基本信息
许瑞明  男  博导  中国科学院生物物理研究所
电子邮件: rmxu@sun5.ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
071011-生物物理学
招生方向
基因转录的表观遗传调控和RNA转录后加工
表观遗传学,结构生物学

教育背景

1985-06--1989-08   美国Brandeis大学物理系   理学博士学位
1984-09--1985-05   美国Brandeis大学物理系   理学硕士学位
1980-09--1984-07   浙江大学物理系   获理学学士学位

工作经历

   
工作简历
2015-12~现在, 中国科学院生物物理研究所, 副所长
2013-05~2015-12,中国科学院前沿科学与教育局, 局长
2012-11~2013-05,中国科学院生物科学与生物技术局, 局长
2010-01~2012-11,中国科学院生物物理研究所, 副所长
2009-01~现在, 中国科学院生物物理研究所, 研究员
2006-01~2008-12,美国纽约大学医学院, 教授(终身)
2005-01~2005-12,美国冷泉港实验室, 教授
2000-01~2004-12,美国冷泉港实验室, 副教授
1996-06~2000-01,美国冷泉港实验室, 助理教授
1993-03~1996-05,美国冷泉港实验室, 访问学者、研究助理
1991-09~1993-03,美国纽约州立大学石溪分校物理系, 博士后
1989-09~1991-09,美国德克萨斯大学奥斯汀分校物理系, 博士后
社会兼职
2015-10-01-今,《Epigenetics & Chromatin》杂志, 编委会成员
2015-03-01-今,《Structure》杂志, 编委会成员
2014-08-01-今,中国生物化学与分子生物学学会, 副理事长
2013-11-01-今,中国生物物理学会, 副理事长
2013-01-01-今,《中国科学:生命科学》英文版, 编委会成员
2011-06-01-今,《BBA‐Gene Regulatory Mechanisms》杂志, 编委会成员
2010-01-01-今,《Protein & Cell》杂志, 副主编
2007-01-01-今,《Genes & Development》杂志, 编委会成员

专利与奖励

   
奖励信息
(1) 全国优秀科技工作者, 国家级, 2016
(2) 中国科学院优秀研究生指导教师奖, , 部委级, 2012
(3) 中国侨界(创新人才)贡献奖, , 其他, 2010
(4) 中国科学院-诺和诺德长城教授奖, , 部委级, 2009
(5) 国家“杰出青年”基金, , 部委级, 2009
(6) 首批****专家, , 国家级, 2008
(7) 中美联合招收物理研究生考试 (CUSPEA) 入选者, , 其他, 1984
(8) 浙江大学优秀毕业论文奖, , 研究所(学校), 1984

