071008-发育生物学

动物克隆与胚胎干细胞

1992-09--1995-07   东北农业大学生物工程系   理学博士

   

2007-12~现在, 中国科学院广州生物医药与健康研究院, 研究员
2006-07~2007-12,美国先进生殖治疗中心, Senior embryologist
2004-07~2006-07,美国密苏里大学国家猪资源保护与研究中心, 研究助理教授
2002-07~2004-07,美国密苏里大学动物研究中心, 研究助理教授
1998-07~2002-07,美国密苏里大学动物研究中心, 博士后
1995-07~1997-07,解放军农牧大学军事兽医研究所转基因动物实验室, 博士后　

   

（1） 猪基因突变技术创新及基因修饰猪模型的建立, 一等奖, 省级, 2016
（2） 大动物基因修饰技术研究及基因修饰动物模型的建立, 一等奖, 市地级, 2013
（3） 国务院政府特殊津贴, , 国家级, 2011

[1] 赖良学, 闫森, 李晓江. 治疗亨廷顿病的药物. 202210417707.7, 2023-04-22.

[2] 赖良学, 吴涵, 陈方兵. 一种Cas12a蛋白突变体、含有其的碱基编辑器和应用. 202211241967.X, 2022-10-11.

[3] 赖良学, 王可品, 石惠, 金琴, 陈方兵. 一种可逆基因敲除系统及其应用. 202210730142.8, 2022-08-02.

[4] 赖良学, 王可品, 金琴. 一种构建可通过药物诱导Cas9蛋白表达的模型猪的方法. 202210822307.4, 2022-07-14.

[5] 赖良学, 闫森, 李晓江. 神经退行性疾病模型的构建方法. 202210545641.X, 2022-05-23.

[6] 赖良学, 王可品, 梁艳慧, 谢精科. 一种融合蛋白及含有其的由双脱氨酶介导的碱基编辑系统和应用. 202210193759.0, 2022-03-24.

[7] 赖良学, 潘光锦, 樊娜娜. 促进人多能干细胞异种嵌合的方法. 202111253933.8, 2021-10-27.

[8] 赖良学, 王可品, 金琴. 一种在猪上诱导高效表达外源基因的方法. CN: CN113817773A, 2021-12-21.

[9] 赖良学, 刘洋, 邹庆剑, 杨洋, 李川, 陈敏. 一种诱导死亡的重组细胞及其应用. CN: CN113736785A, 2021-12-03.

[10] 赖良学, 刘洋, 邹庆剑, 周继曾, 周小青, 杨洋, 李川, 刘玉, 程令印, 郑雨龄. 一种单碱基编辑工具TaC9-ABE及其应用. CN: CN113774085A, 2021-12-10.

[11] 闫森, 宋熙辰, 涂著池, 李晓江, 赖良学, 李世华. 动物脑组织灌流装置. CN: CN215739644U, 2022-02-08.

[12] 赖良学, 周娟娟, 廖媛. WAS基因的gRNA及其应用. CN: CN111808859A, 2020-10-23.

[13] 李莹莹, 樊娜娜, 赖良学. 一种sgRNA及其构建的CREBRF点图变型巴马香猪和应用. CN: CN110862988A, 2020-03-06.

[14] 赖良学, 王可品, 葛维凯, 刘琪帅, 谢精科. 一种重度免疫缺陷猪模型及其构建方法和应用. CN: CN109777834A, 2019-05-21.

[15] 闫森, 李晓江, 赖良学, 李世华. 人亨廷顿基因敲入用重组载体及其构建方法和在模型猪构建中的应用. CN: CN107988256A, 2018-05-04.

[16] 赖良学. 使用表达Cre依赖的Cas9基因的哺乳动物进行基因修饰和疾病建模的方法. CN: CN107739739A, 2018-02-27.

[17] 赖良学. 人源化基因编辑哺乳动物的制备方法及其用途. CN: CN106866813A, 2017-06-20.

