基本信息
赖良学  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: lai_liangxue@gibh.ac.cn
通信地址: 广州市萝岗区开源大道190号
邮政编码: 510530

招生信息

   
招生专业
071008-发育生物学
招生方向
动物克隆与胚胎干细胞

教育背景

1992-09--1995-07   东北农业大学生物工程系   理学博士

工作经历

   
工作简历
2007-12~现在, 中国科学院广州生物医药与健康研究院, 研究员
2006-07~2007-12,美国先进生殖治疗中心, Senior embryologist
2004-07~2006-07,美国密苏里大学国家猪资源保护与研究中心, 研究助理教授
2002-07~2004-07,美国密苏里大学动物研究中心, 研究助理教授
1998-07~2002-07,美国密苏里大学动物研究中心, 博士后
1995-07~1997-07,解放军农牧大学军事兽医研究所转基因动物实验室, 博士后 

专利与奖励

   
奖励信息
(1) 猪基因突变技术创新及基因修饰猪模型的建立, 一等奖, 省级, 2016
(2) 大动物基因修饰技术研究及基因修饰动物模型的建立, 一等奖, 市地级, 2013
(3) 国务院政府特殊津贴, , 国家级, 2011
专利成果
[1] 赖良学, 周娟娟, 廖媛. WAS基因的gRNA及其应用. CN: CN111808859A, 2020-10-23.

[2] 李莹莹, 樊娜娜, 赖良学. 一种sgRNA及其构建的CREBRF点图变型巴马香猪和应用. CN: CN110862988A, 2020-03-06.

[3] 赖良学, 王可品, 葛维凯, 刘琪帅, 谢精科. 一种重度免疫缺陷猪模型及其构建方法和应用. CN: CN109777834A, 2019-05-21.

[4] 闫森, 李晓江, 赖良学, 李世华. 人亨廷顿基因敲入用重组载体及其构建方法和在模型猪构建中的应用. CN: CN107988256A, 2018-05-04.

[5] 赖良学. 使用表达Cre依赖的Cas9基因的哺乳动物进行基因修饰和疾病建模的方法. CN: CN107739739A, 2018-02-27.

[6] 樊娜娜, 韩凯, 赖良学. 无毛模型猪的重构卵及其构建方法和模型猪的构建方法. CN: CN106957856A, 2017-07-18.

[7] 赖良学. 人源化基因编辑哺乳动物的制备方法及其用途. CN: CN106866813A, 2017-06-20.

[8] 赖良学, 信吉阁, 杨化强, 邹庆剑, 樊娜娜. 白化病模型猪的重构卵及其构建方法和模型猪的构建方法. CN: CN104263754A, 2015-01-07.

[9] 裴端卿, 米盖尔·埃斯特班, 徐建勇, 赖良学, 杨佳银, 彭梅秀. 用猪成纤维细胞生成诱导的多能性干细胞的方法. CN: CN101613717A, 2009-12-30.

