基本信息
陈剑峰  男  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: jfchen@sibcb.ac.cn
通信地址: 上海岳阳路320号生化楼715
邮政编码:

研究领域

  • 炎症与癌症中细胞粘附分子的功能调控


招生信息

   
招生专业
071009-细胞生物学
招生方向
炎症与癌症中细胞粘附分子的功能调控

教育背景

1996-09--2001-05 中科院上海生化所 博士
1991-09--1996-07 复旦大学 理学学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2007-01~现在, 中科院生化与细胞所,分子细胞科学卓越创新中心, 研究员
2001-09~2006-12,美国哈佛医学院, 博士后

专利与奖励

   
奖励信息
(1) 亮氨酰-tRNA合成酶对底物的识别,二等奖,省级,2008
(2) 氨基酰-tRNA合成酶及其与相关tRNA的相互作用,一等奖,省级,2000
专利成果
[1] 陈剑峰, 林昶东, 李悦. 筛选抑制新型冠状病毒感染的小分子药物的方法及其应用. CN: CN114159445A, 2022-03-11.
[2] 陈剑峰, 张海龙, 郑雅娟. 调控整合素β亚基的试剂和方法. CN: CN113577281A, 2021-11-02.
[3] 陈剑峰, 季红斌, 郑雅娟, 方兆元, 张箭. 利用肠道细菌检测早期肺癌. CN: CN113151512A, 2021-07-23.
[4] 李典范, 李婷婷, 李艳芳, 赖燕玲, 姚贺帮, 蔡洪敏, 劳蒂米, 周冰洁, 赵雅佩, 孟飞龙, 毕玉海, 刘浏, 张宁, 王燕燕, 龚玉环, 陈剑峰, 吴立刚, 许琛琦, 周海生, 陈珺芳, 孔庆鑫, 孙昼, 李钧, 张学潮. :一种抗新型冠状病毒SARS-CoV-2的抗体及其制备方法和用途. 2020114079067, 2020-12-04.

