基本信息
陈奕  女  博导  中国科学院上海药物研究所
电子邮件: ychen@simm.ac.cn
通信地址: 上海市祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
招生方向
肿瘤药理

教育背景

2001-09--中科院上海药物研究所   获博士学位
1997-09--浙江大学药学院   获硕士学位
1990-09--1994-07   浙江大学(原浙江医科大学)   获学士学位

工作经历

   
工作简历
2006-12~2008-11,美国迈阿密大学, 博士后
2004-07~现在, 中科院上海药物研究所, 副研究员、研究员
2001-09~现在, 中科院上海药物研究所, 获博士学位
1997-09~现在, 浙江大学药学院, 获硕士学位
1994-08~2001-08,浙江大学药学院, 助教、讲师
1990-09~1994-07,浙江大学(原浙江医科大学), 获学士学位
社会兼职
2014-10-01-今,中国抗癌协会抗癌药物专业委员会, 委员
2014-10-01-今,中国药理学会肿瘤药理专业委员会, 委员

专利与奖励

   
奖励信息
(1) 上海市青年五四奖章, , 省级, 2012
(2) Avon Foundation – AACR International Scholar Award, , 其他, 2006
(3) 全国第九届Servier青年药理学工作者奖, , 其他, 2005
专利成果
( 1 ) 一类5,8-二氢萘醌衍生物、其制备方法与应用, 2007, 第 4 作者, 专利号: ZL200410017900.3

( 2 ) 一类喜树碱衍生物及其应用, 2006, 第 5 作者, 专利号: 200610024590.7

出版信息

   
发表论文
(1) G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1, Theranostics, 2018, 通讯作者
(2) G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin, Nat Commun, 2017, 通讯作者
(3) Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma, Hepatology, 2017, 第 4 作者
(4) Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer, Acta Pharmacol Sin, 2017, 通讯作者
(5) Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation, Oncotarget, 2015, 通讯作者
(6) Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents, Bioorg Med Chem., 2015, 通讯作者
(7) G226, a new ETP derivative, triggers DNA damage, and apoptosis via ROS generation, Acta Pharmacol Sin, 2014, 通讯作者
(8) G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro., Acta Pharmacol Sin, 2014, 通讯作者
(9) Design, synthesis and biological evaluation of 4-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors, RSC Advances, 2014, 通讯作者
(10) Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs, Bioorg Med Chem Lett, 2014, 通讯作者
(11) JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1, BMC Cancer, 2013, 通讯作者
(12) Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro, Acta Pharmacol Sin, 2013, 通讯作者
(13) The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase, Bioorg Med Chem, 2013, 通讯作者
(14) The discovery of colchicine-SAHA hybrids as a new class of antitumor agents, Bioorg Med Chem, 2013, 通讯作者
(15) Synthesis and biological evaluation of new homocamptothecin analogues., Eur J Med Chem, 2012, 通讯作者
(16) AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and antitumor activity via targeting VEGFR, FGFR, PDGFR, J Cell Mol Med, 2012, 第 2 作者
(17) Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo., Breast Cancer Res Treat, 2011, 第 1 作者
(18) Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles., Biomaterials, 2011, 第 4 作者
(19) Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents, Eur J Med Chem, 2011, 第 4 作者
(20) Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site. , Cancer Biol Ther., 2010, 第 2 作者
(21) Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide, Mol Cancer, 2010, 通讯作者
(22) The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model., Biomaterials., 2010, 第 3 作者
(23) Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation., Acta Pharmacol Sin. , 2010, 第 2 作者
(24) Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530 resistant tumors., Clin Cancer Res, 2009, 第 1 作者
(25)  Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling., Mol Cancer Res, 2008, 第 2 作者
(26) SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor, Inter J Cancer, 2006, 第 1 作者
(27) The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11’-dideoxyverticillin-induced G2/M arrest, FEBS Lett, 2005, 第 1 作者
(28) Antiangiogenic activity of 11,11’-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola, Biochem Biophys Res Commun, 2005, 第 1 作者

科研活动

   
科研项目
( 1 ) 新乙酰肝素酶抑制剂JG3对上皮间质转化的分子调控机制研究, 负责人, 国家任务, 2011-01--2013-12
( 2 ) 针对老年痴呆症多靶点药物研究, 负责人, 地方任务, 2010-06--2012-06
( 3 ) 靶向乙酰肝素酶类抗肿瘤候选药物JG6的研究开发, 负责人, 国家任务, 2009-01--2010-12
( 4 ) 组蛋白甲基转移酶G9a在乳腺癌转移中的作用及机制研究, 负责人, 国家任务, 2012-01--2016-12
( 5 ) 用于脑部肿瘤治疗的新型纳米药物研究——脑部肿瘤系统靶向性纳米药物的动力学、药效学和安全性研究, 负责人, 国家任务, 2013-01--2017-08
( 6 ) 个性化药物核心资源系统与可持续性研究, 负责人, 中国科学院计划, 2015-10--2020-12
( 7 ) 组蛋白甲基转移酶G9a影响结直肠癌发生发展分子机制研究, 负责人, 国家任务, 2018-01--2021-12
参与会议
(1)Histone methyltransferases regulate breast cancer progression by modulating iron homeostasis   亚洲药学科学联盟2017年学术会议   2017-11-22