(1) HIV-1/HSV-2黏膜感染与免疫 (HIV-1/HSV-2 mucosal infection and immunity)

以黏膜传播病毒为研究对象，聚焦病毒早期黏膜感染、免疫和生物阻断策略。探究黏膜性传播病毒HIV-1和HSV-2感染和免疫逃逸机制，设计和评价不同策略阻断病毒黏膜感染的效果，建立靶向诱导生殖道黏膜免疫应答策略；将以上方法和策略推广到经其它黏膜途径传播的病毒如人诺如病毒HuNoV和腺病毒AdV-3/7。

(2) 高致病性病毒早期感染与免疫干预策略 (Early infecions and immunological interventions of emerging/re-emerging viruses)

针对新发/突发高致病性病毒，研究病毒早期感染和致病机制，研发针对病毒早期感染和传播的新型免疫干预策略。现为全球挑战-人类疫苗网络（HIC-Vac）成员，与疫苗研究知名机构英国St George's University of  London、Imperial College London建立了长期合作关系。

071010-生物化学与分子生物学
100102-免疫学
100103-病原生物学

病毒感染与免疫

2000-06--2003-05   英国伦敦大学   博士
1987-09--1990-06   中国科学院武汉病毒研究所   硕士
1983-09--1987-06   湖南师范大学   学士

   

2009-01~现在, 中国科学院武汉病毒研究所, 研究员
2000-06~2008-12,英国伦敦大学St George医学院, Research Fellow; Senior Research Scientist/Senior Lecturer
2000-03~2000-05,中国科学院武汉病毒研究所, 副研究员
1997-03~2000-02,美国Louisville大学医学院, Visiting Scholar/Research Associate
1990-07~1997-02,中国科学院武汉病毒研究所, 研究实习员；助理研究员

Dynamics of Adaptive Immunity
病毒的装配、转运与释放
病毒的运输、包装及释放

   

（ 1 ） 一种CLD蛋白突变体及应用, 发明专利, 2021, 第 1 作者, 专利号: CN113563480A

（ 2 ） 一株HuNoV GII.4临床分离株序列及其感染性克隆的构建与应用, 发明专利, 2019, 第 1 作者, 专利号: CN110144331A

（ 3 ） 一种可以表达HIV‑1入侵抑制剂ECLD而抑制HIV‑1感染的重组腺相关病毒, 发明专利, 2017, 第 1 作者, 专利号: CN106701692A

（ 4 ） 利用CRISPR/Cas9抑制HIV-1感染原代淋巴细胞的方法, 发明专利, 2015, 第 2 作者, 专利号: CN104694573A

（ 5 ） 一种双价DNA疫苗连接肽及其应用, 发明专利, 2014, 第 1 作者, 专利号: CN103864902A

（ 6 ） 重组融合蛋白CLD的多肽、编码序列及制备方法和应用, 发明专利, 2012, 第 1 作者, 专利号: CN102617738A

（ 7 ） 一种疫苗佐剂CCL28及制备方法和应用, 发明专利, 2012, 第 1 作者, 专利号: CN102559693A

（ 8 ） 一种疫苗佐剂CCL19及制备方法和应用, 发明专利, 2012, 第 1 作者, 专利号: CN102533776A

（ 9 ） 多种病毒同步检测的方法, 发明专利, 2001, 第 6 作者, 专利号: CN1292424A

   

