081703-生物化工
071010-生物化学与分子生物学

进化与代谢工程
代谢工程

1999-09--2003-03   中国科学院微生物研究所   理学博士
1996-09--1999-04   郑州粮食学院   工学硕士
1992-09--1996-06   郑州粮食学院   工学学士

   

2009-05~现在, 中国科学院天津工业生物技术研究所, 研究员/博士研究生
2005-06~2009-04,California Institute of Technology, Postdoctoral Scholar/Research Scientist
2004-01~2005-06,University of Oklahoma, Postdoectoral Research Associate
1999-09~2003-03,中国科学院微生物研究所, 理学博士
1996-09~1999-04,郑州粮食学院, 工学硕士
1992-09~1996-06,郑州粮食学院, 工学学士

2016-12-31-今,Scientific Reports, 编委
2012-10-01-今,生物工程学报, 编委

工业生物技术——生物技术的第三次浪潮系列讲座

   

（1） 国务院政府特殊津贴, , 国家级, 2018
（2） 天津市优秀党员, , 市地级, 2018
（3） 工业合成生物创新团队, , 市地级, 2017
（4） 天津市五一劳动奖章, , 市地级, 2016
（5） 天津市科技系统优秀青年, , 市地级, 2013
（6） 中国科学院“引进杰出人才计划(****), , 院级, 2009

（ 1 ） 一株生产原儿茶酸的大肠杆菌基因工程菌及其构建方法与应用, 2022, 第 1 作者, 专利号: CN109943512B

（ 2 ） 一种应答3-脱氢莽草酸的生物传感器及其应用, 2022, 第 1 作者, 专利号: CN107974451B

（ 3 ） 一株发酵法生产血红素的酿酒酵母基因工程菌构建与应用, 2021, 第 1 作者, 专利号: 202110929121.4

（ 4 ） 一种基因定点突变方法及其胁迫抗性育种应用, 2021, 第 5 作者, 专利号: CN112851776A

（ 5 ） 基于液滴微流控芯片的毕赤酵母高通量筛选方法, 2020, 第 2 作者, 专利号: CN111718862A

（ 6 ） 发酵法生产酪氨酸的大肠杆菌及其构建方法与应用, 2019, 第 1 作者, 专利号: CN109929786A

（ 7 ） 一种基于生物传感器的高通量筛选方法, 2019, 第 3 作者, 专利号: CN109679886A

   