出版信息

   
发表论文
(1) Development of a rabbit model of Wiskott-Aldrich syndrome, FASEB JOURNAL, 2021, 通讯作者
(2) CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, MOLECULAR THERAPY, 2021, 通讯作者
(3) Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide, SCIENCE CHINA-LIFE SCIENCES, 2021, 通讯作者
(4) CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia, Journal of Biological Chemistry, 2021, 第 13 作者
(5) A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems, JOURNAL OF GENETICS AND GENOMICS, 2021, 通讯作者
(6) Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, Journal of Genetics and Genomics, 2021, 通讯作者
(7) CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations, MOLECULAR THERAPY-NUCLEIC ACIDS, 2020, 通讯作者
(8) CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen, GENES, 2020, 通讯作者
(9) AcrIIA5 Suppresses Base Editors and Reduces Their Off-Target Effects, CELLS, 2020, 通讯作者
(10) 糖尿病和心血管病相关的重要靶点基因PPARγ过表达转基因克隆猪模型的建立, Establishment of transgenic pig model of PPAR γ overexpression,an important target gene related to diabetes mellitus and cardiovascular disease, 中国兽医学报, 2020, 第 8 作者
(11) Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System, MOLECULAR THERAPY-NUCLEIC ACIDS, 2020, 通讯作者
(12) Robustly improved base editing efficiency of Cpf1 base editor using optimized cytidine deaminases, CELL DISCOVERY, 2020, 通讯作者
(13) 神经退行性疾病转基因猴模型的构建及相关技术体系建立, Construction of a transgenic monkey model of neurodegenerative diseases and establishment of its related technical system, 畜牧与兽医, 2020, 第 10 作者
(14) Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses, JOURNAL OF IMMUNOLOGY, 2020, 通讯作者
(15) JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency, NATURE COMMUNICATIONS, 2020, 第 32 作者
(16) Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation, Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation, JOURNAL OF GENETICS AND GENOMICS, 2020, 通讯作者
(17) The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation, RNA BIOLOGY, 2020, 通讯作者
(18) A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR, CELL DEATH & DISEASE, 2020, 通讯作者
(19) ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, BMC BIOLOGY, 2020, 通讯作者
(20) Efficient base editing with high precision in rabbits using YFE-BE4max, CELL DEATH & DISEASE, 2020, 通讯作者
(21) 利用TALEN系统对兔进行Tiki1基因敲除, Gene knockout of Tiki1 gene in rabbit by TALEN system, 华南农业大学学报, 2020, 第 8 作者
(22) Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions, BMC BIOLOGY, 2020, 通讯作者
(23) Highly efficient base editing with expanded targeting scope using SpCas9-NG in rabbits, FASEB JOURNAL, 2020, 通讯作者
(24) 利用CRISPR/Cas9系统构建TiKi1和TiKi2双基因敲除兔, Buiding a TiKi2 and TiKi1 knockout rabbit model using the CRISPR/Cas9 system, 畜牧与兽医, 2020, 第 8 作者
(25) LMNA -mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy, AGING AND DISEASE, 2019, 通讯作者
(26) 利用TALEN技术构建猪内源性基因Tiki1打靶猪模型, Construction of Porcine Endogenous Gene Tiki1 Targeted Pig(Sus scrofa)Model Using TALEN Technology, 农业生物技术学报, 2019, 第 8 作者
(27) Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 通讯作者
(28) 利用CRISPR/Cas9系统构建Tiki1基因修饰猪模型, Construction of Tiki1 Gene Modified Pig Model by CRISPR/Cas9 System, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2019, 通讯作者
(29) Mutations of GADD45G in rabbits cause cleft lip by the disorder of proliferation, apoptosis and epithelial-mesenchymal transition (EMT), BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2019, 通讯作者
(30) Efficient base editing for multiple genes and loci in pigs using base editors, Nature Communications, 2019, 通讯作者
(31) Genome editing in large animals:current status and future prospects, Genome editing in large animals:current status and future prospects, 国家科学评论:英文版, 2019, 第 2 作者
(32) Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing (vol 10, 1817, 2019), NATURE COMMUNICATIONS, 2019, 第 10 作者
