[24] 郑小梅, 郑平, 孙际宾. 基于CRISPR/Cas系统的黑曲霉基因组编辑技术. 生物工程学报[J]. 2021, 37(3): 980-990, http://lib.cqvip.com/Qikan/Article/Detail?id=7105044200.
[25] Wang, Yu, Liu, Ye, Zheng, Ping, Sun, Jibin, Wang, Meng. Microbial Base Editing: A Powerful Emerging Technology for Microbial Genome Engineering. TRENDS IN BIOTECHNOLOGYnull. 2021, 39(2): 165-180, http://dx.doi.org/10.1016/j.tibtech.2020.06.010.
[26] 陈久洲, 王钰, 蒲伟, 郑平, 孙际宾. 5-氨基乙酰丙酸生物合成技术的发展及展望. 合成生物学[J]. 2021, 2(6): 1000-1016, http://lib.cqvip.com/Qikan/Article/Detail?id=7106434784.
[27] Zhang, Lihui, Zheng, Xiaomei, Cairns, Timothy C, Zhang, Zhidan, Wang, Depei, Zheng, Ping, Sun, Jibin. Disruption or reduced expression of the orotidine-5 '-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger. MICROBIAL CELL FACTORIES[J]. 2020, 19(1): http://dx.doi.org/10.1186/s12934-020-01334-z.
[28] Li, Mingyue, Chen, Jiuzhou, Wang, Yu, Liu, Jiao, Huang, Jingwen, Chen, Ning, Zheng, Ping, Sun, Jibin. Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/f87f64c6d0d9420fbbd0fbdea99eda61.
[29] Chen, Jiuzhou, Wang, Yu, Guo, Xuan, Rao, Deming, Zhou, Wenjuan, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Efficient bioproduction of 5-aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineered Corynebacterium glutamicum. BIOTECHNOLOGY FOR BIOFUELS[J]. 2020, 13(1): https://doaj.org/article/76327970ce5a4277b911a00b0b226b6a.
[30] Wang, Yu, Fan, Liwen, Tuyishime, Philibert, Liu, Jiao, Zhang, Kun, Gao, Ning, Zhang, Zhihui, Ni, Xiaomeng, Feng, Jinhui, Yuan, Qianqian, Ma, Hongwu, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): http://dx.doi.org/10.1038/s42003-020-0954-9.
[31] 李俊维, 刘叶, 王钰, 郁彭, 郑平, 王猛. 谷氨酸棒杆菌碱基编辑的条件优化. 生物工程学报[J]. 2020, 36(1): 143-151, http://lib.cqvip.com/Qikan/Article/Detail?id=7100862753.
[32] Wang, Yu, Fan, Liwen, Tuyishirne, Philibert, Zheng, Ping, Sun, Jibin. Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing. TRENDS IN BIOTECHNOLOGY[J]. 2020, 38(6): 650-666, http://dx.doi.org/10.1016/j.tibtech.2019.12.013.
[33] Zhang, Kun, Zhang, Zhihui, Kang, Jianan, Chen, Jiuzhou, Liu, Jiao, Gao, Ning, Fan, Liwen, Zheng, Ping, Wang, Yu, Sun, Jibin. CRISPR/Cas13d-Mediated Microbial RNA Knockdown. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/d85c16031ef74534b0f4a19a090235cc.
[34] 张晓梅, 高宇洁, 杨玲, 杨毅, 郑平, 孙际宾, 史劲松, 许正宏. 谷氨酸棒杆菌中氨基酸分泌转运蛋白及其代谢改造研究进展. 生物工程学报[J]. 2020, 36(11): 2250-2259, http://lib.cqvip.com/Qikan/Article/Detail?id=7103383630.
[35] Sun, Dehu, Chen, Jiuzhou, Wang, Yu, Li, Mingyue, Rao, Deming, Guo, Yanmei, Chen, Ning, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Metabolic engineering of Corynebacterium glutamicum by synthetic small regulatory RNAs. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2019, 46(2): 203-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000457989900007.
[36] Liu, Chao, Zhao, Jing, Liu, Jiao, Guo, Xuan, Rao, Deming, Liu, Haiping, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Simultaneously improving the activity and thermostability of a new proline 4-hydroxylase by loop grafting and site-directed mutagenesis. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(1): 265-277, https://www.webofscience.com/wos/woscc/full-record/WOS:000454614300020.
