主要从事人工纳米材料、环境微纳米塑料和持久性有机污染物的毒理学和生物效应机制研究。近年来主持的项目包括国家973项目子课题“BDE和PFC的毒性效应与分子机制研究”，中国科学院前沿科学重点研究项目课题“PBDEs对斑马鱼的生殖发育毒性及其机制”，和国家自然科学基金“几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究” ，“单壁碳纳米管的生物可利用性、生物可降解性及毒性效应”，“单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究”，同时还参与多项国家863计划和自然基金委重大研究计划项目。

欢迎具有生物学、毒理/医学、材料学或分析化学相关专业的同学报考。

083001-环境科学

环境毒理学，基因组毒理学
纳米毒理
细胞毒理学

2000-08--美国田纳西大学   博士

-- 研究生

-- 博士

2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员

2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员

2014-03-14-2019-03-13,食品药品监管总局食品安全风险交流专家组成员, 风险交流专家

纳米毒理学

1.     Oluniyi O. Fadare, Bin Wan*, Keyang Liu, Yu Yang, Lixia Zhao, Liang-Hong Guo*. Eco-corona vs protein corona: effects of humic substances on corona formation and nanoplastic particle toxicity in Daphnia magna. Environmental Science & Technology, 2020, Accepted. (IF=7.149)

2.     Oluniyi O. Fadare, Bin Wan*, Lixia Zhao, Liang-Hong Guo*. Microplastics from consumer plastic food containers: Are we consuming it? Chemosphere, 2020, 253,126787. (IF=5.108)

3.     KeYang Liu, Bin Wan*. An SDS-PAGE based method for the quantification of carbon black in biological samples. Analyst, 2020, 145, 3370–3375. (IF=4.019)

4.     Oluniyi O. Fadare, Bin Wan*, Liang-Hong Guo*, Yan Xin, Weiping Qin, Yu Yang.  Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. Environmental Science-Nano, 2019, 6, 1466-1477. (IF=7.704)

5.     Yan Xin, Bin Wan*. A label-free quantification method for measuring graphene oxide in biological samples. Analytica Chimica Acta, 2019, 1079, 103-110. (IF=5.256)

6.     Yichun Xie, Bin Wan*, Yu Yang, Xuejing Cui, Yan Xin, Liang-Hong Guo. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. Journal of Environmental Science, 2019, 77, 198-209. (IF=3.556)

7.     Xuejing Cui, Bin Wan*, Yu Yang, Yan Xin, Yi-Chun Xie, Liang-Hong Guo*, and Lin L. Mantell. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. Toxicological Sciences, 2019, 172(2), 398-410. (IF=3.564)

8.     Yan Xin, Bin Wan*, Yu Yang, Xue-Jing Cui, Yi-Chun Xie, Liang-Hong Guo*. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. Archives of Toxicology, 2018, 92, 3131–3147. (IF=5.741)

9.     Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. Scientific Reports, 2017, 7, 1518. (IF=4.011)

10.  Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Hui Zhang. Crucial Role of P2X7 Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. Small, 2016, 12, 5998-6011.(Cover Image) (IF=10.856)

11.  Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor. Environmental Science & Technology, 2016, 50, 12473-12483. (IF=7.149)

12.  Jie Hou, Bin Wan*, Yu Yang, Xiao-Min Ren, Liang-Hong Guo*，and Jing-Fu Liu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. International Journal of Molecular Sciences, 2016, 17, 409-426. (IF=4.183)

13.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Lixia Zhao, Yu Yang. In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction. Chemosphere, 2015,120, 621-630. (IF=5.108)

14.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Yu Yang, Xiao-Min Ren, Hui Zhang. In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. Chemico-Biological Interactions, 2015, 240, 84-93. (IF=3.407)

15.  Ping-Xuan Dong, Bin Wan*, Zi-Xia Wang, Liang-Hong Guo*, Yu Yang & Lixia Zhao. Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. Nanotoxicology, 2013, 7(5): 1028-1042. (IF=5.955)

16.  Bin Wan* , Zi-Xia Wang, Qi-Yan Lv, Ping-Xuan Dong, Li-Xia Zhao, Yu Yang, Liang-Hong Guo*. Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. Toxicology Letters, 2013, 221, 118-127. (IF=3.499)

17.  Ping-Xuan Dong, Bin Wan* and Liang-Hong Guo. In vitro toxicity of acid-functionalized Single-Walled Carbon Nanotubes: Effects on Murine Macrophages and Gene Expression Profiling. Nanotoxicology, 2012, 6(3), 288-303. (IF=5.955)

18.  万斌*，郭良宏. 多溴联苯醚的环境毒理学研究进展.环境化学, 2011, 30,  143-152.