出版信息

   
发表论文
[1] Chen Jianfeng. Lin CD#, Li Y#, Zhang YB#. Liu ZY, Mu X, Gu CJ, Liu J, Li YT, Li GH*, Chen JF*. Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction.. Signal Transduct Tar. 2021, [2] MengYa Yuan, YaoYing Wan, Cui Liu, Yue LiZhaoYuan Liu, ChangDong Lin, JianFeng Chen. Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein-ACE2 interaction. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(6): 1562-1564, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100359/.
[3] 陈剑峰. 继往开来谱新篇,携手共建新时代. 生命的化学[J]. 2020, 40(12): 2119-2119, http://lib.cqvip.com/Qikan/Article/Detail?id=7104156567.
[4] 林昶东, 张有华, Kun, Zhang, YaJuan, Zheng, Ling, Lu, HaiShuang, Chang, Hui, Yang, YanRong, Yang, YaoYing, Wan, ShiHui, Wang, MengYa, Yuan, ZhanJun, Yan, RongGuang, Zhang, YongNing, He, GaoXiang, Ge, Dianqing, Wu, 陈剑峰. 发热通过Hsp90-α4整合素热感应信号通路促进T淋巴细胞迁移. 科学新闻[J]. 2020, 57-57, http://lib.cqvip.com/Qikan/Article/Detail?id=7102181332.
[5] Zheng, Yajuan, Fang, Zhaoyuan, Xue, Yun, Zhang, Jian, Zhu, Junjie, Gao, Renyuan, Yao, Shun, Ye, Yi, Wang, Shihui, Lin, Changdong, Chen, Shiyang, Huang, Hsinyi, Hu, Liang, Jiang, GeNing, Qin, Huanlong, Zhang, Peng, Chen, Jianfeng, Ji, Hongbin. Specific gut microbiome signature predicts the early-stage lung cancer. GUT MICROBES[J]. 2020, 11(4): 1030-1042, http://dx.doi.org/10.1080/19490976.2020.1737487.
[6] MengYa Yuan, YanRong Yang, Yue Li, ZhanJun Yan, ChangDong Lin, JianFeng Chen. Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 8: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767916/.
[7] Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen. A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis. BMC BIOLOGY[J]. 2020, 18(1): 1-15, http://dx.doi.org/10.1186/s12915-020-00784-6.
[8] Lin, ChangDong, Chen, JianFeng. Regulation of immune cell trafficking by febrile temperatures. INTERNATIONAL JOURNAL OF HYPERTHERMIA[J]. 2019, 36: 17-21, https://doaj.org/article/997a03ec3b7a47e48acc5bf697f2309e.
[9] ChangDong Lin, YouHua Zhang, Kun Zhang, YaJuan Zheng, Ling Lu, HaiShuang Chang, Hui Yang, YanRong Yang, YaoYing Wan, ShiHui Wang, MengYa Yuan, ZhanJun Yan, RongGuang Zhang, YongNing He, GaoXiang Ge, Dianqing Wu, JianFeng Chen. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. IMMUNITY. 2019, 50(1): 137-151.e6, http://dx.doi.org/10.1016/j.immuni.2018.11.013.
[10] Ge Gaoxiang. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.. Immunity. 2018, [11] Qian Xiao, Jibo Wu, WeiJia Wang, Shiyang Chen, Yingxia Zheng, Xiaoqing Yu, Katrina Meeth, Mahnaz Sahraei, Alfred L M Bothwell, Lieping Chen, Marcus Bosenberg, Jianfeng Chen, Veronika Sexl, Le Sun, Lin Li, Wenwen Tang, Dianqing Wu. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation. NATURE MEDICINE. 2018, 24(3): 262-270, [12] ShiHui Wang, ChenYu Wu, YueBin Zhang, QingLu Zhong, Hao Sun, WenPeng Cao, GaoXiang Ge, GuoHui Li, X Frank Zhang, JianFeng Chen. Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation. THE JOURNAL OF CELL BIOLOGY. 2018, 217(8): 2799-2812, [13] Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Qinshu Wang, Shutan Jiang, Yan Li, Hongbin Shen, Guohui Li, Jianfeng Chen, Chenqi Xu. Intramembrane ionic protein-lipid interaction regulates integrin structure and function. PLOS BIOLOGY[J]. 2018, 16(11): http://202.127.25.143/handle/331003/3429.
[14] Chen Jianfeng. TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.. J Clin Invest.. 2017, [15] Chen Jianfeng. Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model.. Spine. 2017, [16] Lu, Ling, Lin, ChangDong, Yan, ZhanJun, Wang, Shu, Zhang, YouHua, Wang, ShiHui, Wang, JunLei, Liu, Cui, Chen, JianFeng. Kindlin-3 Is Essential for the Resting alpha 4 beta 1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(19): 10363-10371, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000375602800041.