[37] Cairns, Timothy C, Zheng, Xiaomei, Zheng, Ping, Sun, Jibin, Meyer, Vera. Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories. BIOTECHNOLOGY FOR BIOFUELSnull. 2019, 12(1): https://doaj.org/article/bdc26abb049d48efa0720efa8fd00ad8.
[38] Wang, Xiaowei, Li, Qinggang, Sun, Cunmin, Cai, Zhen, Zheng, Xiaomei, Guo, Xuan, Ni, Xiaomeng, Zhou, Wenjuan, Guo, Yanmei, Zheng, Ping, Chen, Ning, Sun, Jibin, Li, Yin, Ma, Yanhe. GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli. MICROBIAL CELL FACTORIES[J]. 2019, 18(1): https://doaj.org/article/ad1df27e2e594f9687f967543ad79416.
[39] 郑小梅, 郑平, 孙际宾. 面向工业生物技术的系统生物学. 生物工程学报[J]. 2019, 35(10): 1955-1973, http://lib.cqvip.com/Qikan/Article/Detail?id=7100162095.
[40] Cairns, Timothy C, Feurstein, Claudia, Zheng, Xiaomei, Zheng, Ping, Sun, Jibin, Meyer, Vera. A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using aplD in Aspergillus niger. BIOTECHNOLOGY FOR BIOFUELS[J]. 2019, 12(1): https://doaj.org/article/fb498d170980426b83d6fa165a3d9aa7.
[41] 周文娟, 刘娇, 李庆刚, 郑平, 孙际宾. 赖氨酸工业发展的机遇与挑战. 生物产业技术[J]. 2019, 84-90, http://lib.cqvip.com/Qikan/Article/Detail?id=7001298268.
[42] Tan, Zijian, Zhao, Jing, Chen, Jiuzhou, Rao, Deming, Zhou, Wenjuan, Chen, Ning, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Enhancing thermostability and removing hemin inhibition of Rhodopseudomonas palustris 5-aminolevulinic acid synthase by computer-aided rational design. BIOTECHNOLOGY LETTERS[J]. 2019, 41(1): 181-191, https://www.webofscience.com/wos/woscc/full-record/WOS:000454783700016.
[43] Zhao, Jing, Liu, Chao, Guo, Xuan, Wang, Jinyu, Liu, Haiping, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Efficient production of trans-3-hydroxyproline by a bacterial trans-3-proline hydroxylase and characterization of enzymatic properties. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2019, 147: 57-61, http://dx.doi.org/10.1016/j.bej.2019.04.006.
[44] Zheng, Xiaomei, Zheng, Ping, Zhang, Kun, Cairns, Timothy C, Meyer, Vera, Sun, Jibin, Ma, Yanhe. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(7): 1568-1574, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957300012.
[45] Wang, Yu, Liu, Ye, Li, Junwei, Yang, Yi, Ni, Xiaomeng, Cheng, Haijiao, Huang, Teng, Guo, Yanmei, Ma, Hongwu, Zheng, Ping, Wang, Meng, Sun, Jibin, Ma, Yanhe. Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2019, 116(11): 3016-3029, [46] Zheng, Xiaomei, Yu, Jiandong, Cairns, Timothy C, Zhang, Lihui, Zhang, Zhidan, Zhang, Qiongqiong, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger. BIOTECHNOLOGY JOURNAL[J]. 2019, 14(3): [47] Zhu, Chengchao, Chen, Jiuzhou, Wang, Yu, Wang, Lixian, Guo, Xuan, Chen, Ning, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Enhancing 5-aminolevulinic acid tolerance and production by engineering the antioxidant defense system of Escherichia coli. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2019, 116(8): 2018-2028, [48] Timothy C Cairns, Claudia Feurstein, Xiaomei Zheng, Li Hui Zhang, Ping Zheng, Jibin Sun, Vera Meyer. Correction to: Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture. FUNGAL BIOLOGY AND BIOTECHNOLOGY[J]. 2019, 6(1): 1-4, http://dx.doi.org/10.1186/s40694-019-0087-4.