[1] MOLECULAR THERAPY. 2024, 第 9 作者
[2] MOLECULAR THERAPY. 2024,   通讯作者  
[3] VACCINES. 2023,   通讯作者  
[4] VIROLOGICA SINICA. 2023,   通讯作者  
[5] Wu, Xilin, Wang, Yaxing, Cheng, Lin, Ni, Fengfeng, Zhu, Linjing, Ma, Sen, Huang, Bilian, Ji, Mengmeng, Hu, Huimin, Li, Yuncheng, Xu, Shijie, Shi, Haixia, Zhang, Doudou, Liu, Linshuo, Nawaz, Waqas, Hu, Qinxue, Ye, Sheng, Liu, Yalan, Wu, Zhiwei. Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22). FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 16 作者13: https://doaj.org/article/4b91cce0f60946198df36a3e74e6a2ef.
[6] Huimin Hu, Ming Fu, Chuntian Li, Binman Zhang, Yuncheng Li, Qinxue Hu, Mudan Zhang. Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 6 作者  通讯作者  13: https://doaj.org/article/98a216681f894592a2add9695eec47c5.
[7] Yan, Yan, Hu, Kai, Fu, Ming, Deng, Xu, Guan, Xinmeng, Luo, Sukun, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. CCL28 Enhances HSV-2 gB-Specific Th1-Polarized Immune Responses against Lethal Vaginal Challenge in Mice. VACCINES[J]. 2022, 第 9 作者  通讯作者  10(8): http://dx.doi.org/10.3390/vaccines10081291.
[8] Liu, Feng, Hu, Huimin, Deng, Mengying, Xiang, Zongqin, Guo, Yuting, Guan, Xinmeng, Li, Dong, Hu, Qinxue, Lei, Wenliang, Peng, Hongjuan, Chu, Jun. A Bright Monomeric Near-Infrared Fluorescent Protein with an Excitation Peak at 633 nm for Labeling Cellular Protein and Reporting Protein-Protein Interaction. ACS SENSORS[J]. 2022, 第 8 作者7(7): 1855-1866, 
[9] Zhang, Mudan, Zhang, Binman, Chen, Rui, Li, Miaomiao, Zheng, Zifeng, Xu, Wanfu, Zhang, Yifan, Gong, Sitang, Hu, Qinxue. Human Norovirus Induces Aquaporin 1 Production by Activating NF-kappa B Signaling Pathway. VIRUSES-BASEL[J]. 2022, 第 9 作者  通讯作者  14(4): http://dx.doi.org/10.3390/v14040842.
[10] Fu, Ming, Xiao, Yingying, Du, Tao, Hu, Huimin, Ni, Fengfeng, Hu, Kai, Hu, Qinxue. Fusion Proteins CLD and CLDmut Demonstrate Potent and Broad Neutralizing Activity against HIV-1. VIRUSES-BASEL[J]. 2022, 第 7 作者  通讯作者  14(7): 
[11] Yan Yan, Qinxue Hu. Molecular Epidemiology of SARS-CoV-2 by Sequencing. Methods Mol Biol[J]. 2022, 第 2 作者  通讯作者  19-32, 
[12] Yan, Yan, Hu, Kai, Fu, Ming, Deng, Xu, Luo, Sukun, Tong, Lina, Guan, Xinmeng, He, Siyi, Li, Chang, Jin, Wei, Du, Tao, Zheng, Zifeng, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. MSPHERE[J]. 2021, 第 15 作者  通讯作者  6(2): http://dx.doi.org/10.1128/mSphere.00058-21..
[13] Li, Xia, Wang, Dianbing, Cui, Zongqiang, Li, Qin, Li, Min, Ma, Yingxin, Hu, Qinxue, Zhou, Yikai, Zhang, XianEn. HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 第 7 作者64(1): 66-76, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6916199&detailType=1.
[14] Yan, Yan, Liu, Bin, Ding, Hui, Wang, Xu, Dai, Yaping, Ding, Difei, Yu, Hui, Sha, Mingchao, Lui, Chunyan, Chantsalmaa, Davgadorj, Qiu, Yuanwang, Huang, Lihua, Hu, Qinxue. Characterizing COVID-19 severity, epidemiology and SARS-CoV-2 genotypes in a regional business hub of China. JOURNAL OF INFECTION. 2021, 第 13 作者  通讯作者  82(2): 317-321, http://dx.doi.org/10.1016/j.jinf.2020.08.031.
[15] Zhang, Mudan, Fu, Ming, Hu, Qinxue. Advances in Human Norovirus Vaccine Research. VACCINES[J]. 2021, 第 3 作者  通讯作者  9(7): http://dx.doi.org/10.3390/vaccines9070732.
[16] Yan, Yan, Jiang, Xiufeng, Wang, Xu, Liu, Bin, Ding, Hui, Jiang, Mengjun, Yang, Zhenkun, Dai, Yaping, Ding, Difei, Yu, Hui, Zhang, Shiliang, Liu, Jun, Sha, Mingchao, Lui, Chunyan, Qiu, Yuanwang, Lu, Hongzhou, Hu, Qinxue. CCL28 mucosal expression in SARS-CoV-2-infected patients with diarrhea in relation to disease severity. JOURNAL OF INFECTION. 2021, 第 17 作者  通讯作者  82(1): E19-E21, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833095/.
[17] Staines, Henry M, Kirwan, Daniela E, Clark, David J, Adams, Emily R, Augustin, Yolanda, Byrne, Rachel L, Cocozza, Michael, CubasAtienzar, Ana, I, Cuevas, Luis E, Cusinato, Martina, Davies, Benedict Mo, Davis, Mark, Davis, Paul, Duvoix, Annelyse, Eckersley, Nicholas M, Forton, Daniel, Fraser, Alice J, Garrod, Gala, Hadcocks, Linda, Hu, Qinxue, Johnson, Michael, Kay, Grant A, Klekotko, Kesja, Lewis, Zawditu, Macallan, Derek C, MensahKane, Josephine, Menzies, Stefanie, Monahan, Irene, Moore, Catherine M, NebevonCaron, Gerhard, Owen, Sophie, I, Sainter, Chris, Sall, Amadou A, Schouten, James, Williams, Christopher T, Wilkins, John, Woolston, Kevin, Fitchett, Joseph Ra, Krishna, Sanjeev, Planche, Tim. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. EMERGING INFECTIOUS DISEASES[J]. 2021, 第 20 作者27(1): 85-91, http://dx.doi.org/10.3201/eid2701.203074.
[18] Li, Chuntian, Zhang, Mudan, Guan, Xinmeng, Hu, Huimin, Fu, Ming, Liu, Yalan, Hu, Qinxue. Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-kappa B Activation by Interacting with p65. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 7 作者  通讯作者  206(12): 2852-2861, http://dx.doi.org/10.4049/jimmunol.2001336.
[19] Yan, Yan, Jiang, Xiufeng, Fu, Juanjuan, Huang, Jiehui, Qiu, Yuanwang, Ding, Difei, Ge, Lina, Zhang, Hao, Huang, Lihua, Lu, Xiaojie, Hu, Qinxue. Immune responses and residual SARS-CoV-2 in two critically ill COVID-19 patients before and after lung transplantation. JOURNAL OF INFECTION. 2021, 第 11 作者  通讯作者  82(4): 102-105, http://dx.doi.org/10.1016/j.jinf.2020.11.006.
[20] Zheng, Zifeng, Li, Yuncheng, Zhang, Mudan, Liu, Yalan, Fu, Ming, Gong, Sitang, Hu, Qinxue. Human Norovirus NTPase Antagonizes Interferon-beta Production by Interacting With IkB Kinase epsilon. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 7 作者  通讯作者  12: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000679181900001.
