基本信息
万斌  男  硕导  中国科学院生态环境研究中心
电子邮件: binwan@rcees.ac.cn
通信地址: 北京海淀区双清路18号环境化学楼B210
邮政编码: 100085

研究领域

主要从事人工纳米材料、环境微纳米塑料和持久性有机污染物的毒理学和生物效应机制研究。近年来主持的项目包括国家973项目子课题“BDEPFC的毒性效应与分子机制研究”,中国科学院前沿科学重点研究项目课题“PBDEs对斑马鱼的生殖发育毒性及其机制”,和国家自然科学基金“几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究” ,“单壁碳纳米管的生物可利用性、生物可降解性及毒性效应”,“单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究”,同时还参与多项国家863计划和自然基金委重大研究计划项目。


招生信息

欢迎具有生物学、毒理/医学、材料学或分析化学相关专业的同学报考。

招生专业
083001-环境科学
招生方向
环境毒理学,基因组毒理学
纳米毒理
细胞毒理学

教育背景

2000-08--美国田纳西大学   博士
学历
-- 研究生
学位
-- 博士

工作经历

2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员

工作简历
2008-04~现在, 中科院生态环境研究中心, 副研究员
2007-03~现在, 中科院生态环境研究中心, 助理研究员
2004-12~现在, 美国田纳西大学, 博士后
2000-07~现在, 中国预防医学科学院, 实习研究员
社会兼职
2014-03-14-2019-03-13,食品药品监管总局食品安全风险交流专家组成员, 风险交流专家

教授课程

纳米毒理学

出版信息

1.     Oluniyi O. Fadare, Bin Wan*, Keyang Liu, Yu Yang, Lixia Zhao, Liang-Hong Guo*. Eco-corona vs protein corona: effects of humic substances on corona formation and nanoplastic particle toxicity in Daphnia magna. Environmental Science & Technology, 2020, Accepted. (IF=7.149)

2.     Oluniyi O. Fadare, Bin Wan*, Lixia Zhao, Liang-Hong Guo*. Microplastics from consumer plastic food containers: Are we consuming it? Chemosphere, 2020, 253,126787. (IF=5.108)

3.     KeYang Liu, Bin Wan*. An SDS-PAGE based method for the quantification of carbon black in biological samples. Analyst, 2020, 145, 3370–3375. (IF=4.019)

4.     Oluniyi O. Fadare, Bin Wan*, Liang-Hong Guo*, Yan Xin, Weiping Qin, Yu Yang.  Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. Environmental Science-Nano, 2019, 6, 1466-1477. (IF=7.704)

5.     Yan Xin, Bin Wan*. A label-free quantification method for measuring graphene oxide in biological samples. Analytica Chimica Acta, 2019, 1079, 103-110. (IF=5.256)

6.     Yichun Xie, Bin Wan*, Yu Yang, Xuejing Cui, Yan Xin, Liang-Hong Guo. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. Journal of Environmental Science, 2019, 77, 198-209. (IF=3.556)

7.     Xuejing Cui, Bin Wan*, Yu Yang, Yan Xin, Yi-Chun Xie, Liang-Hong Guo*, and Lin L. Mantell. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. Toxicological Sciences, 2019, 172(2), 398-410. (IF=3.564)

8.     Yan Xin, Bin Wan*, Yu Yang, Xue-Jing Cui, Yi-Chun Xie, Liang-Hong Guo*. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. Archives of Toxicology, 2018, 92, 3131–3147. (IF=5.741)

9.     Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. Scientific Reports, 2017, 7, 1518. (IF=4.011)

10.  Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Hui Zhang. Crucial Role of P2X7 Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. Small, 2016, 12, 5998-6011.(Cover Image) (IF=10.856)

11.  Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X7 Receptor. Environmental Science & Technology, 2016, 50, 12473-12483. (IF=7.149)

12.  Jie Hou, Bin Wan*, Yu Yang, Xiao-Min Ren, Liang-Hong Guo*and Jing-Fu Liu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. International Journal of Molecular Sciences, 2016, 17, 409-426. (IF=4.183)

13.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Lixia Zhao, Yu Yang. In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction. Chemosphere, 2015,120, 621-630. (IF=5.108)