出版信息

   
发表论文
[1] 许瑞明. Topography of histone H3–H4 interaction with the Hat1–Hat2 acetyltransferase complex. Genes & Dev.[J]. 2022, [2] 许瑞明. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science[J]. 2022, [3] 许瑞明. Topography of histone H3–H4 interaction with the Hat1–Hat2 acetyltransferase complex. Genes & Dev.[J]. 2022, [4] 许瑞明. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science[J]. 2022, [5] 许瑞明. Topography of histone H3–H4 interaction with the Hat1–Hat2 acetyltransferase complex. Genes & Dev.[J]. 2022, [6] 许瑞明. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science[J]. 2022, [7] 许瑞明. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes & Dev[J]. 2021, [8] Xu, Xiang, Wang, Mingzhu, Sun, Jixue, Yu, Zhenyu, Li, Guohong, Yang, Na, Xu, RuiMing. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(13): 7740-7752, http://dx.doi.org/10.1093/nar/gkab542.
[9] 许瑞明. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes & Dev[J]. 2021, [10] Xu, Xiang, Wang, Mingzhu, Sun, Jixue, Yu, Zhenyu, Li, Guohong, Yang, Na, Xu, RuiMing. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(13): 7740-7752, http://dx.doi.org/10.1093/nar/gkab542.
[11] 许瑞明. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes & Dev[J]. 2021, [12] Xu, Xiang, Wang, Mingzhu, Sun, Jixue, Yu, Zhenyu, Li, Guohong, Yang, Na, Xu, RuiMing. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(13): 7740-7752, http://dx.doi.org/10.1093/nar/gkab542.
[13] Gou, LanTao, Lim, DoHwan, Ma, Wubin, Aubol, Brandon E, Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G, Mellon, Pamela L, Adams, Joseph A, Liu, MoFang, Fu, XiangDong. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. CELL[J]. 2020, 180(6): 1212-+, http://dx.doi.org/10.1016/j.cell.2020.02.020.
[14] Gao, Yujing, Chen, Lijia, Han, Yali, Wu, Fangrui, Yang, WenSi, Zhang, Zheng, Huo, Tong, Zhu, Yingmin, Yu, Chengtai, Kim, Hong, Lee, Mark, Tang, Zhen, Phillips, Kevin, He, Bin, Jung, Sung Yun, Song, Yongcheng, Zhu, Bokai, Xu, RuiMing, Feng, Qin. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): http://dx.doi.org/10.1038/s42003-020-0898-0.
[15] Li, Zhiming, Hua, Xu, SerraCardona, Albert, Xu, Xiaowei, Gan, Songlin, Zhou, Hui, Yang, WenSi, Chen, Chunlong, Xu, RuiMing, Zhang, Zhiguo. DNA polymerase alpha interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. SCIENCE ADVANCES[J]. 2020, 6(35): https://www.webofscience.com/wos/woscc/full-record/WOS:000563099200014.
[16] Jin, Wenxing, Wang, Jia, Liu, ChaoPei, Wang, HongWei, Xu, RuiMing. Structural Basis for pri-miRNA Recognition by Drosha. MOLECULAR CELL[J]. 2020, 78(3): 423-+, http://dx.doi.org/10.1016/j.molcel.2020.02.024.
[17] Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng. Structural basis for nucleosome-mediated inhibition of cGAS activity. CELL RESEARCH[J]. 2020, 30(12): 1088-1097, http://lib.cqvip.com/Qikan/Article/Detail?id=7104154142.
[18] Gou, LanTao, Lim, DoHwan, Ma, Wubin, Aubol, Brandon E, Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G, Mellon, Pamela L, Adams, Joseph A, Liu, MoFang, Fu, XiangDong. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. CELL[J]. 2020, 180(6): 1212-+, http://dx.doi.org/10.1016/j.cell.2020.02.020.
[19] Gao, Yujing, Chen, Lijia, Han, Yali, Wu, Fangrui, Yang, WenSi, Zhang, Zheng, Huo, Tong, Zhu, Yingmin, Yu, Chengtai, Kim, Hong, Lee, Mark, Tang, Zhen, Phillips, Kevin, He, Bin, Jung, Sung Yun, Song, Yongcheng, Zhu, Bokai, Xu, RuiMing, Feng, Qin. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): http://dx.doi.org/10.1038/s42003-020-0898-0.
[20] Li, Zhiming, Hua, Xu, SerraCardona, Albert, Xu, Xiaowei, Gan, Songlin, Zhou, Hui, Yang, WenSi, Chen, Chunlong, Xu, RuiMing, Zhang, Zhiguo. DNA polymerase alpha interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. SCIENCE ADVANCES[J]. 2020, 6(35): https://www.webofscience.com/wos/woscc/full-record/WOS:000563099200014.
[21] Jin, Wenxing, Wang, Jia, Liu, ChaoPei, Wang, HongWei, Xu, RuiMing. Structural Basis for pri-miRNA Recognition by Drosha. MOLECULAR CELL[J]. 2020, 78(3): 423-+, http://dx.doi.org/10.1016/j.molcel.2020.02.024.
[22] Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng. Structural basis for nucleosome-mediated inhibition of cGAS activity. CELL RESEARCH[J]. 2020, 30(12): 1088-1097, http://lib.cqvip.com/Qikan/Article/Detail?id=7104154142.
[23] Gou, LanTao, Lim, DoHwan, Ma, Wubin, Aubol, Brandon E, Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G, Mellon, Pamela L, Adams, Joseph A, Liu, MoFang, Fu, XiangDong. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. CELL[J]. 2020, 180(6): 1212-+, http://dx.doi.org/10.1016/j.cell.2020.02.020.