[21] Wu, Xilin, Cheng, Lin, Fu, Ming, Huang, Bilian, Zhu, Linjing, Xu, Shijie, Shi, Haixia, Zhang, Doudou, Yuan, Huanyun, Nawaz, Waqas, Yang, Ping, Hu, Qinxue, Liu, Yalan, Wu, Zhiwei. A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration. CELL REPORTS[J]. 2021, 第 12 作者37(3): 109869-109869, https://doaj.org/article/dc1cf0e95aa34ccfbdd25195cca9304f.
[22] Li, Chuntian, Zhang, Mudan, Guan, Xinmeng, Hu, Huimin, Fu, Ming, Liu, Yalan, Hu, Qinxue. Herpes simplex virus type 2 glycoprotein D inhibits NF-κB activation by interacting with p65. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 7 作者  通讯作者  206(12): 2852-2861, 
[23] Zhang, Mudan, Fu, Ming, Li, Miaomiao, Hu, Huimin, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 6 作者  通讯作者  205(5): 1281-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000562763400010.
[24] DanLuo, ZhiXia, HengLi, DannaTu, TingWang, WeiZhang, LuPeng, WenfuYi, SaiZhang, JunhuaShu, HuiXu, YongLi, BuyunShi, ChengjiaoHuang, WenTang, ShunaXiao, XiaolanShu, YanLiu, YuanZhang, ShanGuo, ZhiYu, BaoxiangWang, YuanGao, QinxueHu, HanzhongWang, XiaohuiSong, HongMei, XiaoqinZhou, ZhenhuaZheng. Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study. Virologica Sinica[J]. 2020, 第 24 作者35(6): 861-867, https://www.virosin.org/article/doi/10.1007/s12250-020-00333-z.
[25] Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua. A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice. VIRUSES-BASEL[J]. 2020, 第 8 作者12(8): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000579055300001.
[26] Yan Yan, Bin Liu, Hui Ding, Xu Wang, Yaping Dai, Difei Ding, Hui Yu, Mingchao Sha, Chunyan Lui, Davgadorj Chantsalmaa, Yuanwang Qiu, Lihua Huang, Qinxue Hu. Characterizing COVID-19 severity, epidemiology and SARS-CoV-2 genotypes in a regional business hub of China. JOURNAL OF INFECTION. 2020, 第 13 作者  通讯作者  
[27] Wang, Ting, Li, Penghui, Zhang, Yuan, Liu, Yan, Tan, Zhongyuan, Sun, Jianhong, Ke, Xianliang, Miao, Yuanjiu, Luo, Dan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua. In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy. THERANOSTICS[J]. 2020, 第 10 作者10(14): 6430-6447, https://www.webofscience.com/wos/woscc/full-record/WOS:000534615100023.
[28] Hu, Kai, Fu, Ming, Wang, Jun, Luo, Sukun, Barreto, Mariana, Singh, Rubin, Chowdhury, Tasnim, Li, Mei, Zhang, Mudan, Guan, Xinmeng, Xiao, Juhua, Hu, Qinxue. HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway. FRONTIERS IN IMMUNOLOGY[J]. 2020, 第 12 作者  通讯作者  11: https://doaj.org/article/61ecfe5de4274daea11a2c12e6b59e55.
[29] Sun, Jianhong, Zhang, Wanpo, Tan, Zhongyuan, Zheng, Caishang, Tang, Yan, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Li, Penghui, Hu, Qinxue, Wang, Hanzhong, Mao, Panyong, Zheng, Zhenhua. Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes. VIRULENCE[J]. 2020, 第 10 作者11(1): 113-131, http://dx.doi.org/10.1080/21505594.2020.1715189.
[30] Li, Mei, Zhang, Di, Li, Chuntian, Zheng, Zifeng, Fu, Ming, Ni, Fengfeng, Liu, Yalan, Du, Tao, Wang, Hanzhong, Griffin, George E, Zhang, Mudan, Hu, Qinxue. Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 12 作者  通讯作者  11: https://doaj.org/article/a0758ba1ab8c477eb31f0436febbec5a.
[31] Fu, Ming, Hu, Kai, Hu, Huimin, Ni, Fengfeng, Du, Tao, Shattock, Robin J, Hu, Qinxue. Antigenicity and immunogenicity of HIV-1 gp140 with different combinations of glycan mutation and V1/V2 region or V3 crown deletion. VACCINE[J]. 2019, 第 7 作者  通讯作者  37(51): 7501-7508, http://dx.doi.org/10.1016/j.vaccine.2019.09.073.
[32] Yan, Yan, Chen, Renfang, Wang, Xu, Hu, Kai, Huang, Lihua, Lu, Mengji, Hu, Qinxue. CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2019, 第 7 作者  通讯作者  7: https://doaj.org/article/ea4cc9dcdfb947a79fa4a567ee99921a.
[33] Guan, Xinmeng, Zhang, Mudan, Fu, Ming, Luo, Sukun, Hu, Qinxue. Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-beta Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. FRONTIERS IN IMMUNOLOGY[J]. 2019, 第 5 作者  通讯作者  10: http://www.corc.org.cn/handle/1471x/2373169.
[34] Mingyuan Du, Ningxing Li, Guobin Mao, Yucheng Liu, Xinxin Wang, Songbai Tian, Qinxue Hu, Xinghu Ji, Yalan Liu, Zhike He. Self-assembled fluorescent Ce(Ⅲ) coordination polymer as ratiometric probe for HIV antigen detection. ANALYTICA CHIMICA ACTA. 2019, 第 7 作者1084: 116-122, http://dx.doi.org/10.1016/j.aca.2019.08.010.
[35] Dihan Zhou, Yi Yang, Bali Zhao, Jie Yu, Yuan Cao, Hu Yan, Wei Zhao, Longyun Chen, Fang Chen, Xiaodan Li, Ejuan Zhang, Jingyi Yang, Maohua Zhong, Mingzhou Chen, Qinxue Hu, Li Deng, Huimin Yan. IgA targeting on the α-molecular recognition element (α-MoRE) of viral phosphoprotein inhibits measles virus replication by interrupting formation and function of P-N complex intracellularly. ANTIVIRAL RESEARCH. 2019, 第 15 作者161: 144-153, http://dx.doi.org/10.1016/j.antiviral.2018.11.014.
[36] Tan, Zhongyuan, Zhang, Wanpo, Sun, Jianhong, Fu, Zuquan, Ke, Xianliang, Zheng, Caishang, Zhang, Yuan, Li, Penghui, Liu, Yan, Hu, Qinxue, Wang, Hanzhong, Zheng, Zhenhua. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. JOURNAL OF NEUROINFLAMMATION[J]. 2018, 第 10 作者15(1): http://www.corc.org.cn/handle/1471x/2373241.
