基本信息
张新刚  男  博导  中国科学院上海有机化学研究所
电子邮件: xgzhang@mail.sioc.ac.cn
通信地址: 上海市零陵路345号
邮政编码: 200032

招生信息

   
招生专业
070303-有机化学
招生方向
有机氟化学
有机合成

教育背景

1998-09--2003-07   中国科学院上海有机化学研究所   博士
1994-09--1998-07   四川大学   学士

工作经历

   
工作简历
2020-04~现在, 中国科学院上海有机化学研究所, 实验室主任
2012-01~现在, 中国科学院上海有机化学研究所, 研究员 所聘**
2008-05~2011-12,中国科学院上海有机化学研究所, 副研究员课题组长
2003-08~2008-03,美国伊利诺伊大学香槟分校(UIUC), 博士后研究助理
1998-09~2003-07,中国科学院上海有机化学研究所, 博士
1994-09~1998-07,四川大学, 学士

专利与奖励

   
奖励信息
(1) “万人计划”科技创新领军人才, , 其他, 2018
(2) 科技部中青年科技创新领军人才, 国家级, 2016
(3) 第五届中国化学会—英国皇家化学会青年化学家奖, 其他, 2015
(4) 2015 RSC Fluorine Chemistry Prize, 其他, 2015
(5) 2015年上海市科技系统青年五四奖章, 其他, 2015
(6) Thieme Chemistry Journal Award, 其他, 2014
(7) 中国科学院“优秀研究生指导教师”奖, 院级, 2013
(8) 上海市启明星计划, 其他, 2009
专利成果
( 1 ) 一种含氟甲基的化合物及其制备方法, 2018, 第 1 作者, 专利号: 201810046072.8