[24] Gao, Yujing, Chen, Lijia, Han, Yali, Wu, Fangrui, Yang, WenSi, Zhang, Zheng, Huo, Tong, Zhu, Yingmin, Yu, Chengtai, Kim, Hong, Lee, Mark, Tang, Zhen, Phillips, Kevin, He, Bin, Jung, Sung Yun, Song, Yongcheng, Zhu, Bokai, Xu, RuiMing, Feng, Qin. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): http://dx.doi.org/10.1038/s42003-020-0898-0.
[25] Li, Zhiming, Hua, Xu, SerraCardona, Albert, Xu, Xiaowei, Gan, Songlin, Zhou, Hui, Yang, WenSi, Chen, Chunlong, Xu, RuiMing, Zhang, Zhiguo. DNA polymerase alpha interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. SCIENCE ADVANCES[J]. 2020, 6(35): https://www.webofscience.com/wos/woscc/full-record/WOS:000563099200014.
[26] Jin, Wenxing, Wang, Jia, Liu, ChaoPei, Wang, HongWei, Xu, RuiMing. Structural Basis for pri-miRNA Recognition by Drosha. MOLECULAR CELL[J]. 2020, 78(3): 423-+, http://dx.doi.org/10.1016/j.molcel.2020.02.024.
[27] Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng. Structural basis for nucleosome-mediated inhibition of cGAS activity. CELL RESEARCH[J]. 2020, 30(12): 1088-1097, http://lib.cqvip.com/Qikan/Article/Detail?id=7104154142.
[28] 张林, Albert, SerraCardona, Hui, Zhou, Mingzhu, Wang, Na, Yang, 张志国, 许瑞明. Rtt109催化组蛋白H3K56的Asf1依赖性乙酰化中的多位点底物识别. 科学新闻. 2019, 56-56, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485153.
[29] Hou, Peini, Huang, Chang, Liu, ChaoPei, Yang, Na, Yu, Tianshu, Yin, Yuxin, Zhu, Bing, Xu, RuiMing. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. STRUCTURE[J]. 2019, 27(5): 837-+, http://dx.doi.org/10.1016/j.str.2019.01.015.
[30] Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Ruiming, Wang, Hailin, Zhu, Bing, Li, Yingfeng. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(22): 8907-8917, http://dx.doi.org/10.1074/jbc.RA119.008008.
[31] 张林, Albert, SerraCardona, Hui, Zhou, Mingzhu, Wang, Na, Yang, 张志国, 许瑞明. Rtt109催化组蛋白H3K56的Asf1依赖性乙酰化中的多位点底物识别. 科学新闻. 2019, 56-56, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485153.
[32] Hou, Peini, Huang, Chang, Liu, ChaoPei, Yang, Na, Yu, Tianshu, Yin, Yuxin, Zhu, Bing, Xu, RuiMing. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. STRUCTURE[J]. 2019, 27(5): 837-+, http://dx.doi.org/10.1016/j.str.2019.01.015.
[33] Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Ruiming, Wang, Hailin, Zhu, Bing, Li, Yingfeng. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(22): 8907-8917, http://dx.doi.org/10.1074/jbc.RA119.008008.
[34] 张林, Albert, SerraCardona, Hui, Zhou, Mingzhu, Wang, Na, Yang, 张志国, 许瑞明. Rtt109催化组蛋白H3K56的Asf1依赖性乙酰化中的多位点底物识别. 科学新闻. 2019, 56-56, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485153.
[35] Hou, Peini, Huang, Chang, Liu, ChaoPei, Yang, Na, Yu, Tianshu, Yin, Yuxin, Zhu, Bing, Xu, RuiMing. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. STRUCTURE[J]. 2019, 27(5): 837-+, http://dx.doi.org/10.1016/j.str.2019.01.015.
[36] Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Ruiming, Wang, Hailin, Zhu, Bing, Li, Yingfeng. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(22): 8907-8917, http://dx.doi.org/10.1074/jbc.RA119.008008.
[37] Xu Ruiming. The road to a first-class research institute: creating an exceptional environment, recruiting outstanding scientists, producing high-impact work, and nurturing a culture of innovation—Preface to the 60th anniversary special issue. Biophysics Reports[J]. 2018, 4(4): 167-169, [38] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): https://doaj.org/article/db45361008fa495f92d8ffb558920954.
[39] 许瑞明. 筑巢引凤产出高水平成果 凝练文化创建一流研究所. 生物化学与生物物理进展. 2018, 45(9): 885-886, http://lib.cqvip.com/Qikan/Article/Detail?id=676250509.
[40] Zhang, Lin, SerraCardona, Albert, Zhou, Hui, Wang, Mingzhu, Yang, Na, Zhang, Zhiguo, Xu, RuiMing. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. CELL[J]. 2018, 174(4): 818-+, http://www.corc.org.cn/handle/1471x/2201300.
[41] Xu Ruiming. The road to a first-class research institute: creating an exceptional environment, recruiting outstanding scientists, producing high-impact work, and nurturing a culture of innovation—Preface to the 60th anniversary special issue. Biophysics Reports[J]. 2018, 4(4): 167-169, [42] 许瑞明. 筑巢引凤产出高水平成果 凝练文化创建一流研究所. 生物化学与生物物理进展. 2018, 45(9): 885-886, http://lib.cqvip.com/Qikan/Article/Detail?id=676250509.
[43] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): https://doaj.org/article/db45361008fa495f92d8ffb558920954.
[44] Zhang, Lin, SerraCardona, Albert, Zhou, Hui, Wang, Mingzhu, Yang, Na, Zhang, Zhiguo, Xu, RuiMing. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. CELL[J]. 2018, 174(4): 818-+, http://www.corc.org.cn/handle/1471x/2201300.
