100706-药理学

肿瘤药理

2001-09--中科院上海药物研究所   获博士学位
1997-09--浙江大学药学院   获硕士学位
1990-09--1994-07   浙江大学（原浙江医科大学）   获学士学位

   

2006-12~2008-11,美国迈阿密大学, 博士后
2004-07~现在, 中科院上海药物研究所, 副研究员、研究员
2001-09~现在, 中科院上海药物研究所, 获博士学位
1997-09~现在, 浙江大学药学院, 获硕士学位
1994-08~2001-08,浙江大学药学院, 助教、讲师
1990-09~1994-07,浙江大学（原浙江医科大学）, 获学士学位

2023-05-30-今,全国卫生产业企业管理协会实验医学（临床病理）第二届专家委员会, 常务委员
2014-10-01-今,中国抗癌协会抗癌药物专业委员会, 委员
2014-10-01-今,中国药理学会肿瘤药理专业委员会, 委员

   

（1） 上海市“科技创新行动计划”优秀学术带头人, 其他, 2022
（2） 上海市青年五四奖章, , 省级, 2012
（3） Avon Foundation – AACR International Scholar Award, , 其他, 2006
（4） 全国第九届Servier青年药理学工作者奖, , 其他, 2005

（ 1 ） 一类5，8-二氢萘醌衍生物、其制备方法与应用, 2007, 第 4 作者, 专利号: ZL200410017900.3

（ 2 ） 一类喜树碱衍生物及其应用, 2006, 第 5 作者, 专利号: 200610024590.7

   

（1） Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3K�� inhibitors, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 11 作者
（2） Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 11 作者
（3） Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 第 11 作者
（4） The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKK? and overcomes gefitinib resistance in non-small cell lung cancer, CANCER BIOLOGY & MEDICINE, 2022, 第 11 作者
（5） Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer, CELL DEATH & DISEASE, 2022, 第 11 作者
（6） PI3K�� inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 11 作者
（7） SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy, JOURNAL OF CONTROLLED RELEASE, 2021, 第 11 作者
（8） The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation, MOLECULAR CANCER THERAPEUTICS, 2021, 第 11 作者
（9） Role of CD8^(+) T lymphocyte cells:Interplay with stromal cells in tumor microenvironment, Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment, ACTA PHARMACEUTICA SINICA B, 2021, 第 11 作者
（10） Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 11 作者
（11） EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma, HAEMATOLOGICA, 2020, 第 11 作者
（12） G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1, THERANOSTICS, 2018, 第 11 作者
（13） Iron Metabolism in Cancer, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 11 作者
（14） Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer., ACTA PHARMACOLOGICA SINICA, 2017, 第 11 作者
（15） Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma, HEPATOLOGY, 2017, 第 4 作者
（16） G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin., NATURE COMMUNICATIONS, 2017, 第 11 作者
（17） Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation, ONCOTARGET, 2015, 第 11 作者
（18） Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 11 作者
（19） G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro, G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro, 中国药理学报：英文版, 2014, 第 4 作者
（20） Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 11 作者
（21） Design, synthesis and biological evaluation of 4 '-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors, RSC ADVANCES, 2014, 第 5 作者
（22） G226, a new ETP derivative, triggers DNA damage, and apoptosis via ROS generation, Acta Pharmacol Sin, 2014, 第 11 作者
（23） JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1, BMC CANCER, 2013, 第 11 作者
（24） The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 11 作者
（25） Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro., ACTA PHARMACOLOGICA SINICA, 2013, 第 6 作者
（26） The discovery of colchicine-SAHA hybrids as a new class of antitumor agents., BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 9 作者
（27） AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and antitumor activity via targeting VEGFR, FGFR, PDGFR, J Cell Mol Med, 2012, 第 1 作者
（28） Synthesis and biological evaluation of new homocamptothecin analogues., Eur J Med Chem, 2012, 第 11 作者
（29） Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo, BREAST CANCER RESEARCH AND TREATMENT, 2011, 第 11 作者
（30） Design, synthesis and biological evaluation of substituted 11 H-benzo acarbazole-5-carboxamides as novel antitumor agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 第 4 作者
（31） Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles, BIOMATERIALS, 2011, 第 4 作者
（32） Increased accumulation of hypoxia-inducible factor-1 alpha with reduced transcriptional activity mediates the antitumor effect of triptolide, MOLECULAR CANCER, 2010, 第 5 作者
（33） Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site, CANCER BIOLOGY & THERAPY, 2010, 第 2 作者
（34） The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model, BIOMATERIALS, 2010, 第 3 作者
（35） Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation., ACTA PHARMACOLOGICA SINICA, 2010, 第 2 作者
（36） Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors., CLINICALCANCERRESEARCHANOFFICIALJOURNALOFTHEAMERICANASSOCIATIONFORCANCERRESEARCH, 2009, 第 1 作者
（37） Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling., MOLECULAR CANCER RESEARCH : MCR, 2008, 第 2 作者
（38） SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor., INTERNATIONAL JOURNAL OF CANCER, 2006, 第 2 作者
（39） The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11���-dideoxyverticillin-induced G 2 /M arrest, FEBSLETTERS, 2005, 
（40） Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus shiraia bambusicola, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 

   

（ 1 ） 分子靶向抗肿瘤药物研究, 负责人, 地方任务, 2022-09--2025-08
（ 2 ） 基于糖受体介导靶向肝癌的糖类AL3810偶联物候选新药发现, 负责人, 地方任务, 2021-01--2022-12
（ 3 ） 组蛋白甲基转移酶G9a影响结直肠癌发生发展分子机制研究, 负责人, 国家任务, 2018-01--2021-12
（ 4 ） 个性化药物核心资源系统与可持续性研究, 负责人, 中国科学院计划, 2015-10--2020-12
（ 5 ） 用于脑部肿瘤治疗的新型纳米药物研究——脑部肿瘤系统靶向性纳米药物的动力学、药效学和安全性研究, 负责人, 国家任务, 2013-01--2017-08
（ 6 ） 组蛋白甲基转移酶G9a在乳腺癌转移中的作用及机制研究, 负责人, 国家任务, 2012-01--2016-12
（ 7 ） 新乙酰肝素酶抑制剂JG3对上皮间质转化的分子调控机制研究, 负责人, 国家任务, 2011-01--2013-12
（ 8 ） 针对老年痴呆症多靶点药物研究, 负责人, 地方任务, 2010-06--2012-06
（ 9 ） 靶向乙酰肝素酶类抗肿瘤候选药物JG6的研究开发, 负责人, 国家任务, 2009-01--2010-12

（1）Histone methyltransferases regulate breast cancer progression by modulating iron homeostasis   亚洲药学科学联盟2017年学术会议   2017-11-22