基本信息
惠利健 男 博导 中国科学院分子细胞科学卓越创新中心
电子邮件: huilab@sibcb.ac.cn
通信地址: 上海市岳阳路320号新生化细胞大楼915
邮政编码:
电子邮件: huilab@sibcb.ac.cn
通信地址: 上海市岳阳路320号新生化细胞大楼915
邮政编码:
招生信息
招生专业
071009-细胞生物学0710J6-再生医学
招生方向
肝脏疾病的分子病理机制
教育背景
1998-09--2003-08 中国科学院上海生命科学院上海细胞研究所 博士1992-09--1997-08 中国科学技术大学生物系 学士
工作经历
工作简历
2008-09~2011-07,中国科学院上海生命科学院上海生物化学和细胞研究所, 研究员2004-08~2008-08,奥地利维也纳Institute of Molecular Pathology (IMP), 博士后1998-09~2003-08,中国科学院上海生命科学院上海细胞研究所, 博士1992-09~1997-08,中国科学技术大学生物系, 学士
社会兼职
2012-07-01-2017-07-01,Journal of Biological Chemistry, 编委
2009-01-01-2016-08-31,中国细胞生物学学报编委,
2009-01-01-2016-08-31,中国细胞生物学学报编委,
专利与奖励
专利成果
( 1 ) Hepatocyte-like cells and uses thereof, 2016, 第 1 作者, 专利号: 13883748( 2 ) Human hepatocyte-like cells and uses thereof, 2015, 第 1 作者, 专利号: 特願2015-556390( 3 ) Human hepatocyte-like cells and uses thereof, 2014, 第 1 作者, 专利号: PCT/CN2014/071898( 4 ) 一种新的制备肝实质细胞的方法, 2013, 第 1 作者, 专利号: zl201010531420.4( 5 ) miRNA-27b在抗肿瘤耐药中的应用, 2013, 第 1 作者, 专利号: 201310368487.4( 6 ) 一种新的制备肝实质细胞的方法, 2013, 第 1 作者, 专利号: 201310050796.7( 7 ) Hepatocyte-like cells and uses thereof , 2011, 第 1 作者, 专利号: PCT/CN2011/001857
出版信息
发表论文
(1) 肝脏类器官的应用, Applications of liver organoids, 中国科学:生命科学, 2023, 第 4 作者(2) 肝癌细胞模型库及其药物基因组学“蓝图”, A Pharmacogenomic Landscape in Human Liver Cancers, 科学新闻, 2020, 第 59 作者(3) 一种由Arid1a蛋白介导的染色体可及性状态调控肝细胞对肝损伤相关的YAP信号的响应, A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, 科学新闻, 2020, 第 32 作者(4) A Pharmacogenomic Landscape in Human Liver Cancers, CANCER CELL, 2019, 第 33 作者 通讯作者(5) A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, CELL STEM CELL, 2019, 第 19 作者 通讯作者(6) Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., Nature Cell Biology, 2019, 第 1 作者 通讯作者(7) Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma, JOURNAL OF HEPATOLOGY, 2018, 第 14 作者 通讯作者(8) High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 第 9 作者 通讯作者(9) Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, STEM CELL REPORTS, 2017, 第 17 作者 通讯作者(10) Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 第 14 作者 通讯作者(11) Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, Hepatology, 2016, 第 1 作者 通讯作者(12) Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, CELL RESEARCH, 2016, 第 18 作者 通讯作者(13) Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, SCIENTIFIC REPORTS, 2016, 第 13 作者 通讯作者(14) Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I, SCIENTIFIC REPORTS, 2016, 第 14 作者 通讯作者(15) DUSP16 ablation arrests the cell cycle and induces cellular senescence, FEBS JOURNAL, 2015, 第 7 作者(16) miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression, CELL RESEARCH, 2015, 第 12 作者 通讯作者(17) Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, CELL STEM CELL, 2014, 第 19 作者 通讯作者(18) Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice, HEPATOLOGY, 2013, 第 6 作者 通讯作者(19) Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts, JOURNAL OF CELLULAR BIOCHEMISTRY, 2013, 第 3 作者 通讯作者(20) Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, NATURE CELL BIOLOGY, 2012, 第 12 作者 通讯作者(21) p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, CELL RESEARCH, 2012, 第 7 作者 通讯作者(22) Mitogen-activated protein kinases in hepatocellular carcinoma development, SEMINARS IN CANCER BIOLOGY, 2011, 第 3 作者 通讯作者(23) Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, NATURE, 2011, 第 9 作者 通讯作者(24) Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice, GASTROENTEROLOGY, 2010, 第 10 作者(25) Antagonistic control of cell fates by JNK and p38-MAPK signaling, CELL DEATH AND DIFFERENTIATION, 2008, (26) p38 alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, NATURE GENETICS, 2007, 第 1 作者(27) p38alpha: a suppressor of cell proiferation and tumorigenesis, Cell Cycle, 2007, 第 1 作者(28) Identification of Alternatively Spliced mRNA Isoforms Associated with Cancers by Genome-wide ESTs Alignment, Oncogene, 2004, 第 1 作者(29) Hepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 7 作者(30) Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation, THE JOURNAL OF CLINICAL INVESTIGATION, 第 1 作者
科研活动
科研项目
( 1 ) 肝脏损伤再生过程巨噬细胞对肝细胞重编程的作用和调控, 负责人, 国家任务, 2020-01--2024-12( 2 ) 肝脏再生过程细胞可塑性的分子调控机制研究, 负责人, 国家任务, 2017-01--2021-12