14.  Qi-Yan Lv, Bin Wan*, Liang-Hong Guo*, Yu Yang, Xiao-Min Ren, Hui Zhang. In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. Chemico-Biological Interactions, 2015, 240, 84-93. (IF=3.407)

15.  Ping-Xuan Dong, Bin Wan*, Zi-Xia Wang, Liang-Hong Guo*, Yu Yang & Lixia Zhao. Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages. Nanotoxicology, 2013, 7(5): 1028-1042. (IF=5.955)

16.  Bin Wan* , Zi-Xia Wang, Qi-Yan Lv, Ping-Xuan Dong, Li-Xia Zhao, Yu Yang, Liang-Hong Guo*. Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages. Toxicology Letters, 2013, 221, 118-127. (IF=3.499)

17.  Ping-Xuan Dong, Bin Wan* and Liang-Hong Guo. In vitro toxicity of acid-functionalized Single-Walled Carbon Nanotubes: Effects on Murine Macrophages and Gene Expression Profiling. Nanotoxicology, 2012, 6(3), 288-303. (IF=5.955)

18.  万斌*,郭良宏. 多溴联苯醚的环境毒理学研究进展.环境化学, 2011, 30,  143-152.

发表论文
[1] Chang, Jing, Jiao, Meng, Zhang, Zhaoguang, Liu, Wentao, Li, Wei, Xu, Peng, Wan, Bin. Mechanistic insight into the adverse outcome of tire wear and road particle leachate exposure in zebrafish (Danio rerio) larvae. ENVIRONMENT INTERNATIONAL[J]. 2023, 178: http://dx.doi.org/10.1016/j.envint.2023.108053.
[2] Liu, Wentao, Pan, Yifan, Yang, Lu, Xie, Yun, Chen, Xuanyue, Chang, Jing, Hao, Weiyu, Zhu, Lifei, Wan, Bin. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2023, 127: 197-209, [3] Pan, Yifan, Chang, Jing, Wan, Bin, Liu, Zijun, Yang, Lu, Xie, Yun, Hao, Weiyu, Li, Jianzhong, Xu, Peng. Integrative analysis of transcriptomics and metabolomics reveals the hepatotoxic mechanism of thiamethoxam on male Coturnix japonica. ENVIRONMENTAL POLLUTION[J]. 2022, 293: http://dx.doi.org/10.1016/j.envpol.2021.118460.
[4] Yifan Pan, Jing Chang, Peng Xu, Yun Xie, Lu Yang, Weiyu Hao, Jianzhong Li, Bin Wan. Twenty-four hours of Thiamethoxam: In vivo and molecular dynamics simulation study on the toxicokinetic and underlying mechanisms in quails (Coturnix japonica). JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 427: [5] 刘文涛, 万斌. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics. Journal of Environmental Sciences[J]. 2022, [6] Chang, Jing, Pan, Yifan, Liu, Wentao, Xu, Peng, Li, Wei, Wan, Bin. Lambda-cyhalothrin and its common metabolite differentially modulate thyroid disruption effects in Chinese lizards (Eremias argus). ENVIRONMENTAL POLLUTION[J]. 2021, 287: http://dx.doi.org/10.1016/j.envpol.2021.117322.
[7] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Zhao, Lixia. Microplastics from consumer plastic food containers: Are we consuming it?. CHEMOSPHERE[J]. 2020, 253: http://dx.doi.org/10.1016/j.chemosphere.2020.126787.
[8] 马增杰, 赵焕新, 张辉, 万斌. 纳米CuO在水体环境中的转化行为及其对大型溞的毒性效应. 环境科学学报[J]. 2020, 40(5): 1858-1864, http://lib.cqvip.com/Qikan/Article/Detail?id=7101890101.
[9] Liu, Keyang, Wan, Bin. An SDS-PAGE based method for the quantification of carbon black in biological samples. ANALYST[J]. 2020, 145(9): 3370-3375, https://www.webofscience.com/wos/woscc/full-record/WOS:000532257200020.
[10] Fadare, Oluniyi O, Wan, Bin, Liu, Keyang, Yang, Yu, Zhao, Lixia, Guo, LiangHong. Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 54(13): 8001-8009, https://www.webofscience.com/wos/woscc/full-record/WOS:000548584900031.
[11] Xin, Yan, Wan, Bin. A label-free quantification method for measuring graphene oxide in biological samples. ANALYTICA CHIMICA ACTA[J]. 2019, 1079: 103-110, http://dx.doi.org/10.1016/j.aca.2019.06.036.
[12] Cui, Xuejing, Wan, Bin, Yang, Yu, Xin, Yan, Xie, YiChun, Guo, LiangHong, Mantell, Lin L. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. TOXICOLOGICAL SCIENCES[J]. 2019, 172(2): 398-410, [13] Xin, Yan, Ren, XiaoMin, Wan, Bin, Guo, LiangHong. Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2019, 53(14): 8371-8380, https://www.webofscience.com/wos/woscc/full-record/WOS:000476685500047.
