基本信息
宫丽崑  女  博导  中国科学院上海药物研究所
电子邮件: lkgong@simm.ac.cn
通信地址: 济阳路333弄9号501
邮政编码: 201204

招生信息

   
招生专业
100706-药理学
100800-中药学
招生方向
药理毒理
中药药理学

教育背景

2002-09--2005-07   中国科学院研究生院   博士学历学位
1997-09--2000-06   中国医科大学   硕士学历学位
1991-09--1996-07   中国医科大学   学士学历学位

工作经历

   
工作简历
2020-07~现在, 中科中山药物创新研究院, 研究员,课题组长,安评中心主任
2011-09~现在, 中国科学院上海药物研究所, 研究员,课题组长,安评中心副主任
2006-11~2008-12,日本东京大学药学院, 日本学术振兴会(JSPS)外国人特别研究员
2005-10~2011-09,中国科学院上海药物研究所, 副研究员
2002-09~2005-07,中国科学院研究生院, 博士学历学位
2000-07~2011-07,中国科学院上海药物研究所, 安评中心专题负责人、部门负责人、中心机构负责人助理
1997-09~2000-06,中国医科大学, 硕士学历学位
1996-07~1997-09,沈阳理工大学医院, 医生
1991-09~1996-07,中国医科大学, 学士学历学位
社会兼职
2018-06-01-今,上海市药理学会, 理事
2018-04-06-今,中国实验动物学会实验动物与毒理学专业委员会, 委员
2017-10-01-今,中国毒理学学会遗传毒性专业委员会, 委员
2016-10-01-今,中国毒理学会生殖毒性专业委员会, 常务委员
2014-01-01-今,中国毒理学会毒理学替代法与转化毒理学专业委员会, 委员
2013-01-01-今,中国药理学会安全药理专业委员会, 常务委员
2012-05-01-今,上海市药理学会毒理专业委员会,
2011-06-10-今,中国毒理学会药物毒理与安全性评价专业委员会, 委员

教授课程

高等药理学

专利与奖励

   
奖励信息
(1) 科技进步奖, 一等奖, 市地级, 2017
(2) 中国药学会科学技术奖, 一等奖, 部委级, 2016
(3) 药物分子毒理学研究及新药安全性评价关键技术的应用和国际认可, 二等奖, 国家级, 2013
(4) 中国药学会科学技术奖, 一等奖, 省级, 2009
(5) 中国毒理学会第五次全国学术大会青年优秀论文奖, , 其他, 2009
(6) 日本学术振兴会(JSPS)Award, , 其他, 2006
(7) 优秀青年科技工作者奖, , 研究所(学校), 2004
专利成果
( 1 ) 新型冠状病毒的串联表位多肽疫苗及其应用, 2021, 第 1 作者, 专利号: CN113801207A

( 2 ) 奈非那韦在制备防治新冠肺炎药物中的应用, 2021, 第 25 作者, 专利号: CN113262224A

( 3 ) 偶联TLR7激动剂的新型冠状病毒多肽疫苗及其应用, 2020, 第 1 作者, 专利号: CN111892648A

( 4 ) 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用, 2019, 第 3 作者, 专利号: CN109358192A