[45] Xu Ruiming. The road to a first-class research institute: creating an exceptional environment, recruiting outstanding scientists, producing high-impact work, and nurturing a culture of innovation—Preface to the 60th anniversary special issue. Biophysics Reports[J]. 2018, 4(4): 167-169, [46] 许瑞明. 筑巢引凤产出高水平成果 凝练文化创建一流研究所. 生物化学与生物物理进展. 2018, 45(9): 885-886, http://lib.cqvip.com/Qikan/Article/Detail?id=676250509.
[47] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): https://doaj.org/article/db45361008fa495f92d8ffb558920954.
[48] Zhang, Lin, SerraCardona, Albert, Zhou, Hui, Wang, Mingzhu, Yang, Na, Zhang, Zhiguo, Xu, RuiMing. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. CELL[J]. 2018, 174(4): 818-+, http://www.corc.org.cn/handle/1471x/2201300.
[49] 杨娜, 许瑞明. 组蛋白变体的功能与识别机制. 生命科学[J]. 2017, 29(10): 946-954, http://lib.cqvip.com/Qikan/Article/Detail?id=674160591.
[50] Kong, GuiMei, Yu, Min, Gu, Zhongping, Chen, Zhi, Xu, RuiMing, OBryant, Deon, Wang, Zhengxin. Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity. PLOS ONE[J]. 2017, 12(8): https://doaj.org/article/2291e2f5c2114d85b6c51266fea9e97d.
[51] 杨娜, 许瑞明. 组蛋白变体的功能与识别机制. 生命科学[J]. 2017, 29(10): 946-954, http://lib.cqvip.com/Qikan/Article/Detail?id=674160591.
[52] Kong, GuiMei, Yu, Min, Gu, Zhongping, Chen, Zhi, Xu, RuiMing, OBryant, Deon, Wang, Zhengxin. Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity. PLOS ONE[J]. 2017, 12(8): https://doaj.org/article/2291e2f5c2114d85b6c51266fea9e97d.
[53] 杨娜, 许瑞明. 组蛋白变体的功能与识别机制. 生命科学[J]. 2017, 29(10): 946-954, http://lib.cqvip.com/Qikan/Article/Detail?id=674160591.
[54] Kong, GuiMei, Yu, Min, Gu, Zhongping, Chen, Zhi, Xu, RuiMing, OBryant, Deon, Wang, Zhengxin. Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity. PLOS ONE[J]. 2017, 12(8): https://doaj.org/article/2291e2f5c2114d85b6c51266fea9e97d.
[55] Fang, Qianglin, Chen, Ping, Wang, Mingzhu, Fang, Junnan, Yang, Na, Li, Guohong, Xu, RuiMing. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. ELIFE[J]. 2016, 5: http://www.corc.org.cn/handle/1471x/2374367.
[56] Jin, Wenxing, Wang, Yi, Liu, ChaoPei, Yang, Na, Jin, Mingliang, Cong, Yao, Wang, Mingzhu, Xu, RuiMing. Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. GENES & DEVELOPMENT[J]. 2016, 30(21): 2391-2403, https://www.webofscience.com/wos/woscc/full-record/WOS:000388810500005.
[57] Fu, Weiqi, Liu, Nan, Qiao, Qi, Wang, Mingzhu, Min, Jinrong, Zhu, Bing, Xu, RuiMing, Yang, Na. Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(17): 9173-9180, http://dx.doi.org/10.1074/jbc.M115.709832.
[58] Fang, Qianglin, Chen, Ping, Wang, Mingzhu, Fang, Junnan, Yang, Na, Li, Guohong, Xu, RuiMing. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. ELIFE[J]. 2016, 5: http://www.corc.org.cn/handle/1471x/2374367.
[59] Jin, Wenxing, Wang, Yi, Liu, ChaoPei, Yang, Na, Jin, Mingliang, Cong, Yao, Wang, Mingzhu, Xu, RuiMing. Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. GENES & DEVELOPMENT[J]. 2016, 30(21): 2391-2403, https://www.webofscience.com/wos/woscc/full-record/WOS:000388810500005.
[60] Fu, Weiqi, Liu, Nan, Qiao, Qi, Wang, Mingzhu, Min, Jinrong, Zhu, Bing, Xu, RuiMing, Yang, Na. Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(17): 9173-9180, http://dx.doi.org/10.1074/jbc.M115.709832.
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[121] Yang, Dongxue, Fang, Qianglin, Wang, Mingzhu, Ren, Ren, Wang, Hong, He, Meng, Sun, Youwei, Yang, Na, Xu, RuiMing. N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2013, 20(9): 1116-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000324160900015.
[122] Hsu, HaoChi, Wang, ChiaLin, Wang, Mingzhu, Yang, Na, Chen, Zhi, Sternglanz, Rolf, Xu, RuiMing. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. GENES & DEVELOPMENT[J]. 2013, 27(1): 64-73, http://www.irgrid.ac.cn/handle/1471x/756561.
[123] Yang, Na, Xu, RuiMing. Structure and function of the BAH domain in chromatin biology. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGYnull. 2013, 48(3): 211-221, http://www.irgrid.ac.cn/handle/1471x/756685.
[124] Rui-Ming Xu. Distinct mode of methyl-H3K4 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci .USA. 2012, [125] Lin, PeiChun, Xu, RuiMing. Structure and assembly of the SF3a splicing factor complex of U2 snRNP. EMBO JOURNAL[J]. 2012, 31(6): 1579-1590, http://www.irgrid.ac.cn/handle/1471x/756948.
[126] 杨福愉. A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature Structural & Molecular Biology[J]. 2012, 19(4): 403-410, http://www.irgrid.ac.cn/handle/1471x/756694.