[14] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Xin, Yan, Qin, Weiping, Yang, Yu. Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. ENVIRONMENTAL SCIENCE-NANO[J]. 2019, 6(5): 1466-1477, https://www.webofscience.com/wos/woscc/full-record/WOS:000473076700013.
[15] Gu, YuXin, Liang, XiaoXing, Yin, NuoYa, Yang, Yu, Wan, Bin, Guo, LiangHong, Faiola, Francesco. New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells. ARCHIVES OF TOXICOLOGY[J]. 2019, 93(9): 2661-2671, https://www.webofscience.com/wos/woscc/full-record/WOS:000487647300016.
[16] Xie, Yichun, Wan, Bin, Yang, Yu, Cui, Xuejing, Xin, Yan, Guo, LiangHong. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. JOURNALOFENVIRONMENTALSCIENCES[J]. 2019, 77: 198-209, http://lib.cqvip.com/Qikan/Article/Detail?id=72747566504849574851484957.
[17] Xin, Yan, Wan, Bin, Yang, Yu, Cui, XueJing, Xie, YiChun, Guo, LiangHong. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. ARCHIVES OF TOXICOLOGY[J]. 2018, 92(10): 3131-3147, http://ir.rcees.ac.cn/handle/311016/41009.
[18] Gu, Yuxin, Yang, Yu, Wan, Bin, Li, Minjie, Guo, LiangHong. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. BIOCHEMICAL PHARMACOLOGY[J]. 2018, 152: 21-33, http://dx.doi.org/10.1016/j.bcp.2018.03.017.
[19] Yang Yu, Gu Yuxin, Wan Bin, Ren Xiaomin, Guo LiangHong. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. BIOSENSORS AND BIOELECTRONICS[J]. 2017, 95: 94-99, http://dx.doi.org/10.1016/j.bios.2017.04.009.
[20] Xuejing Cui, Bin Wan, Yu Yang, Xiaomin Ren, LiangHong Guo. Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. SCIENTIFIC REPORTS[J]. 2017, 7(1518): 1-13, http://ir.rcees.ac.cn/handle/311016/39350.
[21] 郭良宏, 万斌, 崔雪晶. 单壁碳纳米管的外排机制研究. 中国化学会第30届学术年会摘要集-第三十八分会:纳米生物效应与纳米药物化学null. 2016, 1-, http://ir.rcees.ac.cn/handle/311016/39939.
[22] Cui, Xuejing, Wan, Bin, Yang, Yu, Ren, Xiaomin, Guo, LiangHong, Zhang, Hui. Crucial Role of P2X(7) Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. SMALL[J]. 2016, 12(43): 5998-6011, http://ir.rcees.ac.cn/handle/311016/35825.
[23] 郭良宏, 万斌, 侯杰. 巨噬细胞呼吸爆发对单壁碳纳米管生物降解调控研究. 中国化学会第30届学术年会摘要集-第二十六分会:环境化学null. 2016, 1-, http://ir.rcees.ac.cn/handle/311016/39957.
[24] Cui, Xuejing, Wan, Bin, Guo, LiangHong, Yang, Yu, Ren, Xiaomin. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X(7) Receptor. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2016, 50(22): 12473-12483, http://ir.rcees.ac.cn/handle/311016/35877.
[25] 王大彬, 赵利霞, 郭良宏, 张辉, 万斌, 杨郁. 连续流动化学发光法在线定量检测二氧化钛光催化产生的O_2~(·-)和H_2O_2及其生成动力学研究. 化学学报[J]. 2015, 73(5): 388-394, http://ir.rcees.ac.cn/handle/311016/33150.
[26] 吕琪妍, 万斌, 郭良宏. 多溴联苯醚对小鼠原代巨噬细胞的毒性效应和机制研究. 中国化学会第29届学术年会——第20分会:环境与健康null. 2014, http://ir.rcees.ac.cn/handle/311016/24919.
[27] 崔雪晶, 万斌, 郭良宏. 单壁碳纳米管的生物可利用性及可降解性研究. 中国化学会第29届学术年会——第20分会:环境与健康null. 2014, http://ir.rcees.ac.cn/handle/311016/24881.
[28] 杨郁, 吕琪妍, 万斌, 郭良宏. 利用生物传感器揭示全氟有机物对蛋白质磷酸化的干扰效应. 中国化学会第29届学术年会——第04分会:纳米生物传感新方法null. 2014, http://ir.rcees.ac.cn/handle/311016/24951.
[29] 吕琪妍, 万斌, 郭良宏等. 全氟辛烷磺酸基化合物的免疫毒性效应和机制研究. 第七届全国环境化学学术大会null. 2013, http://ir.rcees.ac.cn/handle/311016/29590.
[30] 张建海, 梁琛, 万斌, 吕琪妍, 郭良宏. 羧基化多壁碳纳米管的雄性大鼠生殖毒理效应研究. 中国化学会第28届学术年会null. 2012, http://ir.rcees.ac.cn/handle/311016/32056.
[31] 吕琪妍, 万斌, 郭良宏等. 多溴联苯醚的免疫毒性效应和机制研究. 第六届全国环境化学学术大会论文集null. 2011, 991-, http://ir.rcees.ac.cn/handle/311016/5549.
[32] 董平轩, 万斌, 郭良宏等. 单壁碳纳米管对小鼠原代巨噬细胞功能的影响研究. 第六届全国环境化学学术大会论文集null. 2011, 815-, http://ir.rcees.ac.cn/handle/311016/5559.
[33] 万斌, 郭良宏. 多溴联苯醚的环境毒理学研究进展. 环境化学[J]. 2011, 30(1): 143-152, http://hjhx.rcees.ac.cn/article/id/hjhx_329.
[34] 万斌, 郭良宏. 单壁碳纳米管对小鼠巨噬细胞RAW264.7的毒性影响及其分子机制. 第五届全国环境化学大会会议论文集null. 2008, 553-, http://ir.rcees.ac.cn/handle/311016/5897.

