071003-生理学
100104-病理学与病理生理学

生理学-甲状腺激素调控代谢及甲状腺相关疾病的基础研究和转化研究
病理学与病理生理学-甲状腺激素调控代谢及甲状腺相关疾病的基础研究和转化研究

1996-09--2001-08   中科院上海细胞生物学研究所   博士
1992-09--1996-07   华东理工大学   学士

   

2020-04~现在, 中国科学院上海营养与健康研究所, 研究员，课题组长
2008-07~2020-03,中国科学院上海生命科学研究院营养科学研究所, 研究员，课题组长
2006-12~2008-07,National Institutes of Health, US, Staff Scientist
2001-12~2006-12,National Institutes of Health, US, 博士后
1996-09~2001-08,中科院上海细胞生物学研究所, 博士
1992-09~1996-07,华东理工大学, 学士

2023-01-01-今,中国病理生理学会第二届内分泌与代谢专业委员会, 委员
2021-09-29-今,上海市食品安全风险评估专家委员会产品安全专业委员会, 委员
2020-01-01-今,第二届国家食品安全风险评估专家委员会化学危害分委会, 委员
2019-12-01-今,上海市毒理学会, 副理事长
2019-05-22-今,中国食品卫生杂志, 编委会副主任委员
2018-01-01-今,Nutrition & Metabolism, 副主编
2017-01-01-今,Scientific Reports, 编委
2016-05-19-2020-05-20,中国生物化学与分子生物学会代谢专业委员会理事, 理事
2013-12-30-2017-12-29,《Biophysics Reports》编委, 编委
2013-02-01-今,中国生物物理学会脂代谢与生物能学分会, 理事

营养学

   

（1） 华夏医学科技奖, 三等奖, 其他, 2023
（2） 东方英才计划领军项目, 省级, 2022

（ 1 ） 增强细胞产热和治疗疾病的应用, 2023, 第 3 作者, 专利号: CN113648318B

（ 2 ） miR-378作为胆固醇稳态调控靶点的应用, 2022, 第 1 作者, 专利号: CN114788865A

（ 3 ） MAFG作为胆固醇稳态调控靶点的应用及其调控剂, 2022, 第 1 作者, 专利号: CN114788866A

（ 4 ） 工程改造的肝细胞, 2022, 第 4 作者, 专利号: CN114075573A

   

