071010-生物化学与分子生物学

细胞微环境对肿瘤发生及转移的调控

1996-09--2001-08   中国科学院生物化学研究所   博士
1992-08--1996-08   南京大学   理学学士学位

   

2007-12~现在, 中科院上海生化细胞所, 研究员
2002-10~2007-11,美国威斯康星大学麦迪逊分校, Scientist/博士后
2001-12~2002-09,美国田纳西大学健康科学中心, 博士后
2001-09~2001-11,中科院上海生化细胞所, 助理研究员
1996-09~2001-08,中国科学院生物化学研究所, 博士
1992-08~1996-08,南京大学, 理学学士学位

2020-01-01-今,中国细胞生物学学会细胞结构和行为专业分会, 委员
2019-09-01-今,上海市生物化学与分子生物学学会, 常务理事
2019-06-01-今,中国生理学会基质生物学专业委员会, 副主任委员
2017-04-01-今,中国细胞生物学学会肿瘤细胞生物学分会, 委员
2014-03-01-今,Acta Biochimica et Biophysica Sinica, 编委

分子肿瘤学
细胞生物学

   

（1） Basement membrane promotes tumor development by attenuating T cell activation, Journal of Molecular Cell Biology, 2022, 通讯作者
（2） Integrin alpha E beta 7(+) T cells direct intestinal stem cell fate decisions via adhesion signaling, CELL RESEARCH, 2021, 第 14 作者
（3） Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries, HEPATOLOGY, 2021, 第 8 作者
（4） Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis, Cell Death & Disease, 2021, 通讯作者
（5） A mutation that blocks integrin alpha(4)beta(7) activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis, BMC BIOLOGY, 2020, 第 8 作者
（6） The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, CELL DEATH & DISEASE, 2020, 其他（合作组作者）
（7） Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers, Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers, CELL RESEARCH, 2019, 第 16 作者
（8） Progress of Extracellular Matrix., Chin J Cell Biol, 2019, 通讯作者
（9） Dual function of VGLL 4 in muscle regeneration, The EMBO Journal, 2019, 其他（合作组作者）
（10） Complexity of type IV collagens: from network assembly to function, BIOLOGICAL CHEMISTRY, 2019, 通讯作者
（11） Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., Immunity, 2018, 第 1 作者
（12） FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis, PLoS Biology, 2018, 通讯作者
（13） Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLOS GENETICS, 2018, 通讯作者
（14） Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation, The Journal of Cell Biology, 2018, 第 6 作者
（15） 细胞外基质与肿瘤相关成纤维细, 生物化学与生物物理进展, 2017, 通讯作者
（16） Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1., PLoS Genetics, 2015, 第 9 作者
（17） C/EBP Mediates TNF--Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK, JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 通讯作者
（18） Targeting type I. phosphatidylinositol phosphate kinase inhibits breast cancer metastasis, ONCOGENE, 2015, 
（19） Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, NATURE COMMUNICATIONS, 2014, 其他（合作组作者）
（20） Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 通讯作者
（21） Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 通讯作者
（22） Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 4 作者
（23） Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis, CANCER MICROENVIRONMENT, 2012, 通讯作者
（24） LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor, PROTEIN & CELL, 2011, 第 2 作者
（25） The CC and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin a4b7., J Biol Chem., 2011, 通讯作者
（26） α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues, The Journal of Clinical Investigation, 2011, 第 1 作者
（27） LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 通讯作者
（28） Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 第 4 作者
（29） Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction, NATURE CELL BIOLOGY, 2009, 第 5 作者
（30） ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation, NATURE GENETICS, 2008, 第11作者
（31） Biochem Biophys Res Commun, 2008, 
（32） Bone Morphogenetic Protein 1 Processes Prolactin to a 17kDa Anti-Angiogenic Form., Proc Natl Acad Sci U S A., 2007, 第 1 作者
（33） Bone Morphogenetic Protein 1 Prodomain Specifically Binds, Localizes and Regulates Signaling of Bone Morphogenetic Proteins 2 and 4., J Biol Chem, 2007, 第 1 作者
（34） Developmental roles of the BMP1/TLD metalloproteinases., Birth Defects Res C Embryo Today, 2006, 第 1 作者
（35） bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis, MECHANISMS OF DEVELOPMENT, 2006, 第 3 作者
（36） Mammalian Tolloid-like 1 Binds Procollagen C-proteinase Enhancer Protein 1 and Differs from Bone Morphogenetic Protein 1 in the Functional Roles of Homologous Protein Domains, JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 
（37） TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2, BIOCHEMICAL JOURNAL, 2006, 第 1 作者
（38） Inhibition of Bone Morphogenetic Protein 1 by Native and Altered Forms of α2-Macroglobulin, Journal of Biological Chemistry, 2006, 第 2 作者
（39） Cancer Informatics, 2006, 
（40） GDF11 Forms a Bone Morphogenetic Protein 1-Activated Latent Complex That Can Modulate Nerve Growth Factor-Induced Differentiation of PC12 Cells, MOLECULAR AND CELLULAR BIOLOGY, 2005, 
（41） Bone morphogenetic protein-1/Tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 
（42） Activation mechanism of solubilized epidermal growth factor tyrosine kinase., Biochem Biophys Res Commun, 2002, 第 1 作者
（43） Effect of membrane fluidity on tyrosine kinase activity of reconstituted epidermal growth factor receptor, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 

