主要从事人工纳米材料、环境微纳米塑料和持久性有机污染物的毒理学和生物效应机制研究。近年来主持的项目包括国家973项目子课题“BDE和PFC的毒性效应与分子机制研究”，中国科学院前沿科学重点研究项目课题“PBDEs对斑马鱼的生殖发育毒性及其机制”，和国家自然科学基金“几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究” ，“单壁碳纳米管的生物可利用性、生物可降解性及毒性效应”，“单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究”，同时还参与多项国家863计划和自然基金委重大研究计划项目。

欢迎具有生物学、毒理/医学、材料学或分析化学相关专业的同学报考。

083001-环境科学

环境毒理学，基因组毒理学
纳米毒理
细胞毒理学

2000-08--美国田纳西大学   博士

-- 研究生

-- 博士

2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员

2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员

2014-03-14-2019-03-13,食品药品监管总局食品安全风险交流专家组成员, 风险交流专家

纳米毒理学

1.     Oluniyi O. Fadare, Bin Wan*, Keyang Liu, Yu Yang, Lixia Zhao, Liang-Hong Guo*. Eco-corona vs protein corona: effects of humic substances on corona formation and nanoplastic particle toxicity in Daphnia magna. Environmental Science & Technology, 2020, Accepted. (IF=7.149)

2.     Oluniyi O. Fadare, Bin Wan*, Lixia Zhao, Liang-Hong Guo*. Microplastics from consumer plastic food containers: Are we consuming it? Chemosphere, 2020, 253,126787. (IF=5.108)

3.     KeYang Liu, Bin Wan*. An SDS-PAGE based method for the quantification of carbon black in biological samples. Analyst, 2020, 145, 3370–3375. (IF=4.019)

4.     Oluniyi O. Fadare, Bin Wan*, Liang-Hong Guo*, Yan Xin, Weiping Qin, Yu Yang.  Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. Environmental Science-Nano, 2019, 6, 1466-1477. (IF=7.704)

5.     Yan Xin, Bin Wan*. A label-free quantification method for measuring graphene oxide in biological samples. Analytica Chimica Acta, 2019, 1079, 103-110. (IF=5.256)

6.     Yichun Xie, Bin Wan*, Yu Yang, Xuejing Cui, Yan Xin, Liang-Hong Guo. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. Journal of Environmental Science, 2019, 77, 198-209. (IF=3.556)

7.     Xuejing Cui, Bin Wan*, Yu Yang, Yan Xin, Yi-Chun Xie, Liang-Hong Guo*, and Lin L. Mantell. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. Toxicological Sciences, 2019, 172(2), 398-410. (IF=3.564)

8.     Yan Xin, Bin Wan*, Yu Yang, Xue-Jing Cui, Yi-Chun Xie, Liang-Hong Guo*. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. Archives of Toxicology, 2018, 92, 3131–3147. (IF=5.741)

9.     Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. Scientific Reports, 2017, 7, 1518. (IF=4.011)

10.  Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Hui Zhang. Crucial Role of P2X7 Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. Small, 2016, 12, 5998-6011.(Cover Image) (IF=10.856)

11.  Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor. Environmental Science & Technology, 2016, 50, 12473-12483. (IF=7.149)

12.  Jie Hou, Bin Wan*, Yu Yang, Xiao-Min Ren, Liang-Hong Guo*，and Jing-Fu Liu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. International Journal of Molecular Sciences, 2016, 17, 409-426. (IF=4.183)

13.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Lixia Zhao, Yu Yang. In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction. Chemosphere, 2015,120, 621-630. (IF=5.108)

14.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Yu Yang, Xiao-Min Ren, Hui Zhang. In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. Chemico-Biological Interactions, 2015, 240, 84-93. (IF=3.407)

15.  Ping-Xuan Dong, Bin Wan*, Zi-Xia Wang, Liang-Hong Guo*, Yu Yang & Lixia Zhao. Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. Nanotoxicology, 2013, 7(5): 1028-1042. (IF=5.955)

16.  Bin Wan* , Zi-Xia Wang, Qi-Yan Lv, Ping-Xuan Dong, Li-Xia Zhao, Yu Yang, Liang-Hong Guo*. Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. Toxicology Letters, 2013, 221, 118-127. (IF=3.499)

17.  Ping-Xuan Dong, Bin Wan* and Liang-Hong Guo. In vitro toxicity of acid-functionalized Single-Walled Carbon Nanotubes: Effects on Murine Macrophages and Gene Expression Profiling. Nanotoxicology, 2012, 6(3), 288-303. (IF=5.955)

18.  万斌*，郭良宏. 多溴联苯醚的环境毒理学研究进展.环境化学, 2011, 30,  143-152.

