基本信息
罗成  男  博导  中国科学院上海药物研究所
电子邮件: cluo@simm.ac.cn
通信地址: 上海市祖冲之路555号药物发现与设计中心
邮政编码: 201203

招生信息

   
招生专业
100720-药物设计学
071023-计算生物学
070321-化学生物学
招生方向
药物设计学
计算生物学
结构生物学

教育背景

2005-09--2008-03 宾夕法尼亚大学Wistar研究所 博士后研究(计算生物学,结构生物学)
2001-09--2004-07 中国科学院上海药物研究所 有机化学博士学位
1998-09--2001-09 复旦大学化学系 物理化学(含化学物理)硕士学位
1990-09--1994-07 福州大学化学系 理学学士学位
学历
-- 研究生
学位
-- 博士

专利与奖励

   
专利成果
[1] 张翱, 罗成, 丁春勇, 张豪, 徐珩, 赵洪川, 蒋华良. 一类异喹啉衍生物及其制备和用途. CN: [[[CN111689975A]]], [[["2020-09-22"]]].
[2] 周兵, 罗成, 裴渊, 杨亚玺, 杜道海, 蒋华良, 乔刚. 三氮唑并嘧啶衍生物、其药物组合物及用途. CN115028631A, 2022-09-09.
[3] 张翱, 罗成, 丁春勇, 张豪, 徐珩, 李阳, 蒋华良. 一类雷公藤红素衍生物、其制备方法及用途. CN: CN112110977B, 2022-02-25.
[4] 游书力, 罗成, 刘喜佳, 张闪闪, 张豪, 顾庆. 一种丹酚酸B代谢物、中间体及其制备方法. CN: CN113999112A, 2022-02-01.
[5] 罗成, 奚晓东, 周兵, 朱孔凯, 毛建华, 刘静秋, 杨亚玺, 梅良和, 阮铮, 蒋昊, 奚闻达, 龙章彪, 肖兵, 黄建松, 蒋华良. 一种治疗血栓性疾病的化合物. CN: CN113968855A, 2022-01-25.
[6] 奚晓东, 罗成, 毛建华, 阮铮, 奚闻达, 龙章彪, 朱孔凯, 肖兵, 王韵, 黄建松, 蒋昊, 刘静秋, 蒋华良. 一种c-Src SH3 RT-loop作为靶点用于抗血栓. CN: CN113967257A, 2022-01-25.
[7] 奚晓东, 罗成, 毛建华, 阮铮, 奚闻达, 龙章彪, 朱孔凯, 肖兵, 黄建松, 蒋昊, 刘静秋, 杨亚玺, 周兵, 蒋华良. 一种干扰整合素β3/Src相互作用的化合物的用途. CN: CN113967210A, 2022-01-25.
[8] 郭跃伟, 李序文, 李松威, 吴祺豪, 姚励功, 罗成, 张豪. 吡喃酮类化合物的分离方法、吡喃酮类化合物及其用途. CN: CN113754644A, 2021-12-07.
[9] 张翱, 罗成, 李阳, 张豪, 徐珩, 丁春勇, 蒋华良. 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途. CN: CN112094313A, 2020-12-18.
[10] 周兵, 罗成, 杨亚玺, 张元元, 杜道海, 蒋华良, 乔刚, 王新俊. 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗PRC2 介导的疾病(日本). JP2020535215A, 2020-12-03.