[49] DeleOsibanjo, Taiwo, Li, Qinggang, Zhang, Xiaoli, Guo, Xuan, Feng, Jinhui, Liu, Jiao, Sun, Xue, Wang, Xiaowei, Zhou, Wenjuan, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(20): 8413-8425, https://www.webofscience.com/wos/woscc/full-record/WOS:000491439700013.
[50] Fan, Liwen, Wang, Yu, Tuyishime, Philibert, Gao, Ning, Li, Qinggang, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Engineering Artificial Fusion Proteins for Enhanced Methanol Bioconversion. CHEMBIOCHEM[J]. 2018, 19(23): 2465-2471, https://www.webofscience.com/wos/woscc/full-record/WOS:000452035700008.
[51] Xu, Deyu, Zhao, Jing, Cao, Guoqiang, Wang, Jinyu, Li, Qinggang, Zheng, Ping, Zhao, Shuxin, Sun, Jibin. Removal of Feedback Inhibition of Corynebacterium glutamicum Phosphoenolpyruvate Carboxylase by Addition of a Short Terminal Peptide. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING[J]. 2018, 23(1): 72-78, https://www.webofscience.com/wos/woscc/full-record/WOS:000427741600010.
[52] Wang, Yu, Cao, Guoqiang, Xu, Deyu, Fan, Liwen, Wu, Xinyang, Ni, Xiaomeng, Zhao, Shuxin, Zheng, Ping, Sun, Jibin, Ma, Yanhe. A Novel Corynebacterium glutamicum L-Glutamate Exporter. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000426389400027.
[53] Jibin Sun. Mutations on Peptidoglycan Synthesis Gene ponA Improve Electro-transformation Efficiency of Corynebacterium glutamicum ATCC 13869. Applied and Environmental Microbiology. 2018, [54] Jibin Sun. Comprehensive Optimization of the Metabolomics Methodology for Metabolite Profiling of Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 2018, [55] 曲戈, 赵晶, 郑平, 孙际宾, 孙周通. 定向进化技术的最新进展. 生物工程学报[J]. 2018, 34(1): 1-11, http://lib.cqvip.com/Qikan/Article/Detail?id=674348257.
[56] Kou, Fengyu, Zhao, Jing, Liu, Jiao, Sun, Cunmin, Guo, Yanmei, Tan, Zijian, Cheng, Feng, Li, Zhimin, Zheng, Ping, Sun, Jibin. Enhancement of the thermal and alkaline pH stability of Escherichia coli lysine decarboxylase for efficient cadaverine production. BIOTECHNOLOGY LETTERS[J]. 2018, 40(4): 719-727, https://www.webofscience.com/wos/woscc/full-record/WOS:000428052600013.
[57] Jibin Sun. Heterologous and endogenous U6 snRNA promoters enabled CRISPR/Cas9 mediated genome editing in Aspergillus niger. Fungal Biology and Biotechnology. 2018, [58] Liu, Jiao, Wang, Yu, Zheng, Ping, Sun, Jibin. CRISPR/Cas9-mediated ssDNA Recombineering in Corynebacterium glutamicum. BIO-PROTOCOL[J]. 2018, 8(19): http://dx.doi.org/10.21769/BioProtoc.3038.
[59] Wang, Yu, Liu, Ye, Liu, Jiao, Guo, Yanmei, Fan, Liwen, Ni, Xiaomeng, Zheng, Xiaomei, Wang, Meng, Zheng, Ping, Sun, Jibin, Ma, Yanhe. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. METABOLIC ENGINEERING[J]. 2018, 47: 200-210, http://dx.doi.org/10.1016/j.ymben.2018.02.016.
[60] Liu, Jiao, Wang, Yu, Lu, Yujiao, Ni, Xiaomeng, Guo, Xuan, Zhao, Jing, Chen, Jiuzhou, DeleOsibanjo, Taiwo, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Mutations in Peptidoglycan Synthesis Gene ponA Improve Electrotransformation Efficiency of Corynebacterium glutamicum ATCC 13869. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000451988000019.
[61] Tuyishime, Philibert, Wang, Yu, Fan, Liwen, Zhang, Qiongqiong, Li, Qinggang, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. METABOLIC ENGINEERING[J]. 2018, 49: 220-231, http://dx.doi.org/10.1016/j.ymben.2018.07.011.
