071009-细胞生物学

生殖生物学
发育生物学

1995-09--2001-08   中科院昆明动物研究所   博士研究生

   

2009-05~现在, 中科院昆明动物研究所, 研究员，学科组长
2005-06~2009-03,美国NIH, 博士后
2003-03~2005-06,美国Temple University, 博士后
2001-08~2003-03,中科院昆明动物研究所, 助理研究员
1995-09~2001-08,中科院昆明动物研究所, 博士研究生

   

（ 1 ） MCC950的用途, 2019, 第 5 作者, 专利号: CN110025610A

（ 2 ） 一种建立可持续传代的树鼩精原干细胞细胞系的方法, 2016, 第 1 作者, 专利号: CN106085951A

   

（1） DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 7 作者  通讯作者
（2） Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells, STEM CELL REPORTS, 2023, 第 6 作者  通讯作者
（3） Characterization of long-term ex vivo expansion of tree shrew spermatogonial stem cells., ZOOLOGICAL RESEARCH, 2023, 第 6 作者  通讯作者
（4） Lnc956 -TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis, SCIENCE ADVANCES, 2023, 第 8 作者  通讯作者
（5） Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway, SCIENCE ADVANCES, 2023, 第 5 作者  通讯作者
（6） Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing, INNOVATION-ORGANIZATION & MANAGEMENT, 2022, 第 12 作者
（7） Current understanding of genomic stability maintenance in pluripotent stem cells, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 第 1 作者  通讯作者
（8） Depletion of giant ANK2 in monkeys causes drastic brain volume loss, CELL DISCOVERY, 2021, 第 15 作者  通讯作者
（9） A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability, NATURE COMMUNICATIONS, 2021, 第 6 作者  通讯作者
（10） 灵长类发育研究新阶段：猴胚胎体外培养至受精后20天, 前沿科学, 2020, 第 3 作者
（11） Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation, REDOX BIOLOGY, 2020, 第 10 作者
（12） Comments on ‘In vitro culture of cynomolgus monkey embryos beyond early gastrulation’, Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation', JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 第 3 作者  通讯作者
（13） Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia, SCIENCE ADVANCES, 2020, 第 11 作者  通讯作者
（14） Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019, 第 10 作者
（15） Chromosomal level assembly and population sequencing of the Chinese tree shrew genome, ZOOLOGICAL RESEARCH, 2019, 第 10 作者
（16） KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells, PLOS BIOLOGY, 2019, 第 8 作者  通讯作者
（17） In vitro culture of cynomolgus monkey embryos beyond early gastrulation, SCIENCE, 2019, 第 11 作者  通讯作者
（18） Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys, NATURE COMMUNICATIONS, 2019, 第 13 作者
（19） 多能干细胞维持遗传物质稳定性的研究进展, 山东大学学报(医学版), 2018, 第 3 作者
（20） Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, ZOOLOGICAL RESEARCH, 2018, 第 8 作者  通讯作者
（21） 多能干细胞维持遗传物质稳定性的调控机制, Safeguarding Genomic Stability in Pluripotent Stem Cells, 中国细胞生物学学报, 2018, 第 2 作者
（22） Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, 动物学研究, 2018, 第 8 作者
（23） mouseembryonicstemcellshaveincreasedcapacityforreplicationforkrestartdrivenbythespecificfiliaflopedproteincomplex, CELL RESEARCH, 2018, 第 10 作者  通讯作者
（24） Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos, GENOME RESEARCH, 2018, 第 9 作者  通讯作者
（25） Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring, CELL RESEARCH, 2017, 第 14 作者  通讯作者
（26） Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos (vol 27, pg 567, 2017), GENOME RESEARCH, 2017, 第 8 作者
（27） Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State, CELL STEM CELL, 2017, 第 16 作者
（28） Long-term propagation of tree shrew spermatogonial stem cells (SSCs) in culture and the successful generation of transgenic offspring, Cell Research, 2017, 第 1 作者  通讯作者
（29） Transcriptome analyses of rhesus monkey pre-implantation embryos reveal a reduced capacity for DNA double strand break repair in primate oocytes and early embryos, GENOME RESEARCH, 2017, 第 8 作者  通讯作者
（30） Germ stem cells are active in postnatal mouse ovary under physiological conditions., MOLECULAR HUMAN REPRODUCTION, 2016, 第 5 作者  通讯作者
（31） Early embryonic development and transplantation in tree shrews, ZOOLOGICAL RESEARCH, 2016, 第 7 作者
（32） Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice., MOLECULAR HUMAN REPRODUCTION, 2016, 第 3 作者  通讯作者
（33） Germ stem cells are active in postnatal mouse ovary under physiological conditions, MHRBASICSCIENCEOFREPRODUCTIVEMEDICINE, 2016, 第 5 作者
（34） Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability, CELL STEM CELL, 2015, 第 11 作者  通讯作者
（35） MRNA-Seq and MicroRNA-Seq Whole-Transcriptome Analyses of Rhesus Monkey Embryonic Stem Cell Neural Differentiation Revealed the Potential Regulators of Rosette Neural Stem Cells, DNA RESEARCH, 2014, 第 5 作者
（36） Species-specific alternative splicing leads to unique expression of sno-lncRNAs, BMC GENOMICS, 2014, 第 6 作者