（1） Metabolic engineering of Escherichia coli for high-level production of the biodegradable polyester monomer 2-pyrone-4,6-dicarboxylic acid, Metabolic Engineering, 2024, 
（2） Microfluidic screening and genomic mutation identification for enhancing cellulase production in Pichia pastoris, BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS, 2022, 第 11 作者
（3） Sophorolipids bioproduction in the yeast Starmerella bombicola: Current trends and perspectives, BIORESOURCE TECHNOLOGY, 2022, 第 2 作者
（4） Recent Advances in Directed Yeast Genome Evolution, JOURNAL OF FUNGI, 2022, 第 11 作者
（5） Dissecting carbon metabolism of Yarrowia lipolytica type strain W29 using genome-scale metabolic modelling, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 第 6 作者
（6） Modulating DNA Repair Pathways to Diversify Genomic Alterations in Saccharomyces cerevisiae, MICROBIOLOGY SPECTRUM, 2022, 第 11 作者
（7） Metabolic engineering of Yarrowia lipolytica for terpenoids production: advances and perspectives, CRITICAL REVIEWS IN BIOTECHNOLOGY, 2022, 第 5 作者
（8） Ultrahigh-throughput screening of industrial enzyme-producing strains by droplet-based microfluidic system, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2022, 第 11 作者
（9） Dual ��-oxidation pathway and transcription factor engineering for methyl ketones production in Saccharomyces cerevisiae, METABOLIC ENGINEERING, 2022, 第 4 作者
（10） High-Level Production of Catechol from Glucose by Engineered Escherichia coli, FERMENTATION-BASEL, 2022, 第 11 作者
（11） Cofactor Self-Sufficient Whole-Cell Biocatalysts for the Relay-Race Synthesis of Shikimic Acid, Fermentation, 2022, 第 11 作者
（12） Stress tolerance enhancement via SPT15 base editing in Saccharomyces cerevisiae, Biotechnology for Biofuels, 2021, 
（13） Design and Reconstruction of Regulatory Parts for Fast-frowing Vibrio natriegens Synthetic Biology, ACS SYNTHETIC BIOLOGY, 2020, 第 11 作者
（14） Metabolic engineering of Escherichia coli for polyamides monomer ��-valerolactam production from feedstock lysine., Applied Microbiology And Biotechnology, 2020, 第 11 作者
（15） Biosensor-enabled droplet microfluidic system for the rapid screening of 3-dehydroshikimic acid produced inEscherichia coli, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2020, 第 11 作者
（16） Discovery and identification of medium-chain fatty acid responsive promoters in Saccharomyces cerevisiae, ENGINEERING IN LIFE SCIENCES, 2020, 第 11 作者
（17） Development of a Simple Colorimetric Assay for Determination of the Isoamyl Alcohol-Producing Strain, APPLIEDBIOCHEMISTRYANDBIOTECHNOLOGY, 2020, 第 11 作者
（18） Genomic, transcriptomic, and metabolic characterizations of Escherichia coli adapted to branched-chain higher alcohol tolerance, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 第 11 作者
（19） QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast, BIOTECHNOLOGY FOR BIOFUELS, 2019, 第 11 作者
（20） Development of a Synthetic 3-Dehydroshikimate Biosensor in Escherichia coli for Metabolite Monitoring and Genetic Screening, ACS SYNTHETIC BIOLOGY, 2019, 
（21） Systematically redesigning and optimizing the expression of D-lactate dehydrogenase efficiently produces high-optical-purity D-lactic acid in Saccharomyces cerevisiae, BIOCHEMICAL ENGINEERING JOURNAL, 2019, 第 11 作者
（22） Development and genomic elucidation of hybrid yeast with improved glucose-xylose co-fermentation at high temperature, FEMS YEAST RESEARCH, 2019, 第 11 作者
（23） Production of nonnatural straight-chain amino acid 6-aminocaproat e via an artificial iterative carbon-chain-e xtension cycle., Metabolic Engineering, 2019, 
（24） Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2018, 第 11 作者
（25） Metabolic and genomic characterization of stress tolerant industrial Saccharomyces cerevisiae strains from TALENs-assisted multiplex editing., FEMS Yeast Research, 2018, 第 11 作者
（26） Expanding the repertoire of aromatic chemicals by microbial production, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2018, 第 11 作者
（27） A pH-stable, detergent and chelator resistant type I pullulanase from Bacillus pseudofirmus 703 with high catalytic efficiency. International, Journal of Biological Macromolecules, 2018, 第 1 作者
（28） Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock, JOURNAL OF PROTEOME RESEARCH, 2018, 第 11 作者
（29） Enhanced 5-aminovalerate production in Escherichia coli from l-lysine with ethanol and hydrogen peroxide addition, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2018, 第 11 作者
（30） An economically and environmentally acceptable synthesis of chiral drug intermediate l-pipecolic acid from biomass-derived lysine via artificially engineered microbes, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2018, 第 11 作者
（31） Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection, ANALYTICA CHIMICA ACTA, 2018, 第 5 作者
（32） Designing and Creating a Synthetic Omega Oxidation Pathway in Saccharomyces cerevisiae Enables Production of Medium-Chain ��, ��-Dicarboxylic Acids, FRONTIERS IN MICROBIOLOGY, 2017, 第 6 作者