[1] Yifan Pan, Jing Chang, Bin Wan, Zijun Liu, Lu Yang, Yun Xie, Weiyu Hao, Jianzhong Li, Peng Xu. Integrative analysis of transcriptomics and metabolomics reveals the hepatotoxic mechanism of thiamethoxam on male Coturnix japonica. Environmental Pollution. 2022, 293: [2] Yifan Pan, Jing Chang, Peng Xu, Yun Xie, Lu Yang, Weiyu Hao, Jianzhong Li, Bin Wan. Twenty-four hours of Thiamethoxam: In vivo and molecular dynamics simulation study on the toxicokinetic and underlying mechanisms in quails (Coturnix japonica). Journal of Hazardous Materials[J]. 2022, 427: [3] 刘文涛, 万斌. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics. Journal of Environmental Sciences[J]. 2022, [4] Chang, Jing, Pan, Yifan, Liu, Wentao, Xu, Peng, Li, Wei, Wan, Bin. Lambda-cyhalothrin and its common metabolite differentially modulate thyroid disruption effects in Chinese lizards (Eremias argus). ENVIRONMENTAL POLLUTION[J]. 2021, 287: http://dx.doi.org/10.1016/j.envpol.2021.117322.
[5] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Zhao, Lixia. Microplastics from consumer plastic food containers: Are we consuming it?. CHEMOSPHERE[J]. 2020, 253: http://dx.doi.org/10.1016/j.chemosphere.2020.126787.
[6] Liu, Keyang, Wan, Bin. An SDS-PAGE based method for the quantification of carbon black in biological samples. ANALYST[J]. 2020, 145(9): 3370-3375, https://www.webofscience.com/wos/woscc/full-record/WOS:000532257200020.
[7] Fadare, Oluniyi O, Wan, Bin, Liu, Keyang, Yang, Yu, Zhao, Lixia, Guo, LiangHong. Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 54(13): 8001-8009, https://www.webofscience.com/wos/woscc/full-record/WOS:000548584900031.
[8] Xin, Yan, Wan, Bin. A label-free quantification method for measuring graphene oxide in biological samples. ANALYTICA CHIMICA ACTA[J]. 2019, 1079: 103-110, http://dx.doi.org/10.1016/j.aca.2019.06.036.
[9] Cui, Xuejing, Wan, Bin, Yang, Yu, Xin, Yan, Xie, YiChun, Guo, LiangHong, Mantell, Lin L. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. TOXICOLOGICAL SCIENCES[J]. 2019, 172(2): 398-410, [10] Xin, Yan, Ren, XiaoMin, Wan, Bin, Guo, LiangHong. Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2019, 53(14): 8371-8380, https://www.webofscience.com/wos/woscc/full-record/WOS:000476685500047.
[11] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Xin, Yan, Qin, Weiping, Yang, Yu. Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. ENVIRONMENTAL SCIENCE-NANO[J]. 2019, 6(5): 1466-1477, https://www.webofscience.com/wos/woscc/full-record/WOS:000473076700013.
[12] Xie, Yichun, Wan, Bin, Yang, Yu, Cui, Xuejing, Xin, Yan, Guo, LiangHong. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2019, 77: 198-209, http://lib.cqvip.com/Qikan/Article/Detail?id=72747566504849574851484957.
[13] Xin, Yan, Wan, Bin, Yang, Yu, Cui, XueJing, Xie, YiChun, Guo, LiangHong. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. ARCHIVES OF TOXICOLOGY[J]. 2018, 92(10): 3131-3147, http://ir.rcees.ac.cn/handle/311016/41009.
[14] Gu, Yuxin, Yang, Yu, Wan, Bin, Li, Minjie, Guo, LiangHong. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. BIOCHEMICAL PHARMACOLOGY[J]. 2018, 152: 21-33, http://dx.doi.org/10.1016/j.bcp.2018.03.017.
[15] Yang Yu, Gu Yuxin, Wan Bin, Ren Xiaomin, Guo LiangHong. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. Biosensors and Bioelectronics[J]. 2017, 95: 94-99, http://dx.doi.org/10.1016/j.bios.2017.04.009.
[16] Xuejing Cui, Bin Wan, Yu Yang, Xiaomin Ren, LiangHong Guo. Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://ir.rcees.ac.cn/handle/311016/39350.
[17] Cui, Xuejing, Wan, Bin, Yang, Yu, Ren, Xiaomin, Guo, LiangHong, Zhang, Hui. Crucial Role of P2X(7) Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. SMALL[J]. 2016, 12(43): 5998-6011, http://ir.rcees.ac.cn/handle/311016/35825.
[18] Cui, Xuejing, Wan, Bin, Guo, LiangHong, Yang, Yu, Ren, Xiaomin. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X(7) Receptor. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2016, 50(22): 12473-12483, http://ir.rcees.ac.cn/handle/311016/35877.

   

（ 1 ） 单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究, 主持, 国家级, 2009-01--2011-12
（ 2 ） 持久性有机污染物的环境行为、毒性效应与控制技术原理”——PBDE和PFC的毒性效应与分子机制研究, 参与, 国家级, 2009-01--2013-12
（ 3 ） 松花江水污染生态风险评估关键技术研究, 参与, 国家级, 2009-01--2011-12
（ 4 ） 单壁碳纳米管的生物可利用性、生物可降解性及毒性效应研究, 主持, 国家级, 2013-02--2016-12
（ 5 ） 几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究, 主持, 国家级, 2015-01--2018-12
（ 6 ） PBDEs对斑马鱼的生殖发育毒性及其机制, 主持, 部委级, 2016-08--2020-12

（1）P2X7 receptor regulates the exocytosis of single-walled carbon nanotubes in murine macrophages   中墨纳米材料双边会议   万斌   2017-08-19
（2）巨噬细胞呼吸爆发调控单壁碳纳米管的生物降解   全国环境纳米技术及生物效应学术研讨会   万斌、侯杰、郭良宏   2016-04-08

已指导学生

汪子霞  硕士研究生  430130-环境工程  

侯杰  硕士研究生  085238-生物工程  

现指导学生

谢懿春  硕士研究生  077601-环境科学