   

（ 1 ） 细胞生长过程细胞骨架可塑性的调控机制, 参与, 国家任务, 2010-01--2014-12
（ 2 ） Lysyl Oxidase在肿瘤转移中的作用机制研究, 负责人, 国家任务, 2010-01--2012-12
（ 3 ） 癌症重大科学问题及防治新策略的研究, 参与, 国家任务, 2009-12--2011-07
（ 4 ） ****, 负责人, 国家任务, 2010-01--2012-12
（ 5 ） 赖氨酸氧化酶的调控与功能研究, 负责人, 国家任务, 2014-01--2017-12
（ 6 ） IV型胶原蛋白在肿瘤发生发展中的功能与机制研究, 负责人, 国家任务, 2015-01--2019-12
（ 7 ） 分子病理表型分析, 负责人, 中国科学院计划, 2015-10--2020-09
（ 8 ） 组织器官生长和尺寸控制的信号基础与感知调控, 参与, 国家任务, 2020-12--2024-12
（ 9 ） Hippo信号通路调控肝星状细胞活化机制研究, 负责人, 国家任务, 2021-01--2024-12

（1）FSP1-positive fibroblasts: adipogenic niche in adult adipose homeostasis   第11届亚洲及泛太平洋结缔组织学术研讨会   2018-11-16
（2）Extracellular matrix remodeling in lung fibrosis and cancer   第15届海峡两岸生物医学学术研讨会   2016-10-17
（3）Minor type IV collagen α5 chain promotes cancer progression through collagen receptor DDR1   2013-11-29
（4）Minor Type IV Collagen a5 Chain Promotes Cancer Progression through Collagen Receptor DDR1   2013-11-05
（5）Lysyl Oxidase in Lung Fibrosis and Cancer   第一届中-欧个体化肿瘤免疫标志物专家学术论坛   2013-09-06
（6）Lysyl Oxidase in Lung Fibrosis and Cancer   2013-07-21
（7）Cancer- An Overhealing Wound: Lysyl Oxidase in Lung Fibrosis and Cancer   第一届肿瘤新生血管和肿瘤微环境国际研讨会   Gaoxiang Ge   2011-05-30
（8）LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular   Gaoxiang Ge   2010-11-12
（9）Activation of TGF-？ Family Growth Factors by BMP-1/Tolloid-like Metalloproteinases   Gaoxiang Ge   2009-10-27
（10）Activation of TGF-β family growth factors by BMP-1/Tolloid-like metalloproteinases   Gaoxiang Ge   2009-09-12
（11）GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells   Gaoxiang Ge   2004-10-11
（12）Activation mechanism of solubilized epidermal growth factor tyrosine kinase.   1   2000-10-21