[17] 张海龙, 路玲, 郑雅娟, 袁萌芽, 陈剑峰. 细胞微环境对免疫细胞黏附与迁移的调控. 生命科学[J]. 2016, 28(2): 239-247, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5657607&detailType=1.
[18] Zhang Youhua, Pan Youdong, Lin Changdong, Zheng Yajuan, Sun Hao, Zhang Hailong, Wang Junlei, Yuan Mengya, Duan Tao, Du Qiaoling, Chen Jianfeng. Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2016, 8(6): 530-541,  http://dx.doi.org/10.1093/jmcb/mjw025.
[19] Xiao, Qian, Jiang, Yan, Liu, Qingbo, Yue, Jiao, Liu, Chunying, Zhao, Xiaotong, Qiao, Yuemei, Ji, Hongbin, Chen, Jianfeng, Ge, Gaoxiang. Minor Type IV Collagen alpha 5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1. PLOS GENETICS[J]. 2015, 11(5): http://dx.doi.org/10.1371/journal.pgen.1005249.
[20] Chen Jianfeng. Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity.. Mucosal Immunol. 2015, [21] Chen Jianfeng. Mechanisms Underlying Integrin Deactivation. Chinese Journal of Cell Biology. 2015, [22] Du, QiaoLing, Pan, YouDong, Zhang, YouHua, Zhang, HaiLong, Zheng, YaJuan, Lu, Ling, Wang, JunLei, Duan, Tao, Chen, JianFeng. Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation. BMC MEDICAL GENOMICS[J]. 2014, 7(1): 42-42, https://www.webofscience.com/wos/woscc/full-record/WOS:000339181200002.
[23] Chen Jianfeng. The hydrophobic contacts between the center of βI domain and α1/α7 helices hold integrin α4β7 in low-affinity state. FEBS J.. 2014, [24] Hao Sun, Jie Liu, YaJuan Zheng, YouDong Pan, Kun Zhang, JianFeng Chen. Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing. DEVELOPMENTAL CELL. 2014, 30(1): 61-70, http://dx.doi.org/10.1016/j.devcel.2014.05.002.
[25] Cheng, Tao, Liu, Qingbo, Zhang, Rui, Zhang, Ying, Chen, Jianfeng, Yu, Ronghuan, Ge, Gaoxiang. Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(6): 506-515, http://lib.cqvip.com/Qikan/Article/Detail?id=664916290.
[26] Chen Jianfeng. Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7. J Cell Sci.. 2013, [27] Jiao Yue, YouDong Pan, LiFang Sun, Kun Zhang, Jie Liu, Ling Lu, JianFeng Chen. The Unique Disulfide Bond-stabilized W1 β4-β1 Loop in the α4 β-Propeller Domain Regulates Integrin α4β7 Affinity and Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2013, 288(20): 14228-14237, http://dx.doi.org/10.1074/jbc.M113.462630.
[28] Yamei Yu, Jianghai Zhu, LiZhi Mi, Thomas Walz, Hao Sun, JianFeng Chen, Timothy A Springer. Structural specializations of α 4 β 7 , an integrin that mediates rolling adhesion. THE JOURNAL OF CELL BIOLOGY. 2012, 196(1): 131-146, [29] Zhang, Kun, Chen, JianFeng. The regulation of integrin function by divalent cations. CELL ADHESION & MIGRATIONnull. 2012, 6(1): 20-29, https://www.webofscience.com/wos/woscc/full-record/WOS:000304611500005.
[30] Chen Jianfeng. Identification, characterization and epitope mapping of a human monoclonal antibody J19 that specifically recognizes the activated integrin a4b7. J Biol Chem.. 2012, [31] Jiao Yue, Kun Zhang, JianFeng Chen. Role of Integrins in Regulating Proteases to Mediate Extracellular Matrix Remodeling. CANCER MICROENVIRONMENT[J]. 2012, 5(3): 275-283, [32] Chen Jianfeng. The mechanism of integrin affinity regulation. Chinese Journal of Cell Biology. 2011, [33] Hao Sun, YuMei Wu, JunPeng Qi, YouDong Pan, Gaoxiang Ge, JianFeng Chen. The CC′ and DE Loops in Ig Domains 1 and 2 of MAdCAM-1 Play Different Roles in MAdCAM-1 Binding to Low- and High-affinity Integrin α4β7. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011, 286(14): 12086-12092, http://dx.doi.org/10.1074/jbc.M110.208900.
[34] Pan, YouDong, Zhang, Kun, Qi, JunPeng, Yue, Jiao, Springer, Timothy A, Chen, JianFeng. Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha(4)beta(7). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2010, 107(50): 21388-21393, http://dx.doi.org/10.1073/pnas.1015487107.