[18] 樊娜娜, 韩凯, 赖良学. 无毛模型猪的重构卵及其构建方法和模型猪的构建方法. CN: CN106957856A, 2017-07-18.

[19] 赖良学, 信吉阁, 杨化强, 邹庆剑, 樊娜娜. 白化病模型猪的重构卵及其构建方法和模型猪的构建方法. CN: CN104263754A, 2015-01-07.

[20] 裴端卿, 米盖尔·埃斯特班, 徐建勇, 赖良学, 杨佳银, 彭梅秀. 用猪成纤维细胞生成诱导的多能性干细胞的方法. CN: CN101613717A, 2009-12-30.

   

[1] Ting Lan, Yuling Zheng, Yangyang Suo, Yuhui Wei, Hui Shi, Quanmei Yan, Zhenpeng Zhuang, Huangyao Chen, Quanjun Zhang, Nana Fan, Yu Zhao, Zhen Ouyang, Chengdan Lai, Zhaoming Liu, Jizeng Zhou, Chengcheng Tang, NamHyung Kim, Qingjian Zou, Xiaomin Wang. Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in. JOURNAL OF GENETICS AND GENOMICS. 2023, 50(3): 212-215, http://dx.doi.org/10.1016/j.jgg.2022.05.001.
[2] Yan, Sen, Zheng, Xiao, Lin, Yingqi, Li, Caijuan, Liu, Zhaoming, Li, Jiawei, Tu, Zhuchi, Zhao, Yu, Huang, Chunhui, Chen, Yizhi, Li, Jun, Song, Xichen, Han, Bofeng, Wang, Wei, Liang, Weien, Lai, Liangxue, Li, XiaoJiang, Li, Shihua. Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease. NATURE BIOMEDICAL ENGINEERING. 2023, http://dx.doi.org/10.1038/s41551-023-01007-3.
[3] Jin, Qin, Liu, Xiaoyi, Zhuang, Zhenpeng, Huang, Jiayuan, Gou, Shixue, Shi, Hui, Zhao, Yu, Ouyang, Zhen, Liu, Zhaoming, Li, Lei, Mao, Junjie, Ge, Weikai, Chen, Fangbing, Yu, Manya, Guan, Yezhi, Ye, Yinghua, Tang, Chengcheng, Huang, Ren, Wang, Kepin, Lai, Liangxue. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation. GENOME BIOLOGY[J]. 2023, 24(1): http://dx.doi.org/10.1186/s13059-023-02851-x.
[4] Wang, Xunlei, Jin, Qin, Xiao, Wenwen, Fang, Puxian, Lai, Liangxue, Xiao, Shaobo, Wang, Kepin, Fang, Liurong. Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus. JOURNAL OF VIROLOGY[J]. 2022, 96(24): [5] Liang, Yanhui, Xie, Jingke, Zhang, Quanjun, Wang, Xiaomin, Gou, Shixue, Lin, Lihui, Chen, Tao, Ge, Weikai, Zhuang, Zhenpeng, Lian, Meng, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Lai, Chengdan, Liu, Xiaoyi, Li, Lei, Ye, Yinghua, Wu, Han, Wang, Kepin, Lai, Liangxue. AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(9): 5384-5399, http://dx.doi.org/10.1093/nar/gkac353.
[6] Jin, Qin, Yang, Xiaoyu, Gou, Shixue, Liu, Xiaoyi, Zhuang, Zhenpeng, Liang, Yanhui, Shi, Hui, Huang, Jiayuan, Wu, Han, Zhao, Yu, Ouyang, Zhen, Zhang, Quanjun, Liu, Zhaoming, Chen, Fangbing, Ge, Weikai, Xie, Jingke, Li, Nan, Lai, Chengdan, Zhao, Xiaozhu, Wang, Jiaowei, Lian, Meng, Li, Lei, Quan, Longquan, Ye, Yinghua, Lai, Liangxue, Wang, Kepin. Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(11): 2269-2286, http://dx.doi.org/10.1007/s11427-021-2088-1.
[7] Chen, Siyu, Liu, Zhiquan, Yu, Hao, Lai, Liangxue, Li, Zhanjun. Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells. JOURNAL OF GENETICS AND GENOMICS[J]. 2022, 49(10): 927-933, http://dx.doi.org/10.1016/j.jgg.2022.03.007.
[8] 刘晓艺, 金琴, 王可品, 赖良学. 基因编辑猪中条件性基因修饰系统的研究进展. 生物化学与生物物理进展[J]. 2022, 49(5): 838-848, http://lib.cqvip.com/Qikan/Article/Detail?id=7107379296.