( 2 ) 一种-芳基、杂芳基或烯基-,-二氟甲基类化合物的制备方法, 2017, 第 1 作者, 专利号: 201710059023.3

( 3 ) 含二氟烷基取代的芳基或杂芳基化合物、制备方法和应用, 2016, 第 1 作者, 专利号: 201610124869.6

( 4 ) 含一氟烷基的化合物、其制备方法及应用, 2015, 第 1 作者, 专利号: 201510268169.X

( 5 ) 一种多氟芳烃-杂芳环砌块的合成方法, 2014, 第 1 作者, 专利号: 201110295776.7

( 6 ) 含二氟亚甲基的化合物及其制备方法, 2014, 第 1 作者, 专利号: 201410334117.3

出版信息

   
发表论文
(1) Nickel-Catalyzed Carbonylation of Secondary Trifluoromethylated, Difluoromethylated, and Nonfluorinated Aliphatic Electrophiles with Arylboronic Acids under 1 atm of CO, ACS Catal, 2020, 通讯作者
(2) Palladium Difluorocarbene Involved Catalytic Coupling with Terminal Alkynes, CCS Chem., 2020, 通讯作者
(3) Controllable Catalytic Difluorocarbene Transfer Enables Access to Diversified Fluoroalkylated Arenes, Nat. Chem., 2019, 通讯作者
(4) Copper-Catalyzed Highly Enantioselective Difluoroalkylation of Secondary Propargyl Sulfonates with Difluoroenoxysilanes, Chem, 2019, 通讯作者
(5) Fluoroalkylation-Borylation of Alkynes: An Efficient Method to Obtain (Z)-Tri- and Tetrasubstituted Fluoroalkylated Alkenylboronates, ACS Catal., 2019, 通讯作者
(6) Nickel-Catalyzed Carbonylation of Difluoroalkyl Bromides with Arylboronic Acids, Org. Lett., 2019, 通讯作者
(7) Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides, Acc. Chem. Res., 2018, 通讯作者
(8) Nickel-Catalyzed Difluoromethylation of Arylboronic Acids with Bromodifluoromethane, Chin. J. Chem., 2018, 通讯作者
(9) Highly Selective Pd-Catalyzed Direct C-F Bond Arylation of Simple Polyfluoroarenes, Org. Lett., 2018, 通讯作者
(10) Bulky Diamine Ligand Promoted Cross-Coupling with Difluoroalkyl Bromides via Iron Catalysis, Angew. Chem. Int. Ed., 2018, 通讯作者
(11) Copper-Catalyzed Highly Stereospecific Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates, Angew. Chem. Int. Ed., 2018, 通讯作者
(12) Difluoromethylation of (Hetero)Aryl Chlorides with Chlorodifluoromethane Catalyzed by Nickel, Nat. Commun., 2018, 通讯作者
(13) Highly Selective Nickel-Catalyzed gem-Difluoropropargylation of Unactivated Alkylzinc Reagents, Nat. Commun., 2017, 通讯作者
(14) Access to Difluoromethylene-Skipped 1,4-Diynes with gem-Difluoropropargyl Bromide, Acs Catal., 2017, 通讯作者
(15) Visible-Light-Promoted Tandem Difluoroalkylation-Amidation: Access to Difluorooxindoles from Free Anilines, J. Org. Chem., 2017, 通讯作者
(16) Chlorodifluoromethane-Triggered Formation of Difluoromethylated Arenes Catalysed by Palladium, Nature Chemistry, 2017, 通讯作者
(17) Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate, Org. Lett., 2016, 通讯作者
(18) Pd-Catalyzed gem-difluoroallylation of arylboronic acids with ,-difluoroallylic acetates, Chem. Commun., 2016, 通讯作者
(19) Nickel-Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1-Bromo-1,1-difluoroalkanes, Angew. Chem. Int. Ed., 2016, 通讯作者
(20) Palladiium-Catalyzed Phosphonyldifluoromethylation of Alkenes with Bromodifluoromethyphosphonate, Org. Chem. Front., 2016, 通讯作者
(21) Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel, Angew. Chem. Int. Ed., 2016, 通讯作者
(22) Carbonylation of Difluoroalkyl Bromides Catalyzed by Palladium, Angew. Chem. Int. Ed., 2016, 通讯作者
(23) Copper-Catalyzed Direct Propargylation of Polyfluoroarenes with Secondary Propargyl Phosphates, Org. Lett., 2016, 通讯作者
(24) Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide, Angew. Chem. Int. Ed., 2015, 通讯作者
(25) Rhodium-Catalyzed ortho-Selective C-F Bond Borylation of Polyfluoroarenes with Bpin-Bpin, Angew. Chem.Int. Ed., 2015, 通讯作者
(26) Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides, Org. Lett., 2015, 通讯作者
(27) Palladium-Catalyzed Difluoroalkylation of Isocyanides: Access to Difluoroalkylated Phenanthridine Derivatives, Org. Lett., 2015, 通讯作者
(28) Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides, Synthesis, 2015, 通讯作者
(29) A General Synthesis of Fluoroalkylated Alkenes by Palladium-Catalyzed Heck-Type Reaction of Fluoroalkyl Bromides, Angew. Chem. Int. Ed., 2015, 通讯作者
(30) Heteroaryldifluoromethylation of Organoborons Catalyzed by Palladium: Facile Access to Aryl(Heteroaryl)difluoromethanes, Org. Lett., 2014, 通讯作者
(31) Direct Olefination of Fluorinated Benzothiadiazoles: A New Entry to Optoelectronic Materials, Chem. Eur., 2014, 通讯作者
(32) Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes, Angew. Chem. Int. Ed. , 2014, 通讯作者
(33) Synthesis of ?,?-Difluoromethylene Alkynes by Palladium-Catalyzed gem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents, Angew. Chem. Int. Ed., 2014, 通讯作者
(34) Pd-Catalyzed Difluoroalkylation of Arylboronic Acids: A New Method for Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives, Angew. Chem., Int. Ed., 2014, 通讯作者
(35) Highly Selective gem-Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium, J. Am. Chem. Soc., 2014, 通讯作者
(36) Selective Thienylation of Fluorinated Benzothiadiazoles and Benzotriazoles for Organic Photovoltaics, Chem. Sci., 2014, 通讯作者
(37) Palladium-Catalyzed ortho-Selective C-F Activation of Polyfluroarenes with Triethylsilane: A Facile Access to Partially Fluorinated Aromatics, Angew. Chem. Int. Ed., 2013, 通讯作者
(38) Pd-Catalyzed Oxidative Cross-Coupling between Two Electron Rich Heteroarenes, Chem. Sci., 2013, 通讯作者
(39) Palladium-Catalyzed Aerobic Dehydrogenative Cross-Coupling of Polyfluoroarenes with Thiophenes: Facile Access to Polyfluoroarene-Thiophene Structure, Organometallics, 2012, 通讯作者
(40) Pd-Catalyzed Dehydrogenative Cross-Coupling of Polyfluoroarenes with Heteroatom-Substituted Enones, Org. Lett, 2012, 通讯作者
(41) Pd-Catalyzed Direct Arylation of Polyfluoroarenes on Water under Mild Conditions Using PPh3 Ligand, J. Org. Chem., 2012, 通讯作者
(42) Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozincdifluorophosphonate, Org. Lett., 2012, 通讯作者
(43) Direct Palladium-Catalyzed Intermolecular Allylation of Highly Electron-Deficient Polyfluoroarenes, Angew. Chem. Int. Ed., 2011, 通讯作者
(44) Highly Enantioselective Zinc/BINOL-Catalyzed Alkynylation of alfa-Ketoimine Ester: A New Entry to Optically Active Quaternary alfa-CF3 alfa-Amino Acids , Chem. Commun., 2011, 通讯作者
(45) Highly Diastereoselective Synthesis of Quaternary ?-Trifluoromethyl ?-Amino Acids by Addition of Benzylzinc Reagents to Chiral Imines of Tifluoropyruvate, Tetrahedron Lett, 2011, 通讯作者
(46) Pd-Catalyzed Direct Cross-Coupling of Electron-Deficient Polyfluoroarenes with Heteroaromatic Tosylates, Org. Lett, 2011, 通讯作者
(47) Pd-Catalyzed Highly Regio- and Stereocontrolled Direct Alkenylation of Electron-deficient Polyfluoroarenes, Chem Lett, 2011, 通讯作者
(48) Pd(OAc)2 Catalyzed Olefination of Highly Electron-deficient Perfluoroarenes, J. Am. Chem. Soc., 2010, 通讯作者
(49) Pd-Catalyzed Oxidative Cross-Coupling of Perfluoroarenes with Aromatic Heterocycles, J. Am. Chem. Soc., 2010, 通讯作者
(50) Direct Pd-Catalyzed Benzylation of Highly Electron-Deficient Perfluoroarenes, Chem. Commun., 2010, 通讯作者
(51) Highly Diastereoselective Synthesis of Quaternary alfa-Trifluoromethyl alfa-Amino Acids from Chiral Imines of Trifluoropyruvate, Chem. Commun., 2010, 通讯作者
(52) Diastereoselective Synthesis of Propargylic Fluorides and Its Application in Preparation of Monofluorinated Sugar, Tetrahedron, 2010, 通讯作者