[37] Hu, Kai, Fu, Ming, Guan, Xinmeng, Zhang, Di, Deng, Xu, Xiao, Yingying, Chen, Rui, Liu, Huan, Hu, Qinxue. Penton base induces better protective immune responses than fiber and hexon as a subunit vaccine candidate against adenoviruses. VACCINE[J]. 2018, 第 9 作者  通讯作者  36(29): 4287-4297, http://dx.doi.org/10.1016/j.vaccine.2018.05.118.
[38] Liu, Yalan, Guan, Xinmeng, Li, Chuntian, Ni, Fengfeng, Luo, Sukun, Wang, Jun, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein J promotes viral protein expression and virus spread. VIROLOGY[J]. 2018, 第 9 作者  通讯作者  525: 83-95, http://www.corc.org.cn/handle/1471x/2373205.
[39] Yingxin Ma, Zhike He, Tianwei Tan, Wei Li, Zhiping Zhang, Shuang Song, Xiaowei Zhang, Qinxue Hu, Peng Zhou, Yuntao Wu, XianEn Zhan, Zongqiang Cui. Real-time imaging of single HIV-1 disassembly with multicolor viral particles. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2018, 第 8 作者14(5): 1873-1873, http://dx.doi.org/10.1016/j.nano.2017.11.353.
[40] Li, Penghui, Ke, Xianliang, Wang, Ting, Tan, Zhongyuan, Luo, Dan, Miao, Yuanjiu, Sun, Jianhong, Zhang, Yuan, Liu, Yan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua. Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models. JOURNAL OF VIROLOGY[J]. 2018, 第 10 作者92(17): http://dx.doi.org/10.1128/JVI.00701-18.
[41] Zheng, Zifeng, Yang, Jieyu, Jiang, Xuan, Liu, Yalan, Zhang, Xiaowei, Li, Mei, Zhang, Mudan, Fu, Ming, Hu, Kai, Wang, Hanzhong, Luo, MinHua, Gong, Peng, Hu, Qinxue. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. JOURNAL OF IMMUNOLOGY[J]. 2018, 第 13 作者  通讯作者  201(1): 53-68, http://www.corc.org.cn/handle/1471x/2373246.
[42] Zhang, Mudan, Deng, Xu, Guan, Xinmeng, Geng, Lanlan, Fu, Ming, Zhang, Binman, Chen, Rui, Hu, Huimin, Hu, Kai, Zhang, Di, Li, Mei, Liu, Yalan, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4(+) T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. FRONTIERS IN IMMUNOLOGY[J]. 2018, 第 14 作者  通讯作者  9: http://202.127.146.157/handle/2RYDP1HH/6385.
[43] Qinxue Hu. HSV-2 infection-induced expression of CXCR3 ligands promotes CD4+ T cell migration and is regulated by the viral immediate-early protein ICP4. Front Immunol. 2018, 第 1 作者  通讯作者  
[44] Xie, Li, Lu, Baojing, Zheng, Zhenhua, Miao, Yuanjiu, Liu, Yan, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Hu, Qinxue, Wang, Hanzhong. The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP). JOURNAL OF GENERAL VIROLOGY[J]. 2018, 第 9 作者  通讯作者  99(1): 73-85, http://dx.doi.org/10.1099/jgv.0.000982.
[45] Hu, Kai, He, Siyi, Xiao, Juhua, Li, Mei, Luo, Sukun, Zhang, Mudan, Hu, Qinxue. Interaction between herpesvirus entry mediator and HSV-2 glycoproteins mediates HIV-1 entry of HSV-2-infected epithelial cells. JOURNAL OF GENERAL VIROLOGY[J]. 2017, 第 7 作者  通讯作者  98(9): 2351-2361, http://www.corc.org.cn/handle/1471x/2373392.
[46] Wang, Ping, Li, Mei, Lu, Wei, Zhang, Di, Hu, Qinxue, Liu, Yalan. DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses. VIROLOGICA SINICA[J]. 2017, 第 5 作者  通讯作者  32(6): 495-502, http://www.corc.org.cn/handle/1471x/2373353.
[47] Li, Mei, Wang, Ping, Zheng, Zifeng, Hu, Kai, Zhang, Mudan, Guan, Xinmeng, Fu, Ming, Zhang, Di, Wang, Wei, Xiao, Gengfu, Hu, Qinxue, Liu, Yalan. Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. VIROLOGY[J]. 2017, 第 11 作者  通讯作者  510: 67-75, http://www.corc.org.cn/handle/1471x/2373378.
[48] Zhang, Xiaowei, Zheng, Zhenhua, Liu, Xijuan, Shu, Bo, Mao, Panyong, Bai, Bingke, Hu, Qinxue, Luo, Minhua, Ma, Xiaohe, Cui, Zongqiang, Wang, Hanzhong. Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway. JOURNAL OF NEUROINFLAMMATION[J]. 2016, 第 7 作者13(1): http://dx.doi.org/10.1186/s12974-016-0665-9.
[49] Ma, Yingxin, He, Zhike, Tan, Tianwei, Li, Wei, Zhang, Zhiping, Song, Shuang, Zhang, Xiaowei, Hu, Qinxue, Zhou, Peng, Wu, Yuntao, Zhang, XianEn, Cui, Zongqiang. Real-Time Imaging of Single HIV-1 Disassembly with Multicolor Viral Particles. ACS NANO[J]. 2016, 第 8 作者10(6): 6273-6282, https://www.webofscience.com/wos/woscc/full-record/WOS:000378973700076.
[50] Li, Qian, Zheng, Zhenhua, Liu, Yan, Zhang, Zhenfeng, Liu, Qingshi, Meng, Jin, Ke, Xianliang, Hu, Qinxue, Wang, Hanzhong. 2C Proteins of Enteroviruses Suppress IKK beta Phosphorylation by Recruiting Protein Phosphatase 1. JOURNAL OF VIROLOGY[J]. 2016, 第 8 作者90(10): 5141-5151, https://www.webofscience.com/wos/woscc/full-record/WOS:000375126100026.
[51] Liu, Qingshi, Zhang, Zhenfeng, Zheng, Zhenhua, Zheng, Caishang, Liu, Yan, Hu, Qinxue, Ke, Xianliang, Wang, Hanzhong. Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-alpha-Mediated Activation of NF-kappa B by targeting p65. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者6: http://www.corc.org.cn/handle/1471x/2374573.
[52] Wang, Ping, Hu, Kai, Luo, Sukun, Zhang, Mudan, Deng, Xu, Li, Chang, Jin, Wei, Hu, Bodan, He, Siyi, Li, Mei, Du, Tao, Xiao, Gengfu, Zhang, Bo, Liu, Yalan, Hu, Qinxue. DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein. VIROLOGY[J]. 2016, 第 15 作者  通讯作者  488: 108-119, http://dx.doi.org/10.1016/j.virol.2015.11.006.
[53] Liu, Yalan, Li, Mei, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway. VIROLOGYJOURNAL[J]. 2016, 第 5 作者  通讯作者  13(1): http://www.corc.org.cn/handle/1471x/2376301.
[54] Zhang, Xiaowei, Zheng, Zhenhua, Shu, Bo, Mao, Panyong, Bai, Bingke, Hu, Qinxue, Cui, Zongqiang, Wang, Hanzhong. Isolation and characterization of a Far-Eastern strain of tick-borne encephalitis virus in China. VIRUS RESEARCH[J]. 2016, 第 6 作者213: 6-10, http://dx.doi.org/10.1016/j.virusres.2015.11.006.