[127] Rui-Ming Xu. Crystal structure of TDRD3 and methyl-arginine binding characterizations of TDRD3, SMN and SPF30. 2012, [128] Liu, Ke, Guo, Yahong, Liu, Haiping, Bian, Chuanbing, Lam, Robert, Liu, Yongsong, Mackenzie, Farrell, Rojas, Luis Alejandro, Reinberg, Danny, Bedford, Mark T, Xu, RuiMing, Min, Jinrong. Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30. PLOS ONE[J]. 2012, 7(2): http://www.irgrid.ac.cn/handle/1471x/756755.
[129] Liu, ChaoPei, Xiong, Chaoyang, Wang, Mingzhu, Yu, Zhouliang, Yang, Na, Chen, Ping, Zhang, Zhiguo, Li, Guohong, Xu, RuiMing. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(12): 1287-+, http://www.irgrid.ac.cn/handle/1471x/756950.
[130] Yang, Na, Wang, Weixiang, Wang, Yan, Wang, Mingzhu, Zhao, Qiang, Rao, Zihe, Zhu, Bing, Xu, RuiMing. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(44): 17954-17959, http://www.irgrid.ac.cn/handle/1471x/756775.
[131] Rui-Ming Xu. Distinct mode of methyl-H3K4 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci .USA. 2012, [132] Lin, PeiChun, Xu, RuiMing. Structure and assembly of the SF3a splicing factor complex of U2 snRNP. EMBO JOURNAL[J]. 2012, 31(6): 1579-1590, http://www.irgrid.ac.cn/handle/1471x/756948.
[133] 杨福愉. A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature Structural & Molecular Biology[J]. 2012, 19(4): 403-410, http://www.irgrid.ac.cn/handle/1471x/756694.
[134] Rui-Ming Xu. Crystal structure of TDRD3 and methyl-arginine binding characterizations of TDRD3, SMN and SPF30. 2012, [135] Liu, Ke, Guo, Yahong, Liu, Haiping, Bian, Chuanbing, Lam, Robert, Liu, Yongsong, Mackenzie, Farrell, Rojas, Luis Alejandro, Reinberg, Danny, Bedford, Mark T, Xu, RuiMing, Min, Jinrong. Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30. PLOS ONE[J]. 2012, 7(2): http://www.irgrid.ac.cn/handle/1471x/756755.
[136] Liu, ChaoPei, Xiong, Chaoyang, Wang, Mingzhu, Yu, Zhouliang, Yang, Na, Chen, Ping, Zhang, Zhiguo, Li, Guohong, Xu, RuiMing. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(12): 1287-+, http://www.irgrid.ac.cn/handle/1471x/756950.
[137] Yang, Na, Wang, Weixiang, Wang, Yan, Wang, Mingzhu, Zhao, Qiang, Rao, Zihe, Zhu, Bing, Xu, RuiMing. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(44): 17954-17959, http://www.irgrid.ac.cn/handle/1471x/756775.
[138] Rui-Ming Xu. Distinct mode of methyl-H3K4 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci .USA. 2012, [139] Lin, PeiChun, Xu, RuiMing. Structure and assembly of the SF3a splicing factor complex of U2 snRNP. EMBO JOURNAL[J]. 2012, 31(6): 1579-1590, http://www.irgrid.ac.cn/handle/1471x/756948.
[140] 杨福愉. A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature Structural & Molecular Biology[J]. 2012, 19(4): 403-410, http://www.irgrid.ac.cn/handle/1471x/756694.
[141] Rui-Ming Xu. Crystal structure of TDRD3 and methyl-arginine binding characterizations of TDRD3, SMN and SPF30. 2012, [142] Liu, Ke, Guo, Yahong, Liu, Haiping, Bian, Chuanbing, Lam, Robert, Liu, Yongsong, Mackenzie, Farrell, Rojas, Luis Alejandro, Reinberg, Danny, Bedford, Mark T, Xu, RuiMing, Min, Jinrong. Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30. PLOS ONE[J]. 2012, 7(2): http://www.irgrid.ac.cn/handle/1471x/756755.
[143] Liu, ChaoPei, Xiong, Chaoyang, Wang, Mingzhu, Yu, Zhouliang, Yang, Na, Chen, Ping, Zhang, Zhiguo, Li, Guohong, Xu, RuiMing. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(12): 1287-+, http://www.irgrid.ac.cn/handle/1471x/756950.
[144] Yang, Na, Wang, Weixiang, Wang, Yan, Wang, Mingzhu, Zhao, Qiang, Rao, Zihe, Zhu, Bing, Xu, RuiMing. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(44): 17954-17959, http://www.irgrid.ac.cn/handle/1471x/756775.
[145] Su, Dan, Hu, Qi, Zhou, Hui, Thompson, James R, Xu, RuiMing, Zhang, Zhiguo, Mer, Georges. Structure and Histone Binding Properties of the Vps75-Rtt109 Chaperone-Lysine Acetyltransferase Complex. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(18): 15625-15629, http://dx.doi.org/10.1074/jbc.C111.220715.
[146] Sun, Litao, Wang, Mingzhu, Lv, Zongyang, Yang, Na, Liu, Yingfang, Bao, Shilai, Gong, Weimin, Xu, RuiMing. Structural insights into protein arginine symmetric dimethylation by PRMT5. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(51): 20538-20543, http://www.irgrid.ac.cn/handle/1471x/757305.
[147] Hu, Hao, Liu, Yang, Wang, Mingzhu, Fang, Junnan, Huang, Hongda, Yang, Na, Li, Yanbo, Wang, Jianyu, Yao, Xuebiao, Shi, Yunyu, Li, Guohong, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. GENES & DEVELOPMENT[J]. 2011, 25(9): 901-906, http://www.irgrid.ac.cn/handle/1471x/757447.
[148] Xu, RuiMing. Structural Studies of Histone Methylation. FASEB JOURNALnull. 2011, 25: https://www.webofscience.com/wos/woscc/full-record/WOS:000310708402360.