科研活动

   
科研项目
( 1 ) 一些重要含三氟甲基和多氟苯类氨基酸的立体选择性合成及其在化学生物学中的应用, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 多氟芳烃反应特性研究及应用, 负责人, 国家任务, 2012-01--2015-12
( 3 ) 含氟有机化合物的选择性合成和应用研究, 参与, 国家任务, 2012-01--2016-12
( 4 ) 含氟有机功能分子的可控性合成及应用, 负责人, 国家任务, 2014-01--2018-12
( 5 ) 有机氟化学, 负责人, 国家任务, 2015-01--2019-12
( 6 ) 功能导向的有机氟化学, 参与, 国家任务, 2015-01--2019-12
( 7 ) 耐极端条件的有机含氟分子的构筑方法及反应规律研究, 参与, 国家任务, 2015-01--2019-08
( 8 ) 高性能有机材料分子的创制, 负责人, 中国科学院计划, 2016-07--2021-06
( 9 ) 基于小分子氟烷烃的高效转化研究, 负责人, 国家任务, 2017-01--2020-12
( 10 ) 功能导向的含氟有机化合物的选择性合成, 负责人, 国家任务, 2020-01--2024-12
参与会议
(1)Facile Access to Difluoroalkylated Molcules by Nickel-Catalyzed Carbodifunctionalization of Alkenes   2019-08-25
(2)Catalytic Difluoroalkylation Reactions by Controlled Radical and Difluorocarbene Cross-Couplings   2018-12-17
(3)Copper-Catalyzed Highly Stereoselective Fluoroalkylation of Propargylic Sulfonates   2018-11-14
(4)Catalytic Difluoroalkylations and Applications in Late-Stage Fluorination of Bioactive Molecules   2018-11-05
(5)Catalytic Difluoroalkylations by Controlled Radical and Difluorocarbene Cross-Couplings   2018-05-23
(6)可控自由基/二氟卡宾途径的催化氟烷基化   中国化学会第十届全国有机化学学术会议   2017-12-21
(7)Recent Advances in Fluoroalkylations from Fluoroalkyl Halides   2016-09-22
(8)Transition-Metal-Catalyzed C-F Bond Borylation   2016-09-08
(9)Pd/Ni-Catalyzed Difluoroarylation of Organoborons with Difluoroalkyl Bromides and Chlorides   张新刚   2015-08-24
(10)Transition-Metal-Catalyzed Difluoroalkylation of Arenes   张新刚   2014-05-29
(11)Transition-Metal-Catalyzed ortho-Selective C-F Bond Activation of Polyfluoroarenes   张新刚   2013-07-21
(12)Pd-Catalyzed Direct C-H Functionalization of Highly Electron-Deficient Perfluoroarenes   Xingang Zhang   2010-09-09
(13)Pd-Catalyzed Direct Olefination and Benzylation of Highly Electron-Deficient Perfluoroarenes   Xingang Zhang   2010-07-19