[1] 常静, zhang, L., Zhao, J., Zhang, Z., Wang, Z., Wang, H., 万斌. 6PPD not 6PPD-Quinone induced serious zebrafish eye damage by disrupting the thyroid signaling pathway. Environmental Science & Technology[J]. 2024, 第 7 作者  通讯作者  null(null): 
[2] ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2024, 第 4 作者
[3] Qiong An, Weiyu Hao, Zheng Ma, Leisen Zhang, Zheyuan Song, Bin Wan, \nPeng Xu, Huili Wanga, Jing Changa, Jianzhong Li. Absorption, distribution, metabolism, and elimination of epoxiconazole enantiomers in lizards (Eremias argus). Chemosphere[J]. 2024, 第 6 作者360(/): 142444-142444, https://www.sciencedirect.com/science/article/pii/S0045653524013377.
[4] Chang, Jing, Huang, Rui, Zhang, Zhaoguang, Pan, Yunrui, Ma, Zheng, Wan, Bin, Wang, Huili. A ubiquitous tire rubber additive induced serious eye injury in zebrafish ( Danio rerio ). JOURNAL OF HAZARDOUS MATERIALS[J]. 2024, 第 6 作者472: http://dx.doi.org/10.1016/j.jhazmat.2024.134461.
[5] ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2024, 第 7 作者  通讯作者  
[6] Chang, Jing, Jiao, Meng, Zhang, Zhaoguang, Liu, Wentao, Li, Wei, Xu, Peng, Wan, Bin. Mechanistic insight into the adverse outcome of tire wear and road particle leachate exposure in zebrafish (Danio rerio) larvae. ENVIRONMENT INTERNATIONAL[J]. 2023, 第 7 作者  通讯作者  178(null): 
[7] 赵娟, 常静, 郝伟玉, 马政, 宋哲媛, 万斌, 王会利. 1，3-二苯胍对斑马鱼早期生命阶段的影响. 生态毒理学报[J]. 2023, 第 6 作者18(4): 265-278, 
[8] Liu, Wentao, Pan, Yifan, Yang, Lu, Xie, Yun, Chen, Xuanyue, Chang, Jing, Hao, Weiyu, Zhu, Lifei, Wan, Bin. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2023, 第 9 作者  通讯作者  127(null): 197-209, 
[9] Chang, Jing, An, Qiong, Xie, Yun, Liu, Wentao, Xu, Peng, Hao, Weiyu, Wan, Bin. Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus). ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2023, 第 7 作者57(31): 11612-11625, 
[10] Pan, Yifan, Chang, Jing, Wan, Bin, Liu, Zijun, Yang, Lu, Xie, Yun, Hao, Weiyu, Li, Jianzhong, Xu, Peng. Integrative analysis of transcriptomics and metabolomics reveals the hepatotoxic mechanism of thiamethoxam on male Coturnix japonica. ENVIRONMENTAL POLLUTION[J]. 2022, 第 3 作者293: http://dx.doi.org/10.1016/j.envpol.2021.118460.
[11] Yifan Pan, Jing Chang, Peng Xu, Yun Xie, Lu Yang, Weiyu Hao, Jianzhong Li, Bin Wan. Twenty-four hours of Thiamethoxam: In vivo and molecular dynamics simulation study on the toxicokinetic and underlying mechanisms in quails (Coturnix japonica). JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 第 8 作者  通讯作者  427: 
[12] 刘文涛, 万斌. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics. Journal of Environmental Sciences[J]. 2022, 第 2 作者  通讯作者  
[13] Chang, Jing, Pan, Yifan, Liu, Wentao, Xu, Peng, Li, Wei, Wan, Bin. Lambda-cyhalothrin and its common metabolite differentially modulate thyroid disruption effects in Chinese lizards (Eremias argus). ENVIRONMENTAL POLLUTION[J]. 2021, 第 6 作者  通讯作者  287: http://dx.doi.org/10.1016/j.envpol.2021.117322.
[14] Yifan Pan, Jing Chang, Bin Wan, Zijun Liu, Lu Yang, Yun Xie, Weiyu Hao, Jianzhong Li, Peng Xu. Integrative analysis of transcriptomics and metabolomics reveals the hepatotoxic mechanism of thiamethoxam on male Coturnix japonica. Environ Pollut[J]. 2021, 第 3 作者293(/): 118460-118460, https://www.sciencedirect.com/science/article/pii/S026974912102042X.
[15] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Zhao, Lixia. Microplastics from consumer plastic food containers: Are we consuming it?. CHEMOSPHERE[J]. 2020, 第 2 作者  通讯作者  253: http://dx.doi.org/10.1016/j.chemosphere.2020.126787.
[16] 马增杰, 赵焕新, 张辉, 万斌. 纳米CuO在水体环境中的转化行为及其对大型溞的毒性效应. 环境科学学报[J]. 2020, 第 4 作者40(5): 1858-1864, https://doi.org/10.13671/j.hjkxxb.2019.0492.