[149] Qiao, Qi, Li, Yan, Chen, Zhi, Wang, Mingzhu, Reinberg, Danny, Xu, RuiMing. The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(10): 8361-8368, http://dx.doi.org/10.1074/jbc.M110.204115.
[150] Yang, Na, Hu, Hao, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCESnull. 2011, 67: C50-C51, https://www.webofscience.com/wos/woscc/full-record/WOS:000484219400117.
[151] Wang, Weixiang, Chen, Zhi, Mao, Zhuo, Zhang, Huihui, Ding, Xiaojun, Chen, She, Zhang, Xiaodong, Xu, Ruiming, Zhu, Bing. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO REPORTS[J]. 2011, 12(11): 1160-1166, http://www.irgrid.ac.cn/handle/1471x/757519.
[152] Su, Dan, Hu, Qi, Zhou, Hui, Thompson, James R, Xu, RuiMing, Zhang, Zhiguo, Mer, Georges. Structure and Histone Binding Properties of the Vps75-Rtt109 Chaperone-Lysine Acetyltransferase Complex. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(18): 15625-15629, http://dx.doi.org/10.1074/jbc.C111.220715.
[153] Sun, Litao, Wang, Mingzhu, Lv, Zongyang, Yang, Na, Liu, Yingfang, Bao, Shilai, Gong, Weimin, Xu, RuiMing. Structural insights into protein arginine symmetric dimethylation by PRMT5. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(51): 20538-20543, http://www.irgrid.ac.cn/handle/1471x/757305.
[154] Hu, Hao, Liu, Yang, Wang, Mingzhu, Fang, Junnan, Huang, Hongda, Yang, Na, Li, Yanbo, Wang, Jianyu, Yao, Xuebiao, Shi, Yunyu, Li, Guohong, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. GENES & DEVELOPMENT[J]. 2011, 25(9): 901-906, http://www.irgrid.ac.cn/handle/1471x/757447.
[155] Xu, RuiMing. Structural Studies of Histone Methylation. FASEB JOURNALnull. 2011, 25: https://www.webofscience.com/wos/woscc/full-record/WOS:000310708402360.
[156] Qiao, Qi, Li, Yan, Chen, Zhi, Wang, Mingzhu, Reinberg, Danny, Xu, RuiMing. The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(10): 8361-8368, http://dx.doi.org/10.1074/jbc.M110.204115.
[157] Yang, Na, Hu, Hao, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCESnull. 2011, 67: C50-C51, https://www.webofscience.com/wos/woscc/full-record/WOS:000484219400117.
[158] Wang, Weixiang, Chen, Zhi, Mao, Zhuo, Zhang, Huihui, Ding, Xiaojun, Chen, She, Zhang, Xiaodong, Xu, Ruiming, Zhu, Bing. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO REPORTS[J]. 2011, 12(11): 1160-1166, http://www.irgrid.ac.cn/handle/1471x/757519.
[159] Su, Dan, Hu, Qi, Zhou, Hui, Thompson, James R, Xu, RuiMing, Zhang, Zhiguo, Mer, Georges. Structure and Histone Binding Properties of the Vps75-Rtt109 Chaperone-Lysine Acetyltransferase Complex. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(18): 15625-15629, http://dx.doi.org/10.1074/jbc.C111.220715.
[160] Sun, Litao, Wang, Mingzhu, Lv, Zongyang, Yang, Na, Liu, Yingfang, Bao, Shilai, Gong, Weimin, Xu, RuiMing. Structural insights into protein arginine symmetric dimethylation by PRMT5. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(51): 20538-20543, http://www.irgrid.ac.cn/handle/1471x/757305.
[161] Hu, Hao, Liu, Yang, Wang, Mingzhu, Fang, Junnan, Huang, Hongda, Yang, Na, Li, Yanbo, Wang, Jianyu, Yao, Xuebiao, Shi, Yunyu, Li, Guohong, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. GENES & DEVELOPMENT[J]. 2011, 25(9): 901-906, http://www.irgrid.ac.cn/handle/1471x/757447.
[162] Xu, RuiMing. Structural Studies of Histone Methylation. FASEB JOURNALnull. 2011, 25: https://www.webofscience.com/wos/woscc/full-record/WOS:000310708402360.
[163] Qiao, Qi, Li, Yan, Chen, Zhi, Wang, Mingzhu, Reinberg, Danny, Xu, RuiMing. The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(10): 8361-8368, http://dx.doi.org/10.1074/jbc.M110.204115.
[164] Yang, Na, Hu, Hao, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCESnull. 2011, 67: C50-C51, https://www.webofscience.com/wos/woscc/full-record/WOS:000484219400117.
[165] Wang, Weixiang, Chen, Zhi, Mao, Zhuo, Zhang, Huihui, Ding, Xiaojun, Chen, She, Zhang, Xiaodong, Xu, Ruiming, Zhu, Bing. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO REPORTS[J]. 2011, 12(11): 1160-1166, http://www.irgrid.ac.cn/handle/1471x/757519.
[166] Liu, Haiping, Wang, JuYu S, Huang, Ying, Li, Zhizhong, Gong, Weimin, Lehmann, Ruth, Xu, RuiMing. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. GENES & DEVELOPMENT[J]. 2010, 24(17): 1876-1881, http://www.irgrid.ac.cn/handle/1471x/757062.
[167] Sun, Ming, Xu, RuiMing. Protein science research in China. PROTEIN & CELL[J]. 2010, 1(1): 4-5, https://www.webofscience.com/wos/woscc/full-record/WOS:000208510300003.