(33) Establishment of Porcine and Human Expanded Potential StemCells, NATURE CELL BIOLOGY, 2019, 第 40 作者
(34) The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits, FASEB JOURNAL, 2019, 通讯作者
(35) Circular RNA profile in liver tissue of EpCAM knockout mice, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 通讯作者
(36) 生物医药研究里程碑式突破, 前沿科学, 2019, 第 1 作者
(37) Efficient base editing with expanded targeting scope using an engineered Spy-mac Cas9 variant, CELL DISCOVERY, 2019, 通讯作者
(38) Mutations of GADD45G in rabbits cause cleft lip by the disorder of proliferation, apoptosis and epithelial-mesenchymal transition (EMT), BBA - Molecular Basis of Disease, 2019, 通讯作者
(39) 利用CRISPR/Cas9系统构建Tiki1基因修饰猪模型, Construction of Tiki1 Gene Modified Pig Model by CRISPR/Cas9 System, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2019, 通讯作者
(40) Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7), CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 通讯作者
(41) Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing, Nature Communications, 2019, 第 10 作者
(42) DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture, JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 第 7 作者
(43) Efficient and precise base editing in rabbits using human APOBEC3A-nCas9 fusions, CELL DISCOVERY, 2019, 通讯作者
(44) XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, STEM CELL REPORTS, 2018, 通讯作者
(45) Xist derepression in active x chromosome hinders pig somatic cell nuclear transfer(article), Stem cell reports, 2018, 
(46) Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit, DISEASE MODELS & MECHANISMS, 2018, 通讯作者
(47) 异种移植相关功能蛋白人源化基因修饰猪模型的建立, 实用器官移植电子杂志, 2018, 第 5 作者
(48) 利用人工核酸酶构建基因编辑猪的研究进展, Progress in generation of gene-editing pigs by engineered endonucleases, 生命科学, 2018, 第 3 作者
(49) CRISPR-induced exon skipping is dependent on premature termination codon mutations, GENOME BIOLOGY, 2018, 通讯作者
(50) Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbits, EBIOMEDICINE, 2018, 通讯作者
(51) Highly efficient RNA-guided base editing in rabbit, NATURE COMMUNICATIONS, 2018, 通讯作者
(52) Engineering crispr/cpf1 with trna promotes genome editing capability in mammalian systems, CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 通讯作者
(53) Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer, JOURNAL OF GENETICS AND GENOMICS, 2018, 通讯作者
(54) A huntingtin knock-in pig model recapitulates features of selective neurodegeneration in Huntington’s disease, CELL, 2018, 通讯作者
(55) BMI1 enables interspecies chimerism with human pluripotent stem cells, NATURE COMMUNICATIONS, 2018, 第 27 作者
(56) 基因修饰工具猪模型的建立及应用, Establishment and application of genetically modified pig tool models, 中国实验动物学报, 2017, 第 4 作者
(57) Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9, STEM CELL RESEARCH, 2017, 第 9 作者
(58) CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency, SCIENTIFIC REPORTS, 2017, 第 14 作者
(59) Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation, CELL BIOLOGY INTERNATIONAL, 2017, 通讯作者
(60) Generation of two MEN1 knockout lines from a human embryonic stem cell line, STEM CELL RESEARCH, 2017, 其他(合作组作者)
(61) 恒河猴慢性颞叶癫痫模型的构建, Establishment of a rhesus monkey model of chronic temporal lobe epilepsy, 中华神经医学杂志, 2017, 其他(合作组作者)
(62) Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, GENOME RESEARCH, 2017, 通讯作者
(63) Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells, STEM CELL REPORTS, 2017, 第 24 作者
(64) Deficiency of cholesteryl ester transfer protein protects against atherosclerosis in rabbits, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017, 第 15 作者
(65) Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum - relevance to xenotransplantation, XENOTRANSPLANTATION, 2017, 第 14 作者
(66) Generation of three miR-122 knockout lines from a human embryonic stem cell line, STEM CELL RESEARCH, 2017, 第 15 作者
(67) DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells, PLOS ONE, 2017, 第 16 作者