( 5 ) 具有转录和转录后双水平基因沉默功能的microRNA 的筛选方法, 2014, 第 4 作者, 专利号: CN103571839A

( 6 ) HRN/gpt delta转基因小鼠模型的构建方法, 2012, 第 4 作者, 专利号: CN102524177A

( 7 ) (4-炔基)-芳香酮酸类化合物作为治疗慢性阻塞性肺部疾病的药物, 2006, 第 4 作者, 专利号: CN1718181A

出版信息

   
发表论文
(1) Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 8 作者
(2) Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023, 通讯作者
(3) Development, Validation and Application of a Bridging ELISA for Detection of Antibodies against GQ1001 in Cynomolgus Monkey Serum, MOLECULES, 2023, 通讯作者
(4) Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1-Independent Manner, CANCER IMMUNOLOGY RESEARCH, 2023, 通讯作者
(5) D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2, COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 通讯作者
(6) Multi-Omics Integration Analysis Identifies Lipid Disorder of a Non-Alcoholic Fatty Liver Disease (NAFLD) Mouse Model Improved by Zexie-Baizhu Decoction, FRONTIERS IN PHARMACOLOGY, 2022, 通讯作者
(7) CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, CELL DISCOVERY, 2022, 通讯作者
(8) PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way, JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 通讯作者
(9) Predicting spike protein NTD mutations of SARS-CoV-2 causing immune evasion by molecular dynamics simulations, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2022, 第 6 作者
(10) Novel triterpenoids from Alisma plantago-aquatica with influence on LDL uptake in HepG2 cells by inhibiting PCSK9, PHYTOMEDICINE, 2022, 第 10 作者
(11) Different Immunoregulation Roles of Activin A Compared With TGF-β, FRONTIERS IN IMMUNOLOGY, 2022, 第 5 作者
(12) Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors, EMBOREPORTS, 2022, 第 17 作者
(13) Copy Number Analyses Identified a Novel Gene: APOBEC3A Related to Lipid Metabolism in the Pathogenesis of Preeclampsia, FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 通讯作者
(14) Aberrant peribiliary gland niche exacerbates fibrosis in primary sclerosing cholangitis and a potential therapeutic strategy, BIOMEDICINE & PHARMACOTHERAPY, 2022, 通讯作者
(15) Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy, FRONTIERS IN IMMUNOLOGY, 2022, 通讯作者
(16) Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 通讯作者
(17) One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates, ACTA PHARMACEUTICA SINICA B, 2022, 第 9 作者
(18) MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis, MOLECULAR BIOMEDICINE, 2022, 第 7 作者
(19) Current Analytical Strategies for Antibody-Drug Conjugates in Biomatrices, MOLECULES, 2022, 通讯作者
(20) Simultaneous solubilization and extended release of insoluble drug as payload in highly soluble particles of γ-cyclodextrin metal-organic frameworks, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 第 9 作者
(21) Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(22) Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-alpha, TOXICOLOGY, 2022, 通讯作者
(23) CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 第11作者
(24) New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression, JOURNAL OF MEDICAL VIROLOGY, 2022, 通讯作者
(25) SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2, SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 通讯作者
(26) 国内新药临床前研究阶段的安全药理学研究概况, 医药界, 2021, 第 5 作者
(27) miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder, JOURNAL OF HEPATOLOGY, 2021, 第 9 作者
(28) MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice, METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 第 6 作者
(29) Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury, ACTA PHARMACOLOGICA SINICA, 2021, 通讯作者
(30) GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation, PHARMACOLOGICAL RESEARCH, 2021, 第 6 作者
(31) Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats, Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats, ACTA PHARMACOLOGICA SINICA, 2021, 通讯作者
(32) Prevention of D-GalN/LPS-induced ALI by 18 beta-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation, CELL DEATH & DISEASE, 2021, 通讯作者
(33) A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice, A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice, ACTA PHARMACOLOGICA SINICA, 2020, 通讯作者
(34) SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 202, 第 6 作者