[55] Liu, AnAn, Zhang, Zhenfeng, Sun, EnZe, Zheng, Zhenhua, Zhang, ZhiLing, Hu, Qinxue, Wang, Hanzhong, Pang, DaiWen. Simultaneous Visualization of Parental and Progeny Viruses by a Capsid-Specific HaloTag Labeling Strategy. ACS NANO[J]. 2016, 第 6 作者10(1): 1147-1155, https://www.webofscience.com/wos/woscc/full-record/WOS:000369115800126.
[56] Liu, Yan, Zheng, Zhenhua, Shu, Bo, Meng, Jin, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Gong, Peng, Hu, Qinxue, Wang, Hanzhong. SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. JOURNAL OF VIROLOGY[J]. 2016, 第 9 作者90(23): 10472-10485, http://www.corc.org.cn/handle/1471x/2373494.
[57] Zhang, Mudan, Liu, Yalan, Wang, Ping, Guan, Xinmeng, He, Siyi, Luo, Sukun, Li, Chang, Hu, Kai, Jin, Wei, Du, Tao, Yan, Yan, Zhang, Zhenfeng, Zheng, Zhenhua, Wang, Hanzhong, Hu, Qinxue. HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 15 作者  通讯作者  194(7): 3102-3115, http://dx.doi.org/10.4049/jimmunol.1401538.
[58] Wang, Meng, Zheng, Zhenhua, Meng, Jin, Wang, Han, He, Man, Zhang, Fuxian, Liu, Yan, Hu, Bin, He, Zike, Hu, Qinxue, Wang, Hanzhong. In vivo study of immunogenicity and kinetic characteristics of a quantum dot-labelled baculovirus. BIOMATERIALS[J]. 2015, 第 10 作者64: 78-87, http://dx.doi.org/10.1016/j.biomaterials.2015.06.030.
[59] Hu, Bodan, Du, Tao, Li, Chang, Luo, Sukun, Liu, Yalan, Huang, Xin, Hu, Qinxue. Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 第 7 作者  通讯作者  96: 3660-3666, http://dx.doi.org/10.1099/jgv.0.000299.
[60] Caishang Zheng, Zhenhua Zheng, Zhenfeng Zhang, Jin Meng, Yan Liu, Xianliang Ke, Qinxue Hu, Hanzhong Wang. IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1). CELLULAR SIGNALLING. 2015, 第 7 作者27(12): 2343-2354, http://dx.doi.org/10.1016/j.cellsig.2015.08.018.
[61] Yan, Yan, Hu, Kai, Deng, Xu, Guan, Xinmeng, Luo, Sukun, Tong, Lina, Du, Tao, Fu, Ming, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 11 作者  通讯作者  195(1): 329-338, http://dx.doi.org/10.4049/jimmunol.1500198.
[62] Li, Chang, Guan, Xinmeng, Du, Tao, Jin, Wei, Wu, Biao, Liu, Yalan, Wang, Ping, Hu, Bodan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Inhibition of HIV-1 infection of primary CD4(+) T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 第 11 作者  通讯作者  96: 2381-2393, http://dx.doi.org/10.1099/vir.0.000139.
[63] Liu, Yalan, Luo, Sukun, He, Siyi, Zhang, Mudan, Wang, Ping, Li, Chang, Huang, Wenjie, Hu, Bodan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins. VIROLOGY[J]. 2015, 第 11 作者  通讯作者  475: 96-109, http://dx.doi.org/10.1016/j.virol.2014.11.005.
[64] Zheng, Caishang, Zheng, Zhenhua, Zhang, Zhenfeng, Meng, Jin, Liu, Yan, Ke, Xianliang, Hu, Qinxue, Wang, Hanzhong. IFIT5 positively regulates NF-kappa B signaling through synergizing the recruitment of I kappa B kinase (IKK) to TGF-beta-activated kinase 1 (TAK1). CELLULAR SIGNALLING[J]. 2015, 第 7 作者27(12): 2343-2354, https://www.webofscience.com/wos/woscc/full-record/WOS:000367486400003.
[65] Luo, Sukun, Hu, Kai, He, Siyi, Wang, Ping, Zhang, Mudan, Huang, Xin, Du, Tao, Zheng, Chunfu, Liu, Yalan, Hu, Qinxue. Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry. VIROLOGY[J]. 2015, 第 10 作者  通讯作者  483: 72-82, http://dx.doi.org/10.1016/j.virol.2015.04.005.
[66] Mudan Zhang, Yalan Liu, Zhenfeng Zhang, Sukun Luo, Kai Hu, Hanzhong Wang, Tao Du, Xinmeng Guan, Yan Yan, Qinxue Hu, Chang Li, Siyi He, Wei Jin, Ping Wang, Zhenhua Zheng. HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter. AMERICAN ASSOCIATION OF IMMUNOLOGISTS[J]. 2015, 第 10 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902028151096ZK.
[67] Qinxue Hu. Immunization with CCL19-HSV-2 gB fusion constructs protects mice against lethal vaginal challenge. J Immunol. 2015, 第 1 作者  通讯作者  
[68] Jin, Wei, Li, Chang, Du, Tao, Hu, Kai, Huang, Xin, Hu, Qinxue. DC-SIGN plays a stronger role than DCIR in mediating HIV-1 capture and transfer. VIROLOGY[J]. 2014, 第 6 作者  通讯作者  458: 83-92, http://dx.doi.org/10.1016/j.virol.2014.04.016.
[69] ChangLi, WeiJin, TaoDu, BiaoWu, YalanLiu, RobinJShattock, QinxueHu. Binding of HIV-1 virions to α4β7expressing cells and impact of antagonizing α4β7on HIV-1 infection of primary CD4+T cells. Virologica Sinica[J]. 2014, 第 7 作者29(6): 381-392, https://www.virosin.org/article/doi/10.1007/s12250-014-3525-8.
[70] Zhang, Fuxian, Zheng, Zhenhua, Liu, ShuLin, Lu, Wen, Zhang, Zhenfeng, Zhang, Cuiling, Zhou, Peng, Zhang, Yuan, Long, Gang, He, Zhike, Pang, DaiWen, Hu, Qinxue, Wang, Hanzhong. Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking. BIOMATERIALS[J]. 2013, 第 12 作者34(30): 7506-7518, http://dx.doi.org/10.1016/j.biomaterials.2013.06.030.
[71] Hu, Kai, Luo, Sukun, Tong, Lina, Huang, Xin, Jin, Wei, Huang, Wenjie, Du, Tao, Yan, Yan, He, Siyi, Griffin, George E, Shattock, Robin J, Hu, Qinxue. CCL19 and CCL28 Augment Mucosal and Systemic Immune Responses to HIV-1 gp140 by Mobilizing Responsive Immunocytes into Secondary Lymph Nodes and Mucosal Tissue. JOURNAL OF IMMUNOLOGY[J]. 2013, 第 12 作者  通讯作者  191(4): 1935-1947, http://dx.doi.org/10.4049/jimmunol.1300120.
[72] Zhang, Yuan, Ke, Xianliang, Zheng, Zhenhua, Zhang, Cuiling, Zhang, Zhenfeng, Zhang, Fuxian, Hu, Qinxue, He, Zhike, Wang, Hanzhong. Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection. ACSNANO[J]. 2013, 第 7 作者7(5): 3896-3904, https://www.webofscience.com/wos/woscc/full-record/WOS:000319856300026.