(68) CRISPR/Cas9-Mediated Mutation of alpha A-Crystallin Gene Induces Congenital Cataracts in Rabbits, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 通讯作者
(69) Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9, HUMAN MOLECULAR GENETICS, 2017, 通讯作者
(70) Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 通讯作者
(71) Mutation of the Sp1 binding site in the 5′ flanking region of SRY causes sex reversal in rabbits, ONCOTARGET, 2017, 通讯作者
(72) Identification and gene targeting of the ROSA26 locus in the rabbit genome, TRANSGENIC RESEARCH, 2016, 第 7 作者
(73) CRISPR/Cas9-mediated mutation of PHEX in rabbit recapitulates human X-linked hypophosphatemia (XLH), HUMAN MOLECULAR GENETICS, 2016, 通讯作者
(74) Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering, PLOS ONE, 2016, 第 14 作者
(75) Generation of an Abcc8 heterozygous mutation human embryonic stem cell line using CRISPR/Cas9, STEM CELL RESEARCH, 2016, 第 10 作者
(76) Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9, SCIENTIFIC REPORTS, 2016, 通讯作者
(77) Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, JOURNAL OF MOLECULAR CELL BIOLOGY, 2016, 通讯作者
(78) Generation of an Abcc8 homozygous mutation human embryonic stem cell line using CRISPR/Cas9, STEM CELL RESEARCH, 2016, 第 10 作者
(79) CRISPR/Cas9介导的基因激活系统诱导胚胎干细胞向胚外细胞谱系转换, Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators, SCIENTIFIC REPORTS, 2016, 第 9 作者
(80) Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer, CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 第 16 作者
(81) 融水小型猪的实验动物化系列研究概述, Brief report of series study on Rongshui miniature pig as laboratory animal, 中国比较医学杂志, 2015, 第 9 作者
(82) Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain, MOLECULAR NEURODEGENERATION, 2015, 第 16 作者
(83) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming, NATURE CELL BIOLOGY, 2015, 第 19 作者
(84) Reprogramming mature terminally differentiated adipocytes to induced pluripotent stem cells, SCIENCE BULLETIN, 2015, 通讯作者
(85) 基因修饰猪模型应用于人类健康的相关研究进展, Progress of Genetically-modified Pigs in the Human Health Related Research, 中国基础科学, 2015, 第 2 作者
(86) Faithful expression of imprinted genes in donor cells of SCNT cloned pigs, FEBS LETTERS, 2015, 第 8 作者
(87) Transgenic expression of human cytoxic T-lymphocyte associated antigen4-Immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting, TRANSGENIC RESEARCH, 2015, 第 16 作者
(88) 基于体细胞克隆的猪基因打靶技术研究进展, Gene-targeted pigs based on somatic cell cloning approaches, 生命科学, 2015, 第 2 作者
(89) ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells, HAEMATOLOGICA, 2015, 第 9 作者
(90) Generation of gene-target dogs using CRISPR/Cas9 system, JOURNAL OF MOLECULAR CELL BIOLOGY, 2015, 第 27 作者
(91) Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 第 10 作者
(92) TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain, HUMAN MOLECULAR GENETICS, 2014, 第 5 作者
(93) Transgenic pig models for human neurodegenerative diseases, TRANSGENIC RESEARCH, 2014, 第 1 作者
(94) Aberrant Expression of Xist in Aborted Porcine Fetuses Derived from Somatic Cell Nuclear Transfer Embryos, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 第 10 作者
(95) Direct Conversion of Human Fibroblasts into Neuronal Restricted Progenitors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 通讯作者
(96) Establishment of a Rabbit Oct4 Promoter-Based EGFP Reporter System, PLOS ONE, 2014, 第 10 作者
(97) Species-dependent neuropathology in transgenic SOD1 pigs, CELL RESEARCH, 2014, 第 18 作者
(98) Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing, CELL RESEARCH, 2014, 通讯作者
(99) RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency, JOURNAL OF IMMUNOLOGY, 2014, 通讯作者
(100) Effective gene targeting in rabbits using RNA-guided Cas9 nucleases, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第 5 作者
(101) Telomere Reprogramming and Maintenance in Porcine iPS Cells, PLoS ONE, 2013, 第11作者