（33） Synthetic biology for manufacturing chemicals: constraints drive the use of non-conventional microbial platforms, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 第 2 作者
（34） Characterization of aromatic residue���controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 7 作者
（35） Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system., Lab on a Chip, 2017, 第 1 作者
（36） ��� Li Z, Li Y, Chen W, Cao Q, Guo Y, Wan N, Jiang X, Tang YJ, Wang Q, Shui W. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis., Analytical Chemistry, 2017, 第 1 作者
（37） Characterization of aromatic residue���controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 7 作者
（38） High copy and stable expression of the xylanase XynHB in Saccharomyces cerevisiae by rDNA-mediated integration, SCIENTIFIC REPORTS, 2017, 第 2 作者
（39） High production of fatty alcohols in Escherichia coli with fatty acid starvation, MICROBIAL CELL FACTORIES, 2016, 第 11 作者
（40） High-level expression of improved thermo-stable alkaline xylanase variant in Pichia Pastoris through codon optimization, multiple gene insertion and high-density fermentation, SCIENTIFIC REPORTS, 2016, 第 3 作者
（41） Truncation of the unique N-terminal domain improved the thermos-stability and specific activity of alkaline ��-amylase Amy703, SCIENTIFIC REPORTS, 2016, 第 2 作者
（42） An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry, ANALYTICAL CHEMISTRY, 2016, 第 11 作者
（43） PCR-Based Seamless Genome Editing with High Efficiency and Fidelity in Escherichia coli, PLOS ONE, 2016, 第 10 作者
（44） Understanding the Mechanism of Thermotolerance Distinct From Heat Shock Response Through Proteomic Analysis of Industrial Strains of Saccharomyces cerevisiae *, MOLECULAR & CELLULAR PROTEOMICS : MCP, 2015, 第 9 作者
（45） Structural Insight into and Mutational Analysis of Family 11 Xylanases: Implications for Mechanisms of Higher pH Catalytic Adaptation, PLOS ONE, 2015, 第 4 作者
（46） Genome shuffling of the nonconventional yeast Pichia anomala for improved sugar alcohol production, MICROBIAL CELL FACTORIES, 2015, 第 11 作者
（47） TALENs-Assisted Multiplex Editing for Accelerated Genome Evolution To Improve Yeast Phenotypes, ACS SYNTHETIC BIOLOGY, 2015, 第 11 作者
（48） Rhamnolipid production, characterization and fermentation scale-up by Pseudomonas aeruginosa with plant oils, BIOTECHNOLOGY LETTERS, 2015, 第 3 作者
（49） Engineering catechol 1,2-dioxygenase by design for improving the performance of the cis, cis-muconic acid synthetic pathway in Escherichia coli, SCIENTIFIC REPORTS, 2015, 第 8 作者
（50） Engineering the biosynthesis of novel rhamnolipid biosurfactants in Escherichia coli., Journal of Applied Microbiology, 2014, 第 11 作者
（51） Characterization of the sugar alcohol-producing yeast Pichia anomala, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2014, 第 11 作者
（52） Functional role of �� domain in the Thermoanaerobacter tengcongensis glucoamylase, APPL MICROBIOL BIOTECHNOL, 2014, 第 5 作者
（53） A double-enzyme-coupled assay for high-throughput screening of succinic acid-producing strains, JOURNAL OF APPLIED MICROBIOLOGY, 2013, 
（54） A simple colorimetric method for detection of 16,17-epoxysterol compounds., Chemistry Letters, 2013, 第 11 作者
（55） Directed evolution of cytochrome P450 for sterol epoxidation, BIOTECHNOLOGY LETTERS, 2013, 第 11 作者
（56） Branched-Chain Higher Alcohols, BIOTECHNOLOGY IN CHINA III: BIOFUELS AND BIOENERGY, 2012, 第 11 作者
（57） Ionic liquids-based hydrolysis of Chlorellabiomass for fermentable sugars, BIORESOURCE TECHNOLOGY, 2012, 第 4 作者
（58） High-throughput screening and characterization of xylose-utilizing and ethanol tolerant thermophilic bacteria for bioethanol production., Journal of Applied Microbiology, 2011, 第 11 作者
（59） Hydrolysis of Chlorellabiomass for fermentable sugars in the presence of HCl and MgCl2, BIORESOURCE TECHNOLOGY, 2011, 第 11 作者
（60） The Alcohol Dehydrogenase System in the Xylose-Fermenting YeastCandida maltosa, PLOS ONE, 2010, 第 3 作者
（61） Engineering Bacteria for Production of Rhamnolipid as an Agent for Enhanced Oil Recovery, BIOTECHNOLOGY AND BIOENGINEERING, 2007, 第 1 作者
（62） MukEF Is Required for Stable Association of MukB with the Chromosome ���, JOURNAL OF BACTERIOLOGY, 2007, 第 2 作者
（63） Chromosome Condensation in the Absence of the Non-SMC Subunits of MukBEF ���, JOURNAL OF BACTERIOLOGY, 2006, 第 1 作者
（64） Metabolic engineering of Torulopsis glabrata for improved pyruvate production, ENZYME AND MICROBIAL TECHNOLOGY, 2005, 
（65） C-terminus mutations of Acremonium chrysogenum deacetoxyl/deacetylcephalosporin C synthesis with improved activity toward penicillin analogs, FEMS Microbiology Letters, 2005, 第 1 作者
（66） Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005, JOURNAL OF BIOCHEMISTRY, 2004, 
（67） Screening of pyruvate-producing yeast and effect of nutritional conditions on pyruvate production, LETTERS IN APPLIED MICROBIOLOGY, 2002, 