（1） Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m(6)A methylation and increasing the stability of SREBF1 and ChREBP mRNAs, JOURNAL OF MOLECULAR CELL BIOLOGY, 2023, 第 14 作者  通讯作者
（2） Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation, NUTRIENTS, 2023, 第 10 作者  通讯作者
（3） Adipocyte Thyroid Hormone beta Receptor-Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis, DIABETES, 2023, 第 22 作者  通讯作者
（4） Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism, NATURE COMMUNICATIONS, 2022, 第 21 作者  通讯作者
（5） Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication, DIABETES, 2022, 第 16 作者  通讯作者
（6） miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 10 作者
（7） Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor �� mediated adipocyte progenitor cell proliferation, NATURE COMMUNICATIONS, 2022, 第 23 作者  通讯作者
（8） High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption, NATURE METABOLISM, 2022, 第 14 作者
（9） l-Arabinose suppresses gluconeogenesis through modulating AMP-activated protein kinase in metabolic disorder mice, FOOD & FUNCTION, 2021, 第 12 作者
（10） Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice, MARINE DRUGS, 2021, 第 8 作者  通讯作者
（11） Functional ingredients present in whole-grain foods as therapeutic tools to counteract obesity: Effects on brown and white adipose tissues, TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2021, 第 5 作者
（12） Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis, THERANOSTICS, 2021, 第 16 作者  通讯作者
（13） miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle, EMBO REPORTS, 2021, 第 16 作者  通讯作者
（14） miR-130b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1, miR-130b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1, JOURNAL OF MOLECULAR CELL BIOLOGY, 2021, 第 15 作者  通讯作者
（15） Activation of GCN2/ATF4 signals in amygdalar PKC-delta neurons promotes WAT browning under leucine deprivation, NATURE COMMUNICATIONS, 2020, 第 7 作者
（16） Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening, AUTOPHAGY, 2020, 第 11 作者
（17） Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling, MOLECULAR METABOLISM, 2020, 第 8 作者
（18） MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism, NATURE METABOLISM, 2020, 第 16 作者
（19） Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice, DIABETES, 2019, 第 16 作者
（20） Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes, CELL REPORTS, 2019, 第 13 作者
（21） Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis, NATURE COMMUNICATIONS, 2019, 第 12 作者
（22） Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients, FRONTIERS IN ENDOCRINOLOGY, 2019, 第 5 作者
（23） Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice, DIABETES, 2019, 第 16 作者
（24） Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals, Molecular Metabolism, 2019, 第 15 作者
（25） Elevated serum neuregulin 4 levels in patients with hyperthyroidism, ENDOCRINE CONNECTIONS, 2019, 第 8 作者
（26） Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle, JOURNALOFAGRICULTURALANDFOODCHEMISTRY, 2019, 第 9 作者  通讯作者
（27） Phosphorylation and Enzymatic Hydrolysis with Alcalase and Papain Effectively Reduce Allergic Reactions to Gliadins in Normal Mice, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 第 9 作者
（28） SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity, DIABETES, 2018, 第 11 作者
（29） Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 第 11 作者  通讯作者
（30） Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 第 11 作者  通讯作者
（31） Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity, PLOS BIOLOGY, 2018, 第 19 作者  通讯作者
（32） Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator inHepatic Differentiation of Human Pluripotent Stem Cells, STEM CELL REPORTS, 2018, 第 12 作者
（33） miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-��/Smad Signaling Pathway in Skeletal Muscle Fibrosis, MOLECULAR THERAPY - NUCLEIC ACIDS, 2018, 第 6 作者
（34） microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 20 作者  通讯作者
（35） Effect of V-Pits on the Property of GaN Epilayer Grown by Metalorganic Chemical Vapor Deposition, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2018, 
（36） Effects of functional ��-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 第 11 作者  通讯作者
（37） miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-beta/Smad Signaling Pathway in Skeletal Muscle Fibrosis, MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 第 6 作者  通讯作者
（38） Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 第 11 作者  通讯作者
（39） RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice, CELL REPORTS, 2017, 第 9 作者
（40） RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, CELL DEATH AND DIFFERENTIATION, 2017, 第 13 作者
（41） ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure, DIABETES, 2017, 第 8 作者
（42） miR-146a-5p acts as a negative regulator of TGF-�� signaling in skeletal muscle after acute contusion, Acta Biochimica et Biophysica Sinica, 2017, 第 7 作者
（43） Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBP�� during early adipocyte differentiation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 16 作者  通讯作者
（44） Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet, NUTRIENTS, 2017, 第 11 作者