(102) Generation of RAG 1-and 2-deficient rabbits by embryo microinjection of TALENs, CELL RESEARCH, 2013, 第 15 作者
(103) Piglets Cloned from Induced Pluripotent Stem Cells, CELL RESEARCH, 2013, 通讯作者
(104) Expression of Plant Sweet Protein Brazzein in the Milk of Transgenic Mice, PLOS ONE, 2013, 通讯作者
(105) Genetically Modified Pig Models for Human Diseases, JOURNAL OF GENETICS AND GENOMICS, 2013, 通讯作者
(106) c-kit expression profile and regulatory factors during spermatogonial stem cell differentiation, BMC DEVELOPMENTAL BIOLOGY, 2013, 第 5 作者
(107) Production of PPAR-gamma Knockout Pigs via Zinc-finger Nucleases and Nuclear Transfer Cloning, TRANSGENIC RESEARCH, 2013, 第 1 作者
(108) Dynamic expression pattern of PP1 gamma and its interacting protein Tctex5 during spermatogenesis, ASIA LIFE SCIENCES, 2013, 通讯作者
(109) Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs, PLOS ONE, 2013, 通讯作者
(110) Production of PPAR-gamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning, Cell Research, 2011, 通讯作者
(111) Establishment of a Porcine Oct-4 Promoter-Driven EGFP Reporter System for Monitoring Pluripotency of Porcine Stem Cells, Cell Reprogram, 2011, 第 1 作者
(112) 基因修饰猪作为人类疾病模型的研究进展, Progress on Studies of Genetically Modified Pigs for Human Disease Models, 科技导报, 2011, 第 2 作者
(113) Generation of PPAR-gamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning, CELL RESEARCH, 2011, 通讯作者
(114) Generation of PPARy mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning, Cell Research, 2011, 第 16 作者
(115) Establishment of a Porcine Oct-4 Promoter-Driven EGFP Reporter System for Monitoring Pluripotency of Porcine Stem Cells, CELLULAR REPROGRAMMING, 2011, 通讯作者
(116) Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear Transfer, PLOS ONE, 2011, 第 14 作者
(117) 基因修饰猪作为人类疾病模型的研究进展, Progress on Studies of Genetically Modified Pigs for Human Disease Models, 科技导报, 2011, 第 2 作者
(118) 转基因兔与克隆兔高效胚胎移植体系的建立, Establishment of Efficient Embryo Transfer System in Transgenic Rabbit and Cloned Rabbit production, 实验动物与比较医学, 2011, 第 4 作者
(119) A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts, CELL STEM CELL, 2010, 第 22 作者
(120) 西藏小型猪胚胎成纤维细胞的分离培养及性别鉴定, Isolation of Tibet Mini-pig Fetal Fibroblasts and Sexy Identification, 实用预防医学, 2010, 第 3 作者
(121) 西藏小型猪胚胎成纤维细胞的分离培养及性别鉴定, Isolation of Tibet Minipig Fetal Fibroblasts and Sexy Identification, 中国比较医学杂志, 2010, 第 3 作者
(122) Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs, HUMAN MOLECULAR GENETICS, 2010, 通讯作者
(123) Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 其他(合作组作者)
(124) Nuclear reprosramming by nuclear transplantation and defined transcription factors, Nuclear reprosramming by nuclear transplantation and defined transcription factors, 中国科学通报:英文版, 2009, 第 3 作者
(125) 体细胞核移植诱导的表观遗传学变化, Epigenetic modification related to somatic nuclear transfer, 生命科学, 2009, 第 4 作者
(126) Nuclear reprogramming by nuclear transplantation and defined transcription factors, CHINESE SCIENCE BULLETIN, 2009, 第 3 作者
(127) 克隆猪技术及其在转基因猪研究中的应用, The applications of nuclear transfer technology in production of transgenic pigs, 生命科学, 2009, 第 3 作者
(128) Generation of cloned transgenic pigs rich in omega-3 fatty acids, NATURE BIOTECHNOLOGY, 2006, 
(129) α -1,3-galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutations., 2004, 第 1 作者
(130) Production of α -1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning, Science, 2002, 第 1 作者
(131) Large fragment deletions induced by Cas9 cleavage while not in BEs system, Molecular Therapy - Nucleic Acids, 第 6 作者
(132) A tunable, rapid and precision drug control of protein expression by combining transcriptional and post-translational regulation system, Journal of Genetics and Genomics, 第 8 作者
(133) Establishment of a Porcine Oct-4 Promoter-Driven EGFP Reporter System for Monitoring Pluripotency of Porcine Stem Cells, 