[168] Liu, Haiping, Wang, JuYu S, Huang, Ying, Li, Zhizhong, Gong, Weimin, Lehmann, Ruth, Xu, RuiMing. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. GENES & DEVELOPMENT[J]. 2010, 24(17): 1876-1881, http://www.irgrid.ac.cn/handle/1471x/757062.
[169] Sun, Ming, Xu, RuiMing. Protein science research in China. PROTEIN & CELL[J]. 2010, 1(1): 4-5, https://www.webofscience.com/wos/woscc/full-record/WOS:000208510300003.
[170] Liu, Haiping, Wang, JuYu S, Huang, Ying, Li, Zhizhong, Gong, Weimin, Lehmann, Ruth, Xu, RuiMing. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. GENES & DEVELOPMENT[J]. 2010, 24(17): 1876-1881, http://www.irgrid.ac.cn/handle/1471x/757062.
[171] Sun, Ming, Xu, RuiMing. Protein science research in China. PROTEIN & CELL[J]. 2010, 1(1): 4-5, https://www.webofscience.com/wos/woscc/full-record/WOS:000208510300003.
[172] XU RuiMing. Editoral: Molecular epigenetics: dawn of a new era of biomedical research. Science in China. Series C: Life science[J]. 2009, 52(4): 309-310, [173] Xu RuiMing. Molecular epigenetics: dawn of a new era of biomedical research. SCIENCE IN CHINA SERIES C-LIFE SCIENCESnull. 2009, 52(4): 309-310, http://www.irgrid.ac.cn/handle/1471x/757971.
[174] XU RuiMing. Editoral: Molecular epigenetics: dawn of a new era of biomedical research. Science in China. Series C: Life science[J]. 2009, 52(4): 309-310, [175] Xu RuiMing. Molecular epigenetics: dawn of a new era of biomedical research. SCIENCE IN CHINA SERIES C-LIFE SCIENCESnull. 2009, 52(4): 309-310, http://www.irgrid.ac.cn/handle/1471x/757971.
[176] XU RuiMing. Editoral: Molecular epigenetics: dawn of a new era of biomedical research. Science in China. Series C: Life science[J]. 2009, 52(4): 309-310, [177] Xu RuiMing. Molecular epigenetics: dawn of a new era of biomedical research. SCIENCE IN CHINA SERIES C-LIFE SCIENCESnull. 2009, 52(4): 309-310, http://www.irgrid.ac.cn/handle/1471x/757971.
[178] Huang, Y, Fang, J, Bedford, MT, Zhang, Y, Xu, RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. SCIENCE[J]. 2006, 312(5774): 748-751, https://www.webofscience.com/wos/woscc/full-record/WOS:000237312100051.
[179] Huang, Y, Fang, J, Bedford, MT, Zhang, Y, Xu, RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. SCIENCE[J]. 2006, 312(5774): 748-751, https://www.webofscience.com/wos/woscc/full-record/WOS:000237312100051.
[180] Huang, Y, Fang, J, Bedford, MT, Zhang, Y, Xu, RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. SCIENCE[J]. 2006, 312(5774): 748-751, https://www.webofscience.com/wos/woscc/full-record/WOS:000237312100051.
[181] Rui-Ming Xu. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at lysine 27. Genes and Development. 2003, [182] Min, JR, Feng, Q, Li, ZZ, Zhang, Y, Xu, RM. Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase. CELL[J]. 2003, 112(5): 711-723, http://dx.doi.org/10.1016/S0092-8674(03)00114-4.
[183] Rui-Ming Xu. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at lysine 27. Genes and Development. 2003, [184] Min, JR, Feng, Q, Li, ZZ, Zhang, Y, Xu, RM. Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase. CELL[J]. 2003, 112(5): 711-723, http://dx.doi.org/10.1016/S0092-8674(03)00114-4.
[185] Rui-Ming Xu. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at lysine 27. Genes and Development. 2003, [186] Min, JR, Feng, Q, Li, ZZ, Zhang, Y, Xu, RM. Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase. CELL[J]. 2003, 112(5): 711-723, http://dx.doi.org/10.1016/S0092-8674(03)00114-4.
[187] Min, JR, Landry, J, Sternglanz, R, Xu, RM. Crystal structure of a SIR2 homolog-NAD complex. CELL[J]. 2001, 105(2): 269-279, http://dx.doi.org/10.1016/S0092-8674(01)00317-8.
[188] Min, JR, Landry, J, Sternglanz, R, Xu, RM. Crystal structure of a SIR2 homolog-NAD complex. CELL[J]. 2001, 105(2): 269-279, http://dx.doi.org/10.1016/S0092-8674(01)00317-8.
[189] Min, JR, Landry, J, Sternglanz, R, Xu, RM. Crystal structure of a SIR2 homolog-NAD complex. CELL[J]. 2001, 105(2): 269-279, http://dx.doi.org/10.1016/S0092-8674(01)00317-8.
[190] Qianglin Fang, Ping Chen, Mingzhu Wang, Junnan Fang, Na Yang, Guohong Li, RuiMing Xu. Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. eLife[J]. 5: https://doaj.org/article/5178f46736754da39f94c8b11e21651e.
[191] Qianglin Fang, Ping Chen, Mingzhu Wang, Junnan Fang, Na Yang, Guohong Li, RuiMing Xu. Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. eLife[J]. 5: https://doaj.org/article/5178f46736754da39f94c8b11e21651e.
[192] Qianglin Fang, Ping Chen, Mingzhu Wang, Junnan Fang, Na Yang, Guohong Li, RuiMing Xu. Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. eLife[J]. 5: https://doaj.org/article/5178f46736754da39f94c8b11e21651e.

