基本信息
刘长梅  女  博导  中国科学院动物研究所
电子邮件: liuchm@ioz.ac.cn
通信地址: 大屯路甲三号干细胞与再生医学创新研究院
邮政编码:

招生信息

   
招生专业
071008-发育生物学
071006-神经生物学
招生方向
神经干细胞;表观遗传;神经发育疾病
自闭症;认知障碍
神经损伤修复

教育背景

2001-08--中国协和医科大学   博士

工作经历

   
工作简历
2014-10~现在, 中科院动物研究所, 研究员
2011-05~现在, 美国约翰霍普金斯大学医学院, 博士后
2008-04~现在, 美国新墨西哥大学神经生物学系, 博士后
2004-07~现在, 中国科学院微生物研究所, 助理研究员
2001-08~现在, 中国协和医科大学, 博士

教授课程

再生医学导论
再生医学文献检索

专利与奖励

   
奖励信息
(1) 重点研发项目首席, 一等奖, 国家级, 2021
(2) “****”终期评估优秀奖, 一等奖, 部委级, 2019
专利成果
( 1 ) 一种多能干细胞诱导产生小胶质细胞的方法及试剂盒, 2021, 第 3 作者, 专利号: ZL201910558177.6

( 2 ) 敲低ARID1A在损伤后抑制视网膜神经节细胞凋亡中的应用, 2021, 第 1 作者, 专利号: CN113209293A

( 3 ) 干扰肌肉特异E3泛素蛋白连接酶基因的干扰RNA,包含其的载体及其应用, 2010, 第 1 作者, 专利号: CN101748120A

( 4 ) 治疗病毒感染的方法及其药物, 2008, 第 3 作者, 专利号: CN101314047

( 5 ) 一种抗免疫耐受性和免疫缺陷性病毒的鸡尾酒疫苗及其应用, 2007, 第 3 作者, 专利号: CN101057975

出版信息

   
发表论文
(1) Mouse model of voluntary movement deficits induced by needlestick injuries to the primary motor cortex, JOURNAL OF NEUROSCIENCE METHODS, 2022, 
(2) Loss of microglial EED impairs synapse density, learning, and memory, Molecular Psychiatry, 2022, 
(3) miR-26a promotes axon regeneration in the mammalian central nervous system by suppressing PTEN expression, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 
(4) Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration, GLIA, 2021, 
(5) TREM2, microglia, and Alzheimer’s disease, MECHANISMS OF AGEING AND DEVELOPMENT, 2021, 
(6) Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters, EMBO REPORTS, 2021, 
(7) Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development, CELL PROLIFERATION, 2021, 
(8) Strategies to Promote Long-Distance Optic Nerve Regeneration, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 
(9) Loss of Arid1a Promotes Neuronal Survival Following Optic Nerve Injury, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 
(10) Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2, EXPERIMENTAL NEUROBIOLOGY, 2020, 
(11) Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system, Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system, JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 
(12) UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters, STEM CELL REPORTS, 2020, 
(13) SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury, CELL DEATH DISCOVERY, 2020, 
(14) The Role of Non-Coding RNAs in Neurodevelopmental Disorders, FRONTIERS IN GENETICS, 2019, 
(15) Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus, STEM CELL REPORTS, 2019, 
(16) MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice, FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 
(17) GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells, Stem Cell Research, 2019, 
(18) Commentary: Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus., FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 
(19) Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration, CELL REPORTS, 2018, 
(20) Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration., CELL DEATH AND DIFFERENTIATION, 2018, 
(21) Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 
(22) Partial loss of psychiatric risk gene miR-137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a, NATURE NEUROSCIENCE, 2018, 
(23) Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System, NEUROSCIENTIST, 2018, 
(24) MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells, STEM CELL REPORTS, 2017, 
(25) The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice., FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 
(26) Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury, NEURAL PLASTICITY, 2016, 
(27) MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression., Cell death & disease, 2015, 
(28) Akt-independent GSK3 inactivation downstream of PI3K signaling regulates mammalian axon regeneration., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 
(29) An Epigenetic Feedback Regulatory Loop Involving MicroRNA-195 and MBD1 Governs Neural Stem Cell Differentiation, PLOS ONE, 2013, 
(30) PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1, NATURE COMMUNICATIONS, 2013, 
(31) MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration, Genes and Development, 2013, 
(32) RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression., NEURON, 2011, 
(33) Inhibition of Atrogin-1/MAFbx Expression by Adenovirus-Delivered Small Hairpin RNAs Attenuates Muscle Atrophy in Fasting Mice, HUMAN GENE THERAPY, 2011, 
(34) Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation, CELL STEM CELL, 2010, 
(35) 人肝脏特异性miR-122表达载体的构建及鉴定, Construction and identification of the human liver-specific miR-122 expression vector, 生物工程学报, 2009, 第 2 作者
(36) pH值对FOXO1、GDF-8基因反义RNA寡核苷酸吸收的影响, The Influence of pH Value on the Absorption of RNA Interference Oligos of FOXO1 and GDF-8 Gene, 生物技术通报, 2009, 第 5 作者
(37) 逆转录病毒载体介导的RNA干扰稳定抑制肌肉生长抑制素GDF-8的表达, Inhibiting GDF-8 Expression by Retrovirus-Based RNAi Stably, 生物工程学报, 2008, 第 4 作者
(38) A retrovirus-based system to stably silence gdf-8 expression and enhance myogenic differentiation in human rhabdomyosarcoma cells, JOURNAL OF GENE MEDICINE, 2008, 
(39) Recombinant protein of heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro, VIROLOGY, 2008, 
(40) pSUPER介导的RNAi抗乙肝病毒S基因的研究, Inhibition of Hepatitis B Virus Hepatitis B by pSUPER siRNAs Targeted to virus S gene, 生物技术通报, 2008, 第 1 作者
(41) Stable inhibition of hepatitis B virus expression and replication in HepG2.2.15 cells by RNA interference based on retrovirus delivery, JOURNAL OF BIOTECHNOLOGY, 2007, 
(42) A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference, BIOTECHNOLOGY LETTERS, 2006, 
(43) RNA干扰技术及其在医学研究中的应用, 自然科学进展, 2005, 第 2 作者