[17] Liu, Keyang, Wan, Bin. An SDS-PAGE based method for the quantification of carbon black in biological samples. ANALYST[J]. 2020, 第 2 作者  通讯作者  145(9): 3370-3375, http://dx.doi.org/10.1039/d0an00046a.
[18] Fadare, Oluniyi O, Wan, Bin, Liu, Keyang, Yang, Yu, Zhao, Lixia, Guo, LiangHong. Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 第 2 作者  通讯作者  54(13): 8001-8009, http://dx.doi.org/10.1021/acs.est.0c00615.
[19] Fadare, Oluniyi O, Wan, Bin, Liu, Keyang, Yang, Yu, Zhao, Lixia, Guo, LiangHong. Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 第 2 作者  通讯作者  54(13): 8001-8009, https://www.webofscience.com/wos/woscc/full-record/WOS:000548584900031.
[20] Xin, Yan, Wan, Bin. A label-free quantification method for measuring graphene oxide in biological samples. ANALYTICA CHIMICA ACTA[J]. 2019, 第 2 作者  通讯作者  1079: 103-110, http://dx.doi.org/10.1016/j.aca.2019.06.036.
[21] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Xin, Yan, Qin, Weiping, Yang, Yu. Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. ENVIRONMENTAL SCIENCE-NANO[J]. 2019, 第 2 作者  通讯作者  6(5): 1466-1477, http://dx.doi.org/10.1039/c8en01457d.
[22] Cui, Xuejing, Wan, Bin, Yang, Yu, Xin, Yan, Xie, YiChun, Guo, LiangHong, Mantell, Lin L. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. TOXICOLOGICAL SCIENCES[J]. 2019, 第 2 作者  通讯作者  172(2): 398-410, 
[23] Xin, Yan, Ren, XiaoMin, Wan, Bin, Guo, LiangHong. Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2019, 第 3 作者53(14): 8371-8380, https://www.webofscience.com/wos/woscc/full-record/WOS:000476685500047.
[24] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Xin, Yan, Qin, Weiping, Yang, Yu. Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. ENVIRONMENTAL SCIENCE-NANO[J]. 2019, 第 2 作者  通讯作者  6(5): 1466-1477, https://www.webofscience.com/wos/woscc/full-record/WOS:000473076700013.
[25] Gu, YuXin, Liang, XiaoXing, Yin, NuoYa, Yang, Yu, Wan, Bin, Guo, LiangHong, Faiola, Francesco. New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells. ARCHIVES OF TOXICOLOGY[J]. 2019, 第 5 作者93(9): 2661-2671, https://www.webofscience.com/wos/woscc/full-record/WOS:000487647300016.
[26] Yichun Xie, Bin Wan, Yu Yang, Xuejing Cui, Yan Xin, LiangHong Guo. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. 环境科学学报:英文版[J]. 2019, 第 2 作者  通讯作者  77: 198-209, http://lib.cqvip.com/Qikan/Article/Detail?id=72747566504849574851484957.
[27] Yang, Yu, Wang, Li, Wan, Bin, Gu, Yuxin, Li, Xinxin. Optically Active Nanomaterials for Bioimaging and Targeted Therapy. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2019, 第 3 作者7(320): 1-24, https://doaj.org/article/000d1c3309b94ce3959a428a1a789f49.
[28] Xie, Yichun, Wan, Bin, Yang, Yu, Cui, Xuejing, Xin, Yan, Guo, LiangHong. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. JOURNALOFENVIRONMENTALSCIENCES[J]. 2019, 第 2 作者  通讯作者  77: 198-209, http://lib.cqvip.com/Qikan/Article/Detail?id=72747566504849574851484957.
[29] Xin, Yan, Wan, Bin, Yang, Yu, Cui, XueJing, Xie, YiChun, Guo, LiangHong. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. ARCHIVES OF TOXICOLOGY[J]. 2018, 第 2 作者  通讯作者  92(10): 3131-3147, http://ir.rcees.ac.cn/handle/311016/41009.
[30] Gu, Yuxin, Yang, Yu, Wan, Bin, Li, Minjie, Guo, LiangHong. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. BIOCHEMICAL PHARMACOLOGY[J]. 2018, 第 3 作者152: 21-33, http://dx.doi.org/10.1016/j.bcp.2018.03.017.
[31] Cao, LinYing, Ren, XiaoMin, Li, ChuanHai, Zhang, Jing, Qin, WeiPing, Yang, Yu, Wan, Bin, Guo, LiangHong. Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2017, 第 7 作者51(19): 11423-11430, http://ir.rcees.ac.cn/handle/311016/39259.