[9] Chen, Siyu, Liu, Zhiquan, Lai, Liangxue, Li, Zhanjun. Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions. CRISPR JOURNAL[J]. 2022, 5(3): 389-396, http://dx.doi.org/10.1089/crispr.2021.0124.
[10] Yingqi Jia, Tian Wang, Ding Zhao, Zhiquan Liu, Tingting Sui, Siyu Chen, Jinze Li, Liangxue Lai, Zhanjun Li, Jinsong Li. Targeted mutagenesis in rabbit using an engineered BhCas12b variant. JOURNAL OF MOLECULAR CELL BIOLOGY. 2022, 14(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129383/.
[11] Zhao, Ding, Qian, Yuqiang, Li, Jinze, Li, Zhanjun, Lai, Liangxue. Highly efficient A-to-G base editing by ABE8.17 in rabbits. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2022, 27: 1156-1163, https://doaj.org/article/c201a88261ca446fa1ef6ff463a6384e.
[12] Liu, Zhiquan, Chen, Siyu, Xie, Wanhua, Song, Yuning, Li, Jinze, Lai, Liangxue, Li, Zhanjun. Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9. MOLECULAR THERAPY[J]. 2022, 30(1): 256-267, http://dx.doi.org/10.1016/j.ymthe.2021.06.013.
[13] Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun. Inhibition of base editors with anti-deaminases derived from viruses. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-28300-0.
[14] Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng, Jiahao Tang, Zhanjun Li, Wanhua Xie. PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition. CELL DEATH & DISEASE[J]. 2022, 13(5): 1-14, http://dx.doi.org/10.1038/s41419-022-04940-4.
[15] Liu, Yang, Zhou, Jizeng, Lan, Ting, Zhou, Xiaoqing, Yang, Yang, Li, Chuan, Zhang, Quanjun, Chen, Min, Wei, Shu, Zheng, Shuwen, Cheng, Lingyin, Zheng, Yuling, Lai, Liangxue, Zou, Qingjian. Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites. CELL DISCOVERY. 2022, 8(1): http://dx.doi.org/10.1038/s41421-022-00384-4.
[16] Zheng, Shuwen, Zhong, Haiwen, Zhou, Xiaoqing, Chen, Min, Li, Wansheng, Zi, Yin, Chi, Yue, Wang, Jinling, Zheng, Wei, Zou, Qingjian, Lai, Liangxue, Tang, Chengcheng. Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor. CELLS[J]. 2022, 11(24): http://dx.doi.org/10.3390/cells11243975.
[17] Chen, Fangbing, Lian, Meng, Ma, Bingxiu, Gou, Shixue, Luo, Xian, Yang, Kaiming, Shi, Hui, Xie, Jingke, Ge, Weika, Ouyang, Zhen, Lai, Chengdan, Li, Nan, Zhang, Quanjun, Jin, Qin, Liang, Yanhui, Chen, Tao, Wang, Jiaowei, Zhao, Xiaozhu, Li, Lei, Yu, Manya, Ye, Yinghua, Wang, Kepin, Wu, Han, Lai, Liangxue. Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors. COMMUNICATIONS BIOLOGY[J]. 2022, 5(1): http://dx.doi.org/10.1038/s42003-022-04152-8.
[18] Liu, Zhiquan, Chen, Siyu, Xie, Wanhua, Yu, Hao, Lai, Liangxue, Li, Zhanjun. Versatile and efficient genome editing with Neisseria cinerea Cas9. COMMUNICATIONS BIOLOGY[J]. 2022, 5(1): http://dx.doi.org/10.1038/s42003-022-04258-z.
[19] Liu, Yang, Yang, Yang, Suo, Yangyang, Li, Chuan, Chen, Min, Zheng, Shuwen, Li, Hao, Tang, Chengcheng, Fan, Nana, Lan, Ting, Zhou, Jizeng, Li, Yingying, Wang, Jiaowei, Chen, Huangyao, Zou, Qingjian, Lai, Liangxue. Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT[J]. 2022, 24: 332-341, http://dx.doi.org/10.1016/j.omtm.2022.01.014.