科研活动

   
科研项目
( 1 ) 引进人才科研启动费, 负责人, 研究所自选, 2014-10--2017-09
( 2 ) 干细胞与神经发育疾病, 负责人, 研究所自选, 2014-10--2017-09
( 3 ) 组蛋白H3K27去甲基化与认知功能研究, 负责人, 研究所自选, 2015-01--2016-12
( 4 ) 组蛋白H3K27去甲基化修饰在新生神经元成熟与脑认知中的功能研究, 负责人, 国家任务, 2016-01--2019-12
( 5 ) 灵长类神经系统疾病干细胞模型及靶向基因编辑修复, 负责人, 国家任务, 2016-07--2020-12
( 6 ) SWI/SNF复合体组分ARID1A在海马发育和认知中的调控作用及机制研究, 负责人, 国家任务, 2018-01--2021-12
( 7 ) 组蛋白H3K27me3及去甲基化酶UTX/JMJD3在视神经再生中的功能及分子机制研究, 负责人, 国家任务, 2018-01--2020-12
( 8 ) 脑创伤海马神经再生机制与认知功能改善, 负责人, 中国科学院计划, 2018-08--2022-12
( 9 ) 神经退行性疾病免疫微环境对神经再生的影响机制与干预研究, 负责人, 国家任务, 2021-12--2026-06
参与会议
(1)The Roles of Tri-methylation of Histone H3 Lysine 27-Mediated Pathways in Neurodevelopment   2018-11-03
(2)Deletion of Polycomb Protein EED in Neural Stem Cells Leads to Malformation of the   2018-06-20
(3)Deletion of Polycomb Protein EED in Neural Stem Cells Leads to Malformation of the   2018年神经发育与再生研讨会   2018-01-19
(4) MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells   2017-11-10
(5)Histone H3 Lysine 27 demethylase UTX regulates postnatal hippocampal neurogenesis   2017-06-22
(6)Coordinated Regulation of Group Complexes through MicroRNAs Modulates   Chang-Mei Liu   2015-02-22
(7)Regulation of mammalian axon regeneration by histone methylation   Chang-Mei Liu   2014-11-15
(8)Regulation of mammalian axon regeneration by histone methylation   Chang-Mei Liu   2014-09-16