(35) 新药非临床安全药理学研究进展, Research progress in non-clinical safety pharmacology of innovative drugs, 中国药理学与毒理学杂志, 2019, 第 7 作者
(36) FDA关于DILI上市前评估指南及其修订, 肝脏, 2019, 第 1 作者
(37) Sulfonium, an Underestimated Moiety for Structural Modification, Alters the Antibacterial Profile of Vancomycin Against Multidrug-Resistant Bacteria, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 5 作者
(38) 调节性小非编码RNA在精子发生过程中的作用研究进展, Roles of Regulatory Small Non-coding RNAs in the Spermatogenesis, 中国药学杂志, 2019, 第 3 作者
(39) Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity, differentstructuresofberberineandfiveotherprotoberberinealkaloidsthataffectpglycoproteinmediatedeffluxcapacity, ACTA PHARMACOLOGICA SINICA, 2019, 通讯作者
(40) 一例食蟹猴肠套叠诊断与治疗, Diagnosis and Treatment for Intussusceptions in One Case of Cynomolgus Monkey, 实验动物与比较医学, 2019, 第 6 作者
(41) Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci., JOURNALOFMEDICINALCHEMISTRY, 2018, 第 8 作者
(42) Species-Specific Involvement of Integrin alpha IIb beta 3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys, MOLECULAR THERAPY, 2018, 通讯作者
(43) Species-Specific Involvement of Integrin aIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys, Molecular Therapy, 2018, 通讯作者
(44) Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys, MOLECULAR THERAPY, 2018, 第 14 作者
(45) 18β-Glycyrrhetinic acid protects against alphanaphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway, ACTA PHARMACOLOGICA SINICA, 2018, 第 9 作者
(46) 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate- induced cholestasis through activation of the Sirt1/FXR signaling pathway, 18glycyrrhetinicacidprotectsagainstalphanaphthylisothiocyanateinducedcholestasisthroughactivationofthesirt1fxrsignalingpathway, 中国药理学报:英文版, 2018, 第 9 作者
(47) 18 beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway, ACTA PHARMACOLOGICA SINICA, 2018, 通讯作者
(48) Sensitive detection of Bacillus thuringiensis Cry1B toxin based on camel single-domain antibodies, MICROBIOLOGYOPEN, 2018, 通讯作者
(49) 基于生物信息学分析法探讨丙戊酸钠对肝细胞生物功能网络的干扰作用, Interference Effect of Sodium Valproate on Hepatocyte Biofunctional Networks Based on Bioinformatics Analysis, 中国药物警戒, 2017, 第 5 作者
(50) Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer, CANCER CELL, 2016, 
(51) 食蟹猴外周血淋巴细胞亚群的流式法分析验证和正常参考值测定, Method validation and determination of normal reference values of peripheral blood lymphocytes phenotyping measure-ment in cynomoigus monkeys using flow cytometry, 检验医学与临床, 2015, 第 8 作者
(52) The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity, TOXICOLOGY RESEARCH, 2015, 第 5 作者
(53) Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms., SCIENTIFIC REPORTS, 2015, 通讯作者
(54) Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 第 6 作者
(55) Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice., ACTA PHARMACOLOGICA SINICA, 2014, 第 3 作者
(56) Estimation of acute oral toxicity in rat using local lazy learning, JOURNAL OF CHEMINFORMATICS, 2014, 第 6 作者
(57) 静脉注射酸性pH值注射剂对ICR小鼠自发活动量的影响, 2013, 第 2 作者
(58) ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes., ACTA PHARMACOLOGICA SINICA, 2013, 通讯作者
(59) SD大鼠多次采血对血液学和血浆生化学指标的影响, 2013, 第 3 作者
(60) Role of Multiple MicroRNAs in the Sexually Dimorphic Expression of Cyp2b9 in Mouse Liver, DRUG METABOLISM AND DISPOSITION, 2013, 第 8 作者
(61) Computational Models for Predicting Interactions with Membrane Transporters, CURRENT MEDICINAL CHEMISTRY, 2013, 
(62) A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats, JOURNAL OF ETHNOPHARMACOLOGY, 2013, 第 7 作者
(63) Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms., MOLECULAR PHARMACEUTICS, 2013, 第 5 作者
(64) 关于新药早期探索性-桥接性一般毒理学研究的思考, 中国药学杂志, 2013, 第 2 作者
(65) 单次或多次尾静脉采血对大鼠血液和血清生化指标的影响, Effects on Hematology and Serum Chemistry Parameters after Single or Multiple Blood Collection from Tail Vein of Rats, 实验动物与比较医学, 2013, 第 5 作者
(66) A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats, DRUG AND CHEMICAL TOXICOLOGY, 2013, 通讯作者
(67) The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis, ARCHIVES OF TOXICOLOGY, 2012, 第 7 作者
(68) 代谢酶在马兜铃酸肾病中的作用, Role of metabolic enzymes in aristolochic acid nephropathy, 中草药, 2012, 第 3 作者