[35] Yongli Shan, Lihou Yu, Yan Li, Youdong Pan, Qiangge Zhang, Fubin Wang, Jianfeng Chen, Xueliang Zhu. Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin. PLOS BIOLOGY[J]. 2009, 7(5): http://dx.doi.org/10.1371/journal.pbio.1000116.
[36] Eun Jeong Park, J Rodrigo Mora, Christopher V Carman, JianFeng Chen, Yoshiteru Sasaki, Guiying Cheng, Ulrich H von Andrian, Motomu Shimaoka. Aberrant activation of integrin α 4 β 7 suppresses lymphocyte migration to the gut. THEJOURNALOFCLINICALINVESTIGATION. 2007, 117(9): 2526-2538, [37] Chen, JianFeng, Yang, Wei, Kim, Minsoo, Carman, Christopher V, Springer, Timothy A. Regulation of outside-in signaling and affinity by the beta(2) I domain of integrin alpha(L)beta(2). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2006, 103(35): 13062-13067, https://www.webofscience.com/wos/woscc/full-record/WOS:000240380800023.
[38] Astrof, Nathan S, Salas, Azucena, Shimaoka, Motomu, Chen, JianFeng, Springer, Timothy A. Importance of force linkage in mechanochemistry of adhesion receptors. BIOCHEMISTRY[J]. 2006, 45(50): 15020-15028, https://www.webofscience.com/wos/woscc/full-record/WOS:000242771000015.
[39] Chen, JF, Takagi, J, Xie, C, Xiao, T, Luo, BH, Springer, TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha(4)beta(7). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2004, 279(53): 55556-55561, https://www.webofscience.com/wos/woscc/full-record/WOS:000225960800072.
[40] Wei Yang, Motomu Shimaoka, JianFeng Chen, Timothy A Springer. Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004, 101(8): 2333-2338, [41] Chen, JF, Salas, A, Springer, TA. Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. NATURE STRUCTURAL BIOLOGY[J]. 2003, 10(12): 995-1001, https://www.webofscience.com/wos/woscc/full-record/WOS:000186725900008.
[42] Chen Jianfeng. Enzymes assembled from Aquifex aeolicus and E. coli leucyl-tRNA synthetases. Biochemistry. 2003, [43] Xu, MG, Chen, JF, Martin, F, Zhao, MW, Eriani, G, Wang, ED. Leucyl-tRNA synthetase consisting of two subunits from hyperthermophilic bacteria Aquifex aeolicus. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2002, 277(44): 41590-41596, [44] Chen Jianfeng. The Effect of Alanine-293 Replacement on the Activity, ATP-Binding, and Editing of E. coli Leucyl-tRNA Synthetase.. Biochemistry. 2001, [45] Zheng, YG, Li, Y, Chen, JF, Jiang, WH, Zhao, GP, Wang, ED. Two novel engineered bacteria for secretory expression of glutaryl 7-amino-cephalosporanic acid acylase. BIOTECHNOLOGY LETTERS[J]. 2001, 23(21): 1781-1787, https://www.webofscience.com/wos/woscc/full-record/WOS:000171801000009.
[46] Chen, JF, Guo, NN, Li, T, Wang, ED, Wang, YL. CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function. BIOCHEMISTRY[J]. 2000, 39(22): 6726-6731, https://www.webofscience.com/wos/woscc/full-record/WOS:000087580500017.
[47] Chen, JF, Wang, ED. Monoamine oxidase.. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2000, 27(5): 504-508, https://www.webofscience.com/wos/woscc/full-record/WOS:000090070600013.
[48] Chen Jianfeng. T7 RNA polymerase transcription of Escherichia coli isoacceptor tRNALeu. Science in China (Series C). 1999, [49] Chen Jianfeng. Post-translational Processing and Subunits Reconstitution in vivo of Cephalosporin Acylase from Pseudomonas sp. 130. Eur J Biochem.. 1999, [50] Chen, JF, Li, Y, Wang, ED, Wang, YL. High-level expression and single-step purification of leucyl-tRNA synthetase from Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION[J]. 1999, 15(1): 115-120, http://dx.doi.org/10.1006/prep.1998.0999.
[51] Chen, JF, Li, Y, Jiang, WH, Yang, YL, Zhao, GP, Wang, ED. Secretory expression of GL-7-ACA acylase in E-coli. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 1998, 30(4): 393-396, https://www.webofscience.com/wos/woscc/full-record/WOS:000075146300016.