[73] Zhang, Xiaowei, Zheng, Zhenhua, Shu, Bo, Liu, Xijuan, Zhang, Zhenfeng, Liu, Yan, Bai, Bingke, Hu, Qinxue, Mao, Panyong, Wang, Hanzhong. Human Astrocytic Cells Support Persistent Coxsackievirus B3 Infection. JOURNAL OF VIROLOGY[J]. 2013, 第 8 作者87(22): 12407-12421, https://www.webofscience.com/wos/woscc/full-record/WOS:000325865400041.
[74] Li, Qian, Zhang, Zhenfeng, Zheng, Zhenhua, Ke, Xianliang, Luo, Huanle, Hu, Qinxue, Wang, Hanzhong. Identification and characterization of complex dual nuclear localization signals in human bocavirus NP1. JOURNAL OF GENERAL VIROLOGY[J]. 2013, 第 6 作者94: 1335-1342, http://dx.doi.org/10.1099/vir.0.047530-0.
[75] Luo, Huanle, Zhang, Zhenfeng, Zheng, Zhenhua, Ke, Xianliang, Zhang, Xiaowei, Li, Qian, Liu, Yan, Bai, Bingke, Mao, Panyong, Hu, Qinxue, Wang, Hanzhong. Human Bocavirus VP2 Upregulates IFN-beta Pathway by Inhibiting Ring Finger Protein 125-Mediated Ubiquitination of Retinoic Acid-Inducible Gene-I. JOURNAL OF IMMUNOLOGY[J]. 2013, 第 10 作者191(2): 660-669, https://www.webofscience.com/wos/woscc/full-record/WOS:000321260100018.
[76] Zhang, Xiaowei, Zheng, Zhenhua, Shu, Bo, Liu, Xijuan, Zhang, Zhenfeng, Liu, Yan, Bai, Bingke, Hu, Qinxue, Mao, Panyong, Wang, Hanzhong. Human Astrocytic Cells Support Persistent Coxsackievirus B3 Infection. JOURNAL OF VIROLOGY[J]. 2013, 第 8 作者87(22): 12407-12421, https://www.webofscience.com/wos/woscc/full-record/WOS:000325865400041.
[77] Tao, Ling, Chen, Jianjun, Zheng, Zhenhua, Meng, Jin, Zhang, Zhenfeng, Chen, Yao, Luo, Huanle, Li, Hongxia, Chen, Ze, Hu, Qinxue, Wang, Hanzhong. H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice. CANADIAN JOURNAL OF MICROBIOLOGY[J]. 2012, 第 10 作者58(4): 391-401, http://dx.doi.org/10.1139/W2012-006.
[78] Du, Tao, Hu, Kai, Yang, Jun, Jin, Jing, Li, Chang, Stieh, Daniel, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Bifunctional CD4-DC-SIGN Fusion Proteins Demonstrate Enhanced Avidity to gp120 and Inhibit HIV-1 Infection and Dissemination. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2012, 第 11 作者56(9): 4640-4649, http://dx.doi.org/10.1128/AAC.00623-12.
[79] Huang, Xin, Jin, Wei, Hu, Kai, Luo, Sukun, Du, Tao, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction. VIROLOGY[J]. 2012, 第 8 作者  通讯作者  423(1): 97-106, http://dx.doi.org/10.1016/j.virol.2011.11.023.
[80] Zhang, Zhenfeng, Zheng, Zhenhua, Luo, Huanle, Meng, Jin, Li, Hongxia, Li, Qian, Zhang, Xiaowei, Ke, Xianliang, Bai, Bingke, Mao, Panyong, Hu, Qinxue, Wang, Hanzhong. Human Bocavirus NP1 Inhibits IFN-beta Production by Blocking Association of IFN Regulatory Factor 3 with IFNB Promoter. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 11 作者189(3): 1144-1153, https://www.webofscience.com/wos/woscc/full-record/WOS:000306599100010.
[81] Huang, Wenjie, Hu, Kai, Luo, Sukun, Zhang, Mudan, Li, Chang, Jin, Wei, Liu, Yalan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4(+) T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-beta Pathway. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 10 作者  通讯作者  188(12): 6247-6257, http://dx.doi.org/10.4049/jimmunol.1103706.
[82] Qinxue Hu. HSV-2 infection of human epithelial cells induces CXCL9 expression and CD4+ T cell migration via activation of p38-C/EBP-β pathway. JIMMUNOL. 2012, 第 1 作者  通讯作者  
[83] Du, Tao, Hu, Kai, Yang, Jun, Jin, Jing, Li, Chang, Stieh, Daniel, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Bifunctional CD4-DC-SIGN Fusion Proteins Demonstrate Enhanced Avidity to gp120 and Inhibit HIV-1 Infection and Dissemination. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2012, 第 9 作者  通讯作者  56(9): 4640-4649, https://www.webofscience.com/wos/woscc/full-record/WOS:000307908600009.
[84] Liang, Yu, Zhang, Zhiping, Wei, Hongping, Hu, Qinxue, Deng, Jiaoyu, Guo, Deyin, Cui, Zongqiang, Zhang, XianEn. Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells. BIOSENSORS & BIOELECTRONICS[J]. 2011, 第 4 作者28(1): 270-276, http://www.corc.org.cn/handle/1471x/2375918.
[85] Zheng, Zhenhua, Li, Hongxia, Zhang, Zhenfeng, Meng, Jin, Mao, Da, Bai, Bingke, Lu, Baojing, Mao, Panyong, Hu, Qinxue, Wang, Hanzhong. Enterovirus 71 2C Protein Inhibits TNF-alpha-Mediated Activation of NF-kappa B by Suppressing I kappa B Kinase beta Phosphorylation. JOURNAL OF IMMUNOLOGY[J]. 2011, 第 9 作者187(5): 2202-2212, http://www.corc.org.cn/handle/1471x/2375850.
[86] Huang, Xin, Jin, Wei, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin. JOURNAL OF GENERAL VIROLOGY[J]. 2011, 第 5 作者  通讯作者  92: 2367-2373, http://www.corc.org.cn/handle/1471x/2376024.
[87] Hu, Qinxue, Huang, Xin, Shattock, Robin J. C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors. JOURNAL OF GENERAL VIROLOGY[J]. 2010, 第 1 作者91: 2965-2973, http://dx.doi.org/10.1099/vir.0.025270-0.
[88] Li, Hongxia, Zheng, Zhenhua, Zhou, Peng, Zhang, Bing, Shi, Zhengli, Hu, Qinxue, Wang, Hanzhong. The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation. JOURNAL OF GENERAL VIROLOGY[J]. 2010, 第 6 作者91: 2947-2958, http://www.corc.org.cn/handle/1471x/2375704.
[89] Lu, Baojing, Huang, Yi, Huang, Li, Li, Bao, Zheng, Zhenhua, Chen, Ze, Chen, Jianjun, Hu, Qinxue, Wang, Hanzhong. Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice. IMMUNOLOGY[J]. 2010, 第 8 作者130(2): 254-261, http://www.corc.org.cn/handle/1471x/2375756.
[90] Lu, Baojing, Tao, Ling, Wang, Ting, Zheng, Zhenhua, Li, Bao, Chen, Ze, Huang, Yi, Hu, Qinxue, Wang, Hanzhong. Humoral and Cellular Immune Responses Induced by 3a DNA Vaccines against Severe Acute Respiratory Syndrome (SARS) or SARS-Like Coronavirus in Mice. CLINICAL AND VACCINE IMMUNOLOGY[J]. 2009, 第 8 作者  通讯作者  16(1): 73-77, http://www.corc.org.cn/handle/1471x/2375540.