[20] Zhou, Juanjuan, Yan, Quanmei, Tang, Chengcheng, Liao, Yuan, Zhang, Quanjun, Wang, Xiaomin, Zhou, Xiaoqing, Lai, Liangxue, Zou, Qingjian. Development of a rabbit model of Wiskott-Aldrich syndrome. FASEB JOURNAL[J]. 2021, 35(2): http://dx.doi.org/10.1096/fj.202002118RR.
[21] Li, Nan, Gou, Shixue, Wang, Jiaowei, Zhang, Quanjun, Huang, Xingyun, Xie, Jingke, Li, Li, Jin, Qin, Ouyang, Zhen, Chen, Fangbing, Ge, Weikai, Shi, Hui, Liang, Yanhui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Ye, Yinghua, Quan, Longquan, Wu, Han, Lai, Liangxue, Wang, Kepin. CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I. MOLECULAR THERAPY[J]. 2021, 29(3): 1001-1015, http://dx.doi.org/10.1016/j.ymthe.2020.11.023.
[22] Liu, Zhiquan, Chen, Siyu, Jia, Yingqi, Shan, Huanhuan, Chen, Mao, Song, Yuning, Lai, Liangxue, Li, Zhanjun. Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(8): 1355-1367, http://dx.doi.org/10.1007/s11427-020-1775-2.
[23] Yi Yang, Xiangjin Kang, Shiqi Hu, Bangzhu Chen, Yingjun Xie, Bing Song, Quanjun Zhang, Han Wu, Zhanhui Ou, Yexing Xian, Yong Fan, Xiaoping Li, Liangxue Lai, Xiaofang Sun. CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia. JOURNAL OF BIOLOGICAL CHEMISTRY. 2021, 296: http://dx.doi.org/10.1016/j.jbc.2021.100464.
[24] Li, Li, Meng, Hongyi, Zhang, Jianmin, Liu, Yang, Zou, Qingjian, Gao, Yi, Yang, Huaqiang, Lai, Liangxue. A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 47(11): 705-712, http://dx.doi.org/10.1016/j.jgg.2020.07.009.
[25] Meng Lian, Fangbing Chen, Xingyun Huang, Xiaozhu Zhao, Shixue Gou, Nan Li, Qin Jin, Hui Shi, Yanhui Liang, Jingke Xie, Weikai Ge, Zhenpeng Zhuang, Jiaowei Wang, Yinghua Ye, Yi Yang, Kepin Wang, Liangxue Lai, Han Wu. Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, http://dx.doi.org/10.1016/j.jgg.2020.07.010.
[26] Chen, Siyu, Xie, Wanhua, Liu, Zhiquan, Shan, Huanhuan, Chen, Mao, Song, Yuning, Yu, Hao, Lai, Liangxue, Li, Zhanjun. CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 21: 1062-1073, http://dx.doi.org/10.1016/j.omtn.2020.07.037.
[27] Xu, Yuxin, Liu, Hongmei, Pan, Huilin, Wang, Xinyue, Zhang, Yuxin, Yao, Bing, Li, Nannan, Lai, Liangxue, Li, Zhanjun. CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen. GENES[J]. 2020, 11(3): https://doaj.org/article/a325ae4066c64aa8bd19d607b218d333.
[28] Liang, Mingming, Sui, Tingting, Liu, Zhiquan, Chen, Mao, Liu, Hongmei, Shan, Huanhuan, Lai, Liangxue, Li, Zhanjun. AcrIIA5 Suppresses Base Editors and Reduces Their Off-Target Effects. CELLS[J]. 2020, 9(8): https://doaj.org/article/3f31e74f15c641469f9b82c48664acb1.
[29] 吴彩霞, 刘朝明, 颜泉梅, 张全军, 欧阳振, 赵宇, 樊娜娜, 赖良学. 糖尿病和心血管病相关的重要靶点基因PPARγ过表达转基因克隆猪模型的建立. 中国兽医学报[J]. 2020, 40(7): 1366-1371, http://lib.cqvip.com/Qikan/Article/Detail?id=7102539787.