科研活动

   
科研项目
( 1 ) 单壁碳纳米管的免疫毒理和毒理基因组学分子机制研究, 主持, 国家级, 2009-01--2011-12
( 2 ) 持久性有机污染物的环境行为、毒性效应与控制技术原理”——PBDE和PFC的毒性效应与分子机制研究, 参与, 国家级, 2009-01--2013-12
( 3 ) 松花江水污染生态风险评估关键技术研究, 参与, 国家级, 2009-01--2011-12
( 4 ) 单壁碳纳米管的生物可利用性、生物可降解性及毒性效应研究, 主持, 国家级, 2013-02--2016-12
( 5 ) 几种碳纳米材料诱导的细胞自噬效应及其毒性作用机制研究, 主持, 国家级, 2015-01--2018-12
( 6 ) PBDEs对斑马鱼的生殖发育毒性及其机制, 主持, 部委级, 2016-08--2020-12
参与会议
(1)P2X7 receptor regulates the exocytosis of single-walled carbon nanotubes in murine macrophages   中墨纳米材料双边会议   万斌   2017-08-19
(2)巨噬细胞呼吸爆发调控单壁碳纳米管的生物降解   全国环境纳米技术及生物效应学术研讨会   万斌、侯杰、郭良宏   2016-04-08

指导学生

已指导学生

汪子霞  硕士研究生  430130-环境工程  

侯杰  硕士研究生  085238-生物工程  

现指导学生

谢懿春  硕士研究生  077601-环境科学