（45） Deficiency of p38 in macrophage ameliorates d-galactosamine/TNF--induced acute liver injury in mice, FEBS JOURNAL, 2017, 第 12 作者  通讯作者
（46） microRNA and thyroid hormone signaling in cardiac and skeletal muscle, CELL AND BIOSCIENCE, 2017, 第 8 作者  通讯作者
（47） microRNA and thyroid hormone signaling in cardiac and skeletal muscle, CELL & BIOSCIENCE, 2017, 第 8 作者
（48） miR-146a-5p acts as a negative regulator of TGF-beta signaling in skeletal muscle after acute contusion, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 第 7 作者  通讯作者
（49） Circulating microRNA-1a is a biomarker of Graves' disease patients with atrial fibrillation, ENDOCRINE, 2017, 第 9 作者
（50） miR-146a-5p acts as a negative regulator of TGF-β signaling in skeletal muscle after acute contusion, miR-146a-5p acts as a negative regulator of TGF-�� signaling in skeletal muscle after acute contusion, 生物化学与生物物理学报：英文版, 2017, 第 7 作者
（51） An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity, AUTOPHAGY, 2017, 第 9 作者
（52） AICAR enhances insulin signaling via downregulation of miR-29, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2016, 第 7 作者  通讯作者
（53） Prevention of Muscle Wasting by CRISPR/Cas9-mediated Disruption of Myostatin In Vivo, MOLECULAR THERAPY, 2016, 第 12 作者
（54） CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 第 15 作者  通讯作者
（55） miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle, CELL REPORTS, 2016, 第 25 作者  通讯作者
（56） A Self-restricted CRISPR System to Reduce Off-target Effects, MOLECULAR THERAPY, 2016, 第 5 作者
（57） Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach, PROSTAGLANDINS AND OTHER LIPID MEDIATORS, 2015, 第 10 作者
（58） Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis, ONCOTARGET, 2015, 第 15 作者
（59） Hypoxia-inducible miR-182 enhances HIF1�� signaling via targeting PHD2 and FIH1 in prostate cancer, SCIENTIFIC REPORTS, 2015, 第 13 作者
（60） High salt primes a specific activation state of macrophages, M(Na), CELLRESEARCH, 2015, 第 17 作者
（61） Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach, PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2015, 第 10 作者  通讯作者
（62） Hepatic p38 alpha regulates gluconeogenesis by suppressing AMPK, JOURNAL OF HEPATOLOGY, 2015, 第 12 作者  通讯作者
（63） Hepatic p38�� regulates gluconeogenesis by suppressing AMPK., J Hepatol., 2015, 第 1 作者  通讯作者
（64） Hypoxia-inducible miR-182 enhances HIF1 alpha signaling via targeting PHD2 and FIH1 in prostate cancer, SCIENTIFIC REPORTS, 2015, 第 13 作者
（65） "Micro-managers' of hepatic lipid metabolism and NAFLD, WILEY INTERDISCIPLINARY REVIEWS-RNA, 2015, 第 5 作者  通讯作者
（66） Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver, CELL AND BIOSCIENCE, 2014, 第 11 作者
（67） Hepatic miR-378 targets p110�� and controls glucose and lipid homeostasis by modulating hepatic insulin signalling., Nat Commun, 2014, 第 1 作者  通讯作者
（68） Thyroid Hormone Receptor Coregulators in Metabolic Regulation., J Endocrinol Diabetes Obes, 2014, 第 1 作者  通讯作者
（69） Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients, MOLECULAR THERAPY-NUCLEIC ACIDS, 2014, 第 11 作者  通讯作者
（70） Hepatic miR-378 targets p110 alpha and controls glucose and lipid homeostasis by modulating hepatic insulin signalling, NATURE COMMUNICATIONS, 2014, 第 15 作者  通讯作者
（71） Analysis of microRNA expression profile induced by AICAR in mouse hepatocytes, GENE, 2013, 第 3 作者
（72） Antibacterial susceptibility patterns and characterization of clinical isolates of Elizabethkingia meningoseptica in Henan province, China, APPLIED MECHANICS AND MATERIALS, 2013, 第 2 作者
（73） Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity, DIABETOLOGIA, 2013, 第 13 作者
（74） Attenuation of p38-Mediated miR-1/133 Expression Facilitates Myoblast Proliferation during the Early Stage of Muscle Regeneration, PLOS ONE, 2012, 第 14 作者
（75） Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice, JOURNAL OF HEPATOLOGY, 2012, 第 13 作者  通讯作者
（76） Recent progress in the study of brown adipose tissue, CELL & BIOSCIENCE, 2011, 第 4 作者
（77） Recent progress in the study of brown adipose tissue, CELL AND BIOSCIENCE, 2011, 第 4 作者  通讯作者
（78） Thyroid hormone action in metabolic regulation, Thyroid hormone action in metabolic regulation, PROTEIN & CELL, 2011, 第 3 作者  通讯作者
（79） Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms, MOLECULAR ENDOCRINOLOGY, 2009, 
（80） The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer, ONCOGENE, 2008, 
（81） Impaired adipogenesis caused by a mutated thyroid hormone alpha 1 receptor, MOLECULAR AND CELLULAR BIOLOGY, 2007, 第 1 作者
（82） Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression, JOURNAL OF CLINICAL INVESTIGATION, 2006, 第 1 作者
（83） Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 
（84） Dual Functions of the Steroid Hormone Receptor Coactivator 3 in Modulating Resistance to Thyroid Hormone, MOLECULAR AND CELLULAR BIOLOGY, 2005, 
（85） Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis, CANCER RESEARCH, 2003, 
（86） Thyroid hormone regulates muscle fiber type conversion via miR-133a1, THE JOURNAL OF CELL BIOLOGY, 第 0 作者
（87） miR-24 and miR-122 negatively regulate transforming growth factor-��/Smad signaling pathway in skeletal muscle fibrosis, MOLECULAR THERAPY - NUCLEIC ACIDS, 第 6 作者