[30] Li, Wenjing, Shi, Lei, Zhuang, Zhenpeng, Wu, Han, Lian, Meng, Chen, Yihui, Li, Lei, Ge, Weikai, Jin, Qin, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Ouyang, Zhen, Ye, Yinghua, Li, Yingying, Wang, Hai, Liao, Yuan, Quan, Longquan, Xiao, Lei, Lai, Liangxue, Meng, Guangxun, Wang, Kepin. Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(9): 2532-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000581921400019.
[31] Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin. JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18900-z.
[32] Chen, Siyu, Jia, Yingqi, Liu, Zhiquan, Shan, Huanhuan, Chen, Mao, Yu, Hao, Lai, Liangxue, Li, Zhanjun. Robustly improved base editing efficiency of Cpf1 base editor using optimized cytidine deaminases. CELL DISCOVERY. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00195-5.
[33] Song, Yuning, Liu, Zhiquan, Zhang, Yuxin, Chen, Mao, Sui, Tingting, Lai, Liangxue, Li, Zhanjun. Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 21: 523-526, http://dx.doi.org/10.1016/j.omtn.2020.06.019.
[34] Wang, Xiaomin, Shi, Hui, Zhou, Juanjuan, Zou, Qingjian, Zhang, Quanjun, Gou, Shixue, Chen, Pengfei, Mou, Lisha, Fan, Nana, Suo, Yangyang, Ouyang, Zhen, Lai, Chengdan, Yan, Quanmei, Lai, Liangxue. Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation. JOURNAL OF GENETICS AND GENOMICS[J]. 2020, 47(5): 249-261, http://lib.cqvip.com/Qikan/Article/Detail?id=7102981361.
[35] 吴彩霞, 刘朝明, 张全军, 颜泉梅, 赵宇, 张秀娟, 刘晓明, 欧阳振, 樊娜娜, 赖良学. 神经退行性疾病转基因猴模型的构建及相关技术体系建立. 畜牧与兽医[J]. 2020, 52(5): 123-127, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=XMYS202005023&v=MzIzNjV4WVM3RGgxVDNxVHJXTTFGckNVUjdxZVp1ZHVGeXpnVkwvSVBTRFNmYkc0SE5ITXFvOUhaNFI4ZVgxTHU=.
[36] Liu, Hongmei, Xu, Yuxin, Yao, Bing, Sui, Tingting, Lai, Liangxue, Li, Zhanjun. A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNATHOR. CELL DEATH & DISEASE[J]. 2020, 11(8): http://dx.doi.org/10.1038/s41419-020-02833-y.
[37] Yao, Bing, Liang, Mingming, Liu, Hongmei, Sui, Tingting, Song, Yuning, Zhang, Yuxin, Deng, Jichao, Xu, Yuxin, Lai, Liangxue, Li, Zhanjun. The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation. RNA BIOLOGY[J]. 2020, 17(5): 623-629, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237162/.
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（ 1 ） 基于条件性表达Cas9基因修饰猪的原发性肿瘤模型建立, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 神经、免疫、肝脏和血液系统疾病干细胞治疗大动物模型的建立, 负责人, 地方任务, 2015-06--2018-05
（ 3 ） 南粤百杰人才项目, 负责人, 地方任务, 2013-06--2018-06
（ 4 ） 神经疾病大动物模型的建立及干细胞治疗评价, 负责人, 国家任务, 2017-07--2022-06
（ 5 ） 神经退行性疾病转基因猪模型的构建及其大脑代谢调控机制的研究, 负责人, 地方任务, 2017-05--2020-06
（ 6 ） 利用基因打靶猪模型对受磷蛋白突变心肌病进行干细胞治疗的临床前研究, 负责人, 中国科学院计划, 2016-03--2018-12
（ 7 ） 基于猪等大动物的肾脏异体再造, 负责人, 中国科学院计划, 2017-10--2021-12
（ 8 ） 人源化大动物模型的构建与应用, 负责人, 地方任务, 2018-12--2021-12
（ 9 ） 胶质细胞对神经退行性疾病大动物模型脑病理的作用, 参与, 国家任务, 2019-01--2023-12
（ 10 ） 基因编辑猪重大脑疾病模型的制备与研究, 参与, 地方任务, 2020-04--2023-03
（ 11 ） 五指山猪实验动物模式化研究, 负责人, 地方任务, 2021-01--2023-12