科研活动

   
科研项目
( 1 ) 细胞黏附与迁移机理, 主持, 国家级, 2016-01--2020-12
( 2 ) 妊娠期肝内胆汁淤积症高浓度血胆汁酸诱发胎盘炎性反应的机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究, 参与, 国家级, 2014-01--2018-08
( 4 ) 整合素α4β7介导的淋巴细胞运动与信号转导在肠道免疫与炎症中的功能与机制研究, 主持, 国家级, 2013-01--2016-12
( 5 ) 微环境-细胞交互作用诱导细胞迁移的信号转导机理, 参与, 国家级, 2012-01--2016-12
( 6 ) 特异性识别活化型整合素a4b7的抗体筛选及其在炎症性肠病机理研究和治疗中的应用, 主持, 省级, 2012-01--2014-12
( 7 ) 炎症过程中细胞间相互作用的信号转导机制及其应用研究, 主持, 国家级, 2010-01--2014-08
( 8 ) 炎症相关整合素的亲和性动态调节机制及其对细胞运动的影响, 主持, 国家级, 2010-01--2012-12
( 9 ) "****", 主持, 部委级, 2008-01--2012-12
( 10 ) 整合素的结构、功能及其相关的细胞信号网络, 主持, 国家级, 2008-01--2010-12
( 11 ) 炎症相关的整合素亲和性动态调节的机制与功能, 主持, 省级, 2008-08--2010-08
( 12 ) To develop antibodies specifically block active forms of integrin α4β7 and α4β1 for the treatment of autoimmune diseases 诺和诺德 中科院专项研究经费, 主持, 部委级, 2008-01--2010-12
( 13 ) 细胞迁移在炎症、血栓和肿瘤中的作用, 主持, 部委级, 2006-01--2009-12
( 14 ) 个性化药物——基于疾病分子分型的普惠新药研发, 参与, 部委级, 2015-10--2020-12
( 15 ) 细胞间粘附信号对肠道上皮细胞可塑性的调控及机制, 主持, 国家级, 2021-01--2025-12
( 16 ) 肠道免疫细胞迁移定位与激活分化中的新型蛋白质机器, 主持, 国家级, 2020-11--2025-10
( 17 ) 重要器官细胞增殖与分化过程中关键蛋白质机器的动态调控网络及机制, 参与, 国家级, 2020-11--2021-10
( 18 ) 细胞微环境钙离子对淋巴细胞黏附可塑性的调控及其机制研究, 主持, 国家级, 2019-01--2023-12
参与会议
(1)Regulatory T cell depletion in the gut caused by integrin beta7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity   张海龙   2015-05-10
(2)Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing   第五届细胞结构与功能的信号基础研讨会   孙昊   2014-08-08
(3)Role of disulfide bonds in the regulation of integrin functions   全国生化大会   张坤   2012-08-24
(4)The Bistable Regulation of Integrin Affinity and Signaling by Metal Ions   北京第一届肿瘤新生血管及肿瘤微环境国际研讨会   Youdong Pan, Kun Zhang, Timothy A. Springer and JianFeng Chen   2011-05-30
(5)A novel cation-pi interaction regulates ligand binding affinity and signaling of integrin alpha4beta7.   YouDong Pan, Kun Zhang, JunPeng Qi, Jiao Yue, Timothy A. Springer, JianFeng Chen   2010-07-11

指导学生

已指导学生

潘有东  博士研究生  071009-细胞生物学  

现指导学生

齐俊鹏  博士研究生  071009-细胞生物学  

孙昊  博士研究生  071009-细胞生物学  

岳姣  博士研究生  071009-细胞生物学