[91] Buffa, Viviana, Stieh, Daniel, Mamhood, Naheed, Hu, Qinxue, Fletcher, Patricia, Shattock, Robin J. Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models. JOURNAL OF GENERAL VIROLOGY[J]. 2009, 第 4 作者90: 234-243, https://www.webofscience.com/wos/woscc/full-record/WOS:000262263000027.
[92] ChangLI, QinxueHU. Driving Forces of AIDS Pathogenesis: Massive CD4+T Lymphocyte Depletion and Abnormal Immune Activation. Virologica Sinica[J]. 2009, 第 2 作者24(6): 501-508, https://www.virosin.org/article/doi/10.1007/s12250-009-3063-y.
[93] Bai, Bingke, Lu, Xinya, Meng, Jin, Hu, Qinxue, Mao, Panyong, Lu, Baojing, Chen, Ze, Yuan, Zhiming, Wang, Hanzhong. Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses. MOLECULAR IMMUNOLOGY[J]. 2008, 第 4 作者45(4): 868-875, http://www.corc.org.cn/handle/1471x/2375511.
[94] Bai, Bingke, Hu, Qinxue, Hu, Hui, Zhou, Peng, Shi, Zhengli, Meng, Jin, Lu, Baojing, Huang, Yi, Mao, Panyong, Wang, Hanzhong. Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic Cells. PLOS ONE[J]. 2008, 第 2 作者3(7): http://www.corc.org.cn/handle/1471x/2375474.
[95] Jan Andersson, 李昌, 靳伟, 黄文杰, 胡勤学. 引发宫颈癌的人类乳头状病毒及人类免疫缺陷病毒的发现. 生物物理学报[J]. 2008, 第 5 作者24(6): 409-421, http://lib.cqvip.com/Qikan/Article/Detail?id=29233605.
[96] 胡勤学, 黄鑫, 杜涛. 1／4世纪的艾滋病毒研究——艾滋病毒的发现获得2008年诺贝尔生理学或医学奖. 生命科学[J]. 2008, 第 1 作者20(6): 838-842, http://lib.cqvip.com/Qikan/Article/Detail?id=29270343.
[97] QinxueHu, RobinShattock. Novel Antiviral Agents Targeting HIV Entry and Transmission. Virologica Sinica[J]. 2007, 第 1 作者22(6): 451-461, https://www.virosin.org/article/id/2775a04d-75c2-4061-a1c8-1274feba2ac8.
[98] Hu, Qinxue, Mahmood, Naheed, Shattock, Robin J. High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization. VIROLOGY[J]. 2007, 第 1 作者368(1): 145-154, http://www.corc.org.cn/handle/1471x/2375347.
[99] Tao, Jian, Hu, Qinxue, Yang, Jing, Li, Rurun, Li, Xiuyi, Lu, Chengping, Chen, Chaoyin, Wang, Ling, Shattock, Robin, Ben, Kunlong. In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate. ANTIVIRAL RESEARCH[J]. 2007, 第 2 作者75(3): 227-233, http://dx.doi.org/10.1016/j.antiviral.2007.03.008.
[100] Hu, Qinxue, Younson, Justine, Griffin, George E, Kelly, Charles, Shattock, Robin J. Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway. JOURNAL OF INFECTIOUS DISEASES[J]. 2006, 第 1 作者194(11): 1547-1556, https://www.webofscience.com/wos/woscc/full-record/WOS:000241820800011.
[101] Veazey, RS, Klasse, PJ, Schader, SM, Hu, QX, Ketas, TJ, Lu, M, Marx, PA, Dufour, J, Colonno, RJ, Shattock, RJ, Springer, MS, Moore, JP. Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. NATURE[J]. 2005, 438(7064): 99-102, https://www.webofscience.com/wos/woscc/full-record/WOS:000232979000049.
[102] Hu, QX, Napier, KB, Trent, JO, Wang, ZX, Taylor, S, Griffin, GE, Peiper, SC, Shattock, RJ. Restricted variable residues in the C-terminal segment of HIV-1V3 loop regulate the molecular anatomy of CCR5 utilization. JOURNAL OF MOLECULAR BIOLOGY[J]. 2005, 350(4): 699-712, http://www.corc.org.cn/handle/1471x/2375206.
[103] Hu, QX, Frank, I, Williams, V, Santos, JJ, Watts, P, Griffin, GE, Moore, JR, Pope, M, Shattock, RJ. Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2004, 199(8): 1065-1075, https://www.webofscience.com/wos/woscc/full-record/WOS:000221039100004.
[104] 马新锋, 胡勤学, 崔天盆, 杨继红, 张治平. 可溶性DC—SIGN的表达、纯化及其生物学活性分析. 中华微生物学和免疫学杂志[J]. 2004, 第 2 作者24(1): 67-71, http://lib.cqvip.com/Qikan/Article/Detail?id=9789387.
[105] Veazey, RS, Shattock, RJ, Pope, M, Kirijan, JC, Jones, J, Hu, QX, Ketas, T, Marx, PA, Klasse, PJ, Burton, DR, Moore, JP. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. NATURE MEDICINE[J]. 2003, 9(3): 343-346, https://www.webofscience.com/wos/woscc/full-record/WOS:000181312300036.
[106] 马新锋, 张治平, 杜涛, 杨继红, 胡勤学. 病毒性趋化因子vMIP2的表达、纯化及生物活性研究. 中国病毒学[J]. 2003, 第 5 作者18(5): 446-450, http://lib.cqvip.com/Qikan/Article/Detail?id=8621941.
[107] Murray, JL, Hu, QX, Navenot, JM, Peiper, SC. Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2002, 292(2): 449-455, https://www.webofscience.com/wos/woscc/full-record/WOS:000174793200024.
[108] 马新锋, 张先恩, 胡勤学. 以CCR5为作用靶点的抗艾滋病药物的研究进展. 细胞与分子免疫学杂志[J]. 2002, 第 3 作者18(6): 659-661, http://lib.cqvip.com/Qikan/Article/Detail?id=7062323.
[109] Navenot, JM, Wang, ZX, Trent, JO, Murray, JL, Hu, QX, DeLeeuw, L, Moore, PS, Chang, Y, Peiper, SC. Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: Differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II binding. JOURNAL OF MOLECULAR BIOLOGY[J]. 2001, 313(5): 1181-1193, https://www.webofscience.com/wos/woscc/full-record/WOS:000172195300022.
[110] Hu, QX, Trent, JO, Tomaras, GD, Wang, ZX, Murray, JL, Conolly, SM, Navenot, JM, Barry, AP, Greenberg, ML, Peiper, SC. Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. JOURNAL OF MOLECULAR BIOLOGY[J]. 2000, 302(2): 359-375, http://dx.doi.org/10.1006/jmbi.2000.4076.
[111] Hu, QX, Barry, AP, Wang, ZX, Connolly, SM, Peiper, SC, Greenberg, ML. Evolution of the human immunodeficiency virus type 1 envelope during infection reveals molecular corollaries of specificity for coreceptor utilization and AIDS pathogenesis. JOURNAL OF VIROLOGY[J]. 2000, 74(24): 11858-11872, https://www.webofscience.com/wos/woscc/full-record/WOS:000170365900049.