[62] Zhang, Qiongqiong, Zheng, Xiaomei, Wang, Yu, Yu, Jiandong, Zhang, Zhidan, DeleOsibanjo, Taiwo, Zheng, Ping, Sun, Jibin, Jia, Shiru, Ma, Yanhe. Comprehensive optimization of the metabolomic methodology for metabolite profiling of Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(16): 7113-7121, https://www.webofscience.com/wos/woscc/full-record/WOS:000440109200029.
[63] Wang, XingChu, Liu, Jiao, Zhao, Jing, Ni, XiaoMeng, Zheng, Ping, Guo, Xuan, Sun, CunMin, Sun, JiBin, Ma, YanHe. Efficient production of trans-4-hydroxy-L-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli. JOURNAL OF BIOSCIENCE AND BIOENGINEERING[J]. 2018, 126(4): 470-477, http://dx.doi.org/10.1016/j.jbiosc.2018.04.012.
[64] 王迎春, 刘娇, 倪晓蒙, 雷宇, 郑平, 刁爱坡. 基于时间序列转录组筛选谷氨酸棒杆菌内源高效组成型启动子. 生物工程学报[J]. 2018, 34(11): 1760-1771, http://lib.cqvip.com/Qikan/Article/Detail?id=676852119.
[65] Xiaolu Wang, Yu Wang, Jiao Liu, Qinggang Li, Zhidan Zhang, Ping Zheng, Fuping Lu, Jibin Sun. Biological conversion of methanol by evolved Escherichia coli carrying a linear methanol assimilation pathway. BIORESOURCES AND BIOPROCESSING[J]. 2017, 4(1): 1-6, http://dx.doi.org/10.1186/s40643-017-0172-6.
[66] 饶德明, 张良程, 陈久洲, 孙德虎, 孙村民, 郑小梅, 郑平, 刁爱坡. 谷氨酸棒状杆菌合成5-氨基乙酰丙酸的途径构建与发酵优化. 生物技术通报[J]. 2017, 33(1): 148-156, http://lib.cqvip.com/Qikan/Article/Detail?id=671270638.
[67] Liu, Jiao, Wang, Yu, Lu, Yujiao, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Development of a CRISPR/Cas9 genome editing toolbox for Corynebacterium glutamicum. MICROBIAL CELL FACTORIES[J]. 2017, 16(1): http://dx.doi.org/10.1186/s12934-017-0815-5.
[68] 王晓璐, 王钰, 刘娇, 郑平, 路福平. 利用定向进化提高基因工程大肠杆菌的甲醇利用能力. 生物技术通报[J]. 2017, 33(9): 101-109, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6073830&detailType=1.
[69] 徐德雨, 郑小梅, 赵晶, 郑平, 赵树欣. 谷氨酸棒杆菌天冬氨酸激酶G359D突变解除赖氨酸与苏氨酸协同抑制的研究. 生物技术通报[J]. 2017, 33(11): 143-152, http://lib.cqvip.com/Qikan/Article/Detail?id=673984471.
[70] 郑平. 谷氨酸棒状杆菌利用碳四途径合成5-氨基乙酰丙酸的途径构建与发酵优化. 生物技术通报. 2017, [71] 杨静, 李庆刚, 徐国栋, 郑小梅, 郑平, 牟海津. 产O-乙酰高丝氨酸的大肠杆菌构建与发酵测试. 生物技术通报[J]. 2017, 33(9): 200-209, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6073844&detailType=1.
[72] Wang, Yan, Li, Qinggang, Zheng, Ping, Guo, Yanmei, Wang, Lixian, Zhang, Tongcun, Sun, Jibin, Ma, Yanhe. Evolving the L-lysine high-producing strain of Escherichia coli using a newly developed high-throughput screening method. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2016, 43(9): 1227-1235, http://www.irgrid.ac.cn/handle/1471x/1180936.
[73] Meng, Qunglong, Zhang, Yanfei, Ju, Xiaozhi, Ma, Chunling, Ma, Hongwu, Chen, Jiuzhou, Zheng, Ping, Sun, Jibin, Zhu, Jun, Ma, Yanhe, Zhao, Xueming, Chen, Tao. Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. JOURNAL OF BIOTECHNOLOGY[J]. 2016, 226: 8-13, http://dx.doi.org/10.1016/j.jbiotec.2016.03.024.