   

（ 1 ） 营养素及其代谢物调控重要器官发育与稳态的信号网, 负责人, 国家任务, 2023-12--2028-11
（ 2 ） 中内胚层组织器官间互作对损伤修复中干细胞命运的转录调控研究, 负责人, 国家任务, 2021-12--2026-06
（ 3 ） 产热激素三碘甲状腺原氨酸调控棕色脂肪祖细胞状态和命运的机制研究, 负责人, 国家任务, 2021-01--2026-12
（ 4 ） 甲状腺激素通过调节胆汁酸组成参与组织间的互作及代谢稳态维持的研究, 负责人, 国家任务, 2020-01--2023-12
（ 5 ） 微小RNA介导的甲状腺激素对肝脏胆固醇代谢及胆汁酸合成途径的调控作用及机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 6 ） 空间微重力环境对骨骼肌影响的生物学基础, 负责人, 中国科学院计划, 2018-10--2022-12
（ 7 ） 减肥降脂候选药物TRβ激动剂的研发, 负责人, 中国科学院计划, 2018-01--2019-12
（ 8 ） 环境与遗传致病因素导致2型糖尿病发生发展的机制研究, 负责人, 国家任务, 2016-09--2020-12
（ 9 ） 脂滴及相关蛋白质机器与脂质的储存与水解, 参与, 国家任务, 2016-06--2020-12
（ 10 ） 甲状腺激素作用与代谢调控, 负责人, 国家任务, 2016-01--2020-12
（ 11 ） 配体依赖的辅助抑制因子调控脂肪分化与代谢的作用及机制研究, 负责人, 国家任务, 2014-01--2017-12
（ 12 ） 骨骼肌中受甲状腺激素调控的微RNA的功能鉴定和机制研究, 负责人, 国家任务, 2011-01--2013-12
（ 13 ） 细胞膜重要脂质代谢产物对重大疾病病理生理过程的调控, 负责人, 国家任务, 2010-01--2014-12
（ 14 ） 新 PPARg 辅助因子在脂肪细胞分化和脂代谢中的功能研究, 负责人, 国家任务, 2010-01--2012-12
（ 15 ） 脂质代谢关键蛋白质的功能与调控机制, 参与, 国家任务, 2009-01--2013-12
（ 16 ） 中科院****, 负责人, 中国科学院计划, 2008-09--2010-12

（1）促进白色脂肪棕色化的新靶点-p38   中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议   2018-10-25
（2）甲状腺激素通过微小RNA调控能量代谢的机制   2018营养、能量代谢和肥胖研讨会暨中国营养学会基础营养学分会年会   2018-10-17
（3）p38MAPK in metabolic regulation-Lessons from conditional knockout mice   2018-04-01
（4）MicroRNA Functions in Metabolic Remodeling   国际肿瘤综合疗法探索与发展论坛   2018-01-28
（5）The effects of thyroid hormone regulated-miRNA on skeletal muscle   2017-09-26
（6）p38MAPK in metabolic regulationLessons from conditional knockout mice   2017-09-15
（7）New insight into thyroid hormone action   2017-09-08
（8）Thyroid hormone regulated-microRNA in cholesterol metabolism   2017-06-29
（9）p38MAPK in metabolic regulationLessons from conditional knockout mice.    2017-06-27
（10）miR-182 regulates metabolic homeostasis by modulating glucose utilization in muscle   2016-07-01
（11）Molecular mechanisms underlying the thyroid hormone action   2015-12-18
（12）Thyroid hormone regulatory network-based drug discovery.   2015-11-20
（13）miRNA-133a1 mediates thyroid hormone action on the metabolic phenotype of skeletal muscle   2015-06-28
（14）miR-378 in hepatic glucose and lipid metabolism.    2015-05-14