[11] 罗成, 周兵, 陆文超, 王军, 李勇, 杨亚玺, 丁宏, 陶泓儒, 陈凯先, 蒋华良. 乙烯基磺酰胺或乙烯基酰胺类化合物及其制备方法和用途. CN: CN112010789A, 2020-12-01.
[12] 周兵, 罗成, 李子洲, 杨亚玺, 陈示洁, 丁宏, 蒋华良, 乔刚, 王新俊, 肖森豪. 溴结构域抑制剂化合物及其用途(美国). US20200354371A1, 2020-11-12.
[13] 周兵, 罗成, 杨亚玺, 张元元, 杜道海, 蒋华良, 乔刚, 王新俊. 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗PRC2 介导的疾病(美国). US20200261459A1, 2020-08-20.
[14] 周兵, 罗成, 李子洲, 杨亚玺, 陈示洁, 鹿田, 肖森豪, 蒋华良, 陈超. 一类杂环化合物,其制备及用途. CN: CN111377934A, 2020-07-07.
[15] 李志裕, 罗成, 卞金磊, 赵曜, 丁宏, 田于成, 韩杰, 陈凯先. USP8抑制剂及其制备方法与应用. CN: CN111138358A, 2020-05-12.
[16] 罗成, 李林, 柳红, 陈丽敏, 李昕, 卢俊彦, 林岱宗, 付莉莉, 孔祥谦, 李国, 王雪琦, 梅长林, 蒋华良. 芬戈莫德或其盐在治疗囊肿性疾病中的用途. CN: CN105560219B, 2020-02-11.
[17] 周兵, 罗成, 蒋华良, 杨亚玺, 梅良和, 陆文超, 肖森豪, 陈示洁, 万世力, 乔刚, 张汝康. 组蛋白乙酰转移酶(HAT)抑制剂及其用途. CN: CN110386927A, 2019-10-29.
[18] 周兵, 罗成, 杨亚玺, 张元元, 杜道海, 蒋华良, 乔刚. 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途. CN: CN110156787A, 2019-08-23.
[19] 周兵, 罗成, 李子洲, 杨亚玺, 陈示洁, 丁宏, 蒋华良, 乔刚, 王新俊, 肖森豪. 溴结构域抑制剂化合物及其用途. CN: CN110041333A, 2019-07-23.
[20] 李林, 罗成, 吴明, 戚娜, 胡骏驰, 吕佳怡, 李昕, 薛澄, 宋书伟, 付莉莉, 郁胜强, 梅长林. EZH2在制备预防或治疗多囊肾病药物中的应用. CN: CN109966479A, 2019-07-05.
[21] 周兵, 罗成, 杨亚玺, 张元元, 杜道海, 蒋华良, 乔刚, 王新俊. 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗PRC2介导的疾病. CN: CN109843890A, 2019-06-04.
[22] 周兵, 罗成, 蒋华良, 杨亚玺, 梅良和, 陆文超, 肖森豪, 陈示洁, 万世力, 乔刚, 张汝康. 组蛋白乙酰转移酶(HAT)抑制剂及其用途(日本). JP2021506032, 2019-04-18.
[23] 周兵, 罗成, 杨亚玺, 张元元, 杜道海, 蒋华良, 乔刚. 三氮唑并嘧啶、三氮唑并吡啶化合物及其组合物用于治疗PRC2介导的疾病. CN: CN109575013A, 2019-04-05.