[74] Fengyu Kou, Jing Zhao, Jiao Liu, Jie Shen, Qin Ye, Ping Zheng, Zhimin Li, Jibin Sun, Yanhe Ma. Characterization of a new lysine decarboxylase from Aliivibrio salmonicida for cadaverine production at alkaline pH. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2016, 133: S88-S94, http://dx.doi.org/10.1016/j.molcatb.2016.11.023.
[75] Liu, Yanan, Li, Qinggang, Zheng, Ping, Zhang, Zhidan, Liu, Yongfei, Sun, Cunmin, Cao, Guoqiang, Zhou, Wenjuan, Wang, Xiaowei, Zhang, Dawei, Zhang, Tongcun, Sun, Jibin, Ma, Yanhe. Developing a high-throughput screening method for threonine overproduction based on an artificial promoter. MICROBIAL CELL FACTORIES[J]. 2015, 14(1): http://www.irgrid.ac.cn/handle/1471x/1111645.
[76] 郑小梅, 张晓立, 于建东, 郑平, 孙际宾. CRISPR-Cas9介导的基因组编辑技术的研究进展. 生物技术进展[J]. 2015, 5(1): 1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=663551668.
[77] Wu, Yong, Li, Pengpeng, Zheng, Ping, Zhou, Wenjuan, Chen, Ning, Sun, Jibin. Complete genome sequence of Corynebacterium glutamicum B253, a Chinese lysine-producing strain. JOURNAL OF BIOTECHNOLOGY[J]. 2015, 207: 10-11, http://dx.doi.org/10.1016/j.jbiotec.2015.04.018.
[78] Zhang, Yanfei, Meng, Qinglong, Ma, Hongwu, Liu, Yongfei, Cao, Guoqiang, Zhang, Xiaoran, Zheng, Ping, Sun, Jibin, Zhang, Dawei, Jiang, Wenxia, Ma, Yanhe. Determination of key enzymes for threonine synthesis through in vitro metabolic pathway analysis. MICROBIAL CELL FACTORIES[J]. 2015, 14(1): http://www.irgrid.ac.cn/handle/1471x/1111642.
[79] Xu ZiXiang, Zheng Ping, Sun JiBin. Reconstruction of Whole Cell Network and Design of Cell Factory. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(2): 105-114, http://124.16.173.210/handle/834782/1379.
[80] Zheng, Ping, Sun, Jibin. Protein engineering for strain engineering. NEW BIOTECHNOLOGY[J]. 2014, 31: S163-S163, http://dx.doi.org/10.1016/j.nbt.2014.05.2024.
[81] Xu ZiXiang, Zheng Ping, Sun JiBin. Reconstruction of Whole Cell Network and Design of Cell Factory. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(2): 105-114, http://124.16.173.210/handle/834782/1379.
[82] 孙际宾. 全细胞网络重建与细胞工厂设计. 生物化学与 生物物理进展. 2014, [83] He, Feng Q, Wang, Wei, Zheng, Ping, Sudhakar, Padhmanand, Sun, Jibin, Zeng, AnPing. Essential O-2-responsive genes of Pseudomonas aeruginosa and their network revealed by integrating dynamic data from inverted conditions. INTEGRATIVE BIOLOGY[J]. 2014, 6(2): 215-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000330795500010.
[84] Zixiang Xu, Ping Zheng, Jibin Sun, Yanhe Ma. ReacKnock: Identifying Reaction Deletion Strategies for Microbial Strain Optimization Based on Genome-Scale Metabolic Network. PLOS ONE[J]. 2013, 8(12): http://www.irgrid.ac.cn/handle/1471x/1111630.
[85] Geng, Feng, Chen, Zhen, Zheng, Ping, Sun, Jibin, Zeng, AnPing. Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(5): 1963-1971, http://www.irgrid.ac.cn/handle/1471x/483729.
[86] 蒲伟, 陈久洲, 孙村民, 陈宁, 孙际宾, 郑平, 马延和. 琥珀酸脱氢酶或琥珀酰辅酶A合成酶缺失促进大肠杆菌积累5-氨基乙酰丙酸. 生物工程学报[J]. 2013, 29(10): 1494-1503, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4958966&detailType=1.