科研活动

   
科研项目
( 1 ) 基于条件性表达Cas9基因修饰猪的原发性肿瘤模型建立, 负责人, 国家任务, 2017-01--2020-12
( 2 ) 神经、免疫、肝脏和血液系统疾病干细胞治疗大动物模型的建立, 负责人, 地方任务, 2015-06--2018-05
( 3 ) 南粤百杰人才项目, 负责人, 地方任务, 2013-06--2018-06
( 4 ) 神经疾病大动物模型的建立及干细胞治疗评价, 负责人, 国家任务, 2017-07--2022-06
( 5 ) 神经退行性疾病转基因猪模型的构建及其大脑代谢调控机制的研究, 负责人, 地方任务, 2017-05--2020-06
( 6 ) 利用基因打靶猪模型对受磷蛋白突变心肌病进行干细胞治疗的临床前研究, 负责人, 中国科学院计划, 2016-03--2018-12
( 7 ) 基于猪等大动物的肾脏异体再造, 负责人, 中国科学院计划, 2017-10--2021-12
( 8 ) 人源化大动物模型的构建与应用, 负责人, 地方任务, 2018-12--2021-12
( 9 ) 胶质细胞对神经退行性疾病大动物模型脑病理的作用, 参与, 国家任务, 2019-01--2023-12
( 10 ) 基因编辑猪重大脑疾病模型的制备与研究, 参与, 地方任务, 2020-04--2023-03
( 11 ) 五指山猪实验动物模式化研究, 负责人, 地方任务, 2021-01--2023-12

指导学生

已指导学生

杨化强  博士研究生  071010-生物化学与分子生物学  

汤江静  硕士研究生  071010-生物化学与分子生物学  

邓为  博士研究生  071009-细胞生物学  

蔡杰  硕士研究生  071010-生物化学与分子生物学  

钟娟  硕士研究生  071010-生物化学与分子生物学  

宋军  博士研究生  071010-生物化学与分子生物学  

颜泉梅  博士研究生  071010-生物化学与分子生物学  

张辉  博士研究生  071010-生物化学与分子生物学  

易小玲  硕士研究生  085238-生物工程  

刘涛  硕士研究生  430139-生物工程  

黄姣  博士研究生  071010-生物化学与分子生物学  

赖思思  硕士研究生  085238-生物工程  

江飞  硕士研究生  071008-发育生物学  

魏姝  博士研究生  071008-发育生物学  

周小青  博士研究生  071008-发育生物学  

王可品  博士研究生  071008-发育生物学  

吴涵  博士研究生  071008-发育生物学  

李黎  博士研究生  071008-发育生物学  

彭江云  硕士研究生  085238-生物工程  

阮德功  博士研究生  071010-生物化学与分子生物学  

侯凯丽  硕士研究生  085238-生物工程  

王晓民  博士研究生  071008-发育生物学  

栗楠  博士研究生  071008-发育生物学  

刘琪帅  博士研究生  071008-发育生物学  

石惠  硕士研究生  085238-生物工程  

金琴  博士研究生  071008-发育生物学  

葛维凯  博士研究生  071008-发育生物学  

陈方兵  博士研究生  071008-发育生物学  

谢精科  博士研究生  071008-发育生物学  

黄兴云  硕士研究生  085238-生物工程  

李莹莹  博士研究生  071009-细胞生物学  

苟士学  博士研究生  071008-发育生物学  

梁艳慧  博士研究生  071008-发育生物学  

蓝婷  博士研究生  071008-发育生物学  

石惠  博士研究生  071008-发育生物学  

现指导学生

庄镇鹏  博士研究生  071008-发育生物学  

陈晃耀  博士研究生  071008-发育生物学  

王教伟  博士研究生  071008-发育生物学  

刘晓艺  博士研究生  071008-发育生物学  

李磊  博士研究生  071008-发育生物学  

赵筱竹  博士研究生  071010-生物化学与分子生物学  

夏聪  硕士研究生  071010-生物化学与分子生物学  

琚嘉璐  硕士研究生  071008-发育生物学  

邓玮悦  博士研究生  071008-发育生物学  

陈梦琪  博士研究生  071008-发育生物学  

朱登轩  硕士研究生  071008-发育生物学  

杨元溪  硕士研究生  071008-发育生物学  

穆双双  硕士研究生  071008-发育生物学