[24] 罗成, 姚志艺, 乔刚, 蒋华良, 周宇, 陈丽敏, 刘静秋, 丁宏. 五元杂环类化合物及其制备方法、药物组合物和用途. CN: CN109476650A, 2019-03-15.
[25] 罗成, 姚志艺, 乔刚, 蒋华良, 周宇, 陈丽敏, 刘静秋, 丁宏. 五元杂环类化合物及其制备方法、药物组合物和用途. CN: CN109476649A, 2019-03-15.
[26] 罗成, 姚志艺, 郑明月, 谢轶谦, 张元元, 邢婧, 乔刚, 梅良和, 蒋昊, 蒋华良. 一类稠合双环杂芳基或芳基化合物,及其用途. CN: CN109111426A, 2019-01-01.
[27] 罗成, 郑明月, 谢轶谦, 邢婧, 张元元, 蒋昊, 王晨, 陈凯先, 蒋华良. 8-羟基喹啉类药物或其盐在制备用于治疗与BRD4相关的疾病的药物中的应用. CN: CN109106715A, 2019-01-01.
[28] 罗成, 段文虎, 朱孔凯, 邵敬伟, 毛瑞风, 张元元, 蒋华良. 2-取代硫基乙酰胺类化合物及其制备方法和应用. CN: CN108689946A, 2018-10-23.
[29] 段文虎, 罗成, 邵敬伟, 朱孔凯, 张元元, 丁宏, 蒋华良. 一种具有PRMT5抑制活性的化合物及其制备和应用. CN: CN108570059A, 2018-09-25.
[30] 罗成, 杨亚玺, 乐立艳, 周兵, 杜娟娟, 张元元, 冯慧瑾, 李连春, 艾文, 陈智凤, 张碧东, 万伟, 林婷婷, 蒋华良. 1,4‑双取代‑1,2,3,6‑四氢吡啶类化合物、其制备方法、药物组合物及其应用. CN: CN107602446A, 2018-01-19.
[31] 罗成, 杨亚玺, 乐立艳, 周兵, 杜娟娟, 李连春, 张元元, 冯慧瑾, 艾文, 陈智凤, 张碧东, 林婷婷, 万伟, 蒋华良. 咯哌丁胺衍生物及其在制备治疗混合谱系白血病的药物中的应用. CN: CN107602445A, 2018-01-19.
[32] 杨财广, 刘江, 罗成, 郭中强, 巩守哲, 李家飞, 郑桐, 蒋华良. 2-亚胺-5-酮基-2,5-二氢-1-H-二吡啶并嘧啶类化合物. CN: CN107141287A, 2017-09-08.
[33] 陈畅, 罗成, 蒋华良, 李江美, 高振, 赵丹, 张伦峰, 乔新华. 肌醇磷脂4位激酶二型α亚型特异抑制剂PI-273的应用. CN: CN105326831A, 2016-02-17.
[34] 何川, 王晶, 蒋华良, 罗成, 柳红, 卢俊彦. 用于抑制人铜转运蛋白ATOX1和CCS的方法和组合物. US: CN105189474A, 2015-12-23.
[35] 罗成, 孔祥谦, 陈丽敏, 蒋翔锐, 杜道海, 卢俊彦, 刘静秋, 朱孔凯, 李连春, 丁宏, 陈凯先, 沈敬山, 蒋华良. 阿司咪唑、其盐或溶剂合物在制备预防和/或治疗恶性淋巴瘤的药物中的用途. CN: CN105078983A, 2015-11-25.
[36] 罗成, 李林, 柳红, 陈丽敏, 林岱宗, 李昕, 卢俊彦, 付莉莉, 赵飞, 李连春, 李国, 郁胜强, 梅长林, 蒋华良. 氨基醇类化合物、其制备方法、包含此类化合物的药物组合物及其用途. CN: CN105017034A, 2015-11-04.