[87] Jibin Sun. Cloning of two 5-Aminolevulinic Acid Synthase Isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characters for 5-aminolevulinic acid production. Biotechnology Letters. 2013, [88] Chen, Lin, Chen, Zhen, Zheng, Ping, Sun, Jibin, Zeng, AnPing. Study and reengineering of the binding sites and allosteric regulation of biosynthetic threonine deaminase by isoleucine and valine in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(7): 2939-2949, http://www.irgrid.ac.cn/handle/1471x/483730.
[89] 马延和, 郑平, 陈久洲, 蒲伟, 孙际宾. 5-氨基乙酰丙酸高产菌株及其制备方法和应用. 2013, http://124.16.173.210/handle/312001/336.
[90] Zhang, Lilu, Chen, Jiuzhou, Chen, Ning, Sun, Jibin, Zheng, Ping, Ma, Yanhe. Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production. BIOTECHNOLOGY LETTERS[J]. 2013, 35(5): 763-768, http://124.16.173.210/handle/834782/1295.
[91] 吴新阳, 裴广胜, 郑小梅, 曹国强, 刘娇, 郑平, 王敏, 孙际宾. 不同抑制剂对谷氨酸棒状杆菌磷酸烯醇式丙酮酸羧化酶酶活的影响. 生物技术通报[J]. 2013, 172-178, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4895212&detailType=1.
[92] 姜安娜, 曹名锋, 李庆刚, 郑平, 杨洪江, 孙际宾. 一种改进的赖氨酸浓度测定方法. 生物技术通报[J]. 2013, 190-194, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4780390&detailType=1.
[93] 姜金国, 宋理富, 郑平, 孙际宾, 孙际宾. 谷氨酸棒状杆菌集成细胞网络的构建与结构分析. 生物工程学报[J]. 2012, 28(5): 577-591, http://lib.cqvip.com/Qikan/Article/Detail?id=41939456.
[94] 郭小飞, 陈久洲, 张莉露, 贾士儒, 郑平. 利用5-氨基乙酰丙酸脱水酶缺失的重组大肠杆菌合成5-氨基乙酰丙酸. 天津科技大学学报[J]. 2012, 27(4): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=42984875.
[95] 尚柯, 郭小飞, 王艳萍, 郑平. 5一氨基乙酰丙酸脱水酶缺失对大肠杆菌生长的影响. 现代食品科技[J]. 2011, 27(7): http://124.16.173.210/handle/311007/603.
[96] 尚柯, 郭小飞, 王艳萍, 郑平. 5-氨基乙酰丙酸脱水酶缺失对大肠杆菌生长的影响. 现代食品科技[J]. 2011, 27(7): 742-746, http://lib.cqvip.com/Qikan/Article/Detail?id=38640657.
[97] 马建刚, 刘娇, 曾祥峰, 郑平, 贾士儒, 孙际宾. 大肠杆菌9种有机酸代谢产物的高效液相检测条件优化. 现代食品科技[J]. 2011, 27(5): 591-594, http://lib.cqvip.com/Qikan/Article/Detail?id=37823681.
[98] 孙际宾, 刘娇, 郑平. 苹果酸酶突变体及其应用. 2011, http://124.16.173.210/handle/0/185.
[99] 杨晓涛, 郭艳梅, 曾祥峰, 满云, 郑平, 王昌禄, 孙际宾. 黑曲霉产柠檬酸的发酵过程表征及乙醛酸的形成. 现代食品科技[J]. 2011, 27(10): 1183-1186, http://lib.cqvip.com/Qikan/Article/Detail?id=39651067.
[100] 杨晓涛, 郭艳梅, 曾祥峰, 满云, 郑平, 王昌禄, 孙际宾. 黑曲霉柠檬酸发酵生产过程表征与乙醛酸形成. 现代食品科技[J]. 2011, 27(10): 1183-1186, http://www.irgrid.ac.cn/handle/1471x/483750.
[101] 郭艳梅, 郑平, 孙际宾. 黑曲霉作为细胞工厂:知识准备与技术基础. 生物工程学报[J]. 2010, 1410-1418, http://lib.cqvip.com/Qikan/Article/Detail?id=35657156.