已指导学生

杨化强  博士研究生  071010-生物化学与分子生物学  

汤江静  硕士研究生  071010-生物化学与分子生物学  

邓为  博士研究生  071009-细胞生物学  

蔡杰  硕士研究生  071010-生物化学与分子生物学  

钟娟  硕士研究生  071010-生物化学与分子生物学  

宋军  博士研究生  071010-生物化学与分子生物学  

颜泉梅  博士研究生  071010-生物化学与分子生物学  

张辉  博士研究生  071010-生物化学与分子生物学  

易小玲  硕士研究生  085238-生物工程  

刘涛  硕士研究生  430139-生物工程  

黄姣  博士研究生  071010-生物化学与分子生物学  

赖思思  硕士研究生  085238-生物工程  

江飞  硕士研究生  071008-发育生物学  

魏姝  博士研究生  071008-发育生物学  

周小青  博士研究生  071008-发育生物学  

王可品  博士研究生  071008-发育生物学  

吴涵  博士研究生  071008-发育生物学  

李黎  博士研究生  071008-发育生物学  

彭江云  硕士研究生  085238-生物工程  

阮德功  博士研究生  071010-生物化学与分子生物学  

侯凯丽  硕士研究生  085238-生物工程  

王晓民  博士研究生  071008-发育生物学  

栗楠  博士研究生  071008-发育生物学  

刘琪帅  博士研究生  071008-发育生物学  

石惠  硕士研究生  085238-生物工程  

金琴  博士研究生  071008-发育生物学  

葛维凯  博士研究生  071008-发育生物学  

陈方兵  博士研究生  071008-发育生物学  

谢精科  博士研究生  071008-发育生物学  

黄兴云  硕士研究生  085238-生物工程  

李莹莹  博士研究生  071009-细胞生物学  

苟士学  博士研究生  071008-发育生物学  

梁艳慧  博士研究生  071008-发育生物学  

蓝婷  博士研究生  071008-发育生物学  

石惠  博士研究生  071008-发育生物学  

现指导学生

庄镇鹏  博士研究生  071008-发育生物学  

陈晃耀  博士研究生  071008-发育生物学  

王教伟  博士研究生  071008-发育生物学  

刘晓艺  博士研究生  071008-发育生物学  

李磊  博士研究生  071008-发育生物学  

赵筱竹  博士研究生  071010-生物化学与分子生物学  

夏聪  硕士研究生  071010-生物化学与分子生物学  

琚嘉璐  硕士研究生  071008-发育生物学  

邓玮悦  博士研究生  071008-发育生物学  

陈梦琪  博士研究生  071008-发育生物学  

朱登轩  硕士研究生  071008-发育生物学  

杨元溪  硕士研究生  071008-发育生物学  

穆双双  硕士研究生  071008-发育生物学