（37） miRNA Signature in Mouse Spermatogonial Stem Cells Revealed by High-Throughput Sequencing, BIOMED RESEARCH INTERNATIONAL, 2014, 第 4 作者
（38） The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics, NATURE COMMUNICATIONS, 2014, 第 9 作者
（39） Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene confers risk of schizophrenia in Han Chinese, SCHIZOPHRENIA RESEARCH, 2014, 第 15 作者
（40） mRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential regulators of rosette neural stem cells, DNA Research, 2014, 第 1 作者  通讯作者
（41） Maternal-effect Floped gene is essential for the derivation of embryonic stem cells in mice, Maternal-effect Floped gene is essential for the derivation of embryonic stem cells in mice, 动物学研究, 2013, 第 4 作者
（42） Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal, FASEB JOURNAL, 2013, 第 8 作者
（43） PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes., JOURNAL OF CELL SCIENCE, 2013, 第 1 作者  通讯作者
（44） 哺乳动物卵巢生殖干细胞研究的现状与未来, 动物学研究, 2012, 第 3 作者
（45） PTEN在小鼠卯细胞和早期胚胎发育中的功能研究, Role of PTEN in mouse pre-implantation development, 动物学研究, 2011, 第 5 作者
（46） PTEN在小鼠卵细胞和早期胚胎发育中的功能研究, 动物学研究, 2011, 第 5 作者
（47） Maternal control of early mouse development, DEVELOPMENT, 2010, 第 2 作者
（48） Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embyrogenesis, PNAS, 2009, 第 1 作者
（49） Filia, a maternal effect gene that regulates cleavage embryogenesis in mice, BIOLOGY OF REPRODUCTION, 2008, 第 1 作者
（50） Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos, DEVELOPMENT, 2008, 第 2 作者
（51） Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos., MOLECULAR HUMAN REPRODUCTION, 2007, 第 1 作者
（52） Effects of in vitro maturation of monkey oocytes on their developmental capacity, ANIMAL REPRODUCTION SCIENCE, 2007, 
（53） Expression and downregulation of WNT signaling pathway genes in rhesus monkey oocytes and embryos., MOLECULAR REPRODUCTION AND DEVELOPMENT, 2006, 
（54） Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos., BIOLOGY OF REPRODUCTION, 2005, 
（55） Effects of follicle size and oocyte maturation conditions on maternal message RNA regulation and gene expression in rhesus monkey oocytes and embryos, Biol Reprod, 2005, 第 1 作者
（56） 猕猴胚胎干细胞的分离培养和鉴定, Isolation , cultivation , and identification of embryonic stem cells of rhesus monkey, 第三军医大学学报, 2004, 第 2 作者
（57） 猕猴胚胎干细胞的分离培养和鉴定, Isolation , cultivation , and identification of embryonic stem cells of rhesus monkey, 第三军医大学学报, 2004, 第 2 作者
（58） Expression of Genes Encoding Chromatin Regulatory Factors in Developing Rhesus Monkey Oocytes and Preimplantation Stage Embryos: Possible Roles in Genome Activation1, BIOLOGY OF REPRODUCTION, 2004, 第 1 作者
（59） Effect of Glycerol and Dimethyl Sulfoxide on cyropreservation of rhesus monkey (Macaca mulatta) sperm, Am J Primatol, 2004, 第 1 作者
（60） The primate embryo gene expression resource: A novel resource to facilitate rapid analysis of gene expression patterns in non-human primate oocytes and preimplantation stage embryos, BIOLOGY OF REPRODUCTION, 2004, 
（61） 灵长类卵母细胞体外发育潜能的调控, 动物学研究, 2003, 第 1 作者
（62） Estradiol and progesterone improve in-vitro?Yang JF, Ding CH, Ji WZ. 2003. 17 cytoplasmic maturation of oocytes from unstimulated prepubertal and adult rhesus monkeys, Hum Reprod, 2003, 第 1 作者
（63） Amino acid requirements for maturation of rhesus monkey (Macacca mulatta) oocytes in culture, REPRODUCTION, 2002, 
（64） 纤溶酶原激活因子与猕猴精子运动力的关系及其在附睾和附性腺中的表达调节, 动物学研究, 2002, 第 1 作者
（65） Energy substrate requirement for in vitro maturation of oocytes from unstimulated adult rhesus monkeys., MOLECULAR REPRODUCTION AND DEVELOPMENT, 2001, 
（66） 猕猴精浆纤溶酶原激活因子的来源及在精子获能中的作用, Source of plasminogen activator in rhesus monkey semen and its possible role in sperm capacitation, 生理学报, 2001, 第 1 作者
（67） Maturation of rhesus monkey oocytes in chemically defined culture media and their functional assessmental by IVF and embryo development, Hum Reprod, 2001, 第 1 作者
（68） Effect of age and breeding season on the developmental capacity of oocytes from unstimulated and FSH-stimulated rhesus monkeys, 2001, 第 1 作者
（69） Cryopreservation of rhesus monkey (Macaca mulatta) spermatozoa and their functional assessment by in vitro fertilization., Cryobiology, 2000, 第 1 作者

（ 1 ） 猕猴繁殖生物学, reproduction and breeding of rhesus monkey, 科学出版社, 2013-01, 第 5 作者

   

（ 1 ） 利用猴模型研究人类卵巢衰老调控及干预策略, 负责人, 地方任务, 2023-01--2027-12
（ 2 ） 猴精原干细胞系的建立及基于精原干细胞研发猴高效基因敲入新技术, 负责人, 国家任务, 2022-01--2025-12
（ 3 ） 灵长类多能干细胞基因组稳态调控网络及增强策略, 负责人, 国家任务, 2021-12--2026-06
（ 4 ） 多能干细胞高效调控DNA复制压力反应的关键lncRNA鉴定与功能分析, 负责人, 国家任务, 2020-01--2024-12