科研活动

   
科研项目
( 1 ) 核小体与蛋白质相互作用的结构机理研究, 主持, 国家级, 2015-01--2019-12
( 2 ) 染色质结构及其调控, 主持, 国家级, 2016-01--2021-12
( 3 ) 组蛋白伴侣HIRA特异识别组蛋白变体H3.3-H4的结构研究, 主持, 国家级, 2016-01--2016-12
( 4 ) PRMT5靶点确认及其候选化合物的结构功能机制研究, 主持, 国家级, 2014-01--2016-12
参与会议
(1)Alteration of chromatin folding by the binding of a viral protein to the nucleosome   2016-05-09
(2)Structural characterizations of snRNP assembly   国际剪接体学术研讨大会   2016-04-21
(3)Structural Studies of Histone Chaperones and Nucleosome Assembly Factors   2015-06-07
(4)Chromatin structure and dynamics   2014-12-27
(5)Structural basis for stimulation of SIRT1 activity by resveratrol   2014-05-08
(6)Structural Basis for Chaperone-histone Interactions   第八届亚太表观遗传年会   2013-11-08

指导学生

已指导学生

孙力涛  01  19183  

乔琪  01  19183  

王志峰  02  19184  

任韧  01  19183  

周挺  01  19183  

胡浩  01  19184  

富炜琦  01  19184  

王宏  01  19184  

杨晓诚  02  19184  

高冠男  01  19183  

许翔  01  19183  

曹端方  01  19183  

王景龙  02  19179  

方强林  01  19183  

杨冬雪  01  19183  

现指导学生

王奕  01  19183  

江孝青  02  19182  

宋晓盛  01  19183  

韩晓楠  01  19183  

周家杰  02  19183  

侯佩妮  02  19182  

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