（ 1 ） 《2017高技术发展报告》-工业生物制造技术产业化新进展, 科学出版社, 2017-09, 第 1 作者

   

（ 1 ） 液滴微流控高通量筛选技术平台, 负责人, 境内委托项目, 2021-12--2041-12
（ 2 ） 工业菌种高通量选育技术与装备研发及应用, 负责人, 国家任务, 2021-12--2024-11
（ 3 ） 合成生物制造发展战略研究, 负责人, 中国科学院计划, 2019-01--2019-12
（ 4 ） 变革性的化学品生物制造技术研发及示范（子任务名称：航空航天用环氧树脂生物合成制造及应用测评）, 负责人, 中国科学院计划, 2019-01--2020-12
（ 5 ） 原儿茶酸、红景天苷、灯盏花素合成生物学研究, 负责人, 国家任务, 2018-01--2020-12
（ 6 ） 多尺度微生物单细胞高通量筛选系统研制, 负责人, 中国科学院计划, 2018-01--2019-12
（ 7 ） 发酵法生产3-脱氢莽草酸菌种, 负责人, 境内委托项目, 2017-12--2027-12
（ 8 ） 生物发酵法生产左旋多巴菌种, 负责人, 境内委托项目, 2017-10--2037-10
（ 9 ） 螺旋霉素工业菌株改造提升, 负责人, 境内委托项目, 2017-10--2019-09
（ 10 ） 液滴微流控高通量选育高效产纤维素酶的微生态菌株, 负责人, 境内委托项目, 2017-02--2018-08
（ 11 ） 原料药和药物中间体的生物合成（子课题：治疗老年痴呆原料药左旋多巴生物合成及中试生产）, 参与, 中国科学院计划, 2017-01--2018-12
（ 12 ） 多位点基因组编辑改善酿酒酵母多重胁迫耐性及机理研究, 负责人, 国家任务, 2015-01--2018-12
（ 13 ） 液滴微流控微生物高通量筛选装备研制, 负责人, 地方任务, 2014-10--2017-09
（ 14 ） 生物表面活性剂鼠李糖脂的双相发酵技术, 参与, 国家任务, 2014-01--2016-12
（ 15 ） 绿色生物工艺研发与应用, 负责人, 中国科学院计划, 2013-01--2015-12
（ 16 ） 天然木糖利用麦芽糖假丝酵母葡萄糖阻遏效应及其调控机理研究, 负责人, 国家任务, 2013-01--2016-12
（ 17 ） 生物质液体燃料的高温生物炼制, 参与, 国家任务, 2012-01--2015-12
（ 18 ） 糖醇合成与功能性糖醇的研制, 参与, 国家任务, 2012-01--2015-12
（ 19 ） 人工合成细胞工厂, 参与, 国家任务, 2011-01--2015-08

（1）High efficient production of aromatic chemicals in metabolically engineering Escherichia coli.   2017-05-01
（2）Development and Optimization of droplet microfluidic-based high throughput screening system for industrial microbiology.    2014-07-20
（3）Engineering Escherichia coli for adipic acid production.    2012-10-28
（4）Xylitol production by evolutionarily engineered Candida maltosa.   2011-07-24
（5）功能糖醇的生物制造   功能糖研究开发与应用技术专题研讨会   王钦宏，江宁，贺鹏   2011-06-23
（6）Isolation and Characterization of novel xylose-utilizing and ethanol tolerant thermophilic bacteria.   2010-05-23
（7）Developing Highly Sensitive Micro-Biosensors for in-situ Monitoring Mercury and Chromium (VI) Contaminants by Genetically-evolving and Computer-designing Metal-binding Proteins.   2009-04-20
（8）Engineering mercury biosensor by synthesis and evolution.   2009-01-18