基本信息
陈剑峰  男  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: jfchen@sibcb.ac.cn
通信地址: 上海岳阳路320号生化楼715
邮政编码:

研究领域

  • 炎症与癌症中细胞粘附分子的功能调控


招生信息

   
招生专业
071009-细胞生物学
招生方向
炎症与癌症中细胞粘附分子的功能调控

教育背景

1996-09--2001-05 中科院上海生化所 博士
1991-09--1996-07 复旦大学 理学学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2007-01~现在, 中科院生化与细胞所,分子细胞科学卓越创新中心, 研究员
2001-09~2006-12,美国哈佛医学院, 博士后

专利与奖励

   
奖励信息
(1) 亮氨酰-tRNA合成酶对底物的识别,二等奖,省级,2008
(2) 氨基酰-tRNA合成酶及其与相关tRNA的相互作用,一等奖,省级,2000

出版信息

   
发表论文
(1) Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein-ACE2 interaction., Cell Mol Immunol, 2021, 通讯作者
(2) Lin CD#, Li Y#, Zhang YB#. Liu ZY, Mu X, Gu CJ, Liu J, Li YT, Li GH*, Chen JF*. Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction., Signal Transduct Tar, 2021, 通讯作者
(3) Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion., Front. Cell Dev. Biol., 2020, 通讯作者
(4) Specific gut microbiome signature predicts the early-stage lung cancer, Gut Microbes, 2020, 通讯作者
(5) A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis., BMC Biol., 2020, 通讯作者
(6) Regulation of immune cell trafficking by febrile temperatures, Int. J. Hyperthermia, 2019, 通讯作者
(7) Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins., Immunity, 2019, 通讯作者
(8) Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation, J Cell Biol., 2018, 通讯作者
(9) DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation., Nature Medcine, 2018, 其他(合作组作者)
(10) Intramembrane ionic protein-lipid interaction regulates integrin structure and function., PLoS Biol, 2018, 通讯作者
(11) TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus., J Clin Invest., 2017, 其他(合作组作者)
(12) Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model., Spine, 2017, 通讯作者
(13) Regulation of immune cell adhesion and migration by cell microenvironments, Chinese Bulletin of Life Sciences, 2016, 通讯作者
(14) Kindlin-3 is essential for resting α4β1 integrin-mediated firm cell adhesion under shear flow conditions, J Biol Chem., 2016, 通讯作者
(15) Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy, J Mol Cell Biol., 2016, 通讯作者
(16) Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity., Mucosal Immunol, 2015, 通讯作者
(17) Minor type IV collagen α5 chain promotes cancer progression through discoidin domain receptor-1, PLOS Genet, 2015, 第 4 作者
(18) Mechanisms Underlying Integrin Deactivation, Chinese Journal of Cell Biology, 2015, 通讯作者
(19) Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation, J Mol Cell Biol., 2014, 第 4 作者
(20) Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation, BMC Med Genomics, 2014, 通讯作者
(21) Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homing, Dev Cell, 2014, 通讯作者
(22) The hydrophobic contacts between the center of βI domain and α1/α7 helices hold integrin α4β7 in low-affinity state, FEBS J., 2014, 通讯作者
(23) Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7, J Cell Sci., 2013, 通讯作者
(24) The unique disulfide bond-stabilized W1 β4-β1 loop in α4 β-propeller domain regulates integrin α4β7 affinity and signaling, J Biol Chem., 2013, 通讯作者
(25) Identification, characterization and epitope mapping of a human monoclonal antibody J19 that specifically recognizes the activated integrin a4b7, J Biol Chem., 2012, 通讯作者
(26) Role of integrins in regulating proteases to mediate extracellular matrix remodeling, Cancer Microenviron., 2012, 通讯作者
(27) Structural specializations of α4β7, an Integrin that Mediates Rolling Adhesion, J. Cell Biol., 2012, 第 4 作者
(28) The regulation of integrin function by divalent cations., Cell Adhes Migr., 2012, 通讯作者
(29) The CC and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin α4β7, J Biol Chem, 2011, 通讯作者
(30) The mechanism of integrin affinity regulation, Chinese Journal of Cell Biology, 2011, 通讯作者
(31) The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin α4β7, J Biol Chem., 2011, 通讯作者
(32) Cation-Pi interaction regulates ligand-binding affinity and signaling of integrin α4β7, Proc. Natl. Acad. Sci. U. S. A, 2010, 通讯作者
(33) Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin, PLoS Biol., 2009, 第 4 作者
(34) Aberrant activation of integrin 47 suppresses lymphocyte migration to the gut., J Clin Invest., 2007, 第 4 作者
(35) Importance of force linkage in mechanochemistry of adhesion receptors, Biochemistry, 2006, 第 4 作者
(36) Regulation of Outside-In Signaling and Affinity by the β I domain of Integrin αLβ2, Proc. Natl. Acad. Sci. U. S. A., 2006, 第 1 作者
(37) The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin α4β7, J Biol Chem., 2004, 第 1 作者
(38) Activation of integrin β subunit I-like domains by one-turn C-terminal α-helix deletions, Proc. Natl. Acad. Sci. U. S. A., 2004, 第 3 作者
(39) Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster, Nature Struct Biol., 2003, 第 1 作者
(40) Enzymes assembled from Aquifex aeolicus and E. coli leucyl-tRNA synthetases, Biochemistry, 2003, 第 3 作者
(41) Leucyl-tRNA synthetase consisting of two subunits from hyperthermophilic bacteria Aquifex aeolicus., J Biol Chem, 2002, 第 1 作者
(42) The Effect of Alanine-293 Replacement on the Activity, ATP-Binding, and Editing of E. coli Leucyl-tRNA Synthetase., Biochemistry, 2001, 第 1 作者
(43) Two novel engineered bacteria for secretory expression of glutaryl 7-amino-cephalosporanic acid acylase, Biotechnology Letters, 2001, 第 3 作者
(44) CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function, Biochemistry, 2000, 第 1 作者
(45) Monoamine Oxidase, Progress in Biochemistry and Biophysics, 2000, 第 1 作者
(46) High-level expression and single-step purification of leucyl-tRNA synthetase from Escherichia coli., Protein Expres Purif., 1999, 第 1 作者
(47) Post-translational Processing and Subunits Reconstitution in vivo of Cephalosporin Acylase from Pseudomonas sp. 130, Eur J Biochem., 1999, 第 2 作者
(48) T7 RNA polymerase transcription of Escherichia coli isoacceptor tRNALeu, Science in China (Series C), 1999, 第 2 作者
(49) Secretory Expression of GL-7-ACA Acylase in E. coli., Acta Biochimica et Biophysica Sinica., 1998, 第 1 作者