(69) H-1 NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice, METABOLOMICS, 2012, 第 3 作者
(70) Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2012, 第 6 作者
(71) Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2012, 第 6 作者
(72) Identification of BC005512 as a DNA Damage Responsive Murine Endogenous Retrovirus of GLN Family Involved in Cell Growth Regulation, PLOS ONE, 2012, 第 3 作者
(73) Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes., DRUG METABOLISM AND DISPOSITION: THE BIOLOGICAL FATE OF CHEMICALS, 2011, 第 5 作者
(74) Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I., MOLECULAR PHARMACEUTICS, 2011, 第 2 作者
(75) Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity, TOXICOLOGICAL SCIENCES, 2011, 第 2 作者
(76) Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity, TOXICOLOGY LETTERS, 2011, 通讯作者
(77) 药物性肾损伤机制研究进展, Progress of the study of mechanism on drug induced kidney injury, 药学学报, 2010, 第 2 作者
(78) Emodin Triggers DNA Double-Strand Breaks by Stabilizing Topoisomerase II-DNA Cleavage Complexes and by Inhibiting ATP Hydrolysis of Topoisomerase II, TOXICOLOGICAL SCIENCES, 2010, 第 5 作者
(79) β-Naphthoflavone protects mice from aristolochic acid-l-induced acute kidney injury in a CYP1A dependent mechanism, ACTA PHARMACOLOGICA SINICA, 2009, 第 7 作者
(80) β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism, ACTA PHARMACOLOGICA SINICA, 2009, 第 7 作者
(81) Beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism, ACTA PHARMACOLOGICA SINICA, 2009, 通讯作者
(82) 有机阴离子转运蛋白在外源化学物毒性中的作用, Role of organic anion transporters in xenobiotics induced toxicity, 中国药理学与毒理学杂志, 2009, 第 2 作者
(83) 有机阴离子转运蛋白在药物毒性中的作用, 中国药理学与毒理学杂志, 2009, 第 1 作者
(84) The construction of Williams design and randomization in cross-over clinical trials using SAS., 2009, 第 1 作者
(85) Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice, JOURNAL OF ETHNOPHARMACOLOGY, 2008, 第 3 作者
(86) Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock, BIOCHEMICAL PHARMACOLOGY, 2008, 第 2 作者
(87) Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin, TOXICOLOGY, 2008, 第 3 作者
(88) Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 第 3 作者
(89) Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis, LIVER INTERNATIONAL, 2007, 第 2 作者
(90) 血管紧张素转换酶2在SARS病理途径中的作用, Role of angiotensin converting enzyme 2 in pathogenesis of severe acute respiratory syndrome, 中国药理学与毒理学杂志, 2007, 第 2 作者
(91) Early lung injury contributes to lung fibrosis via AT1 receptor in rats, ACTA PHARMACOLOGICA SINICA, 2007, 第 2 作者
(92) The protective effect of Baicalin on Concavalin A-induced liver injury and the related mechanism, ACTA PHARMACOLOGICA SINICA, 2006, 第 2 作者
(93) Aristolochic acid I targeted to adenine nucleotide translocase sensitizes mitochondrial permeability transition pore opening in vitro, ACTA PHARMACOLOGICA SINICA, 2006, 第 4 作者
(94) DS1 delay lung fibrosis by withstanding HIF-1 alpha, ACTA PHARMACOLOGICA SINICA, 2006, 第 2 作者
(95) A report of oral dose toxicity study of triptolides (Tx) in Sprague-Dawley rat, ACTA PHARMACOLOGICA SINICA, 2006, 第 3 作者
(96) Experimental pathological study on orally administration of Tx to rats, ACTA PHARMACOLOGICA SINICA, 2006, 第 7 作者
(97) Role of hypoxia in bleomycin induced pulmonary fibrosis in rat, ACTA PHARMACOLOGICA SINICA, 2006, 第 1 作者
(98) Tetrandrine inhibits induction of the mitochondrial permeability tansition: a possible mechanism for its protective effect of mitochondria, ACTA PHARMACOLOGICA SINICA, 2006, 第 3 作者
(99) 黄芩甙对于刀豆蛋白A引起的小鼠肝损伤的保护作用及其机制, 毒理学杂志, 2005, 第 2 作者
(100) 肾素-血管紧张素系统对肺纤维化形成的调节, Modulation of pulmonary fibrosis by renin-angiotensin system, 中国药理学与毒理学杂志, 2005, 第 1 作者
(101) 雷公藤衍生物XX对大鼠长期毒性的实验病理研究, 毒理学杂志, 2005, 第 10 作者
(102) 汉防己甲素诱导大鼠原代肝细胞线粒体途径的凋亡:依赖于caspase和由Endonuclease G(Endo G)介导的不依赖于caspase的凋亡途径, 毒理学杂志, 2005, 第 3 作者
(103) HIF-1α在博来霉素致大鼠肺纤维化中的作用, 毒理学杂志, 2005, 第 1 作者
(104) 博来霉素致肺损伤的机制, 毒理学杂志, 2005, 第 2 作者
(105) 肝脏体外模型及其在毒理学方面的应用, In vitro liver models and its application in toxicology, 中国药理学与毒理学杂志, 2004, 第 2 作者
(106) 常规畸试验窝效应的统计处理及统计软件实现, 中国卫生统计, 2003, 第 2 作者
(107) Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 通讯作者
发表著作
( 1 ) 药物毒理学, 人民卫生出版社, 2015-12, 第 5 作者