[37] 杨财广, 罗成, 巩守哲, 刘洪川, 张瑞涵, 张婕, 蒋华良. 3,6-二取代1,2,4三唑3,4-b1,3,4噻二唑化合物及其用途. CN: CN104892639A, 2015-09-09.
[38] 杨财广, 罗成, 黄悦, 巩守哲, 李家飞, 蒋华良. 2-(取代苯氨基)苯甲酸及其酯类化合物制备FTO抑制剂的用途. CN: CN104069092A, 2014-10-01.
[39] 罗成, 柳红, 陈奕, 孔祥谦, 栗增, 冯恩光, 刘世恩, 陈先杰, 朱维良, 丁健, 蒋华良. 2-取代-5-苯基呋喃类化合物、其制备方法、药物组合物及其用途. CN: CN103509009A, 2014-01-15.
[40] 柳红, 耿美玉, 张登友, 艾菁, 罗成, 李淳朴, 陈曦, 梁中洁, 彭霞, 季寅淳, 蒋华良, 丁健, 陈凯先. 新型咪唑并1,2-a吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途. CN: CN103214481A, 2013-07-24.
[41] 朱维良, 曾步斌, 王贺瑶, 闫桂蕊, 黄贤贵, 徐志建, 罗成, 张奇军, 王改红, 杨卓, 张小东, 李波, 徐炜均, 罗小民, 蒋华良, 陈凯先. 取代的酰肼类化合物及其制备方法、药物组合物和用途. CN: CN102775381A, 2012-11-14.
[42] 柳红, 耿美玉, 罗成, 张登友, 艾菁, 梁中洁, 王英, 蒋华良, 陈凯先. 新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途. CN: CN102718745A, 2012-10-10.
[43] 杨财广, 罗成, 叶飞, 陈报恩, 俞璐, 蒋华良. 大黄酸或大黄酸类化合物在制备治疗以FTO 为靶点的疾病的药物中的用途. CN: CN102697762A, 2012-10-03.
[44] 蒋华良, 沈旭, 柳红, 罗小民, 姚志艺, 陈静, 罗成, 周宇, 黎陈静, 左之利, 杜丽, 陈凯先, 乔·L.沙斯曼, 伊斯瑞尔·西尔曼, 泰伦·L.罗森伯瑞, 约瑟夫·L.约翰逊, 哈里·M.格林布莱特, 泰泽维亚·兹-本-莫德柴. 四氢喹啉类化合物、其制备方法及药物组合物. CN: CN101245062A, 2008-08-20.
[45] 朱维良, 李剑, 潘春木, 陈莉莉, 陈刚, 罗成, 左之利, 柳红, 罗小民, 陈凯先, 沈旭, 蒋华良. 3-烷氧取代-2,5,7-三取代苯并吡喃-4-酮类化合物及其制备方法和包含该类化合物的药物组合物. CN: CN1990479A, 2007-07-04.
[46] 朱维良, 潘春木, 陈莉莉, 沈旭, 陈刚, 罗成, 徐炜均, 罗小民, 柳红, 沈建华, 陈凯先, 蒋华良. 五羟黄酮-3-β-半乳糖苷的医药用途及其制剂. CN: CN1830449A, 2006-09-13.
[47] 蒋华良, 沈旭, 左建平, 白东鲁, 沈竞康, 沈建华, 罗小民, 桂春山, 罗成, 杨以阜, 郭虹霞, 陈晴, 刘学军, 王峰, 胡仲良, 杨勤刚, 蔡茂军, 张莉, 王昕, 庄贤韩, 南发俊, 杨一鸣. 一类喹喔啉衍生物及其制备方法和用途. CN: CN1590378A, 2005-03-09.