[32] Yang Yu, Gu Yuxin, Wan Bin, Ren Xiaomin, Guo LiangHong. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. BIOSENSORS AND BIOELECTRONICS[J]. 2017, 第 3 作者95: 94-99, http://dx.doi.org/10.1016/j.bios.2017.04.009.
[33] Wan, Bin. P2X7 receptor regulates the exocytosis of single-walled carbon nanotubes in murine macrophages. TOXICOLOGY LETTERS. 2017, 第 1 作者280: S183-S183, http://dx.doi.org/10.1016/j.toxlet.2017.07.515.
[34] Xuejing Cui, Bin Wan, Yu Yang, Xiaomin Ren, LiangHong Guo. Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. SCIENTIFIC REPORTS[J]. 2017, 第 2 作者  通讯作者  7(1518): 1-13, http://ir.rcees.ac.cn/handle/311016/39350.
[35] Yang, Yu, Lv, QiYan, Guo, LiangHong, Wan, Bin, Ren, XiaoMin, Shi, YaLi, Cai, YaQi. Identification of protein tyrosine phosphatase SHP-2 as a new target of perfluoroalkyl acids in HepG2 cells. ARCHIVES OF TOXICOLOGY[J]. 2017, 第 4 作者91(4): 1697-1707, http://ir.rcees.ac.cn/handle/311016/39335.
[36] Ren, XiaoMin, Cao, LinYing, Zhang, Jing, Qin, WeiPing, Yang, Yu, Wan, Bin, Guo, LiangHong. Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry. BIOCHEMISTRY[J]. 2016, 第 6 作者55(13): 1989-1996, http://ir.rcees.ac.cn/handle/311016/35882.
[37] Wang, Sufang, Lv, Qiyan, Yang, Yu, Guo, LiangHong, Wan, Bin, Ren, Xiaomin, Zhang, Hui. Arginine decarboxylase: A novel biological target of mercury compounds identified in PC12 cells. BIOCHEMICAL PHARMACOLOGY[J]. 2016, 第 5 作者118: 109-120, http://dx.doi.org/10.1016/j.bcp.2016.08.019.
[38] 郭良宏, 万斌, 崔雪晶. 单壁碳纳米管的外排机制研究. 中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学. 2016, 第 2 作者1, http://ir.rcees.ac.cn/handle/311016/39939.
[39] Cui, Xuejing, Wan, Bin, Yang, Yu, Ren, Xiaomin, Guo, LiangHong, Zhang, Hui. Crucial Role of P2X(7) Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. SMALL[J]. 2016, 第 2 作者  通讯作者  12(43): 5998-6011, http://ir.rcees.ac.cn/handle/311016/35825.
[40] Ren, Xiaomin, Cao, Linying, Yang, Yu, Wan, Bin, Wang, Sufang, Guo, Lianghong. In vitro assessment of thyroid hormone receptor activity of four organophosphate esters. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2016, 第 4 作者45: 185-190, http://dx.doi.org/10.1016/j.jes.2015.12.021.
[41] Hou, Jie, Wan, Bin, Yang, Yu, Ren, XiaoMin, Guo, LiangHong, Liu, JingFu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 第 2 作者  通讯作者  17(3): http://ir.rcees.ac.cn/handle/311016/35808.
[42] 郭良宏, 万斌, 侯杰. 巨噬细胞呼吸爆发对单壁碳纳米管生物降解调控研究. 中国化学会第30届学术年会摘要集-第二十六分会：环境化学. 2016, 第 2 作者1, http://ir.rcees.ac.cn/handle/311016/39957.
[43] Cui, Xuejing, Wan, Bin, Guo, LiangHong, Yang, Yu, Ren, Xiaomin. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X(7) Receptor. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2016, 第 2 作者  通讯作者  50(22): 12473-12483, http://ir.rcees.ac.cn/handle/311016/35877.
[44] Zhang, Hui, Zhao, Lixia, Geng, Fanglan, Guo, LiangHong, Wan, Bin, Yang, Yu. Carbon dots decorated graphitic carbon nitride as an efficient metal-free photocatalyst for phenol degradation. APPLIED CATALYSIS B-ENVIRONMENTAL[J]. 2016, 第 5 作者180: 656-662, http://dx.doi.org/10.1016/j.apcatb.2015.06.056.
[45] 王大彬, 赵利霞, 郭良宏, 张辉, 万斌, 杨郁. 连续流动化学发光法在线定量检测二氧化钛光催化产生的O_2~（·-）和H_2O_2及其生成动力学研究. 化学学报[J]. 2015, 第 5 作者73(5): 388-394, http://ir.rcees.ac.cn/handle/311016/33150.
[46] Wang Dabin, Zhao Lixia, Guo Lianghong, Zhang Hui, Wan Bin, Yang Yu. Online Quantification of O-2(center dot-) and H2O2 and Their Formation Kinetics in Ultraviolet (UV)-Irradiated Nano-TiO2 Suspensions by Continuous Flow Chemiluminescence. ACTA CHIMICA SINICA[J]. 2015, 第 5 作者73(5): 388-394, http://ir.rcees.ac.cn/handle/311016/32636.