科研活动

   
科研项目
( 1 ) 细胞与分子水平检测药物肝肾潜在毒性和代谢特征的安全评价关键新技术, 负责人, 国家任务, 2009-01--2011-03
( 2 ) 建立符合国际GLP标准的要求,以毒性病理学为优势的药物安全评价技术平台, 参与, 国家任务, 2008-10--2011-03
( 3 ) 基于人源化动物模型和肝脏生物功能网络的药物肝毒性预测关键新技术, 负责人, 国家任务, 2012-01--2015-12
( 4 ) 治疗重大疾病创新药物的药效学与安全性评价平台能力提升建设11DZ2292500, 参与, 地方任务, 2011-11--2013-09
( 5 ) 靶向自噬的抗AD个性化药物先导物的发现, 参与, 国家任务, 2016-01--2017-12
( 6 ) 全新ADC类抗肿瘤药物ZV0203全套毒理学实验, 负责人, 境内委托项目, 2015-12--2017-12
( 7 ) 全新ADC类抗肿瘤药物MRG003的毒理学试验, 负责人, 境内委托项目, 2015-04--2017-04
( 8 ) 创新药物DC20非临床安全性评价研究, 负责人, 研究所自主部署, 2014-01--2017-06
( 9 ) 以毒性病理学为核心优势的全程式非临床安评创新技术体系建设和应用, 负责人, 国家任务, 2018-01--2020-12
( 10 ) ADC药物PK/PD生物分析和安全性评价技术平台, 负责人, 国家任务, 2018-01--2020-12
( 11 ) 靶向肿瘤的个性化药物的毒性特征和关键技术, 负责人, 中国科学院计划, 2018-01--2020-12
( 12 ) COVID-19新型表位肽疫苗研发, 负责人, 地方任务, 2022-04--2025-03
( 13 ) 基于CYP3A人源化动物模型何首乌肝毒性机制研究, 负责人, 地方任务, 2021-01--2023-12
( 14 ) 食用槟榔产品毒理学及安全性评价研究, 负责人, 地方任务, 2021-12--2024-12
( 15 ) 偶联TLR7小分子激动剂的新型冠状病毒多肽疫苗研发, 负责人, 中国科学院计划, 2020-11--2022-10
( 16 ) 新型糖肽抗生素的临床申报安全性评价与药效药代研究, 参与, 地方任务, 2021-01--2022-12
( 17 ) 18β-甘草次酸对肝损伤的调控作用及其靶点蛋白发现, 负责人, 其他国际合作项目, 2020-09--2022-07
( 18 ) 新冠与流感等大流行风险病原体多肽疫苗的研制, 参与, 国家任务, 2023-01--2025-12
参与会议
(1)细胞治疗的产品安全性评价   中国医药生物技术学会再生医学分会暨干细胞及其衍生技术创新论坛   2023-02-11
(2)重复给药毒性实验伴随中枢神经系统功能评价的实验设计实例   第二届中国安全药理学学术年会   2016-05-25
(3)A 4-Week Repeated-Dose Toxicity Study of TPN902 in Beagle Dogs   SOT 55th annual meeting   2016-03-17
(4)Safety Pharmacology Core Battery and Regulatory Requirements: Case Studies   第三届美中药协学术年会暨第二届SIMM-AZ新药创制高层学术研讨会   2015-09-21