Molecular mechanism of tumor chemoresistance

Mitochindiral homeostasis and neurodegenerative diseases

Bachelor of Medicine, Major: Preventive Medicine; China Medical University, July 1986,  Shenyang , P.R. China.

Master degree of Medicine, Major: Toxicology; Hebei Medical University. July 1989. Shijiazhuang, P.R. China.

Ph.D. of Medicine, Major in Molecular Biology and Toxicology, Institute of Radiation Medicine, July 1995, Beijing, P.R. China.

   

2009-present: Principal investigator, Beijing Institute of Genomics, Chinese Academy of Science, Beijing, China

2003-2019:    Tenure-track Assistant professor, Department of Radiation Oncology, College of Physicians & Surgeons, Columbia University, New York, NY 10032

2001-2003:     Associate Research Scientist, Center for Radiological Research Scientist, Columbia University, New York

1998-2001:     Postdoctoral Research Scientist, Center for Radiological Research, Columbia University, New York.

1989.9-1992.7:  Instructor, Environmental Health and Toxicology, Hebei Medical University

2005.8-2007.11: Instructor, Tumor Biology section for Residents at Radiation Oncology Dept., Columbia University.

2011.9-2012.9:  DNA damage repair and tumor biology for Master candidates of Chinese Academy of Sciences (CAS)

2017.9-2018.9:  Tumor microenvironment and Phamacogenomics for Master candidates of CAS.

2017.10-2018.10: Omics Brush classes for Master candidates of Sina-Danish College, CAS.

1.  Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao YL*. Deubiquitinate USP33 regulates Parkin and antagonizes its role in mitophagy. Autophagy16(4):724-734, 2020.

2. Fang H, Niu K, Mo D, Zhu Y, Tan Q, Wrei D, Li Y, Chen Z, Yang S, Balajee AS*, Zhao Y*. RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity. Oncogenesis 7(9): 68, 2018.

3. Mo D, Zhao Y, Balajee AS*. Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. Cancer Lett 28;413:1-10, 2018. Review.

4. Mo D, Fang H, Niu K, Liu J, Wu M, Li S, Zhu T, Aleskandarany MA, Arora A, Lobo DN, Madhusudan S, Balajee AS, Chi Z, Zhao Y*. Human RecQL4 helicase regulates cisplatin resistance through Akt-YB1-MDR1 pathway in gastric cancer cells. Cancer Res 76(10):3057-66, 2016.

5. Arora A, Agarwal D, Abdel-Fatah TM, Lu H, Croteau DL, Moseley P, Aleskandarany MA, Green AR, Ball G, Rakha EA, Chan SY, Ellis IO, Wang LL, Zhao Y, Balajee AS, Bohr VA, Madhusudan S*. RECQL4 helicase has oncogenic potential in sporadic breast cancers. J Pathol 238(4):495-501, 2016.

6. Liu J, Fang H, Chi Z, Wu Z, Wei D, Mo D, Niu K, Balajee AS, Hei TK, Nie L*, Zhao Y*. XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage. Nucleic Acids Res 43(11):5476-88, 2015.

1. Genomic and mitochondrial genomic stability and neurodegenerative diseases

2. Dysregulated DNA damage repair capacity and tumor chemoresistance​

已指导学生                                                                      Master and PhD students:

彭钊  硕士研究生  071022-基因组学                               Peng Zhao, M.S. in Genomics

陶佳海  硕士研究生  071007-遗传学                               Tao Jiahai, M.S. in Genetics 

池振奋  博士研究生  071007-遗传学                               Chi Zhenfen, Ph.D in Genetics

陈苗  硕士研究生  071010-生物化学与分子生物学          Chen Miao, M.S. in Biochemistry and Molecular Biology 

刘静  博士研究生  071010-生物化学与分子生物学          Liu Jing, Ph.D in Biochemistry and Molecular Biology

吴赞  硕士研究生  071007-遗传学                                   Wu Zan, M.S. in Genetics

段仰苗  硕士研究生  071007-遗传学                                Duan Yangmiao, M.S. in Genetics

吴蕊  硕士研究生  071007-遗传学                                   Wu Rui, M.S. in Genetics  

默董亮  博士研究生  071010-生物化学与分子生物学       Mo Dongliang, Ph.D in Biochemistry and Molecular Biology 

牛凯峰  博士研究生  071010-生物化学与分子生物学       Niu Kaifeng, Ph.D in Biochemistry and Molecular Biology 

檀群松  博士研究生  071007-遗传学                                Tan Qunsong, Ph.D in Genetics

现指导学生                                                                        Master and PhD candidates:

朱宇奇  博士研究生  071007-遗传学                                 Zhu Yuqi, PhD candidate in Genetics  

曹凤阳  硕士研究生  071007-遗传学                                 Cao Fengyang, MS candidate in Genetics

李悦洋  博士研究生  071007-遗传学                                 Li Yueyang, PhD candidate in Genetics

汪青  硕士研究生  071010-生物化学与分子生物学           Wang Qing, MS candidate in Biochemistry and Mol. Biology

陈紫翔  博士研究生  071010-生物化学与分子生物学       Chen Zixiang, PhD candidate in Biochemistry and Mol. Biology

王梦柯  硕士研究生  0710J3-生物信息学                          Wang Mengke, MS candidate in Bioinformatics

张婉莹  硕士研究生  0710Z1-基因组学                              Zhang Wanying, MS candidate in Genomics

于悦  硕士研究生  071010-生物化学与分子生物学            Yu Yue, MS candidate in Biochemistry and Mol. Biology

葛新阳  博士研究生  071010-生物化学与分子生物学        Ge Xinyang, PhD candidate in Biochemistry ad Mol. Biology

李梦鸽  博士研究生  071010-生物化学与分子生物学        Li Mengge, PhD candidate in Biochemistry and Mol. Biology