出版信息

   
发表论文
[1] Nature Communications. 2024, 第 11 作者  通讯作者  
[2] Arong Li, Aqian Li, Cheng Luo, Bo Liu. Assessing heavy metal contamination in Amomum villosum Lour. fruits from plantations in Southern China: Soil-fungi-plant interactions. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2024, 第 3 作者269: http://dx.doi.org/10.1016/j.ecoenv.2023.115789.
[3] Zhen Wang, Fengying Fan, Zhihai Li, Fei Ye, Qingxia Wang, Rongchao Gao, Jiaxuan Qiu, Yixin Lv, Min Lin, Wenwen Xu, Cheng Luo, Xuekui Yu. Structural insights into the functional mechanism of the ubiquitin ligase E6AP. NATURE COMMUNICATIONS. 2024, 第 11 作者15(1): http://dx.doi.org/10.1038/s41467-024-47586-w.
[4] Cancer Cell. 2023, 第 19 作者  通讯作者  
[5] Nature Communications. 2023, 第 29 作者  通讯作者  
[6] Molecular Cell. 2023, 第 16 作者  通讯作者  
[7] Siqi Guo, Tongguan Jia, Xiaoming Xu, Feng Yang, Senhao Xiao, Zeng Hou, Hesong Xu, Shuyuan Ma, Xiao Liu, Cheng Luo, Hualiang Jiang, Hua Chen, Shijie Chen. Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2023, 第 10 作者248: http://dx.doi.org/10.1016/j.ejmech.2023.115093.
[8] Gao, Jing, Yang, Jie, Xue, Shengyu, Ding, Hong, Lin, Hua, Luo, Cheng. A patent review of PRMT5 inhibitors to treat cancer (2018-present). EXPERT OPINION ON THERAPEUTIC PATENTS. 2023, 第 6 作者  通讯作者  33(4): 265-292, http://dx.doi.org/10.1080/13543776.2023.2201436.
[9] Xiao Li, Fei Li, Fei Ye, Haotian Guo, Wentao Chen, Jia Jin, Yiran Wang, Pengfei Dai, Huili Shi, Hongru Tao, Wenzhen Dang, Yiluan Ding, Mingchen Wang, Hualiang Jiang, Kaixian Chen, Naixia Zhang, Dong Gao, Yuanyuan Zhang, Cheng Luo. Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer. CELL REPORTS. 2023, 第 19 作者42(7): http://dx.doi.org/10.1016/j.celrep.2023.112798.
[10] Lixue Lu, Song Chen, Mingcheng Yu, Ronghui Zhou, Siqi Guo, Jian Chen, Haojie Wang, Shijie Chen, Cheng Luo, Qiong Xie, Yonghui Wang. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2023, 第 9 作者256: http://dx.doi.org/10.1016/j.ejmech.2023.115424.
[11] Bai, Zhonghao, Yin, Wen, Liu, Rui, Tang, Minglei, Shi, Xiaokeng, Luo, Cheng, Xie, Xiangyang. PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice. MOLECULAR METABOLISM[J]. 2023, 第 6 作者76: http://dx.doi.org/10.1016/j.molmet.2023.101789.
[12] Xie, Fei, Zhang, Han, Zhu, Kongkai, Jiang, ChengShi, Zhang, Xiaoya, Chang, Hongkai, Qiao, Yaya, Sun, Mingming, Wang, Jiyan, Wang, Mukuo, Tan, Junzhen, Wang, Tao, Zhao, Lianmei, Zhang, Yuan, Lin, Jianping, Zhang, Chunze, Liu, Shuangping, Zhao, Jianguo, Luo, Cheng, Zhang, Shuai, Shan, Changliang. PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1. MEDCOMM[J]. 2023, 第 19 作者4(2): e245, https://doaj.org/article/8c1a0d509b124df5ae4a85577bce88bb.
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科研活动

   
科研项目
(1) 针对重要疾病的新化学实体发现与优化,主持,国家级,2012-01--2016-12
(2) 针对 S1P 代谢通路和NF-kB 通路的网络节点的动力学行为、靶标发现和非可控炎症转化机制研究,主持,国家级,2011-01--2013-12
(3) 针对调控干细胞相关关键酶的药物发现与作用机制研究,主持,国家级,2011-01--2015-12
(4) 军队特需药品发现技术平台(子课题),主持,国家级,2011-01--2015-12
(5) 基于桑叶活性成分为物质基础的a-糖苷酶抑制剂优化研究(子课题),主持,省级,2011-01--2013-12
(6) 针对嘌呤生物合成的抗金黄色葡萄球药物设计研究,主持,其他级,2010-04--2012-03
(7) 抗肿瘤药物先导化合物的优化研究,主持,国家级,2010-01--2012-12
参与会议
(1) 金黄色葡萄球菌ClpP蛋白酶的功能调控研究,福建—香港高校理论化学研讨会,2011-04,罗成

指导学生

已指导学生

张芮菡  硕士研究生  100720-药物设计学  

周然  硕士研究生  078020-药物设计学  

现指导学生

王晨  硕士研究生  0780Z1-药物设计学  

李晓娜  博士研究生  100706-药理学  

徐盼  硕士研究生  0780Z1-药物设计学  

胡骏驰  博士研究生  1007Z1-药物设计学  

工作经历

   
工作简历
2012-10--今 上海药物研究所 研究员
2008-09--2012-09 中国科学院上海药物研究所 副研究员
2008-03--2008-09 中国科学院上海药物研究所 助理研究员
2004-07--2005-08 中国科学院上海药物研究所 助理研究员
1994-11--1998-04 福州市抗生素集团有限公司 助理工程师