[47] Zhang, Hui, Guo, LiangHong, Wang, Dabin, Zhao, Lixia, Wan, Bin. Light-Induced Efficient Molecular Oxygen Activation on a Cu(II)-Grafted TiO2/Graphene Photocatalyst for Phenol Degradation. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 第 5 作者7(3): 1816-1823, http://ir.rcees.ac.cn/handle/311016/32613.
[48] 吕琪妍, 万斌, 郭良宏. 多溴联苯醚对小鼠原代巨噬细胞的毒性效应和机制研究. 中国化学会第29届学术年会——第20分会：环境与健康. 2014, 第 2 作者http://ir.rcees.ac.cn/handle/311016/24919.
[49] Zhang, Lianying, Ren, XiaoMin, Wan, Bin, Guo, LiangHong. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor gamma. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2014, 第 3 作者279(3): 275-283, http://dx.doi.org/10.1016/j.taap.2014.06.020.
[50] 崔雪晶, 万斌, 郭良宏. 单壁碳纳米管的生物可利用性及可降解性研究. 中国化学会第29届学术年会——第20分会：环境与健康. 2014, 第 2 作者http://ir.rcees.ac.cn/handle/311016/24881.
[51] Wang, Sufang, Wan, Bin, Zhang, Lianying, Yang, Yu, Guo, LiangHong. In vitro inhibition of lysine decarboxylase activity by organophosphate esters. BIOCHEMICAL PHARMACOLOGY[J]. 2014, 第 2 作者92(3): 506-516, http://dx.doi.org/10.1016/j.bcp.2014.09.011.
[52] 杨郁, 吕琪妍, 万斌, 郭良宏. 利用生物传感器揭示全氟有机物对蛋白质磷酸化的干扰效应. 中国化学会第29届学术年会——第04分会：纳米生物传感新方法. 2014, 第 3 作者http://ir.rcees.ac.cn/handle/311016/24951.
[53] Wang, Sufang, Lv, Qiyan, Yang, Yu, Guo, LiangHong, Wan, Bin, Zhao, Lixia. Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2014, 第 5 作者496(1): 381-388, http://dx.doi.org/10.1016/j.scitotenv.2014.07.034.
[54] 吕琪妍, 万斌, 郭良宏等. 全氟辛烷磺酸基化合物的免疫毒性效应和机制研究. 第七届全国环境化学学术大会. 2013, 第 2 作者http://ir.rcees.ac.cn/handle/311016/29590.
[55] Zhao, Lixia, Di, Fan, Wang, Dabin, Guo, LiangHong, Yang, Yu, Wan, Bin, Zhang, Hui. Chemiluminescence of carbon dots under strong alkaline solutions: a novel insight into carbon dot optical properties. NANOSCALE[J]. 2013, 第 6 作者5(7): 2655-2658, http://www.irgrid.ac.cn/handle/1471x/844465.
[56] Dong, PingXuan, Wan, Bin, Wang, ZiXia, Guo, LiangHong, Yang, Yu, Zhao, Lixia. Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. NANOTOXICOLOGY[J]. 2013, 第 2 作者  通讯作者  7(5): 1028-1042, http://www.irgrid.ac.cn/handle/1471x/844397.
[57] Ren, XiaoMin, Guo, LiangHong, Gao, Yu, Zhang, BinTian, Wan, Bin. Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2013, 第 5 作者268(3): 256-263, http://dx.doi.org/10.1016/j.taap.2013.01.026.
[58] Wan, Bin, Wang, ZiXia, Lv, QiYan, Dong, PingXuan, Zhao, LiXia, Yang, Yu, Guo, LiangHong. Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. TOXICOLOGY LETTERS[J]. 2013, 第 1 作者  通讯作者  221(2): 118-127, http://dx.doi.org/10.1016/j.toxlet.2013.06.208.
[59] 张建海, 梁琛, 万斌, 吕琪妍, 郭良宏. 羧基化多壁碳纳米管的雄性大鼠生殖毒理效应研究. 中国化学会第28届学术年会. 2012, 第 3 作者http://ir.rcees.ac.cn/handle/311016/32056.
[60] Yang, Yu, Guo, LiangHong, Qu, Na, Wei, MingYuan, Zhao, LiXia, Wan, Bin. Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. BIOSENSORS & BIOELECTRONICS[J]. 2011, 第 6 作者28(1): 284-290, http://dx.doi.org/10.1016/j.bios.2011.07.033.
[61] 吕琪妍, 万斌, 郭良宏等. 多溴联苯醚的免疫毒性效应和机制研究. 第六届全国环境化学学术大会论文集. 2011, 第 2 作者991, http://ir.rcees.ac.cn/handle/311016/5549.
[62] 董平轩, 万斌, 郭良宏等. 单壁碳纳米管对小鼠原代巨噬细胞功能的影响研究. 第六届全国环境化学学术大会论文集. 2011, 第 2 作者815, http://ir.rcees.ac.cn/handle/311016/5559.
[63] 万斌, 郭良宏. 多溴联苯醚的环境毒理学研究进展. 环境化学[J]. 2011, 第 1 作者30(1): 143-152, http://hjhx.rcees.ac.cn/article/id/hjhx_329.
[64] Cao, Jie, Guo, LiangHong, Wan, Bin, Wei, Yin. In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2011, 第 3 作者23(2): 315-321, http://lib.cqvip.com/Qikan/Article/Detail?id=36784960.
[65] Qu, Na, Wan, Bin, Guo, LiangHong. Label-free electrochemical differentiation of phosphorylated and non-phosphorylated peptide by electro-catalyzed tyrosine oxidation. ANALYST[J]. 2008, 第 2 作者133(9): 1246-1249, http://www.irgrid.ac.cn/handle/1471x/972021.
[66] 万斌, 郭良宏. 单壁碳纳米管对小鼠巨噬细胞RAW264.7的毒性影响及其分子机制. 第五届全国环境化学大会会议论文集. 2008, 第 1 作者553, http://ir.rcees.ac.cn/handle/311016/5897.