科研活动

   
科研项目
( 1 ) 细胞黏附与迁移机理, 主持, 国家级, 2016-01--2020-12
( 2 ) 妊娠期肝内胆汁淤积症高浓度血胆汁酸诱发胎盘炎性反应的机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究, 参与, 国家级, 2014-01--2018-08
( 4 ) 整合素α4β7介导的淋巴细胞运动与信号转导在肠道免疫与炎症中的功能与机制研究, 主持, 国家级, 2013-01--2016-12
( 5 ) 微环境-细胞交互作用诱导细胞迁移的信号转导机理, 参与, 国家级, 2012-01--2016-12
( 6 ) 特异性识别活化型整合素a4b7的抗体筛选及其在炎症性肠病机理研究和治疗中的应用, 主持, 省级, 2012-01--2014-12
( 7 ) 炎症过程中细胞间相互作用的信号转导机制及其应用研究, 主持, 国家级, 2010-01--2014-08
( 8 ) 炎症相关整合素的亲和性动态调节机制及其对细胞运动的影响, 主持, 国家级, 2010-01--2012-12
( 9 ) "****", 主持, 部委级, 2008-01--2012-12
( 10 ) 整合素的结构、功能及其相关的细胞信号网络, 主持, 国家级, 2008-01--2010-12
( 11 ) 炎症相关的整合素亲和性动态调节的机制与功能, 主持, 省级, 2008-08--2010-08
( 12 ) To develop antibodies specifically block active forms of integrin α4β7 and α4β1 for the treatment of autoimmune diseases 诺和诺德 中科院专项研究经费, 主持, 部委级, 2008-01--2010-12
( 13 ) 细胞迁移在炎症、血栓和肿瘤中的作用, 主持, 部委级, 2006-01--2009-12
( 14 ) 个性化药物——基于疾病分子分型的普惠新药研发, 参与, 部委级, 2015-10--2020-12
( 15 ) 细胞间粘附信号对肠道上皮细胞可塑性的调控及机制, 主持, 国家级, 2021-01--2025-12
( 16 ) 肠道免疫细胞迁移定位与激活分化中的新型蛋白质机器, 主持, 国家级, 2020-11--2025-10
( 17 ) 重要器官细胞增殖与分化过程中关键蛋白质机器的动态调控网络及机制, 参与, 国家级, 2020-11--2021-10
( 18 ) 细胞微环境钙离子对淋巴细胞黏附可塑性的调控及其机制研究, 主持, 国家级, 2019-01--2023-12
参与会议
(1)Regulatory T cell depletion in the gut caused by integrin beta7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity   张海龙   2015-05-10
(2)Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing   第五届细胞结构与功能的信号基础研讨会   孙昊   2014-08-08
(3)Role of disulfide bonds in the regulation of integrin functions   全国生化大会   张坤   2012-08-24
(4)The Bistable Regulation of Integrin Affinity and Signaling by Metal Ions   北京第一届肿瘤新生血管及肿瘤微环境国际研讨会   Youdong Pan, Kun Zhang, Timothy A. Springer and JianFeng Chen   2011-05-30
(5)A novel cation-pi interaction regulates ligand binding affinity and signaling of integrin alpha4beta7.   YouDong Pan, Kun Zhang, JunPeng Qi, Jiao Yue, Timothy A. Springer, JianFeng Chen   2010-07-11

指导学生

已指导学生

潘有东  博士研究生  071009-细胞生物学  

现指导学生

齐俊鹏  博士研究生  071009-细胞生物学  

孙昊  博士研究生  071009-细胞生物学  

岳姣  博士研究生  071009-细胞生物学