   

（ 1 ） V101疫苗在hACE2转基因小鼠模型中的保护效力评价, 负责人, 企业委托, 2021-09--2025-12
（ 2 ） 重组新型冠状病毒亚单位疫苗在hACE2转基因小鼠模型中的保护效力评价, 负责人, 企业委托, 2021-12--2026-12
（ 3 ） HuNoV GII.4临床分离株序列及其感染性克隆的构建与应用, 负责人, 企业委托, 2022-05--2027-12
（ 4 ） 表达HIV-1入侵抑制剂ECLD而抑制HIV-1感染的重组腺相关病毒, 负责人, 企业委托, 2022-05--2027-12
（ 5 ） CLD蛋白突变体及其应用, 负责人, 企业委托, 2022-05--2027-12
（ 6 ） HSV-2上调TLR9表达的机制及其对HIV-1黏膜共感染的影响研究, 负责人, 国家任务, 2022-01--2025-12
（ 7 ） 人干扰素α2b在hACE2转基因小鼠模型中防治SARS-CoV-2的效力研究, 负责人, 企业委托, 2022-12--2027-12

已指导学生

杜涛  博士研究生  071010-生物化学与分子生物学  

黄鑫  博士研究生  071010-生物化学与分子生物学  

李昌  博士研究生  071010-生物化学与分子生物学  

靳伟  博士研究生  071010-生物化学与分子生物学  

王平  博士研究生  071010-生物化学与分子生物学  

胡凯  博士研究生  071010-生物化学与分子生物学  

罗素坤  博士研究生  071010-生物化学与分子生物学  

何思宜  硕士研究生  071010-生物化学与分子生物学  

阎岩  博士研究生  071010-生物化学与分子生物学  

章牡丹  博士研究生  071010-生物化学与分子生物学  

胡伯丹  硕士研究生  071010-生物化学与分子生物学  

邓旭  硕士研究生  071010-生物化学与分子生物学  

李梅  博士研究生  071010-生物化学与分子生物学  

郑自凤  博士研究生  071010-生物化学与分子生物学  

谢丽  博士研究生  071010-生物化学与分子生物学  

关欣萌  博士研究生  071010-生物化学与分子生物学  

张地  硕士研究生  071010-生物化学与分子生物学  

付明  博士研究生  100102-免疫学  

李春天  博士研究生  100102-免疫学  

谭忠元  博士研究生  071005-微生物学  

肖莹莹  博士研究生  100102-免疫学  

胡慧敏  博士研究生  100102-免疫学  

杨萍  硕士研究生  085238-生物工程  

现指导学生

张彬嫚  博士研究生  100102-免疫学  

倪丰丰  博士研究生  100102-免疫学  

李苗苗  博士研究生  100102-免疫学  

何思雨  硕士研究生  071005-微生物学  

朱智远  硕士研究生  100103-病原生物学  

李运程  博士研究生  100102-免疫学  

程冉卿  硕士研究生  071005-微生物学  

李玮琳  硕士研究生  071010-生物化学与分子生物学