   

（ 1 ） 单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究, 主持, 国家级, 2009-01--2011-12
（ 2 ） 持久性有机污染物的环境行为、毒性效应与控制技术原理”——PBDE和PFC的毒性效应与分子机制研究, 参与, 国家级, 2009-01--2013-12
（ 3 ） 松花江水污染生态风险评估关键技术研究, 参与, 国家级, 2009-01--2011-12
（ 4 ） 单壁碳纳米管的生物可利用性、生物可降解性及毒性效应研究, 主持, 国家级, 2013-02--2016-12
（ 5 ） 几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究, 主持, 国家级, 2015-01--2018-12
（ 6 ） PBDEs对斑马鱼的生殖发育毒性及其机制, 主持, 部委级, 2016-08--2020-12

（1）P2X7 receptor regulates the exocytosis of single-walled carbon nanotubes in murine macrophages   中墨纳米材料双边会议   万斌   2017-08-19
（2）巨噬细胞呼吸爆发调控单壁碳纳米管的生物降解   全国环境纳米技术及生物效应学术研讨会   万斌、侯杰、郭良宏   2016-04-08

已指导学生

汪子霞  硕士研究生  430130-环境工程  

侯杰  硕士研究生  085238-生物工程  

现指导学生

谢懿春  硕士研究生  077601-环境科学