[102] 郑平. 优化条件后高效液相检测大肠杆菌9种有机酸代谢产物. 现代食品科技. 2010, [103] Zheng, Ping, Sun, Jibin, Geffers, Robert, Zeng, AnPing. Functional characterization of the gene PA2384 in large-scale gene regulation in response to iron starvation in Pseudomonas aeruginosa. JOURNAL OF BIOTECHNOLOGY[J]. 2007, 132(4): 342-352, http://dx.doi.org/10.1016/j.jbiotec.2007.08.013.
[104] Zheng, Ping, Wereath, Kirsten, Sun, Jibin, van den Heuvel, Joop, Zeng, AnPing. Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae. PROCESS BIOCHEMISTRY[J]. 2006, 41(10): 2160-2169, http://dx.doi.org/10.1016/j.procbio.2006.06.012.
[105] Zheng, Ping, Sun, Jibin, van den Heuvel, Joop, Zeng, AnPing. Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae. JOURNAL OF BIOTECHNOLOGY[J]. 2006, 125(4): 462-473, http://dx.doi.org/10.1016/j.jbiotec.2006.03.034.
[106] Xiaomei Zheng, Timothy Cairns, Ping Zheng, Vera Meyer, Jibin Sun. Protocol for gene characterization in Aspergillus niger using 5S rRNA-CRISPR/Cas9 mediated Tet-on inducible promoter exchange. STAR PROTOCOLS. http://dx.doi.org/10.1016/j.xpro.2022.101838.
[107] Philibert Tuyishime, Yu Wang, Liwen Fan, Qiongqiong Zhang, Qinggang Li, Ping Zheng, Jibin Sun, Yanhe Ma. TEMPORARY REMOVAL: Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. METABOLIC ENGINEERING. http://dx.doi.org/10.1016/j.ymben.2018.07.011.

科研活动

   
科研项目
( 1 ) 能源微藻采收、油脂提取及生物柴油制备原理与方法, 主持, 国家级, 2011-01--2012-12
( 2 ) 天津工业生物技术研究所优秀青年科技专项, 主持, 部委级, 2011-01--2013-12
( 3 ) 大肠杆菌5-氨基乙酰丙酸穿膜运输的分子基础, 主持, 国家级, 2011-01--2013-12
( 4 ) 生物制造5-氨基乙酰丙酸的关键技术, 主持, 省级, 2010-04--2013-03
( 5 ) 留学人员科技活动项目, 主持, 国家级, 2010-08--2012-07
( 6 ) 黑曲霉整合型细胞网络的构建和在柠檬酸代谢工程方面的应用, 参与, 国家级, 2009-01--2011-12
( 7 ) 琥珀酸发酵生产的系统生物技术改造及中等规模实验, 参与, 省级, 2009-04--2011-09
( 8 ) 异戊醇生物制造的途径构建及系统优化, 参与, 部委级, 2009-01--2011-12
( 9 ) 油藻高值产品开发和整合系统的数学模型, 主持, 国家级, 2011-01--2012-12
( 10 ) 工业微生物基因组测序及分析, 参与, 部委级, 2011-01--2013-12
( 11 ) 大肠杆菌基因组理性设计, 主持, 省级, 2011-10--2014-09
( 12 ) 基因组理性设计与氨基酸生产菌种的构建, 主持, 国家级, 2012-11--2015-12
( 13 ) 赖氨酸高产菌种改造, 参与, 研究所(学校), 2011-09--2014-09
( 14 ) 柠檬酸高产菌株的改造, 参与, 研究所(学校), 2010-10--2012-12
( 15 ) 谷氨酸脱氨与脱羧衍生转化关键技术 , 参与, 国家级, 2014-01--2016-12
( 16 ) 人工细胞工厂创新团队, 参与, 部委级, 2014-01--2016-12
( 17 ) 微生物细胞工厂设计创新团队, 参与, 省级, 2016-01--2017-12
( 18 ) 生物法生产1,5-戊二胺中试放大, 主持, 院级, 2017-10--2018-10
( 19 ) 甲醇制氨基酸, 主持, 部委级, 2016-01--2018-12
( 20 ) 柠檬酸生产菌株高产分析, 主持, 院级, 2017-08--2018-01

指导学生

已指导学生

杨宝银  硕士研究生  430139-生物工程  

潘丹丹  硕士研究生  085238-生物工程  

于